keyword
MENU ▼
Read by QxMD icon Read
search

hypoxic transcription factor

keyword
https://www.readbyqxmd.com/read/28651420/-effects-of-hypoxia-inducible-factor-1%C3%AE-on-p311-and-its-influence-on-the-migration-of-murine-epidermal-stem-cells
#1
Z D Xu, H S Li, S Wang, W F He, J Wu, G X Luo
Objective: To explore the effects of hypoxia inducible factor-1α (HIF-1α) on P311 and its influence on the migration of murine epidermal stem cells (ESCs) under hypoxia in vitro. Methods: Two kinds of murine ESCs were isolated and obtained from 15 neonatal wild-type C57BL/6J mice and 5 congeneric source P311 gene knock-out mice, respectively. The first passage of cells were used in the following experiments after morphologic observation and detection of expression of cell surface markers CD71 and CD49f with flow cytometer...
May 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28646037/early-exposure-to-chronic-hypoxia-induces-short-and-long-term-regulation-of-hemoglobin-gene-expression-in-european-sea-bass-dicentrarchus-labrax
#2
Laura Cadiz, Arianna Servili, Patrick Quazuguel, Lauriane Madec, José-Luis Zambonino-Infante, David Mazurais
European sea bass (Dicentrarchus labrax) inhabits coastal waters and may be exposed to hypoxia at different life stages, requiring physiological and behavioral adaptation. In the present study, we attempted to determine whether regulation of hemoglobin (Hb) gene expression plays a role in the physiological response to chronic moderate hypoxia in whole larvae and hematopoietic tissues (head kidney and spleen) of juveniles. We also tested the hypothesis that hypoxia exposure at the larval stage could induce a long-term effect on the regulation of Hb gene expression...
June 23, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28627618/hypoxia-inducible-factor-1%C3%AE-regulates-autophagy-via-the-p27-e2f1-signaling-pathway
#3
Pan Wang, Meijing Long, Shijie Zhang, Zhenyun Cheng, Xin Zhao, Fucheng He, Hongchun Liu, Liang Ming
Autophagy is a highly conserved process by which the cell contents are delivered to lysosomes for degradation, or are used to provide macromolecules for energy generation under conditions of nutritional starvation. It has previously been demonstrated that cancer cells in hypoxic regions, with an oxygen concentration below the normal physiological level, express hypoxia inducible factor (HIF)‑1α, in order to adapt and survive. HIF‑1α is important in the regulation of oxygen homeostasis and the transcription of hundreds of genes in response to conditions of hypoxia, hence maintaining energy and redox homeostasis...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28617871/hypoxia-inducible-factor-1%C3%AE-plays-roles-in-epstein-barr-virus-s-natural-life-cycle-and-tumorigenesis-by-inducing-lytic-infection-through-direct-binding-to-the-immediate-early-bzlf1-gene-promoter
#4
Richard J Kraus, Xianming Yu, Blue-Leaf A Cordes, Saraniya Sathiamoorthi, Tawin Iempridee, Dhananjay M Nawandar, Shidong Ma, James C Romero-Masters, Kyle G McChesney, Zhen Lin, Kathleen R Makielski, Denis L Lee, Paul F Lambert, Eric C Johannsen, Shannon C Kenney, Janet E Mertz
When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs). We report here that HIF-1α also regulates the life cycle of Epstein-Barr virus (EBV). Incubation of EBV-positive gastric carcinoma AGS-Akata and SNU-719 and Burkitt lymphoma Sal and KemIII cell lines with a prolyl hydroxylase inhibitor, L-mimosine or deferoxamine, or the NEDDylation inhibitor MLN4924 promoted rapid and sustained accumulation of both HIF-1α and lytic EBV antigens...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28615919/sequence-analysis-and-phylogenetic-studies-of-hypoxia-inducible-factor-1%C3%AE
#5
Jagadeesha Poyya, Chandrashekhar G Joshi, D Jagadeesha Kumar, H G Nagendra
Hypoxia-inducible factors (HIF) belong to the basic helix loop helix-PER ARNT SIM (bHLH-PAS) family of transcription factors that induce metabolic reprogramming under hypoxic condition. The phylogenetic studies of hypoxia-inducible factor-1α (HIF-1α) sequences across different organisms/species may leave a clue on the evolutionary relationships and its probable correlation to tumorigenesis and adaptation to low oxygen environments. In this study, we have aimed at the evolutionary investigation of the protein HIF-1α across different species to decipher their sequence variations/mutations and look into the probable causes and abnormal behaviour of this molecule under exotic conditions...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/28600879/ifn-gamma-priming-of-adipose-derived-stromal-cells-at-physiological-hypoxia-and-under-acute-hypoxic-stress
#6
E R Andreeva, O O Udartseva, O V Zhidkova, S V Buravkov, M I Ezdakova, L B Buravkova
Multipotent mesenchymal stromal cells (MSCs) are considered cue regulators of tissue remodelling. Their activity is strongly governed by local milieu, where O2 level is most important. The elevation of inflammatory mediators and acute O2 lowering may additionally modulate MSC activity. In present paper the priming effects of IFN-gamma on adipose tissue-derived MSCs (ASCs) at tissue-related O2 level (5%) and acute hypoxic stress (0.1% O2 ) were assessed as alterations of ASCs' CFU-F, proliferation, migration, osteo-commitment...
