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Lipofuscin

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https://www.readbyqxmd.com/read/28711386/lipofuscin-generated-by-uva-turns-keratinocytes-photosensitive-to-visible-light
#1
Paulo Newton Tonolli, Orlando Chiarelli-Neto, Carolina Santacruz-Perez, Helena Couto Junqueira, Ii-Sei Watanabe, Felipe Gustavo Ravagnani, Waleska Kerllen Martins, Maurício S Baptista
No abstract text is available yet for this article.
July 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28701867/effects-of-korean-ginseng-berry-on-skin-antipigmentation-and-antiaging-via-foxo3a-activation
#2
Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Takahiko Shimizu, Jae Youl Cho, Dae Bang Seo, Song Seok Shin
BACKGROUND: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28673870/fluorescence-lifetime-imaging-ophthalmoscopy
#3
REVIEW
Chantal Dysli, Sebastian Wolf, Mikhail Y Berezin, Lydia Sauer, Martin Hammer, Martin S Zinkernagel
Imaging techniques based on retinal autofluorescence have found broad applications in ophthalmology because they are extremely sensitive and noninvasive. Conventional fundus autofluorescence measures fluorescence intensity of retinal fluorophores. It mainly derives its signal from lipofuscin at the level of the retinal pigment epithelium. Fundus autofluorescence, however, can not only be characterized by the spatial distribution of the fluorescence intensity or emission spectrum, but also by a characteristic fluorescence lifetime function...
June 30, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28651000/assessing-the-impact-of-benzo-a-pyrene-on-marine-mussels-application-of-a-novel-targeted-low-density-microarray-complementing-classical-biomarker-responses
#4
Mohamed Banni, Susanna Sforzini, Volker M Arlt, Audrey Barranger, Lorna J Dallas, Caterina Oliveri, Yann Aminot, Beniamina Pacchioni, Caterina Millino, Gerolamo Lanfranchi, James W Readman, Michael N Moore, Aldo Viarengo, Awadhesh N Jha
Despite the increasing use of mussels in environmental monitoring and ecotoxicological studies, their genomes and gene functions have not been thoroughly explored. Several cDNA microarrays were recently proposed for Mytilus spp., but putatively identified partial transcripts have rendered the generation of robust transcriptional responses difficult in terms of pathway identification. We developed a new low density oligonucleotide microarray with 465 probes covering the same number of genes. Target genes were selected to cover most of the well-known biological processes in the stress response documented over the last decade in bivalve species at the cellular and tissue levels...
2017: PloS One
https://www.readbyqxmd.com/read/28648614/the-effects-of-retinoic-acid-on-mmp-2-production-proliferation-and-ultrastructural-morphology-in-rat-uterus
#5
Tuğba Kotil, Şengül Şentürk, Türkan Sarioğlu, Leyla Tapul
AIMS: Retinoic acid (RA) has a vital importance in order to ensure continuity and morphology in many tissues. Matrix metalloproteinases (MMPs) have significant roles in proliferation, the formation of cancers, and metastasis. In this study the effects of RA on MMP-2 production in cells of rat uterus were investigated. METHODS: Twenty-four adult Spraque Dawley rats were divided into two groups, the experimental group was treated with 40mg/kg/day 13-cis RA for 5days by gavage...
June 22, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28647554/conditional-loss-of-progranulin-in-neurons-is-not-sufficient-to-cause-neuronal-ceroid-lipofuscinosis-like-neuropathology-in-mice
#6
Terri L Petkau, Jake Blanco, Blair R Leavitt
Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-knockout mice display highly exaggerated lipofuscinosis, microgliosis, and astrogliosis, as well as mild cell loss in specific brain regions. Progranulin is a secreted glycoprotein expressed in both neurons and microglia, but not astrocytes, in the brain. We generated conditional progranulin-knockout mice that lack progranulin in nestin-expressing cells (Nes-cKO mice), which include most neurons as well as astrocytes...
