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https://www.readbyqxmd.com/read/28942880/predictors-of-high-killip-class-after-st-segment-elevation-myocardial-infarction-in-the-era-of-primary-reperfusion
#1
Lourdes Vicent, Jesús Velásquez-Rodríguez, María Jesús Valero-Masa, Felipe Díez-Delhoyo, Hugo González-Saldívar, Vanessa Bruña, Carolina Devesa, Miriam Juárez, Iago Sousa-Casasnovas, Francisco Fernández-Avilés, Manuel Martínez-Sellés
BACKGROUND/INTRODUCTION: Outcome after ST segment elevation myocardial infarction (STEMI), has improved but patients with high Killip class still have a poor prognosis, and those ≥II need a closer monitoring in a specialized cardiac care unit. PURPOSE: We aimed to determine the predictors of Killip class in a group of patients admitted for acute STEMI. METHODS: Non-interventional registry in a Cardiac Intensive Care Unit. Patients were consecutively included from January 2010 to April 2015, and multivariate analysis was performed to determine independent predictors of high Killip Class...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28939567/association-between-gender-and-short-term-outcome-in-patients-with-st-elevation-myocardial-infraction-participating-in-the-international-prospective-randomised-administration-of-ticagrelor-in-the-catheterisation-laboratory-or-in-the-ambulance-for-new-st-elevation
#2
Dimitrios Venetsanos, Sofia Sederholm Lawesson, Joakim Alfredsson, Magnus Janzon, Angel Cequier, Mohamed Chettibi, Shaun G Goodman, Arnoud W Van't Hof, Gilles Montalescot, Eva Swahn
OBJECTIVES: To evaluate gender differences in outcomes in patents with ST-segment elevation myocardial infarction (STEMI) planned for primary percutaneous coronary intervention (PPCI). SETTINGS: A prespecified gender analysis of the multicentre, randomised, double-blind Administration of Ticagrelor in the catheterisation Laboratory or in the Ambulance for New ST elevation myocardial Infarction to open the Coronary artery. PARTICIPANTS: Between September 2011 and October 2013, 1862 patients with STEMI and symptom duration <6 hours were included...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28939193/prognostic-impact-of-prepercutaneous-coronary-intervention-timi-flow-in-patients-with-st-segment-and-non-st-segment-elevation-myocardial-infarction-results-from-the-fast-mi-2010-registry
#3
Clotilde Bailleul, Nadia Aissaoui, Guillaume Cayla, Jean-Guillaume Dillinger, Bernard Jouve, François Schiele, Jean Ferrières, Tabassome Simon, Nicolas Danchin, Etienne Puymirat
BACKGROUND: Thrombolysis in myocardial infarction (TIMI) flow grade 2 or 3 before percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) is associated with improved outcomes. However, no recent data are available on its impact beyond 1 year and/or by type of AMI. AIMS: To assess the prognostic impact of prePCI TIMI flow at 30 days and 3 years in patients with ST-segment elevation (STEMI) or non-ST-segment elevation (NSTEMI) AMI. METHODS: We compared long-term outcomes associated with TIMI flow grade 2/3 versus 0/1 in patients referred for PCI in the nationwide French registry of acute ST-segment elevation or non-ST-segment elevation myocardial infarction (FAST-MI) 2010...
September 19, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28938239/absence-of-a-correlation-between-the-abo-blood-group-and-thrombus-burden-in-patients-with-st-segment-elevation-myocardial-infarction
#4
Lutfu Askin, Mustafa Cetin, Serdar Turkmen
OBJECTIVE: ABO antigens are highly abundant in many human cell types, including platelets, vascular endothelium, and red blood cells. The presence of a thrombus is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). We reviewed the relationship between ABO blood groups and thrombus burden in patients with STEMI. PATIENTS AND METHODS: We carried out a retrospective study of 396 patients with STEMI who did not have an ABO blood group or thrombus burden...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28935461/short-and-long-term-outcome-in-very-old-patients-with-st-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#5
Roberta Sappa, Maria Teresa Grillo, Martino Cinquetti, Giulio Prati, Leonardo Spedicato, Gaetano Nucifora, Andrea Perkan, Davide Zanuttini, Gianfranco Sinagra, Alessandro Proclemer
BACKGROUND: Although octogenarians constitute a fast-growing portion of cardiovascular patients, few data are available on the outcome of patients aged ≥85 years with ST-Elevation Myocardial Infarction (STEMI). METHODS AND RESULTS: We analyzed 126 consecutive patients aged ≥85 years (age 88±2 years) with STEMI, undergoing primary percutaneous coronary intervention (pPCI) within 12 hours from symptoms onset. Long-term follow-up (median 898 days) was obtained for the 102 patients surviving the index-hospitalization...
