Xiaoting Shi, Jinwen Liu, Ze Lu, Jiabo Li, Shuwei Zhang, Qian Li, Fengxue Geng, Yaping Pan
OBJECTIVES: This study aims to clarify the effect of ferroptosis by P. gingivalis on periodontal epithelium impairment and potential mechanisms. MATERIALS AND METHODS: The expression of epithelial junction proteins (CDH1, OCLN, ZO-1), FTL and GPX4 in healthy and periodontitis tissues was analyzed using bioinformatics analysis and validated in vivo. An in vitro model was constructed to evaluate ferroptosis by mitochondria morphology, content of iron and GSH, and level of lipid peroxidation, FTL, GPX4 and SLC7A11...
2024: Journal of Oral Microbiology