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https://www.readbyqxmd.com/read/29140878/clear-cell-renal-cell-carcinoma-metastatic-to-the-gynecologic-tract-a-clinicopathologic-analysis-of-17-cases
#1
Oluwole Fadare, Mohamed M Desouki, Katja Gwin, Krisztina Z Hanley, Elke A Jarboe, Sharon X Liang, Charles M Quick, Kojo R Rawish, Andres A Roma, Wenxin Zheng, Jonathan L Hecht, Vinita Parkash, Adeboye O Osunkoya
Clear cell renal cell carcinomas (CCRCC) rarely metastasizes to the gynecologic tract. In this study, we analyzed a multi-institutional data set to provide insights into the clinical, morphologic, and immunophenotypic features of this phenomenon. Seveteen metastatic CCRCC involving the gynecologic tract [ovary/fallopian tube (n=9), vulva (n=2), uterine corpus (n=3), cervix (n=2), uterine serosa (n=1)] were analyzed. Mean patient age was 62 yr (range: 45-79 yr). Most cases (15/17) presented as a recurrence 6 to 72 mo postnephrectomy, 1 case was concurrently diagnosed, and 1 case (a cervical metastasis) was diagnosed prenephrectomy...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29019044/hobnail-variant-of-papillary-thyroid-carcinoma-a-literature-review
#2
REVIEW
Francesca Ambrosi, Alberto Righi, Costantino Ricci, Lori A Erickson, Ricardo V Lloyd, Sofia Asioli
Papillary thyroid carcinoma is the most common thyroid malignancy and it is usually associated with a good prognosis. However, recurrence, metastases, and cancer death may occur in 10 to 15% of patients with more aggressive types of papillary thyroid carcinoma, such as tall cell, columnar cell, solid variant, or the more recently described hobnail variant of papillary thyroid carcinoma. Papillary thyroid carcinoma with a prominent hobnail pattern is a moderately differentiated papillary thyroid carcinoma variant with aggressive clinical behavior and significant mortality...
December 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28932033/glandular-odontogenic-cyst-series-of-five-cases
#3
Aadithya B Urs, Priya Kumar, Jeyaseelan Augustine, Rewa Malhotra
INTRODUCTION: Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour. MATERIALS AND METHODS: Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28744957/glandular-odontogenic-cyst-an-updated-analysis-of-169-cases-reported-in-the-literature
#4
REVIEW
B R Chrcanovic, R S Gomez
OBJECTIVE: To integrate the available data published on glandular odontogenic cyst (GOC) into a comprehensive analysis of its clinical/radiological and histopathological features. METHODS: An electronic search was undertaken in May/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. RESULTS: Fifty-eight publications (169 GOCs) were included. The lesion was slightly more prevalent in men than in women...
July 26, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28731049/composite-hemangioendothelioma-with-neuroendocrine-marker-expression-an-aggressive-variant
#5
Kyle D Perry, Alyaa Al-Lbraheemi, Brian P Rubin, Jin Jen, Hongzheng Ren, Jin Sung Jang, Asha Nair, Jaime Davila, Stefan Pambuccian, Andrew Horvai, William Sukov, Henry D Tazelaar, Andrew L Folpe
Aberrant expression of neuroendocrine markers is extremely rare in endothelial neoplasms, with only a single report describing three cases. Although originally classified as conventional angiosarcoma, further assessment of these tumors revealed a strikingly composite morphology composed of retiform and epithelioid elements reminiscent of composite hemangioendothelioma, a rare subtype of hemangioendothelioma. To further investigate these findings, available materials from 11 morphologically distinctive endothelial tumors showing neuroendocrine marker expression were retrieved from our archives...
November 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28494807/concordant-clear-cell-mesonephric-carcinoma-of-the-bladder-and-lung-adenocarcinoma-with-clear-cell-features-multiple-primaries-versus-metastatic-neoplasms-a-case-report
#6
Sarmad H Jassim, Amer Khiyami, Jane K Nguyen, Santhi Ganesan, Joseph Tomashefski, Joram Sawady
BACKGROUND: Clear cell carcinoma of the bladder is a rare variant of urinary bladder adenocarcinoma. We report a case of a patient with clear cell carcinoma of the bladder and a concordant right upper lobe pulmonary adenocarcinoma with clear cell features, and we address the role of immunohistochemistry and cytogenetic analysis in distinguishing the two primary malignancies. CASE PRESENTATION: Our patient was a 59-year-old African American woman who presented with hematuria...
