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https://www.readbyqxmd.com/read/28445613/neuronal-distribution-of-tyramine-and-the-tyramine-receptor-amtar1-in-the-honeybee-brain
#1
Markus Thamm, Christina Scholl, Tina Reim, Kornelia Grübel, Karin Möller, Wolfgang Rössler, Ricarda Scheiner
Tyramine is an important neurotransmitter, neuromodulator, and neurohormone in insects. In honeybees, it is assumed to have functions in modulating sensory responsiveness and controlling motor behavior. Tyramine can bind to two characterized receptors in honeybees, both of which are coupled to intracellular cAMP pathways. How tyramine acts on neuronal, cellular and circuit levels is unclear. We investigated the spatial brain expression of the tyramine receptor AmTAR1 using a specific antibody. This antibody detects a membrane protein of the expected molecular weight in Western blot analysis...
April 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28445112/tracking-the-evolution-of-non-small-cell-lung-cancer
#2
Mariam Jamal-Hanjani, Gareth A Wilson, Nicholas McGranahan, Nicolai J Birkbak, Thomas B K Watkins, Selvaraju Veeriah, Seema Shafi, Diana H Johnson, Richard Mitter, Rachel Rosenthal, Max Salm, Stuart Horswell, Mickael Escudero, Nik Matthews, Andrew Rowan, Tim Chambers, David A Moore, Samra Turajlic, Hang Xu, Siow-Ming Lee, Martin D Forster, Tanya Ahmad, Crispin T Hiley, Christopher Abbosh, Mary Falzon, Elaine Borg, Teresa Marafioti, David Lawrence, Martin Hayward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M Janes, Ricky Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Rajesh Shah, Leena Joseph, Anne M Quinn, Phil A Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, Marianne Nicolson, Hardy Remmen, Keith Kerr, Mahendran Chetty, Lesley Gomersall, Dean A Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, Jason F Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Stefan Dentro, Philippe Taniere, Brendan O'Sullivan, Helen L Lowe, John A Hartley, Natasha Iles, Harriet Bell, Yenting Ngai, Jacqui A Shaw, Javier Herrero, Zoltan Szallasi, Roland F Schwarz, Aengus Stewart, Sergio A Quezada, John Le Quesne, Peter Van Loo, Caroline Dive, Allan Hackshaw, Charles Swanton
Background Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome and to determine the clonal nature of driver events and evolutionary processes in early-stage NSCLC. Methods In this prospective cohort study, we performed multiregion whole-exome sequencing on 100 early-stage NSCLC tumors that had been resected before systemic therapy...
April 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28444979/false-negative-single-antigen-bead-assay-is-it-always-an-effect-of-prozone
#3
Dharmendra Jain, Jui Choudhuri, Rajni Chauhan, Pranav Dorwal, Deepak Sharma, Aseem K Tiwari, Vimarsh Raina
BACKGROUND: Bead based flow cytometry and Luminex play a major role in identification of alloantibodies in renal transplant work-up. Strong sensitization events may lead to prozone phenomenon that can affect single antigen bead (SAB) assay and result in false negativity. However, this can also be due to high titer of other blocking antibodies. While methods like, heat inactivation, C1 inhibitor, Ethylene diamine tetra-acetic-acid and Dithio threitol treatment can remove interfering antibodies of complement and IgM, these methods are not optimal if false negativity is due to prozone effect, which is high titer of antibodies alone...
