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https://www.readbyqxmd.com/read/28817620/gtsp1-expression-in-non-smoker-and-non-drinker-patients-with-squamous-cell-carcinoma-of-the-head-and-neck
#1
Pamela de Oliveira Soares, Patrícia Maluf Cury, Rossana Verónica Mendoza López, Cláudio Roberto Cernea, Erika Erina Fukuyama, David Livingstone Alves Figueiredo, Francisco Gorgonio da Nobrega, Otavio Alberto Curioni, Fabio Daumas Nunes, Raquel Ajub Moyses, Maria Lúcia Bueno Garcia
INTRODUCTION: The main risk factors for head and neck squamous cell carcinoma (HNSCC) are tobacco and alcohol consumption and human papillomavirus (HPV) infection. However, in a subset of patients, no risk factors can be identified. Glutathione S-transferase π (GTSP1) is a carcinogen-detoxifying enzyme that is activated by exposure to carcinogens, and it is associated with a reduction in response to toxic therapies. We studied the expression of GTSP1 in tumor and non-tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens...
2017: PloS One
https://www.readbyqxmd.com/read/28814712/secondary-compound-hypothesis-revisited-selected-plant-secondary-metabolites-promote-bacterial-degradation-of-cis-1-2-dichloroethylene-cdce
#2
Serena Fraraccio, Michal Strejcek, Iva Dolinova, Tomas Macek, Ondrej Uhlik
Cis-1,2-dichloroethylene (cDCE), which is a common hazardous compound, often accumulates during incomplete reductive dechlorination of higher chlorinated ethenes (CEs) at contaminated sites. Simple monoaromatics, such as toluene and phenol, have been proven to induce biotransformation of cDCE in microbial communities incapable of cDCE degradation in the absence of other carbon sources. The goal of this microcosm-based laboratory study was to discover non-toxic natural monoaromatic secondary plant metabolites (SPMEs) that could enhance cDCE degradation in a similar manner to toluene and phenol...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814126/detection-of-ingested-nitromethane-and-reliable-creatinine-assessment-using-multiple-common-analytical-methods
#3
Christine M Murphy, John J Devlin, Michael C Beuhler, Paul Cheifetz, Susan Maynard, Michael D Schwartz, Sherri Kacinko
AIM: Nitromethane, found in fuels used for short distance racing, model cars, and model airplanes, produces a falsely elevated serum creatinine with standard creatinine analysis via the Jaffé method. Erroneous creatinine elevation often triggers extensive testing, leads to inaccurate diagnoses, and delayed or inappropriate medical interventions. Multiple reports in the literature identify "enzymatic assays" as an alternative method to detect the true value of creatinine, but this ambiguity does not help providers translate what type of enzymatic assay testing can be done in real time to determine if there is indeed false elevation...
August 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28812994/organ-organ-crosstalk-and-alcoholic-liver-disease
#4
REVIEW
Lauren G Poole, Christine E Dolin, Gavin E Arteel
Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well-understood. Given the poor prognosis of treating clinically-relevant alcoholic liver disease (ALD) (i.e., alcoholic hepatitis (AH) and cirrhosis), additional research is required to develop more effective therapies. While the stages of ALD have been well-characterized, targeted therapies to prevent or reverse this process in humans are still needed. Better understanding of risk factors and mechanisms underlying disease progression can lead to the development of rational therapies to prevent or reverse ALD in the clinic...
