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https://www.readbyqxmd.com/read/27908262/sleep-alterations-in-non-demented-older-individuals-the-role-of-cortisol
#1
Ana Belén Castelló-Domenech, Vanessa Ibáñez Del Valle, Julio Fernández-Garrido, Mary Martínez-Martínez, Omar Cauli
BACKGROUND: Sleep alterations can impair quality of life and contribute to disease progression but they, and their features and contributing factors, are rarely analysed in institutionalised older individuals. In this study we investigated sleep alterations, the factors involved, and the role of cortisol in sleep-related problems in institutionalised individuals. METHODS: We conducted a descriptive cross-sectional study in participants living in nursing homes in Valencia (Spain); sleep alterations were determined based on two validated tools: the Athens insomnia scale and Oviedo sleep questionnaire...
November 30, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27747681/mood-personality-and-behavior-changes-during-treatment-with-statins-a-case-series
#2
Stephanie Cham, Hayley J Koslik, Beatrice A Golomb
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may bear on an association. Participants (and/or proxies) self-referred with behavioral and/or mood changes in apparent association with statins completed a survey eliciting cholesterol-lowering drug history, character and impact of behavioral/mood effect, time-course of onset and recovery in relation to drug use/modification, co-occurrence of recognized statin-associated ADRs, and factors relevant to ADR causality determination...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27669996/-how-to-characterize-and-treat-sleep-complaints-in-bipolar-disorders
#3
P A Geoffroy, J-A Micoulaud Franchi, R Lopez, I Poirot, A Brion, S Royant-Parola, B Etain
OBJECTIVES: Sleep complaints are very common in bipolar disorders (BD) both during acute phases (manic and depressive episodes) and remission (about 80 % of patients with remitted BD have poor sleep quality). Sleep complaints during remission are of particular importance since they are associated with more mood relapses and worse outcomes. In this context, this review discusses the characterization and treatment of sleep complaints in BD. METHODS: We examined the international scientific literature in June 2016 and performed a literature search with PubMed electronic database using the following headings: "bipolar disorder" and ("sleep" or "insomnia" or "hypersomnia" or "circadian" or "apnoea" or "apnea" or "restless legs")...
September 23, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27667865/evidence-for-using-doxazosin-in-the-treatment-of-posttraumatic-stress-disorder
#4
Cherish Smith, Maju Mathew Koola
There is evidence that doxazosin is effective in the treatment of posttraumatic stress disorder (PTSD). Doxazosin is a "me-too" drug of prazosin. Doxazosin has an improved absorption profile and this likely minimizes the risk for unintended adverse hypotensive effects. The availability of doxazosin in the gastrointestinal therapeutic system (GITS) form permits a higher initial daily dose (4 mg/day) while avoiding significant first-dose side effects. The treatment of PTSD with prazosin has several disadvantages due to its short duration of action (6-8 hours), which results in multiple doses being required...
2016: Psychiatric Annals
https://www.readbyqxmd.com/read/27622970/propranolol-therapy-for-tardive-dyskinesia-a-retrospective-examination
#5
Jaime M Hatcher-Martin, Karen A Armstrong, Laura M Scorr, Stewart A Factor
OBJECTIVE: To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). BACKGROUND: TD is a disabling, often irreversible, movement disorder that results from chronic therapy with dopamine receptor blocking drugs. There are no treatments currently approved for this disorder. Propranolol, a β-adrenergic blocker, has been reported to alleviate TD in case series and reports. METHODS: Retrospective database search of the Emory movement disorder clinic for TD patients treated with propranolol...
