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Drug-induced nightmares

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https://www.readbyqxmd.com/read/27053542/medication-related-osteonecrosis-of-the-jaw-a-dentist-s-nightmare
#1
Arvind Muthukrishnan, Laliytha Bijai Kumar, Gomathi Ramalingam
Medication-related osteonecrosis of the jaw (MRONJ) is a complication in patients who are on anti-bone resorptive drugs. These drugs are prescribed for patients with multiple myeloma, osteoporosis, metastatic carcinoma and Paget's disease. Common anti-bone resorptive drugs such as bisphosphonate and monoclonal antibodies such as denosumab are prescribed for these patients to prevent bone resorption. Although very effective in preventing bone resorption, a complication arising from these groups of drugs is the development of osteomyelitis of the jaw...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26203180/efavirenz-and-the-cns-what-we-already-know-and-questions-that-need-to-be-answered
#2
REVIEW
Nadezda Apostolova, Haryes A Funes, Ana Blas-Garcia, Maria J Galindo, Angeles Alvarez, Juan V Esplugues
The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and favourable pharmacokinetics. However, growing concern about its adverse effects has sometimes led to efavirenz being replaced by other drugs in the initial treatment selection or to switching of therapy to efavirenz-free regimens in experienced patients. Neurological and neuropsychiatric reactions are the manifestations most frequently experienced by efavirenz-treated patients and range from transitory effects, such as nightmares, dizziness, insomnia, nervousness and lack of concentration, to more severe symptoms including depression, suicidal ideation or even psychosis...
October 2015: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/24637595/off-label-abuse-of-antibiotics-by-bacteria
#3
EDITORIAL
V K Viswanathan
Antibiotics and antibiotic resistance made news on several fronts in the past year. Many public health organizations, including the CDC, used terms such as "crisis", "catastrophic consequences", and "nightmare scenario" to highlight the rapid emergence and spread of antibiotic resistance. A report from the Pew Commission on Industrial Farm Animal Production, on the fifth anniversary of the publication of its landmark 2008 report, noted that state and federal legislative efforts to limit non-therapeutic use of antibiotics in animal production were thwarted by drug and food animal industries...
January 2014: Gut Microbes
https://www.readbyqxmd.com/read/23698878/what-has-been-going-on-with-my-sleep-after-my-car-accident
#4
Veronica Brito, Chrisoula Politis, Shalinee Chawla
SESSION TYPE: Miscellaneous Case Report Posters IPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Hypnagogic hallucinations are hallucinatory experiences that accompany the onset of awakening, they can occur in certain states, such as sleep deprivation and conditions such as narcolepsy. Main neural structures responsible for muscle atonia in REM sleep are dorsolateral portions of the pons and brainstem, cholinergic and cholinoceptive REM sleep-on neurons, monoaminergic REM sleep-off neurons...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/22833552/can-gradual-dose-titration-of-ketamine-for-management-of-neuropathic-pain-prevent-psychotomimetic-effects-in-patients-with-advanced-cancer
#5
Yoshiaki Okamoto, Satoru Tsuneto, Hitoshi Tanimukai, Yoichi Matsuda, Yumiko Ohno, Mamiko Tsugane, Etsuko Uejima
BACKGROUND: Ketamine is often used to manage neuropathic pain in patients with cancer. However, it occasionally causes psychotomimetic effects such as vivid dreams, nightmares, illusions, hallucinations, and altered body image. OBJECTIVE: To examine whether gradual dose titration of ketamine for management of neuropathic pain prevents psychotomimetic effects in patients with advanced cancer. METHODS: This was a retrospective chart review. We administered ketamine when neuropathic pain in patients with advanced cancer became refractory to opioids and oral adjuvant analgesics...
August 2013: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/22416829/a-case-of-serial-nightmares-and-oneiroid-state-under-paroxetine-for-senile-depression
#6
Toshiyuki Kobayashi, Mina Yamauchi
We report on rare side effects of paroxetine. A 67-year-old female patient who had been suffering from prolonged depression for over a year but had not received appropriate treatment was administered 20-mg paroxetine daily. However, the patient required hospital admission after 16 days because of behavioural disturbances and delusions that she was being chased by evil persons from a religious group. The delusions were ultimately confirmed to be serial nightmares and an oneiroid state. The nightmares gradually disappeared following discontinuation of paroxetine...
March 2012: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/22289835/-the-prediction-of-immunogenicity-of-therapeutic-proteins
#7
REVIEW
Bernard Maillère, Stéphanie Delluc, Gilles Ravot
Immunogenicity of therapeutic proteins is a nightmare for industrials because induced antibodies can neutralize the therapeutic activity and provoke autoimmune symptoms. It was believed that sequence humanization would be sufficient to tackle these problems but multiple clinical examples now demonstrate that humanization does not suffice to abrogate immune responses. In order to predict immunogenicity of therapeutic proteins, different approaches have been developed, among which the most relevant ones are based on the evaluation of the response of naïve CD4 T lymphocytes specific for therapeutic proteins...