September 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28927636/feasibility-of-coronary-fractional-flow-reserve-with-dual-anti-platelet-therapy-in-low-risk-coronary-lesions-without-systemic-anticoagulation-results-of-the-smart-ffr-study
#6
Fernando Boccalandro, Mandeep Dhindsa, Prem Subramaniyam, Mary Mok
BACKGROUND: Fractional flow reserve (FFR) is used to assess the functional significance of coronary artery stenoses. The optimal anti-thrombotic regimen for FFR has not been studied. PURPOSE: The goal of this study was to determine whether FFR could be safely performed in Type A coronary lesions, using only upstream dual anti-platelet therapy (DAT) with aspirin and clopidogrel, compared with DAT plus anticoagulation in low risk coronary lesions. METHODS/MATERIALS: Two hundred patients undergoing FFR for Type A intermediate coronary lesions were blindly randomized into two groups of 100 patients each...
August 18, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28898332/-prediction-of-hospital-mortality-of-st-elevation-myocardial-infarction-using-timi-score
#7
Héctor Ugalde, María Cecilia Yubini, Sebastián Rozas, María Ignacia Sanhueza, Hernán Jara
BACKGROUND: Thrombolysis in myocardial infarction risk score (TIMI-RS) was designed to predict early mortality in patients with a ST elevation acute myocardial infarction (STEAMI). AIM: To evaluate the predictive capacity for hospital mortality of TIMI-RS. MATERIAL AND METHODS: Patients with ≤ 12-hour evolution STEAMI were selected from a prospective registry of all patients hospitalized in our coronary unity within January 1988 and December 2005...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28894748/new-antihyperglycemic-drugs-and-heart-failure-synopsis-of-basic-and-clinical-data
#8
REVIEW
Dirk von Lewinski, Ewald Kolesnik, Markus Wallner, Michael Resl, Harald Sourij
The assessment of the cardiovascular safety profile of any newly developed antihyperglycemic drug is mandatory before registration, as a meta-analysis raised alarm describing a significant increase in myocardial infarction with the thiazolidinedione rosiglitazone. The first results from completed cardiovascular outcome trials are already available: TECOS, SAVOR-TIMI, and EXAMINE investigated dipeptidyl peptidase 4 (DPP-4) inhibitors, ELIXA, LEADER, and SUSTAIN-6 investigated glucagon-like peptide 1 (GLP-1) receptor agonists, and EMPA-REG OUTCOME and CANVAS investigated sodium-dependent glucose transporter 2 (SGLT-2) inhibitors...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28891162/integrating-invasive-hemodynamic-parameters-into-risk-stratification-of-acute-myocardial-infarction-and-cardiogenic-shock
#9
EDITORIAL
Gennaro Giustino, George D Dangas
A ratio of systolic blood pressure over left ventricle end-diastolic pressure (SBP/LVEDP) ≤4 identifies patients with ST-elevation myocardial infarction (STEMI) at greater risk of in-hospital mortality or that may require the use of mechanical circulatory support (MCS). The predictive performance of the SBP/LVEDP ratio was comparable to non-invasive hemodynamic parameters (the shock index and the modified shock index) and established clinical risk stratification tools (the TIMI risk score). Alongside established clinical risk factors, invasive hemodynamic parameters may help in identifying STEMI patients who may benefit from early MCS...
