keyword
MENU ▼
Read by QxMD icon Read
search

tuberculosis mdr

keyword
https://www.readbyqxmd.com/read/29770053/tuberculosis-drug-resistance-in-canada-2006-2016
#1
V Gallant, J Vachon, W Siu
Background: Drug-resistant strains of tuberculosis (TB) pose a serious threat to TB prevention and control efforts. The Canadian Tuberculosis Laboratory Surveillance System (CTBLSS) was created in 1998 to monitor emerging trends and patterns in TB drug resistance in Canada. Objective: To present a descriptive overview of TB drug resistance data collected through the CTBLSS for the years 2006 to 2016 in Canada, with a focus on 2016. Methods: The CTBLSS is an isolate-based surveillance system designed to collect data on TB drug resistance across Canada...
November 2, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29765372/is-iqg-607-a-potential-metallodrug-or-metallopro-drug-with-a-defined-molecular-target-in-mycobacterium-tuberculosis
#2
REVIEW
Bruno L Abbadi, Valnês da Silva Rodrigues-Junior, Adilio da Silva Dadda, Kenia Pissinate, Anne D Villela, Maria M Campos, Luiz G de França Lopes, Cristiano V Bizarro, Pablo Machado, Eduardo H S Sousa, Luiz A Basso
The emergence of strains of Mycobacterium tuberculosis resistant to isoniazid (INH) has underscored the need for the development of new anti-tuberculosis agents. INH is activated by the mycobacterial katG -encoded catalase-peroxidase, forming an acylpyridine fragment that is covalently attached to the C4 of NADH. This isonicotinyl-NAD adduct inhibits the activity of 2- trans -enoyl-ACP(CoA) reductase (InhA), which plays a role in mycolic acid biosynthesis. A metal-based INH analog, Na3 [FeII (CN)5 (INH)]·4H2 O, IQG-607, was designed to have an electronic redistribution on INH moiety that would lead to an intramolecular electron transfer to bypass KatG activation...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29755957/molecular-targets-related-drug-resistance-mechanisms-in-mdr-xdr-and-tdr-mycobacterium-tuberculosis-strains
#3
REVIEW
H M Adnan Hameed, Md Mahmudul Islam, Chiranjibi Chhotaray, Changwei Wang, Yang Liu, Yaoju Tan, Xinjie Li, Shouyong Tan, Vincent Delorme, Wing W Yew, Jianxiong Liu, Tianyu Zhang
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis . Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29746491/emergence-and-selection-of-isoniazid-and-rifampin-resistance-in-tuberculosis-granulomas
#4
Elsje Pienaar, Jennifer J Linderman, Denise E Kirschner
Drug resistant tuberculosis is increasing world-wide. Resistance against isoniazid (INH), rifampicin (RIF), or both (multi-drug resistant TB, MDR-TB) is of particular concern, since INH and RIF form part of the standard regimen for TB disease. While it is known that suboptimal treatment can lead to resistance, it remains unclear how host immune responses and antibiotic dynamics within granulomas (sites of infection) affect emergence and selection of drug-resistant bacteria. We take a systems pharmacology approach to explore resistance dynamics within granulomas...
2018: PloS One
https://www.readbyqxmd.com/read/29744042/prevalence-and-patterns-of-drug-resistance-among-pulmonary-tuberculosis-patients-in-hangzhou-china
#5
Qingchun Li, Gang Zhao, Limin Wu, Min Lu, Wei Liu, Yifei Wu, Le Wang, Ke Wang, Han-Zhu Qian, Li Xie
Background: To evaluate prevalence and patterns of drug resistance among pulmonary tuberculosis (TB) patients in Hangzhou City, China. Methods: Sputum samples of smear positive TB patients enrolled in 2011 and 2015 were collected and tested for drug susceptibility, and demographic and medical record data were extracted from the electronic database of China Information System for Disease Control and Prevention. Chi-square test was used to compare drug resistance prevalence between new and treated patients and between male and female patients, and Chi-square test for trend was used to compare the prevalence over calendar years 2011 and 2015...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29742052/clinical-and-drug-resistance-characteristics-of-new-pediatric-tuberculosis-cases-in-northern-china
#6
Ting Wang, Fang Dong, Qin-Jing Li, Qing-Qin Yin, Wen-Qi Song, Igor Mokrousov, Wei-Wei Jiao, A-Dong Shen
AIM: The aim of this study was to evaluate the clinical features and characteristics of drug resistance in newly diagnosed pediatric tuberculosis (TB) patients in northern China. METHODS: Mycobacterium tuberculosis isolates were collected from September 2010 to October 2016 at the Beijing Children's Hospital. Patients were divided into two groups (resistant to at least one drug and pan-susceptible) according to drug susceptibility testing (DST) results. RESULTS: A total of 132 new cases, mainly from northern China (87...
May 9, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29739554/managing-mdr-tuberculosis-in-nepal
#7
Sophie Cousins
No abstract text is available yet for this article.