June 10, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28598679/hypoxia-modulates-epithelial-permeability-via-regulation-of-vascular-endothelial-growth-factor-in-airway-epithelia
#7
Hyun-Ah Song, Yoo-Suk Kim, Hyung-Ju Cho, Soo In Kim, Min Jung Kang, Ji Hyun Kim, Hyun Jin Min, Ju-Wan Kang, Joo-Heon Yoon, Chang-Hoon Kim
Hypoxia resulting from occlusion of the sinus ostium is known to be one of the major pathogenic mechanisms of sinusitis. Hypoxia-inducible factor-1 (HIF-1) is a widely known transcriptional factor that induces the cellular response to hypoxic conditions and activates the transcription of several genes, such as erythropoietin and vascular endothelial growth factor (VEGF). We hypothesized that induced permeability caused by hypoxia is a major pathophysiologic mechanism of upper airway disease such as sinusitis...
June 9, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28592799/whib4-regulates-the-pe-ppe-gene-family-and-is-essential-for-virulence-of-mycobacterium-marinum
#8
Jing Wu, Huan-Wei Ru, Zhi-Hao Xiang, Jun Jiang, Yu-Chen Wang, Lu Zhang, Jun Liu
During the course of infection, pathogenic mycobacteria including Mycobacterium tuberculosis (M. tb) encounter host environments of variable oxygen tension, ranging from the hypoxic center of granulomas to the most oxygenated region in the lung cavities. Mycobacterial responses to changes of oxygen tension are critically related to infection outcomes, such as latency and reactivation. WhiB4 is an iron-sulfur containing transcription factor that is highly sensitive to oxygen exposure. In this study, we found that WhiB4 of Mycobacterium marinum (M...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28592433/bifurcated-bach2-control-coordinates-mantle-cell-lymphoma-survival-and-dispersal-during-hypoxia
#9
Han Zhang, Zheng Chen, Roberto N Miranda, L Jeffrey Medeiros, Nami McCarty
BACH2, a B cell-specific transcription factor, plays a critical role in oxidative stress-mediated drug resistance in mantle cell lymphoma (MCL); however, the biological functions of BACH2 and its regulation of B cell malignancies in chronic hypoxic microenvironment are never studied. Here, we found that silencing BACH2 led to not only increased tumor formation and colony formation but also increased tumor dispersal to spleen and bone marrow. Decreased BACH2 levels in the patients were also correlated to the bone marrow and gastrointestinal dispersal of MCL and blastoid subtypes of MCL...