April 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28444818/reduced-community-viral-load-does-not-coincide-with-a-reduction-in-the-rate-of-new-hiv-diagnoses-and-recent-infections-data-from-a-region-of-southern-italy
#4
L Monno, A Saracino, L Scudeller, C Santoro, G Brindicci, G Punzi, A Lagioia, S Lo Caputo, G Angarano
OBJECTIVES: We assessed whether changes in community viral load (CVL) over time were associated with the rate of new HIV diagnoses (NDs). METHODS: HIV-1-positive individuals referred to our institute and permanently residing in our province were considered for inclusion in the study. A total of 861 HIV-infected adults with at least one HIV RNA measurement (12 530 measurements in total) between 2008 and 2014 were included. Viraemia copy-years were calculated from all HIV RNA values for each patient using the trapezoidal rule; multiple CVL indicators were considered...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444623/treatment-adherence-in-chronic-myeloid-leukaemia-patients-receiving-tyrosine-kinase-inhibitors
#5
Anna Rychter, Piotr Jerzmanowski, Adam Hołub, Zofia Specht-Szwoch, Violetta Kalinowska, Urszula Tęgowska, Ilona Seferyńska, Agnieszka Kołkowska-Leśniak, Ewa Lech-Marańda, Joanna Góra-Tybor
Failure to comply with treatment recommendations is very common in patients, but still poorly recognised by doctors. The current practice of using oral therapy on a large scale has been increasingly adopted for cancer patients. Chronic myeloid leukaemia (CML) is just such an example, where the introduction of taking new oral medications, the tyrosine kinase BCR-ABL inhibitors (TKI), has now revolutionised the treatment. The aim of our study was to assess treatment adherence in a group of Polish CML patients (a survey was conducted on 140 patient aged ≥18 years) treated with oral TKI (imatinib, dasatinib and nilotinib) taking into account the following variables: gender, age, education, place of residence, family circumstances and duration of therapy...
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28444382/xylem-traits-leaf-longevity-and-growth-phenology-predict-growth-and-mortality-response-to-defoliation-in-northern-temperate-forests
#6
Jane R Foster
Defoliation outbreaks are biological disturbances that alter tree growth and mortality in temperate forests. Trees respond to defoliation in many ways; some recover rapidly, while others decline gradually or die. Functional traits such as xylem anatomy, growth phenology or non-structural carbohydrate (NSC) storage could explain these responses, but idiosyncratic measures used by defoliation studies have frustrated efforts to generalize among species. Here, I test for functional differences with published growth and mortality data from 37 studies, including 24 tree species and 11 defoliators from North America and Eurasia...
April 21, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28444207/characterization-of-relative-biological-effectiveness-for-conventional-radiation-therapy-a-comparison-of-clinical-6-mv-x-rays-and-137cs
#7
Michelle Howard, Chris Beltran, Jann Sarkaria, Michael G Herman
Various types of radiation are utilized in the treatment of cancer. Equal physical doses of different radiation types do not always result in the same amount of biological damage. In order to account for these differences, a scaling factor known as the relative biological effectiveness (RBE) can be used. 137Cesium (137Cs) has been used as a source of radiation in a significant body of radiation therapy research. However, high-energy X-rays, such as 6 MV X-rays, are currently used clinically to treat patients...
April 24, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28443810/-transient-monocular-vision-loss
#8
E J Volkers, R C J M Donders, A Algra, L J Kapelle
Transient monocular vision loss (TMVL) caused by temporary disturbance of blood flow to the retina is a harbinger of future vascular complications. The diagnosis may be difficult, not only because it is solely dependent on history taking, but also because the range of monocular visual symptoms a patient may experience is wide. The classic pattern of a sudden black or grey visual field, or a curtain that is drooping in front of one eye, easily fits in the diagnosis of TMVL; however, coloured vision or flashes should not always be considered as benign...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28443601/self-assembly-of-defect-rich-graphene-oxide-nanosheets-with-na-sub-2-sub-ti-sub-3-sub-o-sub-7-sub-nanowires-and-their-superiorly-absorptive-capacity-towards-to-toxic-dyes
#9
Yibai Sun, Wanlin Fu, Yunqian Dai, Yiyang Huang, Jie Zhou, Chengqian Huang, Chongya Yang, Meiyou Huang, Rongwei Ma, Baoping Lin
Graphene sheets, a flexible two-dimensional material with excellent absorptive capacity, have great potential as absorbing materials. However, it has always been suffering from irreversible aggregation and thus lose the abundant active sites and large surface area. In this paper, large-scale graphene oxide (GO) sheets were cut and reduced into tiny reduced graphene oxide (RGO) sheets by a cell-break sonicator, for producing numerous defects which is the center of chemisorption. Furthermore, sodium titanate nanowires functioned as a framework help to disperse tiny RGO sheets uniformly...