May 5, 2018: Lancet
https://www.readbyqxmd.com/read/29726023/the-determination-of-capreomycin-in-human-plasma-by-lc-ms-ms-using-ion-pairing-chromatography-and-solid-phase-extraction
#8
Blessings Thuboy, Tracy Kellermann, Sandra Castel, Jennifer Norman, Anton Joubert, Anthony J Garcia-Prats, Anneke C Hesseling, Lubbe Wiesner
A bioanalytical method was developed and validated for the quantification of Capreomycin (Cm) analogues, Cm IA and Cm IB, in human plasma. This implemented ion-pairing solid phase extraction (IP-SPE), followed by ion-pairing high performance liquid chromatography (IP-HPLC), with tandem mass spectrometry detection. Chromatographic separation was achieved using a Discovery C18, 5μm, 4.6 mm x 50 mm analytical column. An isocratic mobile phase consisting of water and acetonitrile with 0.1% formic acid and 4 mM Heptafluorobutyric acid (80,20; v/v), was used at a flow-rate of 500 μl per minute...
May 3, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29721826/importance-of-differential-identification-of-mycobacterium-tuberculosis-strains-for-understanding-differences-in-their-prevalence-treatment-efficacy-and-vaccine-development
#9
REVIEW
Hansong Chae, Sung Jae Shin
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to control the host immune response and to evade killing by drugs, resulting in the breakdown of BCG vaccine-conferred anti-TB immunity and development of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb. Although genetic components of the genomes of the Mtb complex strains are highly conserved, showing over 99% similarity to other bacterial genera, recently accumulated evidence suggests that the genetic diversity of the Mtb complex strains has implications for treatment outcomes, development of MDR/XDR Mtb, BCG vaccine efficacy, transmissibility, and epidemiological outbreaks...
May 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29720074/tuberculosis-notifications-in-australia-2014
#10
Cindy Toms, Richard Stapledon, Chris Coulter, Paul Douglas
In 2014, the National Notifiable Diseases Surveillance System received 1,339 tuberculosis (TB) notifications, representing a rate of 5.7 per 100,000 population. Australia has achieved and maintained good tuberculosis (TB) control since the mid-1980s, sustaining a low annual TB incidence rate of approximately 5 to 6 cases per 100,000 population. The number of multi-drug resistant TB (MDR-TB) cases diagnosed in Australia is low by international standards, with approximately 1-2% of notifications per year being classified as MDR-TB...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29710471/recent-therapeutic-approaches-for-the-management-of-tuberculosis-challenges-and-opportunities
#11
REVIEW
Kiran Patil, Shashikant Bagade, Smita Bonde, Sanjay Sharma, Gaurav Saraogi
Tuberculosis is a highly contagious disease spread by Mycobacterium tuberculosis. It is responsible for highest numbers of death and soon will surpass the deaths caused by HIV. The pandemic disease causes, estimated 10.4 million new infections, among which 5.9 million were men, 3.5 million were women, 1.0 million were children and the HIV patients co-infected with tuberculosis accounted for 1.2 million of all new cases in 2015, alone. The increased number of drug resistant (MDR/XDR) strains and the failure of the conventional regimens against this strain are the challenges of the coming decades...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29709976/tuberculosis-disease-among-healthcare-workers-clinical-microbiological-characteristics-and-treatment-outcomes-at-chiang-mai-university-hospital-thailand
#12
Juthamas Inchai, Chalerm Liwsrisakun, Chaiwat Bumroongkit, Juntima Eauthrongchit, Pattraporn Tajareunmuang, Chaicharn Pothirat
Tuberculosis (TB) among healthcare workers (HCWs) highly impacts morbidity and TB transmission in hospital. A retrospective cohort study of TB among HCWs (HCW-TB) was conducted using a registered database from 2003 to 2016 at Chiang Mai University Hospital to determine clinical and microbiological characteristics and treatment outcomes of HCW-TB. Seventy-six cases of HCWs, 54 nurses (71.1%), 12 physicians (15.8%) and 10 paramedics (13.2%), were diagnosed with TB disease. Female to male ratio of 51:25, mean age of 37...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29706316/mutations-inside-rifampicin-resistance-determining-region-of-rpob-gene-associated-with-rifampicin-resistance-in-mycobacterium-tuberculosis
#13
REVIEW
Myo T Zaw, Nor A Emran, Zaw Lin
BACKGROUND: Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene. The majority of the mutations in rpoB gene are found within an 81bp RIF-resistance determining region (RRDR). METHODOLOGY: Literatures on RIF resistant mutations published between 2010 and 2016 were thoroughly reviewed...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29702266/genome-sequence-of-mycobacterium-yongonense-rt-955-2015-isolate-from-a-patient-misdiagnosed-with-multi-drug-resistant-tuberculosis-first-clinical-isolate-in-tanzania
#14
Nicholaus Peter Mnyambwa, Dong-Jin Kim, Esther Ngadaya, Jongsik Chun, Sung-Min Ha, Pammla Petrucka, Kennedy Kwasi Addo, Rudovick R Kazwala, Sayoki G Mfinanga
BACKGROUND: Mycobacterium yongonense is a recently described novel species belonging to Mycobacterium avium complex which is the most prevalent etiology of non-tuberculous mycobacteria associated with pulmonary infections, and posing tuberculosis diagnostic challenges in high-burden, resource-constrained settings. METHODS: We used whole genome shotgun sequencing and comparative microbial genomic analyses to characterize the isolate from a patient diagnosed with multi-drug resistant tuberculosis (MDR-TB) after relapse...
