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https://www.readbyqxmd.com/read/29329266/relative-validity-of-a-24-h-recall-in-assessing-intake-of-key-nutrients-in-a-cohort-of-australian-toddlers
#1
Elizabeth Beaton, Janine Wright, Gemma Devenish, Loc Do, Jane Scott
There is limited information concerning the dietary intake of toddlers in Australia. Consequently, there is a need for studies investigating toddler intake that use dietary assessment measures that are valid and place a low participant burden on caregivers. The aim of this study was to determine the relative validity of a single 24-h dietary recall (24HR) in measuring the intake of five nutrients in a cohort of Australian toddlers compared to a combined 24HR and 2-day estimated food record (2DFR). A single 24HR and a 2DFR were collected from a cohort of Australian toddlers (n = 699) at approximately 12 months of age as part of the Study of Mothers' and Infants' Life Events affecting oral health (SMILE) project...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29328981/a-simple-lc-ms-ms-method-for-determination-of-deferasirox-in-human-plasma-troubleshooting-of-interference-from-ferric-ion-in-method-development-and-its-application
#2
Tengfei Li, Zhimin Cui, Yan Wang, Wen Yang, Duo Li, QinXin Song, Luning Sun, Li Ding
As an orally active iron chelator, deferasirox forms its ion complexes in the prepared plasma samples and LC-MS mobile phase where ferric ion exists, and then comparing with the nominal concentration level, a lower detected concentration level of deferasirox would be obtained after LC-MS analysis, if no proper treatment was adopted. Meanwhile, the phenomenon would be observed that multiple repeat injections of the same deferasirox plasma sample in the same tube would show the lower and lower detected concentration levels of deferasirox, which caused by more and more ferric ions from the injection needle dissolved in the sample solution as multiple repeated injections...
December 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29327182/changes-in-iron-absorption-after-roux-en-y-gastric-bypass
#3
Wendy Schijns, Marjolein A P Ligthart, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Edo O Aarts, Hans de Boer
INTRODUCTION: Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency. AIM: The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution. METHOD: Iron absorption in 24 obese women was studied before and 1 month after RYGB...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29323436/molecular-characterization-and-gene-silencing-of-laccase-1-in-the-grain-aphid-sitobion-avenae
#4
Yong Zhang, Jia Fan, Frédéric Francis, Julian Chen
Laccase 1 (Lac1), a polyphenol oxidase, has been proposed to be involved in insect iron metabolism and immunity responses. However, little information is available on the roles of Lac 1 in insect-plant interactions. The grain aphid Sitobion avenae is one of the most destructive pests of cereal, directly drawing phloem sap and transmitting viruses. In the present study, we first cloned the open reading frame (ORF) of Lac 1 from S. avenae, and the putative protein sequence was predicted to have a carboxyl-terminal transmembrane domain...
January 11, 2018: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29323384/tracking-iron-associated-proteomes-in-pathogens-by-a-fluorescence-approach
#5
Nan Jiang, Tianfan Cheng, Minji Wang, Godfrey Chi-Fung Chan, Lijian Jin, Hongyan Li, Hongzhe Sun
Porphyromonas gingivalis is a key oral anaerobic bacterium involved in human periodontitis, which may affect up to 15% adults worldwide. Using the membrane permeable fluorescent probe Fe-TRACER, we identified 17 iron-associated proteins in Porphyromonas gingivalis. We demonstrated the specific binding of the probe towards iron-associated proteins using transferrin as an example and provided an X-ray structure of the fluorescent probe-bound transferrin. Our study provides a basis for the understanding of iron homeostasis in pathogens, and our approach based on the integration of fluorescence imaging with proteomics and bioinformatics can be readily extended to mine other metalloproteomes in microbials...
January 11, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29301124/novel-iron-whey-protein-microspheres-protect-gut-epithelial-cells-from-iron-related-oxidative-stress-and-damage-and-improve-iron-absorption-in-fasting-adults
#6
Jun Wang, Gabor Radics, Michael Whelehan, Aoibhe OʼDriscoll, Anne Marie Healy, John F Gilmer, Mark Ledwidge
BACKGROUND: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated. METHODS: We evaluated novel iron-denatured whey protein (Iron-WP) microspheres on reactive oxygen species (ROS) and viability in gut epithelial (HT29) cells. We compared iron absorption from Iron-WP versus equimolar-dose (25 mg elemental iron) ferrous sulphate (FeSO4) in a prospective, randomised, cross-over study in fasting volunteers (n = 21 per group) dependent on relative iron depletion (a ferritin level ≤/>30 ng/mL)...
January 5, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29289560/tumor-control-by-hypoxia-specific-chemotargeting-of-iron-oxide-nanoparticle-berberine-complexes-in-a-mouse-model
#7
S Sreeja, C K Krishnan Nair
AIM: To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS: NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This complex was orally administered to mice-bearing solid tumor in hind limb. Tumor regression was analysed by measuring tumor volume. Cellular DNA damages wereassessed by comet assay...
