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https://www.readbyqxmd.com/read/29784840/oxidative-stress-and-first-line-antituberculosis-drug-induced-hepatotoxicity
#1
Wing Wai Yew, Kwok Chiu Chang, Denise P Chan
Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even rarely mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Confining to first-line antituberculosis drugs, this review addresses whether and how oxidative stress, and more broadly, disturbance in redox homeostasis alongside mitochondrial dysfunction, may contribute to the hepatotoxicity induced by them. Risk factors for such toxicity that have been identified, in addition to genetic factors, principally include old age, malnutrition, alcoholism, chronic hepatitis C and chronic hepatitis B infection, HIV infection and pre-existing liver disease...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29783682/heat-shock-gene-inactivation-and-protein-aggregation-with-links-to-chronic-diseases
#2
Ian James Martins
The heat shock response involved in protein misfolding is linked to the formation of toxic immunogenic proteins with heat shock proteins (HSP) as regulators of amyloid beta aggregation. The defective amyloid beta trafficking between different intracellular compartments is now relevant to HSPs and autoimmunity. Overnutrition, temperature dysregulation, and stress repress the heat shock gene Sirtuin 1 with the induction of HSP regulated amyloid beta aggregation involved in the autoimmune response. Defective circadian rhythm alterations are connected to inactivation of the peripheral sink amyloid beta clearance pathway and related to insulin resistance, protein aggregation, and autoimmune disease in non-alcoholic fatty liver disease (NAFLD) and various neurodegenerative diseases such as Alzheimer's disease...
May 18, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29778079/advances-in-understanding-the-response-of-fish-to-linear-alcohols-in-the-environment
#3
Scott E Belanger, Jane M Rawlings, Ricky Stackhouse
Short to long chain alcohols have a range of ecotoxicity to aquatic life driven by hydrophobic interactions with biological membranes. Carbon chain length and octanol:water partitioning coefficients are surrogates for hydrophobicity and strongly relate to aquatic toxicity. In these investigations, the toxicity of ethanol to 1-n-dodecanol to juvenile fish in standard acute toxicity tests is reviewed. Toxicity tests employing fish embryos (zebrafish Danio rerio and fathead minnow Pimephales promelas) in the Fish Embryo Test (OECD 236) format were conducted from C2 to C10 to compare against standard juvenile fish toxicity...
April 25, 2018: Chemosphere
https://www.readbyqxmd.com/read/29777920/modeling-and-manova-studies-on-toxicity-and-endocrine-potential-of-packaging-materials-exposed-to-different-extraction-schemes
#4
Natalia Szczepańska, Błażej Kudłak, Stefan Tsakovski, Galina Yotova, Miroslava Nedyalkova, Vasil Simeonov, Anna Dołęga, Jacek Namieśnik
The stability of the linings of packaging that is in contact with the goods stored has been of major concern during decades of the development of packaging materials. In this work, an attempt was undertaken to assess the applicability of using two bioassays (Microtox® and XenoScreen YES/YAS) in estimating the stability of packaging (cans, caps, multilayer material) and the impact of their degradation on the toxicity of some simulated media. The assessment of the impact of packaging storage conditions (temperature, disinfection, preservation, extracting and washing solvents) was planned and performed with i) regression modeling of the experimental effects on the ecotoxicity readings, ii) ANOVA and MANOVA estimation of the experimental conditions as significant factors affecting the toxicity results and iii) FTIR analysis of the packages...
May 16, 2018: Environmental Research
https://www.readbyqxmd.com/read/29773157/genetic-etiology-for-alcohol-induced-cardiac-toxicity
#5
James S Ware, Almudena Amor-Salamanca, Upasana Tayal, Risha Govind, Isabel Serrano, Joel Salazar-Mendiguchía, Jose Manuel García-Pinilla, Domingo A Pascual-Figal, Julio Nuñez, Gonzalo Guzzo-Merello, Emiliano Gonzalez-Vioque, Alfredo Bardaji, Nicolas Manito, Miguel A López-Garrido, Laura Padron-Barthe, Elizabeth Edwards, Nicola Whiffin, Roddy Walsh, Rachel J Buchan, William Midwinter, Alicja Wilk, Sanjay Prasad, Antonis Pantazis, John Baski, Declan P O'Regan, Luis Alonso-Pulpon, Stuart A Cook, Enrique Lara-Pezzi, Paul J Barton, Pablo Garcia-Pavia
BACKGROUND: Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol. OBJECTIVES: This study sought to evaluate the role of variation in cardiomyopathy-associated genes in the pathophysiology of ACM, and to examine the effects of alcohol intake and genotype on dilated cardiomyopathy (DCM) severity. METHODS: The authors characterized 141 ACM cases, 716 DCM cases, and 445 healthy volunteers...