May 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28436289/comparison-of-renal-anastomosing-hemangiomas-in-end-stage-and-non-end-stage-kidneys-a-meta-analysis-with-a-report-of-2-cases
#7
Neslihan Kayisoglu Berker, Aysel Bayram, Serap Tas, Baris Bakir, Yasar Caliskan, Faruk Ozcan, Isin Kilicaslan, Yasemin Ozluk
BACKGROUND: Renal anastomosing hemangioma (RAH) is a very rare distinct entity composed of anastomosing sinusoidal (spleen-like) capillary-sized vessels lined by flat or hobnail endothelial cells. Most of the published cases of RAH occurred in the setting of end-stage renal disease (ESRD). METHODS: We present 2 cases of RAH in ESRD along with a literature review. We compared clinicopathologic features of RAHs in end-stage and non-end-stage kidneys. A meta-analysis was conducted with PubMed and a manual search through references of relevant publications...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28419762/hobnail-variant-of-papillary-thyroid-carcinoma-a-case-with-an-unusual-presentation
#8
Mohammed T Lilo, Justin A Bishop, Syed Z Ali
Variants of papillary thyroid carcinoma (PTC) account for up to 25% of the cases, some of which are proven to be associated with aggressive clinical behavior such as tall cell and columnar cell variants. Hobnail variant of PTC (HVPTC) is recently described as a rare and aggressive variant of PTC. Herein, we are reporting a case of HVPTC in a patient who presented with hemoptysis and an intratracheal blood clot that was aspirated and submitted for cytopathological examination. Cytomorphology displayed neoplastic cells with profound micropapillary architecture, elongated nuclei, and prominent hobnail configuration...
August 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28243494/arborizing-vessels-in-a-targetoid-hemosiderotic-hemangioma-mistaken-dermoscopic-diagnosis-of-basal-cell-carcinoma
#9
María L Enei, Francisco M Paschoal, Rodrigo Valdes
Targetoid hemosiderotic hemangioma (THH) or hobnail hemangioma (HH) is a benign vascular lesion that presents with the classical clinical presentation of a ring-shaped tumor having a targetoid appearance, with a central purple-brown papule surrounded by a thin pale area and an ecchymotic ring on the outside. Dermoscopic features and patterns of HH have been documented and have proven to be sufficient to establish a clinical diagnosis in many cases. We present a facial lesion in which both the clinical presentation and dermoscopy were atypical...
January 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28009606/hobnail-variant-of-papillary-thyroid-carcinoma-clinicopathologic-and-molecular-evidence-of-progression-to-undifferentiated-carcinoma-in-2-cases
#10
José M Cameselle-Teijeiro, Irene Rodríguez-Pérez, Ricardo Celestino, Catarina Eloy, Magalí Piso-Neira, Ihab Abdulkader-Nallib, Paula Soares, Manuel Sobrinho-Simões
The hobnail variant (HV) of papillary thyroid carcinoma (PTC) is an unusual entity recently proposed as an aggressive variant of PTC. We describe the pathologic and molecular features of 2 cases of HV of PTC. Both tumors presented in stage III (pT3 pN1a M0). The first case was diagnosed in a 62-year-old man, whereas the second was in a 53-year-old woman. Both patients were treated with total thyroidectomy and radioactive iodine. The primary tumors showed a hobnail/micropapillary pattern in ≥50% of the neoplasm, and positivity for TTF-1, TTF-2, thyroglobulin (TG), cyclin D1, and p53...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27896649/the-micropapillary-hobnail-variant-of-papillary-thyroid-carcinoma-a-review-of-series-described-in-the-literature-compared-to-a-series-from-one-southern-italy-pathology-institution
#11
REVIEW
Antonio Ieni, Valeria Barresi, Roberta Cardia, Luana Licata, Flavia Di Bari, Salvatore Benvenga, Giovanni Tuccari
Papillary thyroid carcinoma (PTC) has a good prognosis with a 10-yr survival greater than 90%. Recently, a micro-papillary pattern with hobnail appearance (MPHC) in PTC has been indicated as associated with poor prognosis, but this suggestion is based only on a few cases from geographical areas different from ours. Two-hundred ninety-nine consecutive PTC cases were collected between the years of 1992 and 2014 at our institution. The corresponding histologic sections (at least 6 for each case) were stained with hematoxylin and eosin and reviewed independently by two pathologists to reach a consensus on the identification and quantification of the MPHC...
December 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27831959/cystic-nephroma-in-adults-a-clinicopathologic-study-of-46-cases
#12
Anna Caliò, John N Eble, David J Grignon, Brett Delahunt
Cystic nephroma in adults is an uncommon multicystic benign tumor of kidney and, over the last century, only a few small series or case reports have studied it. We analyzed 46 tumors from adults (41 female, median age: 55 y), collecting data on gross, microscopic, and immunohistochemical findings. All of the tumors were composed entirely of cysts separated by septa; the majority were surrounded by a pseudocapsule. Hypocellular fibrous and hypercellular spindle cell stroma were the most common components of the septa...
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27760611/-clinicopathologic-analysis-of-anastomosing-hemangioma-of-the-kidney-and-adrenal-gland
#13
REVIEW
M Zhao, M Kong, J J Yu, X L He, D H Zhang, X D Teng
Objective: To investigate the clinical and histopathologic characteristics, diagnosis, differential diagnosis and prognostic features of anastomosing hemangioma. Methods: Five cases of anastomosing hemangioma of the kidney and adrenal gland were collected, the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed with review of literature. Results: Three patients were male and two were female with ages ranging from 47 to 77 years; three were located in adrenal gland and 2 originated from the kidney...