September 6, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27227130/texting-based-reporting-of-adverse-drug-reactions-to-ensure-patient-safety-a-feasibility-study
#6
Godofreda Vergeire-Dalmacion, Nina T Castillo-Carandang, Noel R Juban, Maria Lourdes Amarillo, Maria Pamela Tagle, Emmanuel S Baja
BACKGROUND: Paper-based adverse drug reaction (ADR) reporting has been in practice for more than 6 decades. Health professionals remain the primary source of reports, while the value of patients' reporting is yet unclear. With the increasing popularity of using electronic gadgets in health, it is expected that the electronic transmission of reports will become the norm within a few years. OBJECTIVE: The aims of this study are to investigate whether short messaging service or texting can provide an alternative or supplemental method for ADR reporting given the increasing role of mobile phones in health care monitoring; to determine the usefulness of texting in addition to paper-based reporting of ADRs by resident physicians; and to describe the barriers to ADR reporting and estimate the cost for setting up and maintaining a texting-computer reporting system...
July 2015: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/27138076/medical-approach-to-the-management-of-traumatized-refugees
#7
J David Kinzie
Refugees are a highly traumatized and culturally diverse group of patients who present many clinical challenges. Refugees have a high prevalence of traumas from torture, ethnic cleansing, and the effects of long civil wars. The most common diagnoses associated with the effects of such traumas are posttraumatic stress disorder (PTSD) or PTSD with comorbid depression; however, psychosis and neurocognitive disorders are also common. For those with PTSD, a suggested treatment approach is long-term supportive psychotherapy with drug treatment directed at reducing the most disruptive symptoms, such as insomnia, nightmares, and irritability or psychosis...
March 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27128564/inferiority-of-ticagrelor-in-the-philo-trial-play-of-chance-in-east-asians-or-nightmare-confirmation-of-plato-usa
#8
EDITORIAL
Victor L Serebruany, Ales Tomek, Yury Pya, Makhabbat Bekbossynova, Moo Hyun Kim
Long-awaiting PHILO trial, conducted in 2011-2012 has been submitted and published late in 2015. In contrast to overall PLATO results, but similar to PLATO-US cohort, PHILO revealed numerical inferiority of ticagrelor with regard to death, myocardial infarction, stroke, and bleeding over clopidogrel. Hence, we comprehend the PHILO results in light of the PLATO-US evidence. To assess the PHILO (n=801) outcomes, applied statistics, and trial conduct, matching them with the PLATO-US (n=1413) patients. The Asian, predominantly Japanese ticagrelor patients had worsened outcomes even when compared to the negative American cohort with regard to death (OR=1...
July 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27122868/nightmare-simultaneous-subacute-stent-thrombosis-of-different-new-generation-drug-eluting-stents-in-multiple-coronary-arteries
#9
Po-Chao Hsu, Chen-An Chiu, Ho-Ming Su, Tsung-Hsien Lin, Chih-Sheng Chu
UNLABELLED: Simultaneous stent thrombosis (ST) of first-generation drug-eluting stents (DES) has been rarely reported and could lead to high morbidity and mortality. However, to date there was no literature discussing simultaneous ST of different new-generation DESs in multiple coronary arteries. Herein, we report a 60-year-old male suffering from acute myocardial infarction complicated with cardiogenic shock. He had percutaneous coronary intervention (PCI) performed approximately 7 days prior to admission at a local teaching hospital, with different DES devices implanted over the left anterior descending and the left circumflex artery...
