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https://www.readbyqxmd.com/read/29924790/-surgical-treatment-of-total-thrombosis-of-an-abdominal-aortic-endograft
#1
V V Shlomin, I V Kas'ianov, I G Drozhzhin, P B Bondarenko, P D Puzdriak
Described in the article is a clinical case report regarding successful surgical treatment of total thrombosis of a stent graft in a high-risk surgical patient, having previously undergone endovascular repair of an abdominal aortic aneurysm by means of a unilateral stent graft with suprarenal fixation of its crown and femorofemoral crossover bypass grafting. 5 months after the operation, the patient began complaining of rest pain in his right leg and trophic ulcers of the foot. The findings of MSCT angiography revealed total thrombosis of the stent graft, to be later on followed by operative intervention, i...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924227/solitary-plantar-basal-cell-carcinoma
#2
Maura Simonetti Junqueira Bourroul, Ludmila Lopes Trindade, Vanessa Soares do Nascimento, Anderson da Costa Lino Costa, Ubirajara Honorato da Silva
Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary non-healing ulcer on the sole of the right foot for two years. Histopathological examination showed a typical nodular basal cell carcinoma, confirmed by positivity to Ber-EP4 on immunohistochemistry. There was no history of trauma, exposure to noxious agents, basal cell nevus syndrome, or xeroderma pigmentosum...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924215/recurrent-skin-ulcer-cross-repair-and-sensory-reconstruction-in-a-wrn-gene-mutational-patient
#3
Jiqiang He, Ding Pan, Panfeng Wu, Juyu Tang
A 37-year-old man complained of a refractory posterior malleolar ulceration on his left ankle. He was diagnosed with Werner syndrome according to the progeroid clinical features and genetic testing. To approach the ulceration, a free flow-through right anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve was harvested. One year later, he was readmitted due to a new ulceration on his right ankle. We harvested the left anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve to reconstruct the defect...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29922458/neuroarthropathy-in-diabetes-pathogenesis-of-charcot-arthropathy
#4
S E Johnson-Lynn, A W McCaskie, A P Coll, A H N Robinson
Charcot neuroarthropathy is a rare but serious complication of diabetes, causing progressive destruction of the bones and joints of the foot leading to deformity, altered biomechanics and an increased risk of ulceration. Management is complicated by a lack of consensus on diagnostic criteria and an incomplete understanding of the pathogenesis. In this review, we consider recent insights into the development of Charcot neuroarthropathy. It is likely to be dependent on several interrelated factors which may include a genetic pre-disposition in combination with diabetic neuropathy...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29917335/assessment-and-management-of-older-people-with-venous-leg-ulcers
#5
Marie Todd
A venous leg ulcer (VLU) is defined as the loss of skin below the knee on the leg or foot in the presence of venous disease, which takes more than two weeks to heal. The prevalence of VLUs is increasing, especially in older people, which will increase the demand for nursing care. Development of a lower leg ulcer should trigger immediate assessment of risk factors for chronic venous disease followed by action to identify the cause and initiate treatment, which should prevent progression to more complex and chronic problems...