December 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/29287748/drug-associated-hyperpigmentation-of-the-oral-mucosa-report-of-four-cases
#8
REVIEW
Konstantinos I Tosios, Eleni-Marina Kalogirou, Alexandra Sklavounou
OBJECTIVE: The aim of this study was to describe 4 patients with oral mucosa hyperpigmentation associated with 4 drug classes and to review the relevant literature. STUDY DESIGN: Two patients under imatinib and hydroxychloroquine treatment exhibited diffuse palatal hyperpigmentation and 2 patients treated with minocycline and golimumab showed multifocal pigmented macules. In all cases, biopsy was performed. RESULTS: Microscopically, in all cases, there was no increase in the number of melanocytes in the epithelium, and pigment granules were present in the lamina propria...
November 3, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29282618/hair-mineral-and-trace-element-contents-as-reliable-markers-of-nutritional-status-compared-to-serum-levels-of-these-elements-in-children-newly-diagnosed-with-inflammatory-bowel-disease
#9
Jin Min Cho, Hye Ran Yang
Patients with inflammatory bowel disease (IBD) are at high risk for nutritional deficiencies because of long-term inflammation in the gut mucosa and decreased oral intake. Because inflammation responses affect serum micronutrient concentrations, serum levels are limited in reflecting body nutrient status in acute and chronic illness. We investigated the usefulness of measuring trace elements in hair as reliable markers of nutritional status compared to serum levels in children with IBD. We retrospectively analyzed pediatric patients newly diagnosed with Crohn's disease (n = 49) and ulcerative colitis (n = 16) and controls (n = 29) from 2012 to 2016...
December 27, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29274326/effect-of-iron-supplementation-on-hba1c-levels-in-pregnant-women-with-and-without-anaemia
#10
Paula Breitenbach Renz, Mayana Kieling Hernandez, Joíza Lins Camargo
BACKGROUND: Iron deficiency anaemia has been associated with higher HbA1c levels. However, during and after iron supplementation there is a decrease in HbA1c results, causing a misinterpretation. Our aim was to analyse the effect of iron supplementation on HbA1c levels in nondiabetic pregnant women with and without anaemia. METHODS: Pregnant women in prenatal care, without gestational diabetes (GDM) or previous diabetes mellitus (DM) that performed an oral glucose tolerance test (OGTT) in the third trimester of pregnancy were invited to participate...
December 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29261547/intravenous-iron-for-treatment-of-anemia-in-the-3-perisurgical-phases-a-review-and-analysis-of-the-current-literature
#11
Frank Peters, Ines Ellermann, Andrea U Steinbicker
Anemia is a common comorbidity throughout the entire hospital stay. Treatment options include intravenous (IV) iron, oral iron, erythropoietin, and red blood cell (RBC) transfusions. IV iron has gained in popularity with the implementation of patient blood management programs. A variety of studies have been performed to investigate the use of IV iron in preoperative, perioperative, and postoperative settings. An objective review on these studies has yet to be performed. The current narrative review provides an overview of trials investigating IV iron use in the preoperative, perioperative, and postoperative settings...
December 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29260510/interventions-for-managing-taste-disturbances
#12
REVIEW
Sumanth Kumbargere Nagraj, Renjith P George, Naresh Shetty, David Levenson, Debra M Ferraiolo, Ashish Shrestha
BACKGROUND: The sense of taste is very much essential to the overall health of an individual. It is a necessary component to enjoy one's food, which in turn provides nutrition to an individual. Any disturbance in taste perception can hamper quality of life in such patients by influencing their appetite, body weight and psychological well-being. Taste disorders have been treated using different modalities of treatment and there is no consensus for the best intervention. Hence this Cochrane Review was undertaken...
December 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29259169/systematic-screening-of-generic-drugs-for-progressive-multiple-sclerosis-identifies-clomipramine-as-a-promising-therapeutic
#13
Simon Faissner, Manoj Mishra, Deepak K Kaushik, Jianxiong Wang, Yan Fan, Claudia Silva, Gail Rauw, Luanne Metz, Marcus Koch, V Wee Yong
The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not simultaneously targeted. Here we present a systematic screen to identify generic, orally available medications that target features of progressive MS. Of 249 medications that cross the blood-brain barrier, 35 prevent iron-mediated neurotoxicity in culture. Of these, several antipsychotics and antidepressants strongly reduce T-cell proliferation and oxidative stress...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29247122/prostaglandin-i2-suppresses-the-development-of-diet-induced-nonalcoholic-steatohepatitis-in-mice
#14
Shima Kumei, Koh-Ichi Yuhki, Fumiaki Kojima, Hitoshi Kashiwagi, Yoshitaka Imamichi, Toshikatsu Okumura, Shuh Narumiya, Fumitaka Ushikubi
Nonalcoholic steatohepatitis (NASH) is a hepatic manifestation of metabolic syndrome. Although the prostaglandin (PG)I2 receptor IP is expressed broadly in the liver, the role of PGI2-IP signaling in the development of NASH remains to be determined. Here, we investigated the role of the PGI2-IP system in the development of steatohepatitis using mice lacking the PGI2 receptor IP [IP-knockout (IP-KO) mice] and beraprost (BPS), a specific IP agonist. IP-KO and wild-type (WT) mice were fed a methionine- and choline-deficient diet (MCDD) for 2, 5, or 10 wk...