March 2015: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27053542/medication-related-osteonecrosis-of-the-jaw-a-dentist-s-nightmare
#10
Arvind Muthukrishnan, Laliytha Bijai Kumar, Gomathi Ramalingam
Medication-related osteonecrosis of the jaw (MRONJ) is a complication in patients who are on anti-bone resorptive drugs. These drugs are prescribed for patients with multiple myeloma, osteoporosis, metastatic carcinoma and Paget's disease. Common anti-bone resorptive drugs such as bisphosphonate and monoclonal antibodies such as denosumab are prescribed for these patients to prevent bone resorption. Although very effective in preventing bone resorption, a complication arising from these groups of drugs is the development of osteomyelitis of the jaw...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26955658/fluoroquinolone-related-neuropsychiatric-and-mitochondrial-toxicity-a-collaborative-investigation-by-scientists-and-members-of-a-social-network
#11
Kamaljeet Kaur, Raja Fayad, Arpit Saxena, Norma Frizzell, Anindya Chanda, Suvarthi Das, Saurabh Chatterjee, Shweta Hegde, Manjeshwar Shrinath Baliga, Venkatesh Ponemone, Matthew Rorro, Jennifer Greene, Yasmine Elraheb, Alan J Redd, John Bian, John Restaino, LeAnn B Norris, Zaina P Qureshi, Bryan L Love, Brandon Brookstaver, Peter Georgantopoulos, Oliver Sartor, Dennis W Raisch, Gowtham Rao, Kevin Lu, Paul Ray, William Hrusheshky, Richard Schulz, Richard Ablin, Virginia Noxon, Charles L Bennett
BACKGROUND: The 3 fluoroquinolone (FQ) antibiotics - ciprofoxacin, levofoxacin, and moxifoxacin - are commonly administered to oncology patients. Although these oral antibiotics are approved by the US Food and Drug Administration (FDA) for treatment of urinary tract infections, acute bacterial sinusitis, or bacterial infection in patients with chronic obstructive pulmonary disease, they are commonly prescribed off-label to neutropenic cancer patients for the prevention and treatment of infections associated with febrile neutropenia...
February 2016: Journal of Community and Supportive Oncology
https://www.readbyqxmd.com/read/26900667/two-case-reports-on-use-of-prazosin-for-drug-dreams
#12
Ganesh Gopalakrishna, Oluwole Popoola, Austin Campbell, Marina A Nemetalla
Substance abuse and dependence is estimated to cost roughly $700 billion annually including direct and indirect care in the United States. Drug dreams (DD), or using dreams, are a reportedly common phenomenon among patients with substance abuse, and have been postulated as triggers for relapse. Prazosin is an alpha-1 receptor antagonist originally approved by the United States Food and Drug Administration for the treatment of hypertension. Prazosin passes the blood brain barrier easily, contributing to central and cognitive effects...
March 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/26890894/sleep-disturbance-in-chronic-military-related-ptsd-clinical-impact-and-response-to-adjunctive-risperidone-in-the-veterans-affairs-cooperative-study-504
#13
John H Krystal, Robert H Pietrzak, Robert A Rosenheck, Joyce A Cramer, Jennifer Vessicchio, Karen M Jones, Grant D Huang, Julia E Vertrees, Joseph Collins, Andrew D Krystal
OBJECTIVE: Sleep disturbances are common among veterans with chronic military-related posttraumatic stress disorder (PTSD). This article reports the results of a multicenter clinical trial that explored the clinical correlates of reported sleep impairment in these veterans and tested the impact of the second-generation antipsychotic risperidone upon these symptoms. METHOD: This article reports secondary analyses of a 24-week multicenter randomized placebo-controlled trial of adjunctive risperidone in patients with chronic military-related PTSD symptoms (n = 267, 97% male) who were symptomatic despite treatment with antidepressants and other medications...
April 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26785978/do-we-need-a-new-fleming-%C3%A3-poque-the-nightmare-of-drug-resistant-tuberculosis
#14
EDITORIAL
Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Marina Tadolini, Paolo Castiglia, Giovanni Battista Migliori
Tuberculosis represents an important clinical and public health problem globally, particularly in low- and middle-income countries. During the last 20 years, two relevant events has changed the epidemiology of the disease: the spread of the TB/HIV co-infection and the emergence and spread of the multi-drug resistance tuberculosis (i.e., tuberculosis caused by strains resistant to at least isoniazid and rifampicin). The latter phenomenon has been generated by the inappropriate management of the anti-tuberculosis drugs...