January 2012: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/22096876/-psychiatric-issues-during-and-after-intensive-care-icu-stays
#8
Frédéric Pochard
Stays in intensive care units (ICUs) are a source of psychological and physical stress, sometimes resulting in psychological disorders that may persist after ICU discharge. ICU stressors include exhaustion, drug-induced sleep privation, intubation, pain, noise, and a disrupted light-dark cycle. Patients remember traumatic experiences, such as a fear of being killed or abandoned, nightmares, and panic attacks. Depression is frequent but difficult to detect. Psychiatric disorders such as delirium and confusion (hallucinations, agitation, stupor) occur in almost half of all ICU patients...
February 2011: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/21909798/a-hidden-markov-model-to-assess-drug-induced-sleep-fragmentation-in-the-telemetered-rat
#9
C Diack, O Ackaert, B A Ploeger, P H van der Graaf, R Gurrell, M Ivarsson, D Fairman
Drug-induced sleep fragmentation can cause sleep disturbances either via their intended pharmacological action or as a side effect. Examples of disturbances include excessive daytime sleepiness, insomnia and nightmares. Developing drugs without these side effects requires insight into the mechanisms leading to sleep disturbance. The characterization of the circadian sleep pattern by EEG following drug exposure has improved our understanding of these mechanisms and their translatability across species. The EEG shows frequent transitions between specific sleep states leading to multiple correlated sojourns in these states...
December 2011: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/21734915/a-lightning-strike-to-the-head-causing-a-visual-cortex-defect-with-simple-and-complex-visual-hallucinations
#10
Ingo Kleiter, Ralf Luerding, Gerhard Diendorfer, Helga Rek, Ulrich Bogdahn, Berthold Schalke
The case of a 23-year-old mountaineer who was hit by a lightning strike to the occiput causing a large central visual field defect and bilateral tympanic membrane ruptures is described. Owing to extreme agitation, the patient was sent into a drug-induced coma for 3 days. After extubation, she experienced simple and complex visual hallucinations for several days, but otherwise largely recovered. Neuropsychological tests revealed deficits in fast visual detection tasks and non-verbal learning and indicated a right temporal lobe dysfunction, consistent with a right temporal focus on electroencephalography...
2009: BMJ Case Reports
https://www.readbyqxmd.com/read/21628140/medication-induced-sleep-disturbances
#11
REVIEW
Pamela Foral, Jon Knezevich, Naresh Dewan, Mark Malesker
OBJECTIVE: To review the literature for medication-induced sleep disturbances. DATA SOURCE: MEDLINE/PUBMED searches (January 2000-May 2010) were conducted to identify pertinent English-language studies. STUDY SELECTION AND DATA EXTRACTION: References were reviewed to identify literature that provided evidence of sleep disturbances caused by prescription medications. DATA SYNTHESIS: Review of studies was performed to determine the effect a given medication had on subjects' sleep architecture or those that induced common sleep disorders...
June 2011: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/20334466/acute-psychosis-associated-with-dissociated-sleep-wakefulness-state-after-mirtazapine-treatment
#12
Alan R Felthous, Philip J Wenger, Rod Hoevet
Tricyclic antidepressants decrease rapid eye movement (REM) sleep and may suppress sleep atonia. Reports indicate that these agents can induce visual hallucinations, sometimes characterized as hypnopompic or associated with a dissociated sleep-wakefulness state. In addition, disturbing dreams and confusional states were reported during clinical trials and in subsequent studies. To our knowledge, only two cases of nightmares associated with mirtazapine, a tetracyclic antidepressant, have been previously reported...
April 2010: Pharmacotherapy
https://www.readbyqxmd.com/read/19384170/rimonabant-affects-cyclosporine-a-but-not-tacrolimus-pharmacokinetics-in-renal-transplant-recipients
#13
Rune Amundsen, Anders Asberg, Ida Robertsen, Nils T Vethe, Stein Bergan, Anders Hartmann, Karsten Midtvedt
BACKGROUND: Obesity is a common problem following renal transplantation. Rimonabant, a cannabinoid-1 receptor blocker, offers a new approach for reducing obesity. METHODS: The potential pharmacokinetic interaction between rimonabant and cyclosporine A (CsA, n=10) and tacrolimus (Tac, n=8) was assessed in stable renal transplant recipients 6.2 (0.9-21.7) years posttransplant. A 12-hour pharmacokinetic profile was obtained before and after two months of concomitant treatment with 20 mg rimonabant each morning...
April 27, 2009: Transplantation
https://www.readbyqxmd.com/read/17430825/adverse-effects-of-opioids-on-the-central-nervous-systems-of-palliative-care-patients
#14
REVIEW
Jane Vella-Brincat, A D Macleod
Opioids, defined as drugs that stimulate opioid receptors, are primarily used in the treatment of moderate to severe pain. They induce central nervous system (CNS) adverse effects which can be divided into three groups. The first group includes effects that lower the level of consciousness-sedation, drowsiness and sleep disturbance. The second group affects the thinking process and the ability to react-cognitive impairment, psychomotor impairment, delirium, hallucinations, dreams and nightmares. The third group is of the direct toxic effects of opioids on neurons and includes myoclonus (perhaps), hyperalgesia and tolerance...
