keyword
https://read.qxmd.com/read/38546923/vascular-mimicry-in-zebrafish-fin-regeneration-how-macrophages-build-new-blood-vessels
#1
JOURNAL ARTICLE
Anita Senk, Jennifer Fazzari, Valentin Djonov
Vascular mimicry has been thoroughly investigated in tumor angiogenesis. In this study, we demonstrate for the first time that a process closely resembling tumor vascular mimicry is present during physiological blood vessel formation in tissue regeneration using the zebrafish fin regeneration assay. At the fin-regenerating front, vasculature is formed by mosaic blood vessels with endothelial-like cells possessing the morphological phenotype of a macrophage and co-expressing both endothelial and macrophage markers within single cells...
March 28, 2024: Angiogenesis
https://read.qxmd.com/read/38533506/engineered-therapeutic-antibodies-with-mannose-6-phosphate-analogues-as-a-tool-to-degrade-extracellular-proteins
#2
JOURNAL ARTICLE
Morgane Daurat, Corentin Gauthier, Khaled El Cheikh, Lamiaa M A Ali, Elodie Morère, Nadir Bettache, Magali Gary-Bobo, Alain Morère, Marcel Garcia, Marie Maynadier, Ilaria Basile
Inducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer. Lysosomal targeting has gained increasing interest in recent years due to its pharmaceutical applications far beyond the treatment of lysosomal diseases, as a way to address proteins to the lysosome for eventual degradation. Mannose 6-phosphonate derivatives (M6Pn), called AMFA, are unique glycovectors that can significantly enhance the cellular internalization of the proteins conjugated to AMFA via the cation-independent mannose 6-phosphate receptor (M6PR) pathway...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529407/direct-male-development-in-chromosomally-zz-zebrafish
#3
JOURNAL ARTICLE
Catherine A Wilson, Peter Batzel, John H Postlethwait
The genetics of sex determination varies across taxa, sometimes even within a species. Major domesticated strains of zebrafish ( Danio rerio ), including AB and TU, lack a strong genetic sex determining locus, but strains more recently derived from nature, like Nadia (NA), possess a ZZ male/ZW female chromosomal sex-determination system. AB fish pass through a juvenile ovary stage, forming oocytes that survive in fish that become females but die in fish that become males. To understand mechanisms of gonad development in NA zebrafish, we studied histology and single cell transcriptomics in developing ZZ and ZW fish...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38527598/exposure-to-the-antineoplastic-ifosfamide-alters-molecular-pathways-related-to-cardiovascular-function-increases-heart-rate-and-induces-hyperactivity-in-zebrafish-danio-rerio
#4
JOURNAL ARTICLE
Cole D English, Kira J Kazi, Isaac Konig, Emma Ivantsova, Christopher L Souders Ii, Christopher J Martyniuk
Ifosfamide is an alkylating antineoplastic drug used in chemotherapy, but it is also detected in wastewater. Here, the objectives were to (1) determine teratogenic, cardiotoxic, and mitochondrial toxicity potential of ifosfamide exposure; (2) elucidate mechanisms of toxicity; (3) characterize exposure effects on larval behavior. Survival rate, hatch rate, and morphological deformity incidence were not different amongst treatments following exposure levels up to 1000µg/L ifosfamide over 7 days. RNA-seq reveled 231 and 93 differentially expressed transcripts in larvae exposed to 1µg/L and 100µg/L ifosfamide respectively...
March 23, 2024: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/38520399/inhibition-of-nf-%C3%AE%C2%BAb-mediated-proinflammatory-transcription-by-ru-ii-complexes-of-anti-angiogenic-ligands-in-triple-negative-breast-cancer
#5
JOURNAL ARTICLE
Ayan Chakraborty, Shilpendu Ghosh, Manas Pratim Chakraborty, Sujato Mukherjee, Shantanu Saha Roy, Rahul Das, Moulinath Acharya, Arindam Mukherjee
Nuclear factor kappa beta (NF-κB) plays a pivotal role in breast cancer, particularly triple-negative breast cancer, by promoting inflammation, proliferation, epithelial-mesenchymal transition, metastasis, and drug resistance. Upregulation of NF-κB boosts vascular endothelial growth factor (VEGF) expression, assisting angiogenesis. The Ru(II) complexes of methyl- and dimethylpyrazolyl-benzimidazole N , N donors inhibit phosphorylation of ser536 in p65 and translocation of the NF-κB heterodimer (p50/p65) to the nucleus, disabling transcription to upregulate inflammatory signaling...
