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Diabetic ulcer foot

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https://www.readbyqxmd.com/read/28430667/investigating-point-to-point-emissivity-variation-of-wounded-tissue
#1
Ellen Keenan, Georgina Gethin, Louisa Flynn, David Watterson, Gerard O'Connor
Infrared cameras are becoming increasingly popular in clinical applications as they allow fast, non-contact temperature measurements. As abnormal heat distribution can indicate illness, infrared cameras have been applied in the prediction, diagnosis and monitoring of conditions (Lahiri, Bagavathiappan, Jayakumar, & Philip, 2012). Current practices, however, often overlook the importance of emissivity when taking thermal measurements. The consensus is that human skin has an emissivity of 0.98 (Soerensen et al...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28424173/association-between-estimated-glomerular-filtration-rate-and-outcomes-in-patients-with-diabetic-foot-ulcers-a-3-year-follow-up-study
#2
Yang He, Hongjie Qian, Lei Xu, Shanshan Zhang, Xueming Gu, Junyi Gu, Jianyuan Shi, Yaping Shen, Jian-Min Liu, Zhengyi Tang
OBJECTIVE: End stage renal disease and dialysis have been proven to be associated with poor prognoses in diabetic foot ulcers (DFU). However, it has rarely been reported whether and to what extent milder renal insufficiency effects the prognosis. The purpose of this study was to investigate the categorized impact of estimated glomerular filtration (eGFR) on the outcomes of patients with DFU. DESIGN AND METHODS: Three hundred and sixty-six DFU patients hospitalized in a Chinese tertiary hospital were recruited and classified into 4 groups according to the eGFRs as follows: normal (≥90), mildly reduced (60-89), moderately reduced (30-59), and severely reduced (<30)...
April 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28423369/mdi-301-a-synthetic-retinoid-depressed-levels-of-matrix-metalloproteinases-and-oxidative-stress-in-diabetic-dermal-fibroblasts
#3
Jianhua Zhai, Yuli Wang
Diabetic foot ulcerations could result in serious consequences such as amputations. The up-regulation of matrix metalloproteinases and down-regulation of TIMP1 were remarked as distinctive biological characteristics in the diabetic dermal fibroblast. The current study was performed in order to clarify the effect of high glucose on formation of diabetic dermal fibroblast cell. In addition, the effect of MDI 301 on ameliorating diabetic fibroblasts was investigated in this study. The mRNA and protein expression levels of MMPs, TIMP1 and catalase were evaluated against fibroblasts treated with high glucose (30 mM) using qRT-PCR, western blotting and zymography assays...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420258/lace-up-for-healthy-feet-the-impact-of-shoe-closure-on-plantar-stress-response
#4
Hadi Rahemi, David G Armstrong, Ana Enriquez, Joshua Owl, Talal K Talal, Bijan Najafi
OBJECTIVE: This study examined the impact of shoe closure on plantar thermal stress response (TSR), which is known to be a surrogate of shear stress and skin perfusion. It is aimed to explore potential impact of shoe closure on increasing risk factors associated with plantar ulcers in people with diabetic peripheral neuropathy (DPN). METHODS: Fifteen eligible subjects were enrolled. The left foot was used as a reference and fitted to a self-adjusted and habitual lace-tightening method by each subject...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28413186/the-characterization-of-a-full-thickness-excision-open-foot-wound-model-in-n5-streptozotocin-stz-induced-type-2-diabetic-rats-that-mimics-diabetic-foot-ulcer-in-terms-of-reduced-blood-circulation-higher-c-reactive-protein-elevated-inflammation-and-reduced-cell
#5
Caroline Oi-Ling Yu, Kwok-Sui Leung, Kwok-Pui Fung, Francis Fu-Yuen Lam, Ethel Sau-Kuen Ng, Kit-Man Lau, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Delayed foot wound healing is a major complication attributed to hyperglycemia in type 2 diabetes mellitus (DM) patients, and these wounds may develop into foot ulcers. There are at least two types of DM wound models used in rodents to study delayed wound healing. However, clinically relevant animal models are not common. Most models use type 1 DM rodents or wounds created on the back rather than on the foot. An open full-thickness excision wound on the footpad of type 2 DM rats is more clinically relevant, but such a model has not yet been characterized systematically...
April 11, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28409210/how-common-are-foot-problems-among-individuals-with-diabetes-diabetic-foot-ulcers-in-the-dutch-population
#6
Robert M Stoekenbroek, Joost L C Lokin, Mark M Nielen, Erik S G Stroes, Mark J W Koelemay
AIMS/HYPOTHESIS: Contemporary data on diabetic foot ulcer prevalence are scarce. Most studies were conducted in the 1990s, reporting incidence rates of 1.9-2.6%. Since then the prevalence of diabetes has doubled and the organisation of diabetes care has undergone major changes. Up-to-date data that quantify the occurrence of diabetic foot ulcers are required and could serve as baseline measures for future studies. METHODS: Individuals with diabetes (n = 81,793) were identified from the NIVEL (Netherlands institute for health services research) Primary Care Database, which contains data for standardised routine care and is representative of the Dutch population...