September 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28887713/determinants-of-slow-flow-following-stent-implantation-in-intravascular-ultrasound-guided-primary-percutaneous-coronary-intervention
#10
Yusuke Watanabe, Kenichi Sakakura, Yousuke Taniguchi, Kei Yamamoto, Hiroshi Wada, Hideo Fujita, Shin-Ichi Momomura
Slow flow is a serious complication in primary percutaneous coronary intervention (PCI) and is associated with poor clinical outcomes. Intravascular ultrasound (IVUS)-guided PCI may improve clinical outcomes after drug-eluting stent implantation. The purpose of this study was to seek the factors of slow flow following stent implantation, including factors related to IVUS-guided primary PCI. The study population consisted of 339 ST-elevation myocardial infarction patients, who underwent stent deployment with IVUS...
September 8, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28882235/efficacy-and-safety-of-ticagrelor-over%C3%A2-time-in-patients-with-prior-mi-in%C3%A2-pegasus-timi-54
#11
RANDOMIZED CONTROLLED TRIAL
Marc P Bonaca, Robert F Storey, Pierre Theroux, P Gabriel Steg, Deepak L Bhatt, Marc C Cohen, KyungAh Im, Sabina A Murphy, Giulia Magnani, Ton Oude Ophuis, Mikhail Rudah, Alexander Parkhomenko, Daniel Isaza, Gabriel Kamensky, Assen Goudev, Gilles Montalescot, Eva C Jensen, Per Johanson, Eugene Braunwald, Marc S Sabatine
BACKGROUND: Ticagrelor reduces ischemic risk in patients with prior myocardial infarction (MI). It remains unclear whether ischemic risk and the benefits of prolonged P2Y12 inhibition in this population remain consistent over time. OBJECTIVES: The study sought to investigate the pattern of ischemic risk over time and whether the efficacy and safety of ticagrelor were similar early and late after randomization. METHODS: The PEGASUS-TIMI (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis In Myocardial Infarction) 54 trial randomized patients with prior MI (median 1...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28867129/frequency-of-cholesterol-crystals-in-culprit-coronary-artery-aspirate-during-acute-myocardial-infarction-and-their-relation-to-inflammation-and-myocardial-injury
#12
George S Abela, Jagadeesh K Kalavakunta, Abed Janoudi, Dale Leffler, Gaurav Dhar, Negar Salehi, Joel Cohn, Ibrahim Shah, Milind Karve, Veera Pavan K Kotaru, Vishal Gupta, Shukri David, Keerthy K Narisetty, Michael Rich, Abigail Vanderberg, Dorothy R Pathak, Fadi E Shamoun
Cholesterol crystals (CCs) have been associated with plaque rupture through mechanical injury and inflammation. This study evaluated the presence of CCs during acute myocardial infarction (AMI) and associated myocardial injury, inflammation, and arterial blood flow before and after percutaneous coronary intervention. Patients presenting with AMI (n = 286) had aspiration of culprit coronary artery obstruction. Aspirates were evaluated for crystal content, size, composition, and morphology by scanning electron microscopy, crystallography, and infrared spectroscopy...
August 31, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28867023/machine-learning-for-prediction-of-30-day-mortality-after-st-elevation-myocardial-infraction-an-acute-coronary-syndrome-israeli-survey-data-mining-study
#13
Roni Shouval, Amir Hadanny, Nir Shlomo, Zaza Iakobishvili, Ron Unger, Doron Zahger, Ronny Alcalai, Shaul Atar, Shmuel Gottlieb, Shlomi Matetzky, Ilan Goldenberg, Roy Beigel
BACKGROUND: Risk scores for prediction of mortality 30-days following a ST-segment elevation myocardial infarction (STEMI) have been developed using a conventional statistical approach. OBJECTIVE: To evaluate an array of machine learning (ML) algorithms for prediction of mortality at 30-days in STEMI patients and to compare these to the conventional validated risk scores. METHODS: This was a retrospective, supervised learning, data mining study...
