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intra venous iron

Andrew M Prantner, Catherine Yin, Kalika Kamat, Khushboo Sharma, Andrew C Lowenthal, Peter B Madrid, Nathalie Scholler
Mesothelin is an epithelial marker highly expressed at the cell surface of cancer cells from diverse origins, including ovarian and pancreatic adenocarcinomas and mesotheliomas. Previously, we identified and characterized an antimesothelin nanobody (NbG3a) for in vitro diagnostic applications. The main goal of this research was to establish the potential of NbG3a as a molecular imaging agent. Site-specific biotinylated NbG3a (bNbG3a) was bound to streptavidin-conjugated reagents for in vitro and in vivo assays...
April 2, 2018: Molecular Pharmaceutics
Dhruvan Patel, Chinmay Trivedi, Nabeel Khan
PURPOSE OF REVIEW: Anemia is the most common complication as well as an extra intestinal manifestation of inflammatory bowel disease (IBD). It is associated with a significant impact on patient's quality of life (QoL); as well it represents a common cause of frequent hospitalization, delay of hospital inpatient discharge and overall increased healthcare burden. In spite of all these, anemia is still often underdiagnosed and undertreated. Our aim in this review is to provide a pathway for physicians to help them achieve early diagnosis as well as timely and appropriate treatment of anemia which in turn would hopefully reduce the prevalence and subsequent complications of this condition among IBD patients...
March 2018: Current Treatment Options in Gastroenterology
Sree Chandana Damineni, Suchitra Thunga
INTRODUCTION: Iron deficiency is the most common cause of Post-partum anaemia, reported as 50-60% in India. It is primarily due to inadequate iron intake and due to peripartum blood loss. It has been associated with significant post-partum complications. Therefore, Post-partum iron deficiency warrants greater attention and higher quality care. Oral iron treatment has been considered the standard of care. However, parenteral iron treatment is expected to be advantageous in cases where oral iron therapy is not possible...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
Takehiko Doi, Natsuko Masumoto, Motoshi Sonoda, Hideki Nakayama, Yuji Mizuno
Blue rubber bleb nevus syndrome (BRBNS) involves cutaneous vascular malformation characterized by multiple venous malformations. This commonly affects the skin and gastrointestinal tract. BRBNS is associated with anemia and occasionally involves orthopedic manifestations. A 6-year-old boy was referred to hospital for evaluation of anemia. He presented with a rubber-like soft-tissue mass in the left knee and the right side of the neck, recurrent pain, and fixed flexion contracture of the knee. Blood examination indicated consumption coagulopathy and anemia caused by not only iron-deficiency anemia but also microangiopathy...
August 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Steven P Grover, Prakash Saha, Julia Jenkins, Arun Mukkavilli, Oliver T Lyons, Ashish S Patel, Kavitha Sunassee, Bijan Modarai, Alberto Smith
INTRODUCTION: The assessment of thrombus size following treatments directed at preventing thrombosis or enhancing its resolution has generally relied on physical or histological methods. This cross-sectional design imposes the need for increased numbers of animals for experiments. Micro-computed tomography (microCT) has been used to detect the presence of venous thrombus in experimental models but has yet to be used in a quantitative manner. In this study, we investigate the use of contrast-enhanced microCT for the longitudinal assessment of experimental venous thrombus resolution...
December 2015: Thrombosis Research
T P Gwetu, M K Chhagan
BACKGROUND: The prevalence of anaemia in school-aged children is reported to be high (>10%), yet neither the onset of anaemia nor the disease causing it is easily established. Any form of anaemia, even if mild, can compromise children's health and survival. This study was conducted to generate data to support or reject use of the HemoCue device as a potential point-of-care method for haemoglobin (Hb) assessment in field and primary healthcare settings. OBJECTIVE: To assess the validity of the HemoCue in relation to the gold-standard laboratory method...
July 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
C B Dogaru, C Capusa, L Gaman, E Torac, D Lixandru, M Gilca, L Iosif, C Muscurel, I Stoian, G Mircescu, V Atanasiu
Introduction Intravenous iron administration in patients treated by haemodialysis for end stage renal disease can exacerbate oxidative stress by increasing the level of free redox active iron. A way to reduce the impact of iron on oxidative stress in haemodialysis patients may be the administration of iron through arterial extracorporeal circuit. Objective The aim of our study was to compare the influence of iron route of administration (venous versus arterial extracorporeal circuit infusion) on antioxidant parameters in red blood cells of haemodialysis patients in order to clarify if arterial iron administration can have positive impacts related to iron induced oxidative stress...