June 19, 2018: Nursing Older People
https://www.readbyqxmd.com/read/29916424/footwear-in-the-causation-and-prevention-of-foot-ulcers-in-diabetes-mellitus
#6
Ramaswamy Premkumar, Pitchaimuthu Rajan, Jeeva Rima, Joseph Richard
Background.: Inappropriate footwear may be a major cause of foot ulceration among patients with diabetic neuropathy in India. No study has specifically examined the types of footwear or its components in patients with diabetes mellitus and their role in causing foot ulcers. We analysed the role of commonly used footwear in India in inducing first foot ulcers (FFU) in people with diabetes. Methods.: Of 4800 patients with diabetes attending our centre over 1 year, 301 had FFU from different causes...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916286/chinese-medicine-ulcer-oil-promotes-the-healing-of-diabetic-foot-ulcers
#7
Hui Jia, Bohua Yang, Youshan Li, Chen Liang, Haibin Lu, Dongyang Lin, Ju Shang
Objective This study aimed to investigate the mechanism by which Chinese herbal medicine ulcer oil (UO) accelerates ulcer healing in a diabetic ulcer rat model. Methods Sprague Dawley rats were allocated at random into four groups: a control group, a positive control group (PC), a UO treatment group and an ethacridine lactate solution treatment group. Subcutaneous tissue was surgically removed from the rats on days 3, 7 and 14. The levels of protein phosphotyrosine phosphatase 1B (PTP1B), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and advanced glycation end products (AGEs) were detected using western blot analysis...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29914816/analysis-of-recurrent-ulcerations-at-a-multidisciplinary-diabetic-foot-unit-after-implementation-of-a-comprehensive-foot-care-program
#8
Sara Jiménez, José Antonio Rubio, Julia Álvarez, José Luis Lázaro-Martínez
BACKGROUND AND OBJECTIVE: The aim of this study was to assess the risk factors associated to recurrent diabetic foot ulcers after implementing a new preventive comprehensive foot care (CFC) program carried out by a podiatrist and an endocrinologist at a multidisciplinary diabetic foot unit (MDFU) and its potential impact in decreasing recurrent ulcers. MATERIAL AND METHODS: A retrospective cohort study including consecutive patients who attended the MDFU for the first time from 2008 to 2014 complaining of a diabetic foot ulcer that finally healed...
June 15, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29914066/connexin-43-based-therapeutics-for-dermal-wound-healing
#9
REVIEW
Jade Montgomery, Gautam S Ghatnekar, Christina L Grek, Kurtis E Moyer, Robert G Gourdie
The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of interest for modulating the dermal wound healing response. Observational studies found associations between Cx43 at the wound edge and poor healing response, and subsequent studies utilizing local knockdown of Cx43 found improvements in wound closure rate and final scar appearance. Further preclinical work conducted using Cx43-based peptide therapeutics, including alpha connexin carboxyl terminus 1 (αCT1), a peptide mimetic of the Cx43 carboxyl terminus, reported similar improvements in wound healing and scar formation...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29912253/-prevalence-and-susceptibility-pattern-of-bacteria-isolated-from-infected-chronic-wounds-in-adult-patients
#10
Víctor Silva, Alicia Marcoleta, Viviana Silva, Dángelo Flores, Teresa Aparicio, Isabel Aburto, Cecilia Latrach, Naldy Febré
BACKGROUND: Chronic wounds are considered a public health problem that may be complicated by bacterial infections, mainly caused by resistant strains. AIM: To study the bacteria prevalence and antimicrobial susceptibility in samples from adult patients with chronic wounds. METHODS: Patients treated at National Institute of Wounds Foundation between May and July 2014, with chronic ulcers in lower extremities with clinical inflammatory signs were recluted...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29910628/autoamputation-of-diabetic-toe-with-dry-gangrene-a-myth-or-a-fact
#11
REVIEW
Abdullah Al Wahbi
Diabetes is associated with various complications and reduced quality of life. Of the many complications, some are life-threatening. Among these, foot complications remain an important concern. The major foot complications include foot ulceration, cellulitis, abscess, wet gangrene, dry gangrene, and necrotizing fasciitis, with different pathophysiological concepts behind each of them. Gangrene occurs due to reduced blood supply in the body tissues that leads to necrosis. This condition may arise because of an injury, infection, or other health conditions, majorly diabetes...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29909087/critical-appraisal-of-the-quality-of-evidence-addressing-the-diagnosis-prognosis-and-management-of-peripheral-artery-disease-in-patients-with-diabetic-foot-ulceration
#12
Stephen R Ali, Baris A Ozdemir, Robert J Hinchliffe
AIMS: There is a paucity of robust evidence on prevention and management of diabetic foot ulcers (DFUs) to inform treatment. This study appraises the current quality of the evidence addressing diagnosis, prognosis, and management of peripheral artery disease (PAD) in patients with DFUs using a newly devised 21 point scoring (TOPS) disease specific research appraisal tool published by the International Working Group on the Diabetic Foot (IWGDF) and European Wound Management Association...
