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Toxic alcohol

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https://www.readbyqxmd.com/read/28921991/direct-palladium-catalyzed-carbonylative-transformation-of-allylic-alcohols-and-related-derivatives
#1
Fu-Peng Wu, Jin-Bao Peng, Lu-Yang Fu, Xinxin Qi, Xiao-Feng Wu
A direct, palladium-catalyzed, carbonylative transformation of allylic alcohols for the synthesis of β,γ-unsaturated carboxylic acids has been developed. With formic acid as the CO source, various allylic alcohols were conveniently transformed into the corresponding β,γ-unsaturated carboxylic acids with excellent linear and (E)-selectivity. The reaction was performed under mild conditions; toxic CO gas manipulation and high-pressure equipment were avoided in this procedure.
September 18, 2017: Organic Letters
https://www.readbyqxmd.com/read/28915823/patients-with-acute-poisoning-presenting-to-an-urban-emergency-department-of-a-tertiary-hospital-in-tanzania
#2
Ghaniya S Mbarouk, Hendry R Sawe, Juma A Mfinanga, John Stein, Shankar Levin, Victor Mwafongo, Michael S Runyon, Teri A Reynolds, Kent R Olson
BACKGROUND: Poisoning is a major public health concern in sub-Saharan Africa, affecting patients of all age groups. Poisoned patients often present to the emergency department (ED) and prompt evaluation and appropriate management are imperative to ensure optimal outcomes. Unfortunately, little is known about the specific presentations of poisoned patients in East Africa. We describe the clinical and epidemiological features of patients presenting to the Muhimbili National Hospital (MNH) ED with suspected toxicological syndromes...
September 16, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28912413/-a-case-of-alcoholic-liver-disease-presenting-as-prominent-accumulation-of-ascites-associated-with-liver-damage-due-to-capeox
#3
Yoshikuni Yonenaga, Marika Nio, Yoshihiro Yata, Shunichi Higashide
A 75-year-old man with rectal cancer had consumed an average of6 6 g of alcohol per day for 47 years. However, his liver function was within normal limits and his Child-Pugh classification was A before initiation of therapy. He underwent neoadjuvant chemoradiation and a low anterior resection. The patient then received CapeOX as an adjuvant therapy. During the fourth cycle of CapeOX, computed tomography(CT)showed massive ascites. The chemotherapy was discontinued and treatment including a diuretic agent was initiated...
September 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28903180/diamine-derivative-anti-trichomonas-vaginalis-and-anti-tritrichomonas-foetus-activities-by-effect-on-polyamine-metabolism
#4
Graziela Vargas Rigo, Márcia Rodrigues Trein, Danielle da Silva Trentin, Alexandre José Macedo, Bruno Assis de Oliveira, Angelina Maria de Almeida, Raquel Brandt Giordani, Mauro Vieira de Almeida, Tiana Tasca
Human and bovine trichomoniasis are sexually transmitted diseases (STD) caused by Trichomonas vaginalis and Tritrichomonas foetus, respectively. Human trichomoniasis is the most common non-viral STD in the world and bovine trichomoniasis causes significant economic losses to breeders. Considering the significant impact of the infections caused by these protozoa and the treatment failures, the search for new therapeutic alternatives becomes crucial. In this study the effect of diamines and amino alcohols in the in vitro viability of trichomonads was evaluated...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28898300/-marijuana-a-toxicological-approach
#5
Silvia Cortese
From an adult perspective, both marijuana and alcohol consumption are becoming natural. Among illegal substances, marijuana has disseminated all over the word and specially in Argentina. Thus, a scientifc approach towards this issue must be developed and we should spread what we know about toxicity and adverse effects, particularly among adolescents. The impact of this kind of toxic during the neurodevelopmental period, both in cognitive and impulse control areas, may involve negative consequences for users at a later age...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28895434/genetic-variation-and-risk-of-dna-damage-in-peripheral-blood-lymphocytes-of-iranian-formaldehyde-exposed-workers
#6
Rezvan Zendehdel, Parviz Abdolmaleki, Fatemeh Javani Jouni, Mohammad Mazinani
Formaldehyde (FA) has given positive results for the genetic damage evaluated in human peripheral blood lymphocytes. Polymorphism plays a special role in the toxicity of chemicals. DNA damage in blood cells was evaluated in workers who were occupationally exposed to FA. This study tested the association of alcohol dehydrogenase III (ADH3) and manganese-superoxide dismutase (Mn-SOD) gene polymorphism, with DNA damage of peripheral blood lymphocytes. Gene polymorphisms were evaluated in 54 workers from melamine dinnerware workshops and 34 workers from dairy production workshops...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28894627/mangifera-indica-l-leaf-extract-alleviates-doxorubicin-induced-cardiac-stress
#7
Laxit Bhatt, Viraj Joshi
AIM: The study was undertaken to evaluate the cardioprotective effect of the alcoholic leaf extract of Mangifera indica L. against cardiac stress caused by doxorubicin (DOX). MATERIALS AND METHODS: Rats were treated with 100 mg/kg of M. indica leaf extract (MILE) in alone and interactive groups for 21 days. Apart from the normal and MILE control groups, all the groups were subjected to DOX (15 mg/kg, i.p.) toxicity for 21 days and effects of different treatments were analyzed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile, and histopathological evaluation...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28892742/toxicity-teratogenicity-and-antibacterial-activity-of-posterior-salivary-gland-psg-toxin-from-the-cuttlefish-sepia-pharaonis-ehrenberg-1831
#8
Ramachandran Karthik, Venkatesan Manigandan, Ramachandran Saravanan
Toxins from the posterior salivary gland (PSG) of cuttlefishes are known toxins with pronounced toxicity. In the present study, ionic peptide rich PSG toxin from the cuttlefish S. pharaonis was isolated by ion exchange chromatography and purified by Reversed Phase High Performance Liquid Chromatography (RP-HPLC), with active fraction at a retention time of 26min. The net protein content of the PSG toxin was estimated to be 46.6mg at a proximate molecular weight of∼50kDa. Fourier Transform Infrared Spectroscopy (FT-IR) of PSG toxin revealed the presence of alcoholic OH, primary NH, alkyl CH and conjugated CONH functional groups...