June 21, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28609345/histopathologic-findings-of-cutaneous-hyperpigmentation-in-addison-disease-and-immunostain-of-the-melanocytic-population
#7
Angel Fernandez-Flores, David S Cassarino
The histopathological features of cutaneous hyperpigmentation in Addison disease have very occasionally been reported, and they include acanthosis, hyperkeratosis, focal parakeratosis, spongiosis, superficial perivascular lymphocytic infiltrate, basal melanin hyperpigmentation, and superficial dermal melanophages. We present a study on 2 biopsies from the arm and the thigh in a 77-year-old woman with a long clinical history of Addison disease as well as senile purpura and alopecia of female pattern. The patient presented diffuse hyperpigmentation of the skin, more pronounced on her face, and left upper forehead...
May 31, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28598683/buffered-romanowsky-giemsa-method-for-formalin-fixed-paraffin-embedded-sections-taming-a-traditional-stain
#8
D Stefanović, G Samardžija, A Redžek, M Arnaut, Z Nikin, M Stefanović
Romanowsky-Giemsa (RG) stains were devised during the 19th century for identifying plasmodia parasites in blood smears. Later, RG stains became standard procedures for hematology and cytology. Numerous attempts have been made to apply RG staining to formalin-fixed paraffin-embedded tissue sections, with varied success. Most published work on this topic described RG staining methods in which sections were overstained, then subjected to acid differentiation; unfortunately, the differentiation step often caused inconsistent staining outcomes...
June 9, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28597061/progressive-accumulation-of-autofluorescent-granules-in-macrophages-in-rat-striatum-after-systemic-3-nitropropionic-acid-a-correlative-light-and-electron-microscopic-study
#9
Tae-Ryong Riew, Hong Lim Kim, Jeong-Heon Choi, Xuyan Jin, Yoo-Jin Shin, Mun-Yong Lee
A variety of tissue biomolecules and intracellular structures are known to be autofluorescent. However, autofluorescent signals in brain tissues often confound analysis of the fluorescent markers used for immunohistochemistry. While investigating tissue and cellular pathologies induced by 3-nitropropionic acid, a mitochondrial toxin selective for striatal neurons, we encountered many autofluorescent signals confined to the lesion core. These structures were excited by blue (wavelength = 488 nm) and yellow-orange (555 nm), but not by red (639 nm) or violet (405 nm) lasers, indicating that this autofluorescence overlaps with the emission spectra of commonly used fluorophores...
June 9, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28575570/-aging-of-the-myocardium-and-dilated-cardiomyopathy-morphological-and-molecular-aspects
#10
I B Antonov, K L Kozlov, N S Linkova, E M Paltseva, E O Kykanova
The review considers various aspects of myocardium aging in normal and dilated cardiomyopathy (DC). There is a partial fibrosis of the heart tissue due to accumulation of collagen type 1, and accumulation of amyloid during normal aging. Men myocardial aging is accompanied by loss of cardiomyocytes and increased volume of the remaining cells, whereas in women this effect is absent. There is an expression of nuclear proteins decrease (lamin A and C), the accumulation of lipofuscin, increased content of reactive oxygen species, reduction of protein synthesis Sirt1 in cardiomyocytes with aging...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28570738/cellular-senescence-is-associated-with-human-retinal-microaneurysm-formation-during-aging
#11
Mariana López-Luppo, Joana Catita, David Ramos, Marc Navarro, Ana Carretero, Luísa Mendes-Jorge, Pura Muñoz-Cánoves, Alfonso Rodriguez-Baeza, Victor Nacher, Jesus Ruberte
Purpose: Microaneurysms are present in healthy old-age human retinas. However, to date, no age-related pathogenic mechanism has been implicated in their formation. Here, cellular senescence, a hallmark of aging and several age-related diseases, has been analyzed in the old-age human retina and in the retina of a progeric mouse. Methods: Retinas were obtained from 17 nondiabetic donors and from mice deficient in Bmi1. Cellular senescence was analyzed by immunohistochemistry, senescent-associated β-galactosidase activity assay, Sudan black B staining, conventional transmission electron microscopy, and immunoelectronmicroscopy...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28543767/muscle-ceroid-lipofuscin-like-deposits-in-a-patient-with-corticobasal-syndrome-due-to-a-progranulin-mutation
#12
Rossana Terlizzi, Maria Lucia Valentino, Anna Bartoletti-Stella, Marta Columbaro, Silvia Piras, Michelangelo Stanzani-Maserati, Marialuisa Quadri, Guido J Breedveld, Vincenzo Bonifati, Paolo Martinelli, Piero Parchi, Sabina Capellari
No abstract text is available yet for this article.