April 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28443588/solitary-fibrous-tumors-of-chest-another-look-with-the-oncologic-perspective
#10
Mert Saynak, Nirmal K Veeramachaneni, Jessica L Hubbs, Dilruba Okumuş, Lawrence B Marks
B Solitary fibrous tumors (SFT) are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Most patients are asymptomatic at diagnosis, with lesions being detected incidentally. Nevertheless, some patients present due to symptoms from local tumor compression (eg. of the airways and pulmonary parenchyma). Furthermore, radiological methods are not always conclusive in making a diagnosis, and thus, pathological analysis is often required. In the past three decades, immunohistochemical techniques have provided a gold standard in SFT diagnosis...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443584/is-the-diagnosis-of-celiac-disease-possible-without-intestinal-biopsy
#11
Maha Shomaf, Mohammad Rashid, Dana Faydi, Ahmad Halawa
BACKGROUND: Celiac disease, is defined as a state of immune mediated hyper responsiveness to dietary gluten as wheat, barley, or rye in genetically predisposed individuals, resulting in tissue damage. It affects approximately 1% of populations worldwide. The diagnosis is done by microscopic examination of small intestinal biopsy, although serologic testing for antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptide can be of great advantage. It has been suggested that duodenal biopsy can be avoided in patients with high levels of tTG antibody since a relationship was found to be present between tTG antibody titers and celiac disease...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443518/limitations-of-current-therapeutic-options-possible-drug-targets-and-scope-of-natural-products-in-control-of-leishmaniasis
#12
Neeraj Tiwari, Mallikarjuna Rao Gedda, Vinod K Tiwari, Surya P Singh, Rakesh K Singh
Soon after the identification of Leishmania parasites,the pentavalent antimony compounds have been the mainstay to treat leishmanial infections, worldwide. These compounds were also considered true antileishmanial but the growing incidences of resistance have forced clinicians to use other options. However, due to unavailability of antileishmanial compounds, few drugs like pentamidine (antimicrobial), amphotericin B (antifungal) or miltefosine (antitumor) agents, which are associated with serious side effects, are currently being used...
April 24, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28443516/synergistic-effect-of-graphene-oxide-coated-nanotised-apigenin-with-paclitaxel-go-na-ptx-a-ros-dependent-mitochondrial-mediated-apoptosis-in-ovarian-cancer
#13
Manish Kumar Pal, Shyam Pyari Jaiswar, Ashish Dwivedi, Shruti Goyal, Vinay Nand Dwivedi, Anumesh Kumar Pathak, Vinod Kumar, Pushp Lata Sankhwar, Ratan Singh Ray
Ovarian cancer is most lethal among all gynecologic malignancies. Paclitaxel (PTX) is well used chemotherapeutic regimen for cancer control; however its undesired toxicity has been always a matter of concern for clinicians. Here we used the graphene oxide coated nanotised apigenin (GO-NA) as chemo sensitizing agent to enhance the efficacy of paclitaxel to overcome the limitations of chemotherapy. GO and GO-Apigenin was prepared by modified Hummers method and the nanoparticles were characterized by dynamic light scattering and transmission electron microscopy Human ovarian adenocarcinomas (SKOV-3) cells was treated by DMSO, Group I (Control)-McCoy's 5A Medium, Group II-Paclitaxel (5nM) alone, Group III- Nanotised Apigenin (GO-NA-10μM) Group IV- Paclitaxel (5nM) + GO-NA (10μM)...
April 24, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28443400/-in-my-experience%C3%A2
#14
Mandy Day-Calder
Nurses are a wise group, but we aren't always smart enough to look after ourselves properly. Yes, we have the knowledge and we know that if we practised what we preached we could be healthier, but sometimes life just isn't that simple.