2015: Journal of Medicine and Life
Shobha Prakash, Kunaal Dhingra, Shanmuga Priya
OBJECTIVE: There are conflicting reports in the past literature documenting the tendency of anemia in patients with periodontitis. Hence, this study was undertaken to assess whether periodontitis may cause an anemic state, by evaluating and comparing the red blood cell count, levels of hemoglobin, hematocrit, erythrocyte sedimentation rate (ESR), serum iron and serum ferritin between subjects with and without periodontitis. METHODS: In this cross-sectional study, 140 systemically healthy subjects of both sexes (mean age 46 years) were recruited as control group (50 subjects without periodontitis) and study groups comprising 30 patients each with mild, moderate and severe chronic generalized periodontitis...
July 2012: European Journal of Dentistry
Hitoshi Maruyama, Hiroyuki Ishibashi, Masanori Takahashi, Taro Shimada, Hidehiro Kamesaki, Osamu Yokosuka
OBJECTIVE: To examine whether intra-thrombus enhancement on contrast-enhanced sonograms can predict the recanalization by anticoagulation for recent portal thrombosis. METHODS: This prospective study included 10 patients with a recent portal thrombosis and 20 controls (10 cirrhosis patients and 10 healthy subjects, all without thrombosis). The diagnosis of thrombosis was based on clinical and ultrasound findings. Pre-anticoagulation intra-thrombus enhancement on the contrast-enhanced sonogram was examined with respect to the post-anticoagulation results or portal enhancement in controls...
June 2012: Abdominal Imaging
Yuji Uchikawa, Hiroshi Kitamura, Shin-ichi Miyagawa
PURPOSE: We report two cases in which portal blood flow via the peribiliary vascular plexus (PBP) was clearly demonstrated using contrast-enhanced intra-operative ultrasonography (CE-IOUS). METHODS: Two patients who underwent hemihepatectomies were investigated using CE-IOUS. Before injection of the contrast medium, both the hepatic arterial and portal venous flows of the hemiliver to be resected were interrupted by ligating those corresponding vessels at the hepatic hilum...
July 2011: Journal of Hepato-biliary-pancreatic Sciences
Chris Karlovich, Guillemette Duchateau-Nguyen, Andrea Johnson, Patricia McLoughlin, Mercidita Navarro, Carole Fleurbaey, Lori Steiner, Michel Tessier, Tracy Nguyen, Monika Wilhelm-Seiler, John P Caulfield
BACKGROUND: The use of gene expression in venous blood either as a pharmacodynamic marker in clinical trials of drugs or as a diagnostic test requires knowledge of the variability in expression over time in healthy volunteers. Here we defined a normal range of gene expression over 6 months in the blood of four cohorts of healthy men and women who were stratified by age (22-55 years and > 55 years) and gender. METHODS: Eleven immunomodulatory genes likely to play important roles in inflammatory conditions such as rheumatoid arthritis and infection in addition to four genes typically used as reference genes were examined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), as well as the full genome as represented by Affymetrix HG U133 Plus 2...
2009: BMC Medical Genomics
Ilse Pynaert, Dirk De Bacquer, Christophe Matthys, Joris Delanghe, Marleen Temmerman, Guy De Backer, Stefaan De Henauw
OBJECTIVE: To investigate associations between nutritional and non-nutritional variables and Fe status parameters, i.e. serum ferritin and soluble transferrin receptors (sTfR). DESIGN: Cross-sectional design. Fe status parameters were determined on a fasting venous blood sample. Nutritional variables were assessed using a 2 d food record and non-nutritional variables by a general questionnaire. A general linear model was used to investigate associations between the variables and Fe status parameters...
October 2009: Public Health Nutrition
No abstract text is available yet for this article.