June 7, 2017: Blood
https://www.readbyqxmd.com/read/28589898/the-zebrafish-mir-125c-is-induced-under-hypoxic-stress-via-hypoxia-inducible-factor-1%C3%AE-and-functions-in-cellular-adaptations-and-embryogenesis
#10
Yan He, Chun-Xiao Huang, Nan Chen, Meng Wu, Yan Huang, Hong Liu, Rong Tang, Wei-Min Wang, Huan-Ling Wang
Hypoxia is a unique environmental stress. Hypoxia inducible factor-lα (HIF-lα) is a major transcriptional regulator of cellular adaptations to hypoxic stress. MicroRNAs (miRNAs) as posttranscriptional gene expression regulators occupy a crucial role in cell survival under low-oxygen environment. Previous evidences suggested that miR-125c is involved in hypoxia adaptation, but its precise biological roles and the regulatory mechanism underlying hypoxic responses remain unknown. The present study showed that zebrafish miR-125c is upregulated by hypoxia in a Hif-lα-mediated manner in vitro and in vivo...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28589371/activator-protein-1-ap-1-a-bridge-between-life-and-death-in-lung-epithelial-a549-cells-under-hypoxia
#11
Seema Yadav, Namita Kalra, Lilly Ganju, Mrinalini Singh
Activator protein-1 (AP-1) transcription factor plays a central role in hypoxia to modulate the expression of genes that decides the fate of the cell. The aim of the present study was to explore the role of AP-1 subunits in lung epithelial (A549) cells under hypoxia. Cell cycle studies by flow cytometry indicated that cell viability was unaffected by the initial hypoxia exposure (0.5% O2 at 37 °C) for 6 and 12 h. However, both transient cell cycle arrest and cell death was detected at 24 and 48 h. Flow cytometry and spectrofluorometry data confirmed the increase in ROS levels...
June 6, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28587375/c-x-c-motif-chemokine-ligand-8-promotes-endothelial-cell-homing-via-the-akt-signal-transducer-and-activator-of-transcription-pathway-to-accelerate-healing-of-ischemic-and-hypoxic-skin-ulcers
#12
Lei Shen, Peng Zhang, Shanqiang Zhang, Liping Xie, Lijie Yao, Weiya Lang, Jie Lian, Wei Qin, Meng Zhang, Liang Ji
C-X-C motif chemokine ligand 8 (CXCL-8) promotes cell homing and angiogenesis. However, under hypoxic conditions, the role of CXCL-8 in the homing of human umbilical vein endothelial cells (HUVECs), and its effect on the healing of skin ulcers caused by ischemia and hypoxia remain unknown. In the current study, assays measuring cell proliferation, in vitro angiogenesis and cell migration were performed to evaluate alterations in the proliferation, angiogenic capacity and chemotaxis of HUVECs treated with CXCL-8 protein and/or an Akt inhibitor (AZD5363 group) under hypoxic conditions...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28586054/propofol-reduces-hypoxia%C3%A2-induced-autophagic-cell-death-through-downregulating-hif-1%C3%AE-in-alveolar-epithelial-type-ii-cells-of-rats
#13
Hui-Jie Ning, Hong-Bin Yuan, Hai-Tao Xu, Xing-Ying He
Propofol (2,6‑diisopropylphenol) exerts protective effects on alveolar epithelial type II (ATII) cells, partly through attenuating hypoxia‑induced apoptosis. Autophagy is involved in the activation of apoptosis. Therefore, the present study investigated the modulating effect of propofol against autophagy in ATII cells under hypoxia. Western blot analysis was performed to detect the protein expression of the autophagy molecular marker, microtubule‑associated protein 1 light chain 3 (LC3)‑II, under various conditions...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28585205/adipose-tissue-hypoxia-in-obesity-and-its-impact-on-preadipocytes-and-macrophages-hypoxia-hypothesis
#14
Atilla Engin
Obese subjects exhibit lower adipose tissue oxygen consumption in accordance with the lower adipose tissue blood flow. Thus, compared with lean subjects, obese subjects have 44% lower capillary density and 58% lower vascular endothelial growth factor (VEGF). The VEGF expression together with hypoxia-inducible transcription factor-1 (HIF-1) activity also requires phosphatidylinositol 3-kinase (PI3K)- and target of rapamycin (TOR)-mediated signaling. HIF-1alpha is an important signaling molecule for hypoxia to induce the inflammatory responses...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28574600/diallyl-trisulfides-a-natural-histone-deacetylase-inhibitor-attenuate-hif-1%C3%AE-synthesis-and-decreases-breast-cancer-metastasis
#15
Zhonghong Wei, Yunlong Shan, Li Tao, Yuping Liu, Zhijie Zhu, Zhaoguo Liu, Yuanyuan Wu, Wenxing Chen, Aiyun Wang, Yin Lu
Intratumoral hypoxia promotes the distant metastasis of cancer subclones. The clinical expression level of hypoxia-inducible factor-1α (HIF-1α) reflects the prognosis of a variety of cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF-1α protein due to von Hippel-Lindau protein-dependent degradation. Dietary organosulfur compounds, such as those in garlic, have been reported as HDAC inhibitors. The effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) on the ratio of firefly/Renilla luciferase activity in hypoxic MDA-MB-231 cells were determined...