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29764253/anti-inflammatory-local-effect-of-hydroxytyrosol-combined-with-pectin-alginate-and-olive-oil-on-trinitrobenzene-sulfonic-acid-induced-colitis-in-wistar-rats
#6
A Voltes, A Bermúdez, G Rodríguez-Gutiérrez, M L Reyes, C Olano, J Fernández-Bolaños, F de la Portilla
PURPOSE: Evaluate the efficacy of hydroxytyrosol in the local treatment of inflammatory colitis. Currently, the existing treatments for inflammatory bowel diseases does not cure the disease and it is associated with high rates of side effects and complications. Hydroxytyrosol is a phenyl-ethyl-alcohol derived from the hydrolysis of oleuropein and present in olive oil, previous studies have demonstrated the anti-inflammatory effect of dietary hydroxytyrosol supplement, with no toxicity...
May 15, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29761897/chronic-ethanol-exposure-of-human-pancreatic-normal-ductal-epithelial-cells-induces-cancer-stem-cell-phenotype-through-satb2
#7
Wei Yu, Yuming Ma, Sharmila Shankar, Rakesh K Srivastava
The incidence of pancreatic cancer is on the rise. Risk factors for pancreatic cancer include alcohol toxicity and metabolic conditions such as obesity, hypertension, dyslipidaemia, insulin resistance and type 2 diabetes. However, the molecular mechanism by which chronic alcohol consumption contributes to pancreatic cancer is not well understood. The purpose of the study was to demonstrate the effects of long-term chronic ethanol exposure on the transformation of human pancreatic normal ductal epithelial (HPNE) cells...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29761541/telfairia-occidentalis-supplemented-diet-induces-changes-in-sperm-parameters-and-testosterone-level-in-rats
#8
R-C C Njoku, S O Abarikwu, A A Uwakwe, C J Mgbudom-Okah
The growing patronage on herbal remedies and formulations from natural products in most developing countries has warranted research into certain health challenges including their antifertility effects. This study assessed the effects of boiled Telfairia occidentalis (TO) seed-supplemented diets on the level of testosterone and semen quality in Wistar rats. Boiled TO seed diets at 10%, 15% and 30% were given to rats for 60 days. Our study showed that sperm quality was impaired as evidenced by the decreased number of motile spermatozoa, epididymal sperm numbers, percentage live/dead ratio and increased numbers of abnormal spermatozoa comparable to control values (p < ...
May 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29760777/a-pseudomonas-putida-efflux-pump-acts-on-short-chain-alcohols
#9
Georg Basler, Mitchell Thompson, Danielle Tullman-Ercek, Jay Keasling
Background: The microbial production of biofuels is complicated by a tradeoff between yield and toxicity of many fuels. Efflux pumps enable bacteria to tolerate toxic substances by their removal from the cells while bypassing the periplasm. Their use for the microbial production of biofuels can help to improve cell survival, product recovery, and productivity. However, no native efflux pump is known to act on the class of short-chain alcohols, important next-generation biofuels, and it was considered unlikely that such an efflux pump exists...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29758527/removal-biotransformation-and-toxicity-variations-of-climbazole-by-freshwater-algae-scenedesmus-obliquus
#10
Chang-Gui Pan, Feng-Jiao Peng, Guang-Guo Ying
Climbazole (CBZ) is an antibacterial and antifungal agent widely used in personal care products. In this study, we investigated the interactions between climbazole (CBZ) and freshwater microalgae Scenedesmus obliquus (S. obliquus). Dose-effect relationships between CBZ concentrations and growth inhibitions or chlorophyll a content were observed. After 12 days of incubation, the algae density and chlorophyll a content in 2 mg/L treatment group was 56.6% and 15.8% of those in the control group, respectively...