September 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28891397/pharmacokinetic-evaluation-of-%C3%AE-caryophyllene-alcohol-in-rats-and-beagle-dogs
#9
Jiake He, Sufeng Zhou, Xiaonan Li, Chunfeng Wang, Yang Yu, Xijing Chen, Yang Lu
1. β-caryophyllene alcohol (BCPA) has shown therapeutic promise in the treatment of asthma and inflammation with low toxicity. The aim of the current study was to report the pharmacokinetic profiles of BCPA in rats and dogs. 2. Following intravenous administration, BCPA exhibited moderate volumes of distribution (Vz) ranging from 5.63 to 8.97 L/kg in rats and low Vz (2.89 ± 1.12 L/kg) in dogs. Systemic plasma clearance was high in both species, resulting in a short elimination half-life ranging from 29...
September 11, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28886743/fatal-poisonings-in-northern-finland-causes-incidence-and-rural-urban-differences
#10
Lauri Koskela, Lasse Raatiniemi, Håkon Kvåle Bakke, Tero Ala-Kokko, Janne Liisanantti
BACKGROUND: In this study we evaluate differences between rural and urban areas in the causes and incidence of fatal poisonings. METHODS: Data from all fatal poisonings that occurred in Northern Finland from 2007 to 2011 were retrieved from Cause of Death Registry death certificates provided by Statistics Finland. The demographics and causes of fatalities were compared between rural and urban areas. Incidences were calculated based on the population data. RESULTS: There were a total of 684 fatal poisonings during the study period and 57...
September 8, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28884605/nanomedicines-a-theranostic-approach-for-hepatocellular-carcinoma
#11
Afreen Usmani, Anuradha Mishra, Mohd Ahmad
The liver is an imperative organ of tremendous importance concerned with maintenance of metabolic functions and detoxification of exogenous and endogenous challenges like xenobiotics, viral infections and chronic alcoholism. Liver diseases particularly hepatitis B virus infections, liver cirrhosis and hepatocellular carcinoma continue to pose a significant health challenge worldwide due to the lack of therapeutic management options besides liver resection and transplantation. Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer mortality worldwide...
September 8, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28882281/the-state-of-the-residential-fire-fatality-problem-in-sweden-epidemiology-risk-factors-and-event-typologies
#12
Anders Jonsson, Carl Bonander, Finn Nilson, Fredrik Huss
INTRODUCTION: Residential fires represent the largest category of fatal fires in Sweden. The purpose of this study was to describe the epidemiology of fatal residential fires in Sweden and to identify clusters of events. METHOD: Data was collected from a database that combines information on fatal fires with data from forensic examinations and the Swedish Cause of Death-register. Mortality rates were calculated for different strata using population statistics and rescue service turnout reports...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28881148/protective-effect-of-%C3%AE-bisabolol-on-rotenone-induced-toxicity-in-i-drosophila-melanogaster-i
#13
Gerlânia de Oliveira Leite, Assis Ecker, Rodrigo Lopes Seeger, Bárbara Nunes Krum, Thiago Henrique Lugokenski, Roselei Fachinetto, Jéssie Haigert Sudati, Nilda Vargas Barbosa, Caroline Wagner
(-)-α-Bisabolol (BISA) is a sesquiterpene alcohol, which has with several recognized biological activities, including anti-inflammatory, anti-irritant, and antibacterial properties. In the present study, we investigated the influence of BISA (5, 25, and 250 μM) on rotenone (500 μM)-induced toxicity in <i>Drosophila melanogaster</i> for 7 days. BISA supplementation significantly decreased rotenone-induced mortality and locomotor deficits. The loss of motor function induced by rotenone correlated with a significant change in stress response factors; it decreased thiol levels, inhibited mitochondria complex I, and increased the mRNA expression of antioxidant marker proteins such as superoxide dismutase (SOD), catalase (CAT), and the keap1 gene product...