December 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29244881/treating-iron-deficiency-in-patients-with-gastrointestinal-disease-risk-of-re-attendance-in-secondary-care
#15
Susannah Tomkins, Callum Chapman, Melissa Myland, Rachel Tham, Rachael de Nobrega, Brinley Jackson, Satish Keshav
BACKGROUND: Patients with gastrointestinal disease may have comorbid iron deficiency anaemia (IDA) and an increased risk of hospitalisation and re-attendance in hospital. The purpose of this study was to determine if oral and intravenous (IV) treatment of IDA in patients with gastrointestinal disease attending hospital were associated with differential rates of subsequent re-attendance. METHODS AND FINDINGS: Data from the Clinical Practice Research Datalink (primary care) and Hospital Treatment Insights (secondary care) databases in England were used to conduct this retrospective cohort study...
2017: PloS One
https://www.readbyqxmd.com/read/29241581/iron-induced-chelation-alleviates-the-potential-allergenicity-of-ovotransferrin-in-a-balb-c-mouse-model
#16
Ping Tong, Lin Gao, Jinyan Gao, Xin Li, Zhihua Wu, Anshu Yang, Hongbing Chen
Ovotransferrin (OVT) is one of the main egg allergens with 2 iron-binding sites. Several studies have demonstrated that iron-chelation decreased the allergenicity of milk allergen and birch pollen allergens. Therefore, we hypothesized that iron-chelation could also reduce the allergenicity of OVT. Apo-OVT (iron-free OVT, the natural state in egg white) and Holo-OVT (iron-chelated OVT) were prepared, and the allergenicity of them were assessed and compared using a BALB/c mouse model as well as dendritic cells (DCs) based on antigen uptake...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29235012/implications-of-celiac-disease-among-patients-undergoing-gastric-bypass
#17
Lindsey M Freeman, Andrew T Strong, Gautam Sharma, Suriya Punchai, John H Rodriguez, Donald F Kirby, Matthew Kroh
INTRODUCTION: Bariatric surgery is generally safe and effective, but co-existing malabsorptive processes may increase the risk of complications or nutritional deficiencies. Bariatric surgery has not been well studied in the setting of pre-existing celiac disease. MATERIALS AND METHODS: Patients who underwent Roux-en-Y gastric bypass (RYGB) from January 2002 to December 2015 were retrospectively reviewed for either diagnosis of or serum testing for celiac disease...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29233512/response-to-oral-sucrosomial-iron-supplementation-in-patients-undergoing-bariatric-surgery-the-bari-fer-study
#18
Andreea Ciudin, Olga Simó-Servat, Jose Maria Balibrea, Ramon Vilallonga, Cristina Hernandez, Rafael Simó, Jordi Mesa
BACKGROUND: Chronic intravenous iron administration is often required after bariatric surgery. Oral sucrosomial iron has a particular form of absorption and may represent an alternative treatment. OBJECTIVE: To assess the effect of switching to oral sucrosomial iron in patients receiving intravenous iron supplementation after bariatric surgery. PATIENTS AND METHODS: A case-control study was conducted on 40 women of childbearing age, of whom 20 were switched to oral sucrosomial iron, while 20 patients continued on intravenous iron sucrose every three months...
December 7, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29231165/polyvalent-immunoglobulins-with-vitamin-d3-and-vitamin-b12-in-the-treatment-of-sjogren-s-syndrome-in-a-vegetarian-with-stomatitis-glossodynia-xerostomia-and-elevated-antinuclear-antibodies-case-report%C3%A2
#19
Clemens Cuny, Barbara Vaerst, Jennis Gabrielpillai, Aykut Tahtali, Sven Balster, Reinhard Lissner, Barry G Woodcock
BACKGROUND: Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are limited and, as in the case of methotrexate, have a low therapeutic index. CASE REPORT: This case report concerns a male patient, aged 75 years and vegetarian, with Sjogren's syndrome subsequently confirmed by salivary gland biopsy. Serum antinuclear antibodies (ANA) were elevated (1 : 320)...
December 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29225819/intravenous-iron-therapy-in-patients-with-chronic-kidney-disease-recent-evidence-and-future-directions
#20
REVIEW
Iain C Macdougall
Current recommendations for the use of intravenous iron therapy in the management of anaemia in patients with chronic kidney disease (CKD) are based on limited clinical evidence. Since the publication of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Anaemia in Chronic Kidney Disease in 2012, a number of randomized clinical trials [notably, the Ferinject Assessment in Patients with Iron Deficiency Anaemia (FIND-CKD) and Randomized Trial to Evaluate IV and Oral Iron in Chronic Kidney Disease (REVOKE) trials] and observational studies have been completed, and a further large clinical trial-Proactive IV Iron Therapy in Dialysis Patients (PIVOTAL)-is currently underway...
December 2017: Clinical Kidney Journal
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