May 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28529701/recent-advances-in-the-management-of-dry-age-related-macular-degeneration-a-review
#13
REVIEW
Francesco Bandello, Riccardo Sacconi, Lea Querques, Eleonora Corbelli, Maria Vittoria Cicinelli, Giuseppe Querques
Age-related macular degeneration (AMD), the most important cause of vision loss in elderly people, is a degenerative disorder of the central retina with a multifactorial etiopathology. AMD is classified in dry AMD (d-AMD) or neovascular AMD depending on the presence of choroidal neovascularization. Currently, no therapy is approved for geographic atrophy, the late form of d-AMD, because no treatment can restore the damage of retinal pigment epithelium (RPE) or photoreceptors. For this reason, all treatment approaches in d-AMD are only likely to prevent and slow down the progression of existing atrophy...
2017: F1000Research
https://www.readbyqxmd.com/read/28526856/2-hydroxypropyl-beta-cyclodextrin-hp%C3%AE-cd-reduces-age-related-lipofuscin-accumulation-through-a-cholesterol-associated-pathway
#14
Jason Gaspar, Jacques Mathieu, Pedro Alvarez
Oxidative stress causes significant increases in both cholesterol uptake and intracellular accumulation of the aging biomarker lipofuscin. Here we show that HPβCD addition mitigates these adverse effects in human fibroblasts by significantly reducing LDLr and SREBP1 gene expression. In the absence of oxidative stress, HPβCD addition induces a paradoxical response, increasing cholesterol accumulation (but not lipofuscin) via upregulation of cholesterol biosynthesis. These two distinct, but opposite effects highlight a previously overlooked therapeutic consideration: the cholesterol content of the treated cell determines which cholesterol pathways, either beneficial or harmful, are responsive to HPβCD...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28509387/progranulin-increases-phagocytosis-by-retinal-pigment-epithelial-cells-in-culture
#15
Hiromi Murase, Kazuhiro Tsuruma, Yoshiki Kuse, Masamitsu Shimazawa, Hideaki Hara
Retinal pigment epithelium (RPE) cells take part in retinal preservation, such as phagocytizing the shed photoreceptor outer segments (POS), every day. The incomplete phagocytic function accelerates RPE degeneration and formation of the toxic by-product lipofuscin. Excessive lipofuscin accumulation is characteristic of various blinding diseases in the human eye. Progranulin is a cysteine-rich protein that has multiple biological activities, and it has a high presence in the retina. Progranulin has been recognized to be involved in macrophage phagocytosis in the brain...