September 2013: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/26746320/-seasons-circadian-rhythms-sleep-and-suicidal-behaviors-vulnerability
#15
V Benard, P A Geoffroy, F Bellivier
INTRODUCTION: Suicidal behaviors are common in the general population and are so a major public health problem. In order to improve suicide prevention and to reduce the mortality by suicide, it appears essential to better identify suicide risk factors. Seasonality, circadian rhythms and sleep abnormalities have been already associated with numerous psychiatric disorders. This review aimed to characterize the associations between seasonality, circadian rhythms, sleep and suicidal behaviors including suicide attempts and completed suicides...
September 2015: L'Encéphale
https://www.readbyqxmd.com/read/26715405/sleep-disturbances-and-nightmares-in-a-patient-treated-with-prazosin
#16
Sam Kosari, Mark Naunton
Prazosin is increasingly being used off-label to treat nightmares in patients with posttraumatic stress disorder. The literature about the psychiatric adverse effects of prazosin is very limited. We present a case in which low-dose prazosin was associated with nightmares and sleep disturbances in an elderly patient without previously diagnosed mental illness or coexisting environmental risk factors for nightmares. Insomnia and hallucinations are listed as some of the rare side effects of prazosin by the manufacturer...
April 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26222247/the-use-of-propofol-for-procedural-sedation-in-emergency-departments
#17
REVIEW
Abel Wakai, Carol Blackburn, Aileen McCabe, Emilia Reece, Ger O'Connor, John Glasheen, Paul Staunton, John Cronin, Christopher Sampson, Siobhan C McCoy, Ronan O'Sullivan, Fergal Cummins
BACKGROUND: There is increasing evidence that propofol is efficacious and safe for procedural sedation (PS) in the emergency department (ED) setting. However, propofol has a narrow therapeutic window and lacks of a reversal agent. The aim of this review was to cohere the evidence base regarding the efficacy and safety profile of propofol when used in the ED setting for PS. OBJECTIVES: To identify and evaluate all randomized controlled trials (RCTs) comparing propofol with alternative drugs (benzodiazepines, barbiturates, etomidate and ketamine) used in the ED setting for PS...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26203180/efavirenz-and-the-cns-what-we-already-know-and-questions-that-need-to-be-answered
#18
REVIEW
Nadezda Apostolova, Haryes A Funes, Ana Blas-Garcia, Maria J Galindo, Angeles Alvarez, Juan V Esplugues
The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and favourable pharmacokinetics. However, growing concern about its adverse effects has sometimes led to efavirenz being replaced by other drugs in the initial treatment selection or to switching of therapy to efavirenz-free regimens in experienced patients. Neurological and neuropsychiatric reactions are the manifestations most frequently experienced by efavirenz-treated patients and range from transitory effects, such as nightmares, dizziness, insomnia, nervousness and lack of concentration, to more severe symptoms including depression, suicidal ideation or even psychosis...
October 2015: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/26149044/triple-therapy-for-percutaneous-coronary-intervention-in-atrial-fibrillation-standard-of-care-or-a-nightmare-soon-to-end
#19
REVIEW
F W A Verheugt
The need to combine anticoagulant and antiplatelet therapy ('triple therapy') in patients with atrial fibrillation and coronary artery disease increases the risk of bleeding. As percutaneous intervention is now the dominant therapy for coronary disease, clinicians question how to manage the risk of stroke in patients with atrial fibrillation and a coronary stent that require dual antiplatelet therapy. In this review, the risk of stroke and coronary thrombosis in this difficult group of patients will be summarized using current recommendations and guidelines...
June 2015: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/26072564/what-becomes-of-infantile-traumatic-memories-an-adult-wild-child-is-asked-to-remember
#20
Lenore C Terr
A severely traumatized child, acting like a wild animal, was removed from her parents at thirteen months of age when her three-week-old sister was found, bitten and shaken to death. (Her father was later convicted of manslaughter and imprisoned.) The older child was also covered with bite marks. When she was twenty-nine months old, this child, whom I call "Cammie," was brought to me from miles away by herfoster parents for once-monthly psychotherapy. I have treated her, stressing abreaction, context, and correction, once a month ever since...
2013: Psychoanalytic Study of the Child
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