April 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28402558/effect-of-cadexomer-iodine-on-the-microbial-load-and-diversity-of-chronic-non-healing-diabetic-foot-ulcers-complicated-by-biofilm-in-vivo
#7
M Malone, K Johani, S O Jensen, I B Gosbell, H G Dickson, S McLennan, H Hu, K Vickery
Objectives: The performance of cadexomer iodine was determined against microbial populations from chronic non-healing diabetic foot ulcers (DFUs) complicated by biofilm in vivo , using molecular, microscopy and zymography methods. Methods: Chronic non-healing DFUs due to suspected biofilm involvement were eligible for enrolment. DNA sequencing and real-time quantitative PCR was used to determine the microbial load and diversity of tissue punch biopsies obtained pre- and post-treatment...
April 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28395911/a-predictive-model-of-anxiety-and-depression-symptoms-after-a-lower-limb-amputation
#8
Susana Pedras, Rui Carvalho, M Graça Pereira
BACKGROUND: Patients with Diabetic Foot Ulcer (DFU) show high levels of depression and anxiety symptoms. The loss of a limb is undoubtedly a devastating experience and several studies have shown that anxiety and depression symptoms are a common reaction after a lower limb amputation (LLA). However, no study has focused on the immediate emotional reactions to LLA as a personal factor based on the ICF Model. OBJECTIVE: This study focused on the characterization of anxiety and depression levels, before and after surgery, differences in levels of depression and anxiety before and after surgery and the predictors of anxiety and depression one month after surgery, in a sample of patients with DFU...
March 27, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28395131/the-effects-of-zinc-supplementation-on-wound-healing-and-metabolic-status-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#9
Mansooreh Momen-Heravi, Elham Barahimi, Reza Razzaghi, Fereshteh Bahmani, Hamidreza Gilasi, Zatollah Asemi
This study was performed to determine the effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer. The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 40-85 years old) with grade 3 diabetic foot ulcer. Participants were randomly divided into two groups (30 participants in each group) to take either 220 mg zinc sulfate supplements containing 50 mg elemental zinc or placebo daily for 12 weeks. After the 12-week intervention, compared with the placebo, zinc supplementation was associated with significant reductions in ulcer length (-1...
April 10, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28394682/combined-treatment-of-diabetic-foot-ulcer-with-tarsal-tunnel-release-and-perilesional-injections-of-peripheral-blood-mononuclear-cells
#10
Emilio Trignano, Nefer Fallico, Gino Zingone, Corrado Rubino, Fabio Santanelli Di Pompeo, Gian Vittorio Campus
No abstract text is available yet for this article.
March 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28393586/evaluation-of-glycated-albumin-ga-and-ga-hba1c-ratio-for-diagnosis-of-diabetes-and-glycemic-control-a-comprehensive-review
#11
Sara Yazdanpanah, Mohammad Rabiee, Mohammadreza Tahriri, Mojgan Abdolrahim, Asadollah Rajab, Hossein E Jazayeri, Lobat Tayebi
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and non-ketotic hyperosmolar coma. In addition, possible long-term complications include impotence, nerve damage, stroke, chronic kidney failure, cardiovascular disease, foot ulcers, and retinopathy. Historically, universal methods to measure glycemic control for the diagnosis of diabetes included fasting plasma glucose level (FPG), 2-h plasma glucose (2HP), and random plasma glucose...
April 10, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28388680/association-between-diabetic-foot-ulcer-and-diabetic-retinopathy
#12
Duck Jin Hwang, Kyoung Min Lee, Moon Seok Park, Sung Hee Choi, Ji In Park, Joon Hee Cho, Kyu Hyung Park, Se Joon Woo
PURPOSE: We aimed to investigate the prevalence of diabetic retinopathy (DR) in patients with diabetic foot ulcer (DFU) and elucidate the association between DR and DFU severities and their shared risk factors. METHODS: A retrospective review was conducted on DFU patients who underwent ophthalmic and vascular examinations within 6 months; 100 type 2 diabetic patients with DFU were included. The medical records of 2496 type 2 diabetic patients without DFU served as control data...
2017: PloS One
https://www.readbyqxmd.com/read/28387580/the-effects-of-social-support-and-hope-in-the-healing-of-diabetic-foot-ulcers-treated-with-standard-care
#13
Ayfer Peker, Süreyya Karaöz
No abstract text is available yet for this article.
April 7, 2017: Population Health Management
https://www.readbyqxmd.com/read/28386568/mesenchymal-stem-cells-improve-healing-of-diabetic-foot-ulcer
#14
REVIEW
Yue Cao, Xiaokun Gang, Chenglin Sun, Guixia Wang
Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28379102/cost-of-illness-studies-in-chronic-ulcers-a-systematic-review
#15
B Chan, S Cadarette, W Wodchis, J Wong, N Mittmann, M Krahn
OBJECTIVE: To systematically review the published academic literature on the cost of chronic ulcers. METHODS: A literature search was conducted in MEDLINE, EMBASE, HealthSTAR, Econlit and CINAHL up to 12 May 2016 to identify potential studies for review. Cost search terms were based on validated algorithms. Clinical search terms were based on recent Cochrane reviews of interventions for chronic ulcers. Titles and abstracts were screened by two reviewers to determine eligibility for full text review...