March 23, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38482694/zebrafish-apob-containing-lipoprotein-metabolism-a-closer-look
#6
REVIEW
Tabea Moll, Steven A Farber
Zebrafish have become a powerful model of mammalian lipoprotein metabolism and lipid cell biology. Most key proteins involved in lipid metabolism, including cholesteryl ester transfer protein, are conserved in zebrafish. Consequently, zebrafish exhibit a human-like lipoprotein profile. Zebrafish with mutations in genes linked to human metabolic diseases often mimic the human phenotype. Zebrafish larvae develop rapidly and externally around the maternally deposited yolk. Recent work revealed that any disturbance of lipoprotein formation leads to the accumulation of cytoplasmic lipid droplets and an opaque yolk, providing a visible phenotype to investigate disturbances of the lipoprotein pathway, already leading to discoveries in microsomal triglyceride transfer protein and ApoB (apolipoprotein B)...
March 14, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38474201/hypolipidemic-effect-of-rice-bran-oil-extract-tocotrienol-in-high-fat-diet-induced-hyperlipidemia-zebrafish-danio-rerio-induced-by-high-fat-diet
#7
JOURNAL ARTICLE
Naicheng Liu, Peng Zhang, Mingyang Xue, Mengwei Zhang, Zhenyu Huang, Chen Xu, Yan Meng, Yuding Fan, Wei Liu, Feixiang Zhang, Peng Chen, Yong Zhou
In recent years, the potent influence of tocotrienol (T3) on diminishing blood glucose and lipid concentrations in both Mus musculus (rats) and Homo sapiens (humans) has been established. However, the comprehensive exploration of tocotrienol's hypolipidemic impact and the corresponding mechanisms in aquatic species remains inadequate. In this study, we established a zebrafish model of a type 2 diabetes mellitus (T2DM) model through high-fat diet administration to zebrafish. In the T2DM zebrafish, the thickness of ocular vascular walls significantly increased compared to the control group, which was mitigated after treatment with T3...
March 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38431221/somatic-loss-of-function-pik3r1-and-activating-non-hotspot-pik3ca-mutations-associated-with-capillary-malformation-with-dilated-veins-cmdv
#8
JOURNAL ARTICLE
Martina De Bortoli, Angela Queisser, Van Cuong Pham, Anne Dompmartin, Raphaël Helaers, Simon Boutry, Cathy Claus, An-Katrien De Roo, Frank Hammer, Pascal Brouillard, Salim Abdelilah-Seyfried, Laurence M Boon, Miikka Vikkula
Common capillary malformations are red vascular skin lesions, most commonly associated with somatic activating GNAQ or GNA11 mutations. We focused on capillary malformations lacking such a mutation to identify previously unreported genetic causes. We used targeted next-generation sequencing on 82 lesions. Bioinformatic analysis allowed the identification of 9 somatic pathogenic variants in PIK3R1 and PIK3CA, encoding for the regulatory and catalytic subunits of phosphoinositide 3-kinase, respectively. Recharacterization of these lesions unraveled a common phenotype: a pale capillary malformation associated with visible dilated veins...
February 29, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38414014/the-cytoskeleton-adaptor-protein-sorbs1-controls-the-development-of-lymphatic-and-venous-vessels-in-zebrafish
#9
JOURNAL ARTICLE
Alexandra Veloso, Anouk Bleuart, Louise Conrard, Tanguy Orban, Jonathan Bruyr, Pauline Cabochette, Raoul F V Germano, Giel Schevenels, Alice Bernard, Egor Zindy, Sofie Demeyer, Benoit Vanhollebeke, Franck Dequiedt, Maud Martin
BACKGROUND: Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the development of the venous vasculature, both at the cellular and molecular levels. Here, we identify a novel role for Sorbs1, the founding member of the SoHo family of cytoskeleton adaptor proteins, in vascular and lymphatic development in the zebrafish. RESULTS: We show that Sorbs1 is required for secondary sprouting and emergence of several vascular structures specifically derived from the axial vein...
February 27, 2024: BMC Biology
https://read.qxmd.com/read/38387487/tissue-specific-compensatory-mechanisms-maintain-tissue-architecture-and-body-size-independent-of-cell-size-in-polyploid-zebrafish
#10
JOURNAL ARTICLE
C D Small, T J Benfey, B D Crawford
Genome duplications and ploidy transitions have occurred in nearly every major taxon of eukaryotes, but they are far more common in plants than in animals. Due to the conservation of the nuclear:cytoplasmic volume ratio increased DNA content results in larger cells. In plants, polyploid organisms are larger than diploids as cell number remains relatively constant. Conversely, vertebrate body size does not correlate with cell size and ploidy as vertebrates compensate for increased cell size to maintain tissue architecture and body size...