May 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29757947/membrane-remodeling-as-a-key-player-of-the-hepatotoxicity-induced-by-co-exposure-to-benzo-a-pyrene-and-ethanol-of-obese-zebrafish-larvae
#11
Muhammad Imran, Odile Sergent, Arnaud Tête, Isabelle Gallais, Martine Chevanne, Dominique Lagadic-Gossmann, Normand Podechard
The rise in prevalence of non-alcoholic fatty liver disease (NAFLD) constitutes an important public health concern worldwide. Including obesity, numerous risk factors of NAFLD such as benzo[a]pyrene (B[a]P) and ethanol have been identified as modifying the physicochemical properties of the plasma membrane in vitro thus causing membrane remodeling-changes in membrane fluidity and lipid-raft characteristics. In this study, the possible involvement of membrane remodeling in the in vivo progression of steatosis to a steatohepatitis-like state upon co-exposure to B[a]P and ethanol was tested in obese zebrafish larvae...
May 14, 2018: Biomolecules
https://www.readbyqxmd.com/read/29750384/effects-of-moderate-voluntary-ethanol-consumption-on-the-rat-and-human-gut-microbiome
#12
Kassi L Kosnicki, Jerrold C Penprase, Patricia Cintora, Pedro J Torres, Greg L Harris, Susan M Brasser, Scott T Kelley
Many alcohol-induced health complications are directly attributable to the toxicity of alcohol or its metabolites, but another potential health impact of alcohol may be on the microbial communities of the human gut. Clear distinctions between healthy and diseased-state gut microbiota have been observed in subjects with metabolic diseases, and recent studies suggest that chronic alcoholism is linked to gut microbiome dysbiosis. Here, we investigated the effects of moderate levels of alcohol consumption on the gut microbiome in both rats and humans...
May 11, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29747104/possibilities-of-the-utilization-of-char-from-the-pyrolysis-of-tetrapak
#13
Helena Raclavská, Jana Růžičková, Hana Škrobánková, Silvie Koval, Marek Kucbel, Konstantin Raclavský, Barbora Švédová, Petr Pavlík, Dagmar Juchelková
Since the cellulose used in the production of tetrapak is of very high quality, the char generated during pyrolysis should be influenced mainly by the pyrolysis temperature. This article aims to determine the chemical composition of biochar prepared at the temperatures of 400, 500, 600 and 700 °C and its environmental properties determined by the presence of organic compounds with toxicity and relatively high mobility in the environment. The analytical pyrolysis of char was used to identify the following groups of organic compounds: alkanes, cycloalkanes, alkenes, cycloalkenes, alkynes, alkadiens, ethers, alcohols, nitrogen compounds, nitrils, ketones and aldehydes, compounds containing phenols, furans, benzofurans, PAHs (polycyclic aromatic hydrocarbons), carboxylic acids, compounds containing benzenes and markers indicative of the presence of synthetic polymers (polyethylene layers, a part of dyes, antioxidants, stabilizers), and fragments of cellulose...
May 7, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29745505/-preparation-and-study-of-vaccarin-loaded-nanofibers-used-as-wound-healing-material
#14
Yuyu Qiu, Weiwei Cai, Liying Qiu, Qingqing Wang, Qufu Wei
A drug vaccarin loaded polymer poly (vinyl alcohol) (PVA)-stilbazole quaternized (SbQ)/Zein was prepared in this study, using co-electrospun method. Then the morphologies and structures of PVA-SbQ/Zein composite nanofibers were observed by scanning electron microscope (SEM) and Fourier transform infrared spectrum (FTIR), respectively. Finally, biocompatibility of PVA-SbQ/Zein nanofibers with drug and without drug was evaluated. Results showed that vaccarin-loaded PVA-SbQ/Zein nanofibers had smooth surface and showed non-toxic to L929 cells...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744630/novel-wine-yeast-with-aro4-and-tyr1-mutations-that-overproduce-floral-aroma-compounds-2-phenylethanol-and-2-phenylethyl-acetate
#15
Antonio G Cordente, Mark Solomon, Alex Schulkin, I Leigh Francis, Alice Barker, Anthony R Borneman, Christopher D Curtin
It is well established that the choice of yeast used to perform wine fermentation significantly influences the sensory attributes of wines; different yeast species and strains impart different profiles of esters, volatile fatty acids, higher alcohols, and volatile sulphur compounds. Indeed, choice of yeast remains one of the simplest means by which winemakers can modulate the sensory characteristics of wine. Consequently, there are more than 100 commercially available Saccharomyces cerevisiae wine yeast strains available, mostly derived by isolation from vineyards and successful fermentations...
