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carboplatin hypersensitivity reaction

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https://www.readbyqxmd.com/read/27856924/prevention-of-carboplatin-induced-hypersensitivity-reactions-in-women-with-ovarian-cancer
#1
Katarzyna J Jerzak, Shaidah Deghan Manshadi, Pamela Ng, Manjula Maganti, Jeanna M McCuaig, Marcus Bulter, Amit Oza, Helen J Mackay
BACKGROUND: Carboplatin-based chemotherapy offers high response rates and improved overall survival for women with epithelial ovarian cancer, but its use is limited by the occurrence of hypersensitivity reactions. To evaluate the efficacy of prophylactic diphenhydramine for hypersensitivity reaction prevention, we reviewed the incidence of hypersensitivity reactions and identified patients at high risk of hypersensitivity reactions. METHODS: Women receiving ≥6 cycles of carboplatin-based chemotherapy for epithelial ovarian cancer were identified from our institutional database at the Princess Margaret Cancer Centre...
November 17, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27789084/platinum-desensitization-in-patients-with-carboplatin-hypersensitivity-a-single-institution-retrospective-study
#2
Gary Altwerger, Gregory M Gressel, Diana P English, Wendelin K Nelson, Nina Carusillo, Dan-Arin Silasi, Masoud Azodi, Alessandro Santin, Peter E Schwartz, Elena S Ratner
OBJECTIVES: The carboplatin desensitization (CD) protocol presented here allows patients with either a positive skin test or a prior hypersensitivity reaction (HSR) to safely, rapidly and effectively continue with carboplatin infusions. Newly described factors can identify patients at risk for developing adverse events during CD. METHODS: A retrospective review was performed on patients with gynecologic cancer who underwent CD between 2005 and 2014. The CD protocol uses a four-step dilution process over 3...
October 24, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27641482/extended-carboplatin-infusion-does-not-reduce-frequency-of-hypersensitivity-reaction-at-initiation-of-retreatment-in-patients-with-recurrent-platinum-sensitive-ovarian-cancer
#3
Timothy Lax, Don S Dizon, Michael Birrer, Aidan Long, Marcela Del Carmen, Annekathryn Goodman, Carolyn Krasner, Richard T Penson, Whitfield Growdon, Carlos A Camargo, Aleena Banerji
No abstract text is available yet for this article.
September 15, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27221832/clinical-features-of-oxaliplatin-induced-hypersensitivity-reactions-and-therapeutic-approaches
#4
Nusrat Bano, Rahila Najam, Faaiza Qazi, Ahmed Mateen
Oxaliplatin, a third generation novel platinum compound is the most effective first line chemotherapeutic agent for colorectal cancer (CRC) in combination with 5FU and leucovorin. It is indicated for pancreatic, gastric and testicular cancers combined with bevacuzimab, capecitabine, irinotecan and other cytotoxic agents. However, moderate to severe hypersensitivity reactions (HSR) during or after oxaliplatin infusion usually require cessation of chemotherapy or substitution of the key therapeutic drug which largely interferes with improved patient prognosis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27196693/effect-of-prophylactic-extended-infusion-carboplatin-on-incidence-of-hypersensitivity-reactions-in-patients-with-ovarian-fallopian-tube-or-peritoneal-carcinomas
#5
Amy L Pasternak, Nicholas A Link, Carolyn M Richardson, Peter G Rose
STUDY OBJECTIVE: To determine whether extended-infusion carboplatin, initiated at approximately the eighth cumulative carboplatin cycle and prior to development of carboplatin hypersensitivity, reduces the incidence of carboplatin hypersensitivity reactions in patients with ovarian, fallopian tube, or peritoneal cancer. DESIGN: Retrospective chart review. SETTING: Large integrated health system. PATIENTS: A total of 326 patients with ovarian, fallopian tube, or primary peritoneal cancer who received at least eight cumulative cycles of carboplatin between January 2007 and September 2014 were included...