April 23, 1949: Lancet
Mirjana Lausević, Vidosava Nesić, Natasa Jovanović, Biljana Stojimirović
A normocytic normochromic anemia is one of the first signs of renal failure. Since anemia increases morbidity and mortality, its elimination is one of the essential objectives of the treatment. Human recombinant erythropoietin (rHuEPO) has changed the therapeutical approach to anemia. The aim of the present study was to compare efficacy of anemia correction in peritoneal dialysis patients depending on treatment and dialysis modality. The study is the retrospective analysis of 64 patients who presented to our Clinic in 2003...
March 2006: Srpski Arhiv za Celokupno Lekarstvo
Luigi Grazioli, Giovanni Morana, Miles A Kirchin, Paolo Caccia, Laura Romanini, Maria P Bondioni, Carlo Procacci, Antonio Chiesa
PURPOSE: To compare the efficacy of two different MR contrast agents for the detection and diagnosis of focal nodular hyperplasia (FNH). MATERIALS AND METHODS: Fifty patients with 83 FNH lesions detected on spiral CT were studied in two different MRI sessions with Gd-BOPTA (MultiHance) and ferumoxides (Endorem). MRI with Gd-BOPTA was performed precontrast (T1wGRE and T2wTSE sequences) and during the dynamic and late (1-3 hours) phases after injection (T1wGRE sequences only)...
May 2003: Journal of Magnetic Resonance Imaging: JMRI
S J Duffy, E S Biegelsen, M Holbrook, J D Russell, N Gokce, J F Keaney, J A Vita
BACKGROUND: Some epidemiological studies have shown that increased iron stores are associated with increased cardiovascular events. Redox-active iron may contribute to lipid peroxidation, endothelial cell activation, and generation of reactive oxygen species (especially hydroxyl radical, via Fenton chemistry). Increased oxidative stress is associated with impaired action of endothelium-derived nitric oxide in patients with atherosclerosis. METHODS AND RESULTS: To test the hypothesis that reducing vascular iron stores would reverse endothelial dysfunction, we examined the effects of the iron chelator deferoxamine (500 mg intra-arterially over 1 hour) on vasomotor function in forearm resistance vessels of patients with coronary artery disease by venous occlusion plethysmography...
June 12, 2001: Circulation
M Rudin, N Beckmann, A Sauter
Determination of tissue perfusion rates by MRI bolus tracking methods relies on the central volume principle which states that tissue blood flow is given by the tissue blood volume divided by the mean tracer transit time (MTT). Accurate determination of the MTT requires knowledge of the arterial input function which in MRI experiments is usually not known, especially when using small animals. The problem of unknown arterial input can be circumvented in animal experiments by directly injecting the contrast agent into a feeding artery of the tissue of interest...
1997: Magnetic Resonance Imaging
C L Marsh, P H Lange
Surgical approaches used in orthotopic liver transplantation and for multiorgan procurement have been applied to urological cases involving the upper abdomen and retroperitoneum. The method uses the liver transplant incision (bilateral subcostal incision with a cephalad T extension) in combination with a surgical retraction system (Iron Intern and Olivier retractors), providing access for control of the liver and great vessels, and excellent exposure necessary for most difficult urological cases. The incision can be extended if necessary to the lower abdomen or chest...
June 1994: Journal of Urology
M Valenti, R Bergia, E Caramello, P Dionisio, F Nerva, M Graziola, E Lanza, P Bajardi
In forty-nine patients on regular dialysis treatment (RDT) we evaluated following parameters for a period of twenty-four months: serum ferritin (SF), transferrin, T.I.B.C. percental saturation (Fe/TIBC%), haemoglobin (Hb). Twenty-five patients had received more than 5 g intra-venous iron or several blood transfusions, before the beginning of the study, while the other twenty four patients had never received iron treatment nor transfusions. Serum ferritin and Fe/TIBC% proved to be a good estimate of iron stores in RDT patients...
September 22, 1986: Minerva Medica
D L Johnston, R Rokey, R D Okada
Nuclear magnetic resonance (NMR) imaging provides a noninvasive method of detecting and characterizing several clinically important cardiac diseases. These include hypertrophic cardiomyopathy, several congenital disorders, especially those with abnormalities of the surrounding great vessels and those with surgical shunts in place, intra and extra cardiac masses and constrictive pericarditis. NMR imaging is becoming useful in the visualization of aortic disease, particular for the serial management of coarctation, and for the diagnosis of thoracic and abdominal aneurysms and dissections...
February 1987: Herz
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