April 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28378156/a-randomized-open-label-controlled-trial-to-evaluate-the-antimicrobial-and-surgical-effect-of-co2-laser-treatment-in-diabetic-infected-foot-ulcers-dulcis-diabetic-ulcer-co2-laser-and-infections-study
#16
M Monami, A Scatena, S Zannoni, S Aleffi, C Mirabella, L Giannoni, E Mannucci
AIM: Debridement of fibrin and necrotic tissue from the ulcer surface is an important component of the treatment of diabetic ulcers. A possible alternative to standard lancets is represented by CO2 laser, which vaporizes necrotic tissues together with any pathogen. The present trial is aimed at verifying the effect of a CO2 laser on bacterial load in the debridement of infected diabetic foot ulcers. METHODS: In this open-label randomized controlled trial (NCT02677779), patients with diabetes and an infected foot ulcers were randomized to either CO2 laser or traditional debridement...
April 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28374714/-assessment-of-changes-in-the-lesions-sizes-and-the-incidence-of-complete-epithelialization-during-the-treatment-of-diabetic-foot-syndrome-over-a-period-of-4-weeks-multicenter-study
#17
V A Stupin, E V Silina, S V Goryunov, V A Gorsky, V T Krivikhin, M S Bogomolov, E R Barantsevich, K A Koreiba
AIM: To assess the effectiveness of the collagen biomaterial in treatment process in patients with DFS. MATERIAL AND METHODS: 71 patients 30-80 y.o. with diabetic foot syndrome of varying severity were included in prospective multicenter study. Patients were randomized into two homogeneous groups: control group (n=35) - standard therapy, other 36 patients (main group) were additionally treated with medical device (MD) Collost in accordance with the instructions for use...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28371685/angiogenic-effects-of-low-intensity-cathodal-direct-current-on-ischemic-diabetic-foot-ulcers-a-randomized-controlled-trial
#18
Mohammad Reza Asadi, Giti Torkaman, Mehdi Hedayati, Mohammad Reza Mohajeri-Tehrani, Mousa Ahmadi, Roghieh Fathi Gohardani
AIMS: This study investigated the effect of low-intensity cathodal direct current (CDC) of electrical stimulation (ES) on the release of hypoxic inducible factor-1α (HIF-1α), nitric oxide (NO), vascular endothelial growth factor (VEGF), and soluble VEGF receptor-2 (sVEGFR-2) in the wound fluid of ischemic diabetic foot ulcers (DFUs). METHODS: This study was a randomized, single-blind, placebo-controlled trial. Thirty type 2 diabetes patients with ischemic foot ulcerations were randomly assigned to receive either low-intensity CDC at sensory threshold (ES group, n=15) or placebo treatment (control group, n=15) for 1h/day, 3days/week, for 4weeks (12 sessions)...
March 21, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28370839/recurrent-and-other-new-foot-ulcers-after-healed-plantar-forefoot-diabetic-ulcer
#19
Hedvig Örneholm, Jan Apelqvist, Jan Larsson, Magnus Eneroth
Diabetic foot ulcer is a serious complication in patients with diabetes. In most outcome studies of this condition, there is a combination of various types of ulcer and ulcer locations. Plantar ulcers are usually localized to the forefoot, and constitute a quarter of all diabetic foot ulcers. There are a limited number of studies regarding development of new ulcers following healing of a plantar forefoot ulcer, and there are no uniform definitions of recurrent and other new ulcers. The aim of this study was to evaluate the outcome of a large cohort of consecutively treated patients with diabetes mellitus and a healed planter forefoot ulcer (n=617) with regard to development, characteristics, and outcome of recurrent and other new ulcers...
April 1, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28361041/decrease-of-staphylococcus-aureus-virulence-by-helcococcus-kunzii-in-a-caenorhabditis-elegans-model
#20
Christelle Ngba Essebe, Orane Visvikis, Marguerite Fines-Guyon, Anne Vergne, Vincent Cattoir, Alain Lecoustumier, Emmanuel Lemichez, Albert Sotto, Jean-Philippe Lavigne, Catherine Dunyach-Remy
Social bacterial interactions are considered essential in numerous infectious diseases, particularly in wounds. Foot ulcers are a common complication in diabetic patients and these ulcers become frequently infected. This infection is usually polymicrobial promoting cell-to-cell communications. Staphylococcus aureus is the most prevalent pathogen isolated. Its association with Helcococcus kunzii, commensal Gram-positive cocci, is frequently described. The aim of this study was to assess the impact of co-infection on virulence of both H...
2017: Frontiers in Cellular and Infection Microbiology
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