July 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27181615/clinical-utility-of-basophil-cd203c-as-a-biomarker-for-predicting-the-timing-of-hypersensitivity-reaction-in-carboplatin-rechallenge-three-case-reports
#6
Takuya Iwamoto, Hiroko Sugimoto, Tsutomu Tabata, Masahiro Okuda
PURPOSE: Drug desensitization has been found to be an effective option for carboplatin rechallenge in patients at risk for severe hypersensitivity reaction. However, identifying such patients requires precise clinical tests. This study was performed to evaluate the clinical utility of basophil CD203c to predict the timing of carboplatin-induced severe hypersensitivity reaction. METHODS: Here we report on 3 patients undergoing a carboplatin-desensitization protocol at Mie University Hospital...
June 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27098551/intravenous-versus-oral-dexamethasone-for-prophylaxis-of-paclitaxel-associated-hypersensitivity-reaction-in-patients-with-primary-ovarian-fallopian-tube-and-peritoneal-cancer-a-double-blind-randomized-controlled-trial
#7
Marut Yanaranop, Surasith Chaithongwongwatthana
AIM: To compare the efficacies and side effects of intravenous and oral dexamethasone (IV-D and PO-D) for paclitaxel-associated hypersensitivity reaction (P-HSR) prophylaxis in patients with primary ovarian, fallopian tube and peritoneal carcinomas (POC/PFTC/PPC) receiving a first cycle of paclitaxel plus carboplatin (TC). METHODS: In this double-blind randomized controlled trial, patients with POC/PFTC/PPC receiving a first cycle of TC were randomly allocated in a 1:1 ratio to either the IV-D or PO-D groups...
September 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26990212/adjunct-histamine-blockers-as-premedications-to-prevent-carboplatin-hypersensitivity-reactions
#8
Claire M Mach, Elisabeth A Lapp, Kellie J Weddle, Rodney J Hunter, Kimberly A Burns, Crystal Parker, Jubilee Brown, Judith A Smith
OBJECTIVE: The objective of this study was to evaluate the impact of premedications given as an adjunct to carboplatin on the incidence of hypersensitivity reactions in women with ovarian cancer. Medications of interest include a histamine1 (H1 ) and histamine2 (H2 ) blocker in addition to dexamethasone. METHODS: This was a retrospective chart review evaluating the addition of an H1 and H2 blocker in addition to dexamethasone as standard premedications on the incidence of carboplatin hypersensitivity reactions (CHRs) in women with ovarian cancer...
May 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26895621/safety-costs-and-efficacy-of-rapid-drug-desensitizations-to-chemotherapy-and-monoclonal-antibodies
#9
David Sloane, Usha Govindarajulu, Jacob Harrow-Mortelliti, William Barry, Florence Ida Hsu, David Hong, Tanya Laidlaw, Ross Palis, Henry Legere, Supinda Bunyavanich, Rebecca Breslow, Duane Wesemann, Nora Barrett, Patrick Brennan, Hey Jin Chong, Anne Liu, James Fernandez, Laura Fanning, Timothy Kyin, Katherine Cahill, Lora Bankova, Ashly Lynch, Suzanne Berlin, Susana Campos, Charles Fuchs, Robert Mayer, Ursula Matulonis, Mariana Castells
BACKGROUND: Rapid drug desensitization (RDD) is used to address hypersensitivity reactions to chemotherapeutics and monoclonal antibodies, allowing patients to be treated with optimal pharmacological agents. RDD protocols are tailored to each individual patient's reaction and needs, and protect against anaphylaxis, but overall risks, costs, and benefits have not been determined. OBJECTIVE: We investigated the safety, efficacy, costs, and life expectancy of patients in a large population undergoing RDD...