May 16, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28507486/melanin-and-lipofuscin-as-hallmarks-of-skin-aging
#16
REVIEW
Anna Skoczyńska, Elżbieta Budzisz, Ewa Trznadel-Grodzka, Helena Rotsztejn
Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins, lipids and carbohydrates. It is described as an age pigment because its content increases with age. The formation and accumulation of lipofuscin is inevitable and leads to cell and homeostasis dysfunction because it reduces the proteasome activity...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28507131/involvement-of-a-gut-retina-axis-in-protection-against-dietary-glycemia-induced-age-related-macular-degeneration
#17
Sheldon Rowan, Shuhong Jiang, Tal Korem, Jedrzej Szymanski, Min-Lee Chang, Jason Szelog, Christa Cassalman, Kalavathi Dasuri, Christina McGuire, Ryoji Nagai, Xue-Liang Du, Michael Brownlee, Naila Rabbani, Paul J Thornalley, James D Baleja, Amy A Deik, Kerry A Pierce, Justin M Scott, Clary B Clish, Donald E Smith, Adina Weinberger, Tali Avnit-Sagi, Maya Lotan-Pompan, Eran Segal, Allen Taylor
Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and loss of photoreceptor cells. Epidemiologic studies indicate important contributions of dietary patterns to the risk for AMD, but the mechanisms relating diet to disease remain unclear. Here we investigate the effect on AMD of isocaloric diets that differ only in the type of dietary carbohydrate in a wild-type aged-mouse model. The consumption of a high-glycemia (HG) diet resulted in many AMD features (AMDf), including RPE hypopigmentation and atrophy, lipofuscin accumulation, and photoreceptor degeneration, whereas consumption of the lower-glycemia (LG) diet did not...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28503972/molecular-mechanisms-of-anti-oxidant-and-anti-aging-effects-induced-by-convallatoxin-in-caenorhabditis-elegans
#18
Jia Xu, Youming Guo, Tianzhuo Sui, Qifei Wang, Yue Zhang, Ruining Zhang, Mingyang Wang, Shuwen Guan, Liping Wang
Convallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective mechanisms on inflammation and cellular proliferation. However, convallatoxin has not been investigated in its antioxidant effects and lifespan extension in Caenorhabditis elegans. In this study, we found that convallatoxin (20 μM) could significantly prolong the lifespan of wild-type C. elegans up to 16.3% through daf-16, but not sir-2.1 signaling and increased thermotolerance and resistance to paraquat-induced oxidative stress...
May 14, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28467791/dry-age-related-macular-degeneration-like-pathology-in-aged-5xfad-mice-ultrastructure-and-microarray-analysis
#19
Sung Wook Park, Sora Im, Hyoung Oh Jun, Kihwang Lee, Young-Jun Park, Jin Hyoung Kim, Woo Jin Park, Young-Hoon Lee, Jeong Hun Kim
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. The two types of AMD are: dry and wet AMD. While laser-induced choroidal neovascularization has been used extensively in the studies of wet AMD, there is no established mouse model that fully recapitulates the cardinal features of dry AMD. A lack of appropriate mouse model for dry AMD has hampered the translational research on the pathogenesis of the disease and the development of therapeutic agents. We hypothesized that 5XFAD mice, an animal model for the study of Alzheimer's disease, can be used as a mouse model for dry AMD with regard to the amyloid beta (Aβ) related pathology...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28456123/integrative-biomarker-assessment-of-the-effects-of-chemically-and-mechanically-dispersed-crude-oil-in-pacific-oysters-crassostrea-gigas
#20
Andrea Luna-Acosta, Paco Bustamante, Hélène Thomas-Guyon, Beñat Zaldibar, Urtzi Izagirre, Ionan Marigómez
The impact of dispersed crude oil and dispersant on adult Pacific oysters, Crassostrea gigas, was evaluated through an integrative biomarker approach including (1) biochemical (plasma catecholase- and laccase-type phenoloxidase and superoxide dismutase), (2) histological (digestive cell lysosomal responses, digestive gland histopathology) and (3) physiological (flesh condition index) endpoints in the haemolymph and digestive gland. Adult oysters were exposed to non-contaminated water (control), chemically-dispersed oil (Brut Arabian Light), mechanically-dispersed oil and dispersant (FINASOL®) alone for 2days, and further depurated in non-contaminated water for 4weeks...
November 15, 2017: Science of the Total Environment
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