Jennifer A Schumacher, Zoë A Wright, Diandra Rufin Florat, Surendra K Anand, Manish Dasyani, Surya Prakash Rao Batta, Valentina Laverde, Kaitlin Ferrari, Laurita Klimkaite, Nina O Bredemeier, Suman Gurung, Gretchen M Koller, Kalia N Aguera, Griffin P Chadwick, Riley D Johnson, George E Davis, Saulius Sumanas
Blood vessels in different vascular beds vary in size, which is essential for their function and fluid flow along the vascular network. Molecular mechanisms involved in the formation of a vascular lumen of appropriate size, or tubulogenesis, are still only partially understood. Src homology 2 domain containing E (She) protein was previously identified in a screen for proteins that interact with Abelson (Abl)-kinase. However, its biological role has remained unknown. Here we demonstrate that She and Abl signaling regulate vessel size in zebrafish embryos and human endothelial cell culture...
January 8, 2024: PLoS Genetics