April 24, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29697293/benzothiazole-analogues-as-potential-anti-tb-agents-computational-input-and-molecular-dynamics
#15
Katharigatta N Venugopala, Mohammed A Khedr, Melendhran Pillay, Susanta K Nayak, Sandeep Chandrashekharappa, Bandar E Al Dhubiab, Sree Harsha, Mahesh Attimarad, Bharti Odhav
Biotin is very important for the survival of Mycobacterium tuberculosis. 7,8-Diamino pelargonic acid aminotransaminase (DAPA) is a transaminase enzyme involved in the biosynthesis of biotin. The benzothiazole title compounds were investigated for their in vitro anti-tubercular activity against two tubercular strains: H37Rv (ATCC 25177) and MDR-MTB (multidrug-resistant M. tuberculosis, resistant to isoniazid, rifampicin, and ethambutol) by an agar incorporation method. The possible binding mode and predicted affinity were computed using a molecular docking study...
April 26, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29691959/the-relationship-between-social-support-treatment-interruption-and-treatment-outcome-in-patients-with-multidrug-resistant-tuberculosis-in-china-a-mixed-methods-study
#16
Jia Yin, Xiaomeng Wang, Lin Zhou, Xiaolin Wei
OBJECTIVE: Multidrug-resistant tuberculosis (MDR-TB) has been a major threat for successful TB control. We examined the relationship between social support and treatment outcomes in MDR-TB patients and evaluated barriers to social support. METHODS: Retrospective cohort study with MDR-TB patients enrolled in the Global Fund program between 1 January 2009 and 30 June 2014 in Zhejiang, China. We reviewed all MDR-TB patients' diagnoses and treatment outcomes. In-depth interviews were conducted with 10 community health workers and 10 patients...
April 24, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29688486/congenital-multidrug-resistant-tuberculosis-in-a-neonate-a-case-report
#17
Tenzin Lhadon, Sophie Jullien
Multidrug-resistant tuberculosis (MDR-TB) is a well-identified raising public health concern worldwide. However, the data available on MDR-TB in children and particularly in the neonate age group are limited. Congenital tuberculosis (TB) is rare, and its diagnosis is challenging because of non-specific manifestations. The choice of anti-tubercular drugs is difficult because of the lack of international consensus as a consequence of the scarcity of evidence-based data on this age group. We hereby present a case from Bhutan of a 23-day-old male neonate with congenital MDR-TB...
April 20, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29686171/influence-of-diabetes-mellitus-on-the-development-of-multi-drug-resistant-tuberculosis-in-yogyakarta
#18
Antonia Morita Iswari Saktiawati, Yanri Wijayanti Subronto
BACKGROUND: the correlation between diabetes mellitus (DM) and Multi-Drug-Resistant Tuberculosis (MDR-TB) has never been studied among patients with tuberculosis (TB) in Indonesia, while DM has been identified to alter immune response and pharmacokinetics of TB medications that may lead to a failure of TB treatment and develop MDR-TB. Our study aimed to analyze the influence of diabetes mellitus on the development of MDR-TB. METHODS: a retrospective cohort study was carried out on 356 TB patients at the Provincial Lung Clinics and Sardjito Hospital, Yogyakarta, Indonesia between 2010 and 2014...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29686169/risk-factors-for-multidrug-resistant-tuberculosis
#19
Cleopas Martin Rumende
In 2015, 10.4 million people developed tuberculosis (TB) and 580,000 amongst them suffered from multidrug-resistant TB (MDR-TB). From those 580,000 cases of MDR-TB, only 125,000 were detected and reported. A total of 111,000 people began to receive MDR-TB treatment in 2014 while 190,000 MDR-TB patients were estimated to have died, largely due to lack of access to effective treatment. The mechanism of drug resistance can be caused by genetic factors, factors related to previous treatment and other factors such as comorbidity with diabetes mellitus...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29686156/metabolism-of-sklb-tb1001-a-potent-antituberculosis-agent-in-animals
#20
Lu Xiong, Chao Gao, Yao-Jie Shi, Xin Tao, Cui-Ting Peng, Juan Rong, Kun-Lin Liu, Qian Lei, Yi-Wen Zhang, Ning-Yu Wang, Luo-Ting Yu
Tuberculosis (TB) is a major global health problem, and the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has increased the difficulty of treating this disease. Among the novel antituberculosis drugs in the pipeline, decaprenylphosphoryl-beta-D-ribose-2-epimerase (DprE1) inhibitors such as BTZ043 and pBTZ169 exhibited extraordinary antituberculosis potency. Herein, the metabolites of the new DprE1 inhibitor SKLB-TB1001 in vivo and its inhibition of cytochrome P450 isoforms and plasma protein binding (PPB) in vitro were studied...
April 23, 2018: Antimicrobial Agents and Chemotherapy
keyword
keyword
114342
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"