June 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28571880/%C3%AE-tocopherol-especially-%C3%AE-tocopherol-phosphate-exerts-antiapoptotic-and-angiogenic-effects-on-rat-bone-marrow-derived-endothelial-progenitor-cells-under-high-glucose-and-hypoxia-conditions
#16
Ziheng Wu, Xiangtao Zheng, Luyang Meng, Xin Fang, Yangyan He, Donglin Li, Chengfei Zheng, Hongkun Zhang
OBJECTIVE: Considering the poor efficacy of local intramuscular injections with endothelial progenitor cells (EPCs) for critical limb ischemia in patients with diabetes, the study aimed to investigate the effect of α-tocopherol (α-T) and α-tocopherol phosphate (α-TP) on apoptosis and angiogenesis in a rat model under oxidative stress conditions. METHODS: Primary EPCs from Sprague-Dawley rats were harvested and treated with α-T and α-TP for 24 hours. Gene transcription and protein expression were evaluated by real-time polymerase chain reaction and Western blot, respectively...
May 29, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28565876/effects-of-17%C3%AE-estradiol-and-2-methoxyestradiol-on-the-oxidative-stress-hypoxia-inducible-factor-1-pathway-in-hypoxic-pulmonary-hypertensive-rats
#17
Li Wang, Quan Zheng, Yadong Yuan, Yanpeng Li, Xiaowei Gong
The present study aimed to investigate the effects of 17β-estradiol (E2) and 2-methoxyestradiol (2ME) on the oxidative stress-hypoxia inducible factor-1 (OS-HIF-1) pathway in hypoxic pulmonary hypertensive rats. Female Sprague-Dawley rats were divided randomly into 4 groups, as follows: i) Control (Group A); ii) ovariectomy (OVX) + hypoxia (Group B); iii) OVX + hypoxia + E2 injection (Group C); and iv) 2ME injection (Group D). The rats were maintained under hypoxic conditions for 8 weeks, and mean pulmonary artery pressure (mPAP) and pulmonary arteriole morphology were measured...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560518/mir-210-expression-in-pbmcs-from-patients-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#18
Q Huang, S-S Chen, J Li, S-S Tao, M Wang, R-X Leng, H-F Pan, D-Q Ye
BACKGROUND: In hypoxic conditions, miRNA-210 plays an important role in regulating the expression of hypoxia-inducing factor-1α (HIF-1α) and the differentiation of T helper 17 (Th17) cells, and this may be involved in the development and function of the immune system. AIMS: This study was to investigate the miR-210 expression levels in peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and its association with the clinical and laboratory features of both diseases...
May 30, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28553287/hypoxia-modulates-the-response-of-mast-cells-to-staphylococcus-aureus-infection
#19
Helene Möllerherm, Katja Branitzki-Heinemann, Graham Brogden, Ayssar A Elamin, Wulf Oehlmann, Herbert Fuhrmann, Mahavir Singh, Hassan Y Naim, Maren von Köckritz-Blickwede
To study the antimicrobial function of immune cells ex vivo, cells are commonly cultivated under atmospheric oxygen concentrations (20-21%; normoxia), although the physiological oxygen conditions in vivo are significantly lower in most tissues. Especially during an acute infection, oxygen concentration locally decreases to hypoxic levels around or below 1%. The goal of this study was to investigate the effect of hypoxia on the activity of mast cells (MCs). MCs were cultivated for 3 or 24 h at 1% O2 in a hypoxia glove box and co-incubated with heat-inactivated Staphylococcus aureus...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28546087/region-specific-oligodendrocyte-transcription-factor-expression-in-a-model-of-neonatal-hypoxic-injury
#20
Bethann M Affeldt, Andre Obenaus, Jonathan Chan, Andrea C Pardo
White matter injury (WMI) of prematurity is associated with a spectrum of neurological disorders ranging from mild cognitive and behavioral deficits to cerebral palsy. Translational studies have implicated impaired oligodendrocyte development after hypoxia as the primary cause of WMI, but the underlying mechanisms remain poorly understood. The goal of this study was to identify alterations in the expression of oligodendrocyte precursor cell transcription factors in a mouse model of transient mild global hypoxia...
May 22, 2017: International Journal of Developmental Neuroscience
keyword
keyword
114326
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"