August 16, 2017: Biomolecules
https://www.readbyqxmd.com/read/28806069/oxidation-kinetics-of-bromophenols-by-nonradical-activation-of-peroxydisulfate-in-the-presence-of-carbon-nanotube-and-formation-of-brominated-polymeric-products
#5
Chao-Ting Guan, Jin Jiang, Cong-Wei Luo, Jun Ma, Su-Yan Pang, Yang Zhou, Yi Yang
This work demonstrated that bromophenols (BrPs) could be readily oxidized by peroxydisulfate (PDS) activated by a commercial carbon nanotube (CNT), while furfuryl alcohol (a chemical probe for singlet oxygen (1O2)) was quite refractory. Results obtained by radical quenching experiments, electron paramagnetic resonance spectroscopy, and Fourier transform infrared spectroscopy further confirmed the involvement of nonradical PDS-CNT complexes rather than 1O2. Bicarbonate and chloride ion exhibited negligible impacts on BrPs degradation by the PDS/CNT system, while a significant inhibitory effect was observed for natural organic matter...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28803749/the-effects-of-17%C3%AE-estradiol-on-blood-brain-barrier-integrity-in-the-absence-of-the-estrogen-receptor-alpha-an-in-vitro-model
#6
Serap Erdem Kuruca, Sabriye Karadenizli, Kadriye Akgun-Dar, Aysegul Kapucu, Zulal Kaptan, Gulay Uzum
The blood-brain barrier (BBB), which saves the brain from toxic substances, is formed by endothelial cells. It is mainly composed of tight junction (TJ) proteins existing between endothelial cells. Estrogen is an important regulatory hormone of BBB permeability. It protects the BBB before menopause, but may increase BBB permeability with aging. In addition, nitric oxide modulates BBB permeability. Alcohol impairs the integrity of the BBB with oxidants and inflammatory mediators such as iNOS. We investigated the effects of estrogen on BBB integrity in an in vitro BBB model created with ERα-free HUVEC (human umbilical vein endothelial-like cells) to mimics the menopausal period...
August 10, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28800449/enhanced-adsorption-removal-of-antibiotics-from-aqueous-solutions-by-modified-alginate-graphene-double-network-porous-hydrogel
#7
Yuan Zhuang, Fei Yu, Jie Ma, Junhong Chen
Alginate/graphene double network hydrogel has recently been demonstrated as a promising adsorbent for water pollutants. To improve the adsorption capacity of the double network hydrogel, physical and chemical modifications are made to obtain an excellent porous structure and more functional groups. As-modified alginate/graphene double network hydrogel has a higher hydroxyl group content under a higher polyvinyl alcohol content and a higher carboxyl group content with a higher oxidation degree. Moreover, the CO2 produced by CaCO3 is used as pore formation agent avoiding the use of toxic organic matters...
July 11, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28795319/levofloxacin-is-phytotoxic-and-modifies-the-protein-profile-of-lupin-seedlings
#8
Aleksandra Orzoł, Agnieszka I Piotrowicz-Cieślak
The toxicity of levofloxacin to yellow lupin plants was evaluated in this study. Recommended indexes of plant (roots and shoots) growth were determined and new indexes were proposed which better characterise the phytotoxicity of levofloxacin. These were, in particular, the activity of antioxidative enzymes, the content of free radicals, as well as the root protein content and the root protein profile. The results showed that levofloxacin considerably affected EC50, measured as the activity of catalase in roots, and leaves (1...
August 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28793200/fasd-folic-acid-and-formic-acid-an-unholy-alliance-in-the-alcohol-abusing-mother
#9
Bhushan M Kapur, Marta Baber
Alcohol consumption during pregnancy remains a significant cause of preventable birth defects and developmental disabilities, however, the mechanism of toxicity remains unclear. Methanol is present as a congener in many alcoholic beverages and is formed endogenously. Since ethanol is preferentially metabolized over methanol, it has been found in the sera and CSF of alcoholics. Toxicity resulting from methanol has been attributed to formic acid. Formic acid is present in significantly higher quantities in biofluids of alcoholic patients...
August 9, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28780476/health-behaviour-information-provided-to-clients-during-midwife-led-prenatal-booking-visits-findings-from-video-analyses
#10
Ruth Baron, Linda Martin, Janneke T Gitsels-van der Wal, Janneke Noordman, Martijn W Heymans, Evelien R Spelten, Johannes Brug, Eileen K Hutton
OBJECTIVE: to quantify to what extent evidence-based health behaviour topics relevant for pregnancy are discussed with clients during midwife-led prenatal booking visits and to assess the association of client characteristics with the extent of information provided. DESIGN: quantitative video analyses. SETTING AND PARTICIPANTS: 173 video recordings of prenatal booking visits with primary care midwives and clients in the Netherlands taking place between August 2010 and April 2011...