May 9, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29744465/starch-based-nanofibrous-scaffolds-for-wound-healing-applications
#16
Vijaya Sadashiv Waghmare, Pallavi Ravindra Wadke, Sathish Dyawanapelly, Aparna Deshpande, Ratnesh Jain, Prajakta Dandekar
Starch is an attractive polymer for wound healing applications because of its wide availability, low cost, biocompatibility, biodegradability and wound-healing property. Here, we have fabricated starch-based nanofibrous scaffolds by electrospinning for wound healing applications. The diameter of the optimized nanofibers was determined by field emission scanning electron microscopy (FE-SEM) and was found to be in the range of 110-300 nm. The mechanical strength (0.5-0.8 MPa) of the nanofibrous scaffolds was attuned using polyvinyl alcohol (plasticizer) and glutaraldehyde (crosslinking agent), to impart them with sufficient durability for skin tissue engineering...
September 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29742202/chemistry-inspired-by-the-colors-of-fruits-flowers-and-wine
#17
Frank H Quina, Erick L Bastos
An overview is provided of the status of research at the frontiers of investigation of the chemistry and photochemistry of two classes of natural plant pigments, the anthocyanins and the betalains, as well as of the pyranoanthocyanin pigments formed from anthocyanins during the maturation of red wine. Together, anthocyanins and betalains are responsible for almost all of the red, purple and blue colors of fruits and flowers and anthocyanins and pyranoanthocyanins are major contributors to the color of red wines...
2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29740333/flavonoids-in-kidney-health-and-disease
#18
REVIEW
Félix Vargas, Paola Romecín, Ana I García-Guillén, Rosemary Wangesteen, Pablo Vargas-Tendero, M Dolores Paredes, Noemí M Atucha, Joaquín García-Estañ
This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and antiinflammatory effects, among other therapeutic activities. Many of them also exert renoprotective actions that may be of interest in diseases such as glomerulonephritis, diabetic nephropathy, and chemically-induced kidney insufficiency. They affect several renal factors that promote diuresis and natriuresis, which may contribute to their well-known antihypertensive effect...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29738233/solvent-free-synthesis-of-zeolites-mechanism-and-utility
#19
Qinming Wu, Xiangju Meng, Xionghou Gao, Feng-Shou Xiao
Zeolites have been extensively studied for years in different areas of chemical industry, such as shape selective catalysis, ion-exchange, and gas adsorption and separation. Generally, zeolites are prepared from solvothermal synthesis in the presence of a large amounts of solvents such as water and alcohols in sealed autoclaves under autogenous pressure. Water has been regarded as essential to synthesize zeolites for fast mass transfer of reactants, but it occupies a large space in autoclaves, which greatly reduces the yield of zeolite products...
May 8, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29734864/preparation-of-sponge-like-macroporous-pva-hydrogels-via-n-ha-enhanced-phase-separation-and-their-potential-as-wound-dressing
#20
Ruirui Feng, Rongzhan Fu, Zhiguang Duan, Chenhui Zhu, Xiaoxuan Ma, Daidi Fan, Xian Li
Polyvinyl alcohol (PVA) hydrogels have been widely studied for biomedical applications due to their water solubility, non-toxicity, non-carcinogenicity, and biocompatibility. However, PVA hydrogels prepared by the physical crosslinking method usually do not exhibit a macroporous structure, which limits their application when PVA hydrogels are used alone as a wound dressing. Here, we reported a sponge-like macroporous PVA hydrogel (SPH) prepared by employing polyethylene glycol and nano-hydroxyapatite (n-HA) to enhance phase separation...
May 7, 2018: Journal of Biomaterials Science. Polymer Edition
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