May 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26854461/hypersensitivity-reactions-to-platinum-derivatives-findings-of-new-predictive-markers
#10
Sinziana Cetean, Tudor Ciuleanu, Daniel-Corneliu Leucuta, Calin Cainap, Anne-Marie Constantin, Irina Cazacu, Simona Cainap, Alexandra Gherman, Luminita Oprean, Adriana Hangan, Radu Oprean
PURPOSE: Platinum derivatives play a very important role in cancer therapy. Despite their outstanding results in the treatment of tumors with different locations, the occurrence of hypersensitivity reactions raises issues when it comes to therapy decision, because the changing of chemotherapy line could influence the tumor's evolution. Over the years the scientific community has paid particular attention to the mechanism by which this occurs and to identification of predictive factors...
November 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/26759527/limitations-to-the-use-of-carboplatin-based-therapy-in-advanced-ovarian-cancer
#11
Christina Fotopoulou
Most patients with recurrent ovarian cancer (ROC) undergo a series of remissions and recurrences, therefore the additive or cumulative toxicity of chemotherapy must be factored into their treatment plan. There are challenges in defining tailored therapeutic approaches, including optimal timing and drug sequencing management strategies to treat patients with ROC. This is particularly relevant as new cytotoxic drugs and biological agents become available. Many of these drugs are associated with increased toxicity and with no observable survival advantage...
December 2014: EJC Supplements: EJC
https://www.readbyqxmd.com/read/26662632/efficacy-of-aprepitant-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-with-a-moderately-emetogenic-chemotherapy-regimen-a-multicenter-placebo-controlled-double-blind-randomized-study-in-patients-with-gynecologic-cancer-receiving-paclitaxel-and
#12
Hideaki Yahata, Hiroaki Kobayashi, Kenzo Sonoda, Mototsugu Shimokawa, Tatsuhiro Ohgami, Toshiaki Saito, Shinji Ogawa, Kunihiro Sakai, Akimasa Ichinoe, Yousuke Ueoka, Yasuyuki Hasuo, Makoto Nishida, Satohiro Masuda, Kiyoko Kato
BACKGROUND: Substance P contributes to the hypersensitivity reaction (HSR) to paclitaxel in a rat model. Aprepitant acts as an inhibitor of the binding of substance P to the neurokinin-1 receptor and, consequently, may reduce the frequency of paclitaxel-induced HSR. While aprepitant has a prophylactic effect against vomiting caused by high-dose cisplatin, the benefits of aprepitant have not been clearly demonstrated in patients receiving paclitaxel and carboplatin (TC) combination chemotherapy...
June 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26451866/carboplatin-rechallenge-after-hypersensitivity-reactions-in-pediatric-patients-with-low-grade-glioma-how-far-should-we-push
#13
Lucie Lafay-Cousin
No abstract text is available yet for this article.
January 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26432514/skin-testing-in-the-evaluation-and-management-of-carboplatin-related-hypersensitivity-reactions
#14
REVIEW
Timothy Lax, Aidan Long, Aleena Banerji
Carboplatin-induced hypersensitivity reactions (HSRs) are a frequent occurrence in patients being retreated for malignancy. The most common and severe reactions are thought to be IgE mediated. Currently, skin testing is the only method used clinically to identify individuals sensitized to carboplatin. Despite almost 20 years of clinical use, a standardized approach to skin testing and its use in the management of carboplatin HSRs has not been well established. We review the utility of carboplatin skin testing and discuss factors that influence the interpretation of skin testing results...
November 2015: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26298407/risk-stratification-protocol-for-carboplatin-and-oxaliplatin-hypersensitivity-repeat-skin-testing-to-identify-drug-allergy
#15
Alberta L Wang, Sarita U Patil, Aidan A Long, Aleena Banerji
BACKGROUND: Hypersensitivity reactions (HSRs) to platinum-based chemotherapies are increasingly being recognized. The authors developed a novel risk-stratification protocol that was used successfully in a small number of patients with carboplatin-induced HSRs. OBJECTIVE: To describe the utility of this protocol in a large number of patients with carboplatin- or oxaliplatin-induced HSRs. METHODS: A 5-year retrospective review of patients referred to Massachusetts General Hospital with carboplatin- or oxaliplatin-induced HSR was performed...