July 10, 2017: Midwifery
https://www.readbyqxmd.com/read/28771357/class-i-hdac-inhibitors-potential-new-epigenetic-therapeutics-for-alcohol-use-disorder-aud
#11
Erika Bourguet, Katarzyna Ozdarska, Gautier Moroy, Jérôme Jeanblanc, Mickael Naassila
Alcohol use disorder (AUD) represents a serious public health issue, and discovery of new therapies is a pressing necessity. Alcohol exposure has been widely demonstrated to modulate epigenetic mechanisms, such as histone acetylation/deacetylation balance, in part via histone deacetylase (HDAC) inhibition. Epigenetic factors have been suggested to play a key role in AUD. To date, 18 different mammalian HDAC isoforms have been identified, and these have been divided into four classes. Since recent studies have suggested that both epigenetic mechanisms underlying AUD and the efficacy of HDAC inhibitors (HDACIs) in different animal models of AUD may involve class I HDACs, we herein report the development of class I HDACIs, including information regarding their structure, potency, and selectivity...
August 3, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28770944/deposition-of-metallic-silver-coatings-by-aerosol-assisted-mocvd-using-two-new-silver-%C3%AE-diketonate-adduct-metalorganic-precursors
#12
H Liu, S Battiato, A L Pellegrino, P Paoli, P Rossi, C Jiménez, G Malandrino, D Muñoz-Rojas
This work reports two new silver metalorganic precursors for the chemical vapor deposition of Ag metallic coatings. Both precursors are based on β-diketonate adducts, namely, Ag(hfac)(L) (H-hfac = 1,1,1,5,5,5-hexafluoro-2,4-pentanedione), where L is 1,10-phenanthroline (phen) or 2,5,8,11-tetraoxadodecane (triglyme). Using these ligands, the designed precursors have better solubility in alcoholic solvents and are less toxic and costly than previously reported ones. The new precursors have been characterized and their crystallographic structure solved...
August 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28766523/-the-morphological-diagnostics-of-the-toxic-effects-of-the-smoking-blends-in-the-cases-of-fatal-intoxication-with-pyrrolidinovalerophenone
#13
P G Dzhuvalyakov, Yu V Zbrueva, S S Kabakova, D V Bogomolov, M R Bekeshov
The objective of the present study was the development of the morphological criteria for the diagnostics of fatal intoxication with the herbal smoking blends (spices) using the samples of the biological materials obtained from the victims of pyrrolidinovalerophenone poisoning. The samples were taken from 13 autopsied cadavers of 11 men and 2 women at the age from 26 to 39 years based at the Astrakhan Regional Bureau of Forensic Medical Expertise during the period from 21011 to 2015. The diagnosis of pyrrolidinvalerpphenon poisoning was verified to the letter...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28766521/-the-experimental-and-postmortem-morphological-characteristic-of-the-chronic-action-of-alcohol-on-the-testicles
#14
V S Ulanov
The objective of the present study was to analyze the dynamics of the morphological changes that manifest themselves in the testicles of mature rats exposed to chronic alcohol intoxication over a period up to 6 months and to compare them with the analogous changes in the testicles of men who had had the long history of alcohol dependence and died with the pronounced symptoms of alcohol intoxication. The study has demonstrated the strong resemblance between the changes in the testes of men and animals including such as the dystrophic alteration of the spermatogenic epithelium, diffuse overgrowth of the connective tissue, well apparent signs of disturbed blood circulation, and suppression of spermatogenesis...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28763661/the-mechanism-and-efficiency-of-mno2-activated-persulfate-process-coupled-with-electrolysis
#15
Yin Xu, Heng Lin, Yukun Li, Hui Zhang
Pure three-dimensional manganese oxides (MnO2) were successfully synthesized by a simple one-step hydrothermal process. The obtained particles were characterized via XRD, BET, SEM, XPS and FTIR techniques. To enhance the efficiency of heterogeneous catalytic process, a facile and effective electrochemical method was introduced. The degradation of C. I. Acid Orange 7 (AO7) as the target pollutant in aqueous solution by an oxidation system involving MnO2 activated peroxydisulfate (PDS) coupled with electrochemical method is reported herein...