June 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29907536/methicillin-resistant-staphylococcus-aureus-nasal-carriage-and-infection-among-patients-with-diabetic-foot-ulcer
#13
Shin-Yi Lin, Nai-Yu Lin, Yu-Yao Huang, Chi-Chun Hsieh, Yhu-Chering Huang
PURPOSE: To evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in patients with diabetic foot ulcer (DFU) in Taiwan, and to assess the concordance between colonizing and clinical MRSA isolates from the patients. METHOD: A total of 354 nasal specimens were collected from 112 to 242 diabetic patients with and without foot ulcer, respectively. MRSA clinical isolates from DFU wound cultures were collected for comparison. RESULTS: Nasal carriage rate of S...
June 4, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29907172/-nursing-care-of-a-patient-admitted-to-a-hyperbaric-chamber-for-a-chronic-wound
#14
Stéphanie Chevallier, Simon Le Nabat, Arnaud Druelle, Hugues Lefort, Jean-Éric Blatteau
The hyperbaric chamber is a particularly relevant therapy for the healing of chronic wounds such as radiation-induced wounds, ulcers, diabetic foot or osteomyelitis. This article describes the pathway of a patient with a chronic wound from the perspective of a hyperbaric medicine nurse.
June 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#15
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29904416/experimental-study-of-epidermal-growth-factor-and-acidic-fibroblast-growth-factor-in-the-treatment-of-diabetic-foot-wounds
#16
Jiasheng Xu, Dinghong Min, Guanghua Guo, Xincheng Liao, Zhonghua Fu
The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human EGF group (n=50), an aFGF group (n=50), a combined EGF and aFGF group (n=50) and a normal saline control group (n=49). Patients in all groups received a daily dressing change and growth factor reagents were applied topically when dressing...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904239/kinetic-studies-of-complex-biomedical-process-by-magnetic-resonance-cuban-experiences
#17
Carlos Cabal Mirabal, Adolfo Fernández García, Manuel Lores Guevara, Evelio González, Leonardo Oramas Díaz
The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with molecular, preclinical and clinical studies of significant diseases and drugs development. MR "in vitro" and "in vivo" studies of sickle cell disease, the diabetic foot ulcer, the brain tumor response and the magnetic nano-particle pharmacokinetics, are presented as example...
2018: Applied Magnetic Resonance
https://www.readbyqxmd.com/read/29902542/topical-epidermal-growth-factor-spray-for-the-treatment-of-chronic-diabetic-foot-ulcers-a-phase-iii-multicenter-double-blind-randomized-placebo-controlled-trial
#18
Kwang Hwan Park, Seung Hwan Han, Joon Pio Hong, Seung-Kyu Han, Doo-Hyung Lee, Bom Soo Kim, Jae Hoon Ahn, Jin Woo Lee
AIMS: This study was conducted to evaluate the efficacy and safety of a novel spray-applied growth factor therapy containing recombinant human epidermal growth factor (rhEGF) for the treatment of chronic diabetic foot ulcers (DFU). METHODS: This study was a phase III double-blind, randomized, placebo-controlled trial. 167 adult patients at six medical centers were randomized to receive routine wound care plus either topical spray treatment with 0.005% rhEGF (n = 82) or an equivalent volume of saline spray (n = 85) twice a day until ulcer healing or for up to 12 weeks...
June 11, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29901584/the-association-between-mcp-1-vegf-polymorphisms-and-their-serum-levels-in-patients-with-diabetic-foot-ulcer
#19
Xiaolei Li
The purpose of the present study was to investigate distribution of monocyte chemoattractant protein-1 (MCP-1) -2518A/G and vascular endothelial growth factor (VEGF) -634G/C polymorphisms in type 2 diabetes melitus patients (T2DM) presenting diabetic foot ulcer (DFU). Additionally, we evaluated the effects of these 2 polymorphisms on serum levels of MCP-1 and VEGF in the study population.Patients diagnosed with T2DM without or with DFU were recruited in the study. The distribution of MCP-1 -2518A/G and VEGF -634G/C polymorphisms was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898825/improvement-of-the-quality-of-evidence-of-peripheral-artery-disease-in-diabetic-foot-ulceration-small-step-for-a-doctor-giant-leap-for-mankind
#20
Cornelis G Vos, Jean-Paul P M de Vries
No abstract text is available yet for this article.
June 10, 2018: European Journal of Vascular and Endovascular Surgery
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