November 2015: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/26235452/carboplatin-rechallenge-after-hypersensitivity-reactions-in-pediatric-patients-with-low-grade-glioma
#16
Amish C Shah, Jane E Minturn, Yimei Li, Jean B Belasco, Peter C Phillips, Tammy I Kang, Kristina A Cole, Angela J Waanders, Rosanna Pollack, Concetta Didomenico, Cynthia Wildes, Michael J Fisher
BACKGROUND: The high prevalence of carboplatin hypersensitivity reactions (HSR) significantly affects the treatment of pediatric patients with low-grade glioma (LGG). Rechallenging patients is an option that must balance the risks of repeat allergic reaction to the benefits of retaining an effective anti-tumor regimen. PROCEDURE: We performed a retrospective review of children with LGG treated with carboplatin and vincristine between October 2000 and April 2013, who had a documented HSR to carboplatin...
January 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26207610/carboplatin-hypersensitivity-reactions-in-pediatric-low-grade-glioma-are-protocol-specific-and-desensitization-shows-poor-efficacy
#17
Andrew J Dodgshun, Jordan R Hansford, Theresa Cole, Sharon Choo, Michael J Sullivan
BACKGROUND: The use of carboplatin for the treatment of pediatric low grade gliomas (PLGG) is often limited by the development of carboplatin hypersensitivity. Reported rates of carboplatin hypersensitivity reactions vary between 6% and 32% in these patients. Here we report the frequency of carboplatin hypersensitivity reactions depending on the treatment regimen used, and outcomes of carboplatin desensitization. METHODS: The records of all patients in a single institution who were treated with carboplatin for PLGG were accessed and all patients receiving more than one dose of carboplatin are reported...
January 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26197756/-a-patient-with-recurrent-ovarian-cancer-who-was-hypersensitive-to-carboplatin-exhibited-complete-response-to-gemcitabine-and-nedaplatin
#18
Yuka Asami, Ryo Kitagawa, Moe Iiba, Asami Uenoyama, Kazunari Kondo, Nakako Sato, Kaoru Tadauchi, Masatoshi Sugita, Hajime Tsunoda
A 57-year-old multiparous woman with FIGO stage IV ovarian cancer underwent primary surgery and was administered postoperative chemotherapy consisting of paclitaxel and carboplatin (TC). Complete response was confirmed on computed tomography. After a 20-month platinum free interval (PFI), an elevated serum CA125 level and recurrence in the peritoneum were confirmed, and she was retreated with TC as second-line chemotherapy. A hypersensitivity reaction occurred after administering the second dose of carboplatin; therefore, carboplatin was changed to nedaplatin...
July 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26130472/presentation-and-diagnosis-of-hypersensitivity-to-platinum-drugs
#19
REVIEW
Joana Caiado, Mariana Castells
Hypersensitivity reactions (HSRs) to platinum drugs are increasing due to their extensive use in a wide variety of malignancies and the repeated exposures in patients with increased life expectancy. Understanding the incidence of HSR to platinum drugs and associated risk factors can help with the diagnosis and may provide protection against severe HSRs. A thorough clinical history with identification of the typical and atypical symptoms, the relationship with the platin administration, and the number of previous exposures are the key to the diagnosis...
April 2015: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/25955691/a-hyposensitive-anticancer-drug-induces-higher-surface-expression-and-release-of-heat-shock-proteins-in-a-human-hepatocellular-carcinoma-cell-line
#20
Mei Yang, Zhe Xu, Qi Wang, An-Qin Zhang, Jun Min
Heat shock proteins (HSPs) respond to multiple stresses and have been implicated as essential immune chaperones that regulate innate and adaptive immunity. The exposure of HSPs containing tumour peptide complex to immune surveillance elements may elicit a specific anti-tumour response. The present study examined the potential of anticancer drugs to induce apoptosis of HepG2 cells and elicit the expression of HSP proteins, including HSP70 and gp96, on the membrane or their release to the extracellular environment, leading to HSP exposure...
August 2015: Molecular Medicine Reports
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