April 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28443287/brachial-approach-as-an-alternative-technique-of-fibrin-sheath-removal-for-implanted-venous-access-devices
#15
Charalampos Sotiriadis, Steven David Hajdu, Francesco Doenz, Salah D Qanadli
Implanted venous access device (IVAD) late dysfunction is commonly caused by fibrin sheath formation. The standard method of endovascular fibrin sheath removal is performed via the femoral vein. However, it is not always technically feasible and sometimes contraindicated. Moreover, approximately 4-6 h of bed rest is necessary after the procedure. In this article, we describe an alternative method of fibrin sheath removal using the brachial vein approach in a young woman receiving chemotherapy for breast cancer...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28443129/maximum-plant-uptakes-for-water-nutrients-and-oxygen-are-not-always-met-by-irrigation-rate-and-distribution-in-water-based-cultivation-systems
#16
Chris Blok, Brian E Jackson, Xianfeng Guo, Pieter H B de Visser, Leo F M Marcelis
Growing on rooting media other than soils in situ -i.e., substrate-based growing- allows for higher yields than soil-based growing as transport rates of water, nutrients, and oxygen in substrate surpass those in soil. Possibly water-based growing allows for even higher yields as transport rates of water and nutrients in water surpass those in substrate, even though the transport of oxygen may be more complex. Transport rates can only limit growth when they are below a rate corresponding to maximum plant uptake...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28443120/dissecting-low-atmospheric-pressure-stress-transcriptome-responses-to-the-components-of-hypobaria-in-arabidopsis
#17
Mingqi Zhou, Jordan B Callaham, Matthew Reyes, Michael Stasiak, Alberto Riva, Agata K Zupanska, Mike A Dixon, Anna-Lisa Paul, Robert J Ferl
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology, yet the apparent components of hypobaria are stresses typical of terrestrial ecosystems. High altitude, for example, presents terrestrial hypobaria always with hypoxia as a component stress, since the relative partial pressure of O2 is constant in the atmosphere. Laboratory-controlled hypobaria, however, allows the dissection of pressure effects away from the effects typically associated with altitude, in particular hypoxia, as the partial pressure of O2 can be varied...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28443000/the-olfactory-system-revealed-non-invasive-mapping-by-using-constrained-spherical-deconvolution-tractography-in-healthy-humans
#18
Demetrio Milardi, Alberto Cacciola, Alessandro Calamuneri, Maria F Ghilardi, Fabrizia Caminiti, Filippo Cascio, Veronica Andronaco, Giuseppe Anastasi, Enricomaria Mormina, Alessandro Arrigo, Daniele Bruschetta, Angelo Quartarone
Although the olfactory sense has always been considered with less interest than the visual, auditive or somatic senses, it does plays a major role in our ordinary life, with important implication in dangerous situations or in social and emotional behaviors. Traditional Diffusion Tensor signal model and related tractography have been used in the past years to reconstruct the cranial nerves, including the olfactory nerve (ON). However, no supplementary information with regard to the pathways of the olfactory network have been provided...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28442845/perforative-peritonitis-gastrointestinal-tract-may-not-always-be-the-source
#19
Abhay Y Desai, Bhakti Palande, Sangram Dhabolkar, Vishwas D Pai
Perforative peritonitis is the most common surgical emergency in general surgical practice. Gastrointestinal perforation is the etiology in the vast majority of the patients. However, occasionally, other rare causes may be encountered. One such cause of peritonitis is spontaneous perforation of non-gravid uterus. Uterine perforation is a potential complication of any intrauterine procedure and may be associated with injury to surrounding blood vessels or viscera such as the urinary bladder or intestine. Spontaneous uterine perforation is rare and less than 50 cases have been reported in the English literature...
April 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28442699/does-the-rapid-fecal-calprotectin-test-equally-predict-mucosal-inflammation-in-both-ulcerative-colitis-uc-and-crohn-s-disease-cd-a-prospective-analysis-of-an-ibd-cohort
#20
Andrzej Moniuszko, Stanisław Głuszek, Grażyna Rydzewska
INTRODUCTION    Fecal calprotectin (FC) is a well-established biomarker of intestinal inflammation in CD and UC. However, standard laboratory methods are time consuming and not always useful in clinical practice.  OBJECTIVES    We analyzed the efficacy of a rapid bedside FC test to detect disease flares in a hospital setting. We also assessed the influence of disease location on diagnostic accuracy. PATIENTS AND METHODS    140 patients were prospectively enrolled in the study (46 UC, 94 CD). FC was measured both by ELISA and by the rapid Quantum Blue® test...
April 26, 2017: Polish Archives of Internal Medicine
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