February 20, 2024: Developmental Biology
https://read.qxmd.com/read/38382586/the-angiogenesis-modulating-effects-of-coumarin-derivatives
#11
JOURNAL ARTICLE
Han-Ting Huang, Ching-Yuan Huang, Chih-Jou Lee, Bo-Jie Sun, Zong-Wei Jhang, Chi-Chung Wen, Yun-Hsin Wang, Tao-Sheng Li, Ching-Yuh Chern, Yau-Hung Chen
Coumarin is a natural compound that is rich in plants. Coumarin and its derivates were reported to have many biological activities, such as anti-bacterial, anti-tumor, and anti-coagulation. In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5-100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19...
February 19, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://read.qxmd.com/read/38355946/apela-promotes-blood-vessel-regeneration-and-remodeling-in-zebrafish
#12
JOURNAL ARTICLE
Nicolas Nys, Abdel-Majid Khatib, Geraldine Siegfried
In contrast to adult mammals, zebrafish display a high capacity to heal injuries and repair damage to various organs. One of the earliest responses to injury in adult zebrafish is revascularization, followed by tissue morphogenesis. Tissue vascularization entails the formation of a blood vessel plexus that remodels into arteries and veins. The mechanisms that coordinate these processes during vessel regeneration are poorly understood. Hence, investigating and identifying the factors that promote revascularization and vessel remodeling have great therapeutic potential...
February 14, 2024: Scientific Reports
https://read.qxmd.com/read/38342258/multi-functional-bandage-bioactive-glass-metal-oxides-alginate-composites-based-regenerative-membrane-facilitating-re-epithelialization-in-diabetic-wounds-with-sustained-drug-delivery-and-anti-bactericidal-efficacy
#13
JOURNAL ARTICLE
P Bargavi, S Balakumar, S Raghunandhakumar
Chronic wounds, especially diabetic, foot and pressure ulcers are a major health problem affecting >10 % of the world's populace. Calcium phosphate materials, particularly, bioactive glasses (BG), used as a potential material for hard and soft tissue repair. This study combines nanostructured 45S5 BG with titania (TiO2 ) and alumina (Al2 O3 ) into a composite via simple sol-gel method. Prepared composites with alginate (Alg) formed a bioactive nanocomposite hydrogel membrane via freezing method. X-ray diffraction revealed formation of two phases such as Na1...
February 9, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38340011/requirement-of-a-novel-gene-drish-in-the-zebrafish-retinal-ganglion-cell-and-primary-motor-axon-development
#14
JOURNAL ARTICLE
Suman Gurung, Nicole K Restrepo, Surendra Kumar Anand, Vinoth Sittaramane, Saulius Sumanas
BACKGROUND: During neurogenesis, growing axons must navigate through the complex extracellular environment and make correct synaptic connections for the proper functioning of neural circuits. The mechanisms underlying the formation of functional neural networks are still only partially understood. RESULTS: Here we analyzed the role of a novel gene si:ch73-364h19.1/drish in the neural and vascular development of zebrafish embryos. We show that drish mRNA is expressed broadly and dynamically in multiple cell types including neural, glial, retinal progenitor and vascular endothelial cells throughout the early stages of embryonic development...
February 10, 2024: Developmental Dynamics
https://read.qxmd.com/read/38334606/moderate-elevation-of-homocysteine-induces-endothelial-dysfunction-through-adaptive-upr-activation-and-metabolic-rewiring
#15
JOURNAL ARTICLE
Barun Chatterjee, Fabeha Fatima, Surabhi Seth, Soumya Sinha Roy
Elevation of the intermediate amino acid metabolite Homocysteine (Hcy) causes Hyperhomocysteinemia (HHcy), a metabolic disorder frequently associated with mutations in the methionine-cysteine metabolic cycle as well as with nutritional deficiency and aging. The previous literature suggests that HHcy is a strong risk factor for cardiovascular diseases. Severe HHcy is well-established to correlate with vascular pathologies primarily via endothelial cell death. Though moderate HHcy is more prevalent and associated with an increased risk of cardiovascular abnormalities in later part of life, its precise role in endothelial physiology is largely unknown...
