Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C Saido, Benjamin Wolozin
INTRODUCTION: The study of the pathophysiology study of Alzheimer's disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular -amyloid (A) deposition, intracellular aggregation of microtubule associated protein tau (MAPT), inflammation and neurodegeneration. METHODS: The humanized APPNL-G-F knock-in mouse line was crossed to the PS19 MAPTP301S , over-expression mouse line to create the dual APPNL-G-F/PS19 MAPTP301S line...
2024: Frontiers in Neuroscience