July 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28758797/an-in-vitro-evaluation-of-the-effects-of-a-yucca-schidigera-extract-and-chestnut-tannins-on-composition-and-metabolic-profiles-of-canine-and-feline-faecal-microbiota
#16
Carlo Pinna, Carla Giuditta Vecchiato, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Claudio Stefanelli, Monica Grandi, Pier Paolo Gatta, Giacomo Biagi
The in vitro effect of a Yucca schidigera extract (YSE) and tannins from chestnut wood on composition and metabolic activity of canine and feline faecal microbiota was evaluated. Four treatments were carried out: control diet, chestnut tannins (CT), YSE and CT + YSE. The YSE was added to canine and feline faecal cultures at 0.1 g/l, while CT were added at 0.3 g/l for a 24-h incubation. A total of 130 volatile compounds were detected by means of headspace-solid phase microextraction gas-chromatography/mass spectrometry analyses...
July 31, 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28758286/sequential-extraction-of-flavonoids-and-pectin-from-yellow-passion-fruit-rind-using-pressurized-solvent-or-ultrasound
#17
Caroline Gondim de Souza, Tigressa Helena Soares Rodrigues, Lorena Mara Alexandre eSilva, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito
BACKGROUND: Passion fruit rind (PFR) represents 90% of the total fruit weight and is wasted during juice processing. Passion fruit rind is known to contain flavonoids and pectin. An alternative use for this fruit juice industrial residue is to obtain these compounds. This study aimed to verify the influence of pressurized solvent extraction (PSE) or ultrasound assisted extraction (UAE) of flavonoid and pectin in a sequential process. RESULTS: The PSE using ethanol at 60:40 (v/v) yielded a total polyphenol content of 4...
July 31, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28756822/exposure-to-toxics-during-pregnancy-and-childhood-and-asthma-in-children-a-pilot-study
#18
Souheil Hallit, Pascale Salameh
Environmental factors, pesticides, alcohol and smoking are linked to asthma in children. The association of toxic substances exposure with asthma has not been evaluated. Our objective is to assess such associations among children aged less than 16years old. This is a cross-sectional study, conducted between January and May 2015, using a sample of Lebanese students from private schools in Beirut and Mount Lebanon. Out of 700 distributed questionnaires, 527 (75.2%) were returned to us. Verbal informed consent was also obtained from all parents prior to participating in the study...
September 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28753046/levetiracetam-in-toxic-seizures
#19
Ted Lee, Brandon J Warrick, Preeyaporn Sarangarm, Robert L Alunday, Silas Bussmann, Susan C Smolinske, Steven A Seifert
BACKGROUND/OBJECTIVES: The use of levetiracetam (LEV) in the management of drug-induced seizures has not been systematically investigated. Repetitive and continuous seizures that do not respond to benzodiazepines require second line therapy. Levetiracetam has a unique receptor binding site, rapid absorption, no known cardiac effects at therapeutic doses, and is theoretically a good candidate for use in drug-induced seizures. We evaluate the safety of LEV and its association with seizure cessation in this retrospective chart review of patients who received LEV as a control agent in drug-induced seizures...
July 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28750752/aging-and-circadian-dysfunction-increase-alcohol-sensitivity-and-exacerbate-mortality-in-drosophila-melanogaster
#20
Aliza K De Nobrega, Alana P Mellers, Lisa C Lyons
Alcohol abuse is a rising problem in middle-aged and older individuals resulting in serious health, family and economic consequences. Effective treatment necessitates the identification of factors influencing alcohol toxicity with aging. We investigated the interaction between aging, alcohol toxicity and circadian function using Drosophila as a model system. We found as wild type flies age, sensitivity to alcohol increases and circadian regulation of alcohol-induced behaviors weakens. Decreased circadian modulation is correlated with significantly greater alcohol sensitivity during the subjective day...
July 25, 2017: Experimental Gerontology
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