2007: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/17369595/a-lightning-strike-to-the-head-causing-a-visual-cortex-defect-with-simple-and-complex-visual-hallucinations
#15
Ingo Kleiter, Ralf Luerding, Gerhard Diendorfer, Helga Rek, Ulrich Bogdahn, Berthold Schalke
The case of a 23-year-old mountaineer who was hit by a lightning strike to the occiput causing a large central visual field defect and bilateral tympanic membrane ruptures is described. Owing to extreme agitation, the patient was set to a drug-induced coma for 3 days. After extubation, she experienced simple and complex visual hallucinations for several days, but otherwise recovered largely. Neuropsychological tests revealed deficits in fast visual detection tasks and non-verbal learning, and indicated a right temporal lobe dysfunction, consistent with a right temporal focus on electroencephalography...
April 2007: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/17367260/neuropsychiatric-side-effects-of-efavirenz-therapy
#16
REVIEW
Gabriele Arendt, Dominique de Nocker, Hans-Juergen von Giesen, Thorsten Nolting
The non-nucleoside analogue inhibitor of the reverse transcriptase, efavirenz (EFV), has become commonly used in highly active antiretroviral combination therapy in the treatment of HIV infection. Although being effective in suppressing plasma viral load, neuropsychiatric side effects have been reported in individuals treated with EFV. There are early complications, such as acute psychosis resembling reactions to LSD intake, as well as nightmares occurring for several days up to 4 weeks after the start of therapy...
March 2007: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/17317642/treatment-of-acute-promyelocytic-leukaemia-with-all-trans-retinoic-acid-and-arsenic-trioxide-a-paradigm-of-synergistic-molecular-targeting-therapy
#17
REVIEW
Guang-Biao Zhou, Ji Zhang, Zhen-Yi Wang, Sai-Juan Chen, Zhu Chen
To turn a disease from highly fatal to highly curable is extremely difficult, especially when the disease is a type of cancer. However, we can gain some insight into how this can be done by looking back over the 50-year history of taming acute promyelocytic leukaemia (APL). APL is the M3 type of acute myeloid leukaemia characterized by an accumulation of abnormal promyelocytes in bone marrow, a severe bleeding tendency and the presence of the chromosomal translocation t(15;17) or variants. APL was considered the most fatal type of acute leukaemia five decades ago and the treatment of APL was a nightmare for physicians...
June 29, 2007: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/16175159/the-neuropsychiatry-of-parkinson-s-disease
#18
REVIEW
E C Lauterbach
The neuropsychiatry of Parkinson's disease (PD) and its correlates are reviewed. Dementia occurs in up to 30% and can be treated with cholinesterase inhibitors. Cognitive impairments involve executive, visuospatial, attentional, and memory dysfunctions. Apathy may respond to dopamine agonists or cholines-terase inhibitors. Cognitive impairment, psychosis, and depression predict quality of life. Visual hallucinations and paranoia are common, and respond to low dose clozapine. Depression is common and predicts caregiver burden and depression...
June 2005: Minerva Medica
https://www.readbyqxmd.com/read/15910512/a-randomized-placebo-controlled-trial-of-an-nmda-receptor-antagonist-in-sleep-disordered-breathing
#19
RANDOMIZED CONTROLLED TRIAL
Stefan Torvaldsson, Ludger Grote, Yüksel Peker, Hans Basun, Jan Hedner
Hypoxemia is a powerful stimulus of glutamate release in the central nervous system (CNS) and a hallmark phenomenon in sleep disordered breathing (SDB). Glutamate effects that include neuronal damage and apoptosis following hypoxemia and apnea following microinjections in animal models are in part mediated via postjunctional N-methyl-D-aspartate (NMDA) receptors. This was a double blind, randomized, placebo-controlled single dose cross-over study of the NMDA receptor antagonist AR-R15896AR in 15 male patients with moderate to severe SDB...
June 2005: Journal of Sleep Research
https://www.readbyqxmd.com/read/15765332/incidence-and-severity-of-recovery-agitation-after-ketamine-sedation-in-young-adults
#20
Steven M Green, Thomas S Sherwin
PURPOSES: Psychic recovery reactions after ketamine administration are not uncommon in adults, but yet are rare in children 15 years old and younger. The nature of such reactions has not been previously described in young adults, and accordingly we wished to quantify the incidence and severity of recovery agitation after ketamine sedation in patients aged 16 to 21 years. BASIC PROCEDURES: We prospectively collected data on 26 young adults aged 16 to 21 years who received ketamine for emergency department procedures, and treating physicians rated recovery "agitation," "crying," and "unpleasant hallucinations or nightmares" each on a 100-mm visual analog scale (0 mm="none," 100 mm="worst possible")...
March 2005: American Journal of Emergency Medicine
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