September 7, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28880010/chronic-pancreatitis
#14
REVIEW
Jorg Kleeff, David C Whitcomb, Tooru Shimosegawa, Irene Esposito, Markus M Lerch, Thomas Gress, Julia Mayerle, Asbjørn Mohr Drewes, Vinciane Rebours, Fatih Akisik, J Enrique Domínguez Muñoz, John P Neoptolemos
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood...
September 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28867857/ethnopharmacological-based-evaluation-of-anogeissus-pendula-edgew-extracts-for-antioxidant-and-hepatoprotective-potential
#15
Deeksha Singh, Uttam Singh Baghel, Manmeet Singh Pannu, Rakesh Yadav
BACKGROUND: Anogeissus pendula has various reported ethnomedicinal uses and is reported to contain phenolic compounds which have antioxidant potential. AIM: The present study was undertaken to evaluate the in vitro antioxidant potential and in vivo hepatoprotective activity along with the oxidative stress parameters of stem bark and leaves of Anogeissus pendula for the first time. SETTINGS AND DESIGN: Albino rats were divided into seven groups of six animals each...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28867650/a-postoperative-anti-adhesion-barrier-based-on-photoinduced-imine-crosslinking-hydrogel-with-tissue-adhesive-ability
#16
Yunlong Yang, Xiaolin Liu, Yan Li, Yang Wang, Chunyan Bao, Yunfeng Chen, Qiuning Lin, Linyong Zhu
Postoperative adhesion is a serious complication that can further lead to morbidity and/or mortality. Polymer anti-adhesion barrier material provides an effective precaution to reduce the probability of postoperative adhesion. Clinical application requires these materials to be easily handled, biocompatible, biodegradable, and most importantly tissue adherent to provide target sites with reliable isolation. However, currently there is nearly no polymer barrier material that can fully satisfy these requirements...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28867424/psychosocial-and-behavioral-factors-in-acetaminophen-related-acute-liver-failure-and-liver-injury
#17
Carla Pezzia, Corron Sanders, Suzanne Welch, Angela Bowling, William M Lee
OBJECTIVES: Acetaminophen overdoses result in nearly 500 deaths annually and a much larger number of hospitalizations. Suicidal overdoses are exceeded in number in the United States by unintentional overdoses. We evaluated clinical, demographic and psychosocial factors among unintentional and intentional overdose patients whose acetaminophen (APAP) toxicity had resulted in acute liver failure. We hypothesized that APAP overdose patients would be more likely to suffer from behavioral health issues and display higher impulsivity scores than the general population...
October 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28865661/methods-to-assess-adverse-childhood-experiences-of-children-and-families-toward-approaches-to-promote-child-well-being-in-policy-and-practice
#18
Christina D Bethell, Adam Carle, James Hudziak, Narangerel Gombojav, Kathleen Powers, Roy Wade, Paula Braveman
BACKGROUND: Advances in human development sciences point to tremendous possibilities to promote healthy child development and well-being across life by proactively supporting safe, stable and nurturing family relationships (SSNRs), teaching resilience, and intervening early to promote healing the trauma and stress associated with disruptions in SSNRs. Assessing potential disruptions in SSNRs, such as adverse childhood experiences (ACEs), can contribute to assessing risk for trauma and chronic and toxic stress by asking about ACEs can help with efforts to prevent and attenuate negative impacts on child development and both child and family well-being...
September 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28865386/response-of-rhizobium-to-cd-exposure-a-volatile-perspective
#19
Paulo Cardoso, Magda Santos, Rosa Freitas, Sílvia M Rocha, Etelvina Figueira
The volatile metabolome of Rhizobium sp. strain E20-8 exposed to three concentrations of cadmium (2.5, 5.0 and 7.5 μM) was screened using comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry (GC × GC-ToFMS), combined with headspace solid phase microextraction (HS-SPME). Cd exposure induced a global increase in the concentration of volatile organic compounds (VOCs) both intra and extracellularly. Peak areas of several linear alkanes, ketones, aldehydes, alcohols, terpenic and volatile sulfur compounds, and one ester (ethyl acetate), were especially increased when compared with the control condition (no Cd)...
August 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28864856/comparison-of-adverse-events-following-injection-of-original-or-generic-docetaxel-for-the-treatment-of-breast-cancer
#20
Nao Tagawa, Erika Sugiyama, Masataka Tajima, Yasutsuna Sasaki, Seigo Nakamura, Hiromi Okuyama, Hisanori Shimizu, Vilasinee Hirunpanich Sato, Tadanori Sasaki, Hitoshi Sato
PURPOSE: The approval of injectable generic drugs does not require bioequivalence testing. However, although generic products contain the same level of the active compound, the levels and types of additives present can differ from those used in the original product. Since docetaxel is highly lipophilic, polysorbate 80 (PS80), polyethylene glycol (PEG), and ethyl alcohol are employed to solubilize this anticancer agent. This retrospective study compared the safety of five docetaxel products (Taxotere(®), Docetaxel Hospira, Docetaxel Sandoz, Docetaxel Sawai, and Docetaxel EE)...
September 1, 2017: Cancer Chemotherapy and Pharmacology
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