January 24, 2024: Cells
https://read.qxmd.com/read/38328083/paraoxonase-like-apmap-maintains-endoplasmic-reticulum-associated-lipid-and-lipoprotein-homeostasis
#16
Blessy Paul, Holly Merta, Rupali Ugrankar-Banerjee, Monica Hensley, Son Tran, Goncalo Dias do Vale, Jeffrey G McDonald, Steven A Farber, W Mike Henne
UNLABELLED: Oxidative stress perturbs lipid homeostasis and contributes to metabolic diseases. Though ignored compared to mitochondrial oxidation, the endoplasmic reticulum (ER) generates reactive oxygen species requiring antioxidant quality control. Using multi-organismal profiling featuring Drosophila , zebrafish, and mammalian cells, here we characterize the paraoxonase-like APMAP as an ER-localized protein that promotes redox and lipid homeostasis and lipoprotein maturation. APMAP-depleted mammalian cells exhibit defective ER morphology, elevated ER and oxidative stress, lipid droplet accumulation, and perturbed ApoB-lipoprotein homeostasis...
January 27, 2024: bioRxiv
https://read.qxmd.com/read/38316882/cardiac-manifestations-of-human-acta2-variants-recapitulated-in-a-zebrafish-model
#17
JOURNAL ARTICLE
Wulan Apridita Sebastian, Masanori Inoue, Nobuyuki Shimizu, Ryosuke Sato, Saori Oguri, Tomoyo Itonaga, Shintaro Kishimoto, Hiroshi Shiraishi, Toshikatsu Hanada, Kenji Ihara
The ACTA2 gene encodes actin α2, a major smooth muscle protein in vascular smooth muscle cells. Missense variants in the ACTA2 gene can cause inherited thoracic aortic diseases with characteristic symptoms, such as dysfunction of smooth muscle cells in the lungs, brain vessels, intestines, pupils, bladder, or heart. We identified a heterozygous missense variant of Gly148Arg (G148R) in a patient with a thoracic aortic aneurysm, dissection, and left ventricular non-compaction. We used zebrafish as an in vivo model to investigate whether or not the variants might cause functional or histopathological abnormalities in the heart...
February 5, 2024: Journal of Human Genetics
https://read.qxmd.com/read/38297099/lactylation-driven-fto-targets-cdk2-to-aggravate-microvascular-anomalies-in-diabetic-retinopathy
#18
JOURNAL ARTICLE
Xue Chen, Ying Wang, Jia-Nan Wang, Yi-Chen Zhang, Ye-Ran Zhang, Ru-Xu Sun, Bing Qin, Yuan-Xin Dai, Hong-Jing Zhu, Jin-Xiang Zhao, Wei-Wei Zhang, Jiang-Dong Ji, Song-Tao Yuan, Qun-Dong Shen, Qing-Huai Liu
Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age populations. Fat mass and obesity-associated protein (FTO) is an N6 -methyladenosine (m6 A) demethylase that demethylates RNAs involved in energy homeostasis, though its influence on DR is not well studied. Herein, we detected elevated FTO expression in vitreous fibrovascular membranes of patients with proliferative DR. FTO promoted cell cycle progression and tip cell formation of endothelial cells (ECs) to facilitate angiogenesis in vitro, in mice, and in zebrafish...
February 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38291192/understanding-the-pathophysiology-of-acute-critical-illness-translational-lessons-from-zebrafish-models
#19
REVIEW
Kensuke Fujii, Kazuma Yamakawa, Yuriko Takeda, Natsuko Okuda, Akira Takasu, Fumihito Ono
The models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish (Danio rerio) is a popular model organism for studying diseases due to its transparency and rapid development. The genes and signaling pathways involved in acute critical illness appear highly conserved among zebrafish and humans. Forward genetics such as random mutagenesis by a chemical mutagen or reverse genetics methods represented by CRISPR/Cas9 allowed researchers to reveal multiple novel aspects of pathological processes in areas including infection, immunity, and regeneration...
January 31, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38286156/potent-anti-angiogenic-component-in-kaempferia-galanga-l-and-its-mechanism-of-action
#20
JOURNAL ARTICLE
Weihuan Huang, Nianjue Zheng, Naxin Niu, Ying Tan, Yaolan Li, Haiyan Tian
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, the roots of Kaempferia galanga has been used to treat high blood pressure, chest pain, headache, toothache, rheumatism, indigestion, cough, inflammation and cancer in Asia. Nevertheless, most of its pharmacological studies were focused on ethanolic extracts and volatile oils. The exact active chemical constituents and their underlying mechanisms are still poorly understood, especially towards its anti-cancer treatment. Inhibition of angiogenesis is an important atrategy to inhibit tumor growth...
January 27, 2024: Journal of Ethnopharmacology
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