October 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27708135/hobnail-hemangioma-with-an-unusual-clinical-presentation
#14
María Librada Porriño-Bustamante, José Aneiros-Fernández, Juan Antonio Retámero, María Antonia Fernández-Pugnaire
Hobnail hemangioma, also known as targetoid hemosiderotic hemangioma, is an uncommon vascular proliferation that clinically presents as a small solitary red to purple papule or macule, located on the limbs or trunk. Multiple lesions and atypical locations have been described. Histopathologically, it exhibits a biphasic pattern, with dilated vessels in the superficial dermis and angulated vessels in the deeper dermis, with endothelial cells that show a hobnail appearance. There is controversy about the histogenetic origin of hobnail hemangioma, although recent studies support that it is a lymphatic malformation...
March 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27543862/review-of-renal-anastomosing-hemangioma-with-focus-on-clinical-and-pathological-aspects
#15
N Kuroda, C Ohe, S Deepika, K Yorita, S Mikami, M Furuya, Y Nagashima, O Hes, A Agaimy, M Michal, M B Amin
Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27379325/primary-clear-cell-carcinoma-of-the-urinary-bladder
#16
REVIEW
Anthony Kodzo-Grey Venyo
Primary clear cell carcinoma of the urinary bladder (PCCUB) is rare. Literature review has revealed 47 cases of PCCUB which commonly affects women. The histogenesis of PCCUB is not certain and Müllerian origin and urotheilal origin have been postulated. The microscopic characteristics of PCCUB include cells with abundant clear cytoplasm, arranged in a solid, glandular, tubulocystic, or papillary pattern. The cells may be flat or cuboidal with abundant clear eosinophilic cytoplasm. Hobnailing may be evident...
2014: International Scholarly Research Notices
https://www.readbyqxmd.com/read/27318413/contributions-of-dr-juan-rosai-to-the-pathology-of-cutaneous-vascular-proliferations-a-review-of-selected-lesions
#17
REVIEW
Mark R Wick
Vascular proliferations in the skin have been thoroughly studied over the past 35 years, and a great deal of knowledge has been accrued regarding their pathobiological features. Dr. Juan Rosai has been a consistent contributor to the literature on this topic throughout most of his career, and this article reviews selected cutaneous endothelial lesions that he helped to characterize. They include histiocytoid-epithelioid hemangioma, targetoid-hobnail hemangioma, acquired tufted hemangioma, glomeruloid hemangioma, spindle cell hemangioma, retiform hemangioendothelioma, and angiosarcoma...
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27086595/non-small-cell-lung-cancer-with-concomitant-egfr-kras-and-alk-mutation-clinicopathologic-features-of-12-cases
#18
Taebum Lee, Boram Lee, Yoon-La Choi, Joungho Han, Myung-Ju Ahn, Sang-Won Um
BACKGROUND: Although epidermal growth factor receptor (EGFR), v-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and anaplastic lymphoma kinase (ALK) mutations in non-small cell lung cancer (NSCLC) were thought to be mutually exclusive, some tumors harbor concomitant mutations. Discovering a driver mutation on the basis of morphologic features and therapeutic responses with mutation analysis can be used to understand pathogenesis and predict resistance in targeted therapy. METHODS: In 6,637 patients with NSCLC, 12 patients who had concomitant mutations were selected and clinicopathologic features were reviewed...
May 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/26945338/anastomosing-hemangiomas-arising-in-unusual-locations-a-clinicopathologic-study-of-17-soft-tissue-cases-showing-a-predilection-for-the-paraspinal-region
#19
Ivy John, Andrew L Folpe
Anastomosing hemangioma, a recently recognized benign vascular neoplasm originally described in the kidney, may be confused with well-differentiated angiosarcoma. Rare cases of anastomosing hemangiomas have been described in the liver and in nonrenal genitourinary sites. We report a series of 17 anastomosing hemangiomas occurring in unusual locations, in particular in the paravertebral soft tissues. The 17 tumors occurred in 10 male and 6 female patients, ranging in age from 2 to 85 years. One patient had bilateral, synchronous tumors involving the right paracaval and left para-aortic soft tissues...
August 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26863062/congenital-blaschkoid-angiolymphoid-hyperplasia-with-eosinophilia-of-the-anogenital-region
#20
Hai-Hui Su, Shi-Jun Shan, Dirk M Elston, Ying Guo, Jian-Long Men
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, idiopathic vascular disorder. It manifests as dermal or subcutaneous red to brown papules or nodules, most commonly on the head and neck; other less common sites include the trunk, extremities, genitalia, lips, and oral mucosa. Although ALHE is a benign disease, lesions are often persistent and difficult to eradicate. ALHE occurs more frequently in Asian young and middle-aged women. Histologically, it is characterized by a florid vascular proliferation with hobnail epithelioid endothelial cells surrounding by lymphocytic and eosinophilic infiltrate...
April 2016: American Journal of Dermatopathology
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