November 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28864718/assessment-of-the-2016-national-institute-for-health-and-care-excellence-high-sensitivity-troponin-rule-out-strategy
#14
Edward Watts Carlton, John William Pickering, Jaimi Greenslade, Louise Cullen, Martin Than, Jason Kendall, Richard Body, William A Parsonage, Ahmed Khattab, Kim Greaves
OBJECTIVE: We aimed to evaluate the limit of detection of high-sensitivity troponin (hs-cTn) and Thrombolysis In Myocardial Infarction (TIMI) score combination rule-out strategy suggested within the 2016 National Institute for Health and Care Excellence (NICE) Chest Pain of Recent Onset guidelines and establish the optimal TIMI score threshold for clinical use. METHODS: A pooled analysis of adult patients presenting to the emergency department with chest pain and a non-ischaemic ECG, recruited into six prospective studies, from Australia, New Zealand and the UK...
September 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28862934/impact-of-spontaneous-extracranial-bleeding-events-on-health-state-utility-in-patients-with-atrial-fibrillation-results-from-the-engage-af-timi-48-trial
#15
Kaijun Wang, Haiyan Li, Winghan J Kwong, Elliott M Antman, Christian T Ruff, Robert P Giugliano, David J Cohen, Elizabeth A Magnuson
BACKGROUND: The impact of different types of extracranial bleeding events on health-related quality of life and health-state utility among patients with atrial fibrillation is not well understood. METHODS AND RESULTS: The ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation...
August 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28862032/heparin-pre-treatment-in-patients-with-st-segment-elevation-myocardial-infarction-and-the-risk-of-intracoronary-thrombus-and-total-vessel-occlusion-insights-from-the-taste-trial
#16
Sofia Karlsson, Pontus Andell, Moman A Mohammad, Sasha Koul, Göran K Olivecrona, Stefan K James, Ole Fröbert, David Erlinge
BACKGROUND: Pre-treatment with unfractionated heparin is common in ST-segment elevation myocardial infarction (STEMI) protocols, but the effect on intracoronary thrombus burden is unknown. We studied the effect of heparin pre-treatment on intracoronary thrombus burden and Thrombolysis in Myocardial Infarction (TIMI) flow prior to percutaneous coronary intervention in patients with STEMI. METHODS: The Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia (TASTE) trial angiographically assessed intracoronary thrombus burden and TIMI flow, prior to percutaneous coronary intervention, in patients with STEMI...
August 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28859968/dipeptidyl-peptidase-4-independent-cardiac-dysfunction-links-saxagliptin-to-heart-failure
#17
Chintan N Koyani, Ewald Kolesnik, Gerald Wölkart, Niroj Shrestha, Susanne Scheruebel, Christopher Trummer, Klaus Zorn-Pauly, Astrid Hammer, Petra Lang, Helga Reicher, Heinrich Maechler, Klaus Groschner, Bernd Mayer, Peter P Rainer, Harald Sourij, Wolfgang Sattler, Ernst Malle, Brigitte Pelzmann, Dirk von Lewinski
Saxagliptin treatment has been associated with increased rate of hospitalization for heart failure in type 2 diabetic patients, though the underlying mechanism(s) remain elusive. To address this, we assessed the effects of saxagliptin on human atrial trabeculae, guinea pig hearts and cardiomyocytes. We found that the primary target of saxagliptin, dipeptidyl peptidase-4, is absent in cardiomyocytes, yet saxagliptin internalized into cardiomyocytes and impaired cardiac contractility via inhibition of the Ca(2+)/calmodulin-dependent protein kinase II-phospholamban-sarcoplasmic reticulum Ca(2+)-ATPase 2a axis and Na(+)-Ca(2+) exchanger function in Ca(2+) extrusion...
August 30, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28857445/contemporary-antiplatelet-therapy-in-acute-coronary-syndromes-are-there-differences-in-outcomes-and-discontinuation-between-clopidogrel-and-ticagrelor
#18
Scott A Harding, Ana Holley, Ben Wilkins, Sarah Fairley, Mark Simmonds, Peter D Larsen
BACKGROUND: We studied clinical outcomes and discontinuation rates in a "real world" population presenting with myocardial infarction treated with ticagrelor or clopidogrel. METHODS: Between January 2012 and May 2015, 992 patients with acute myocardial infarction undergoing invasive management and adequately pre-treated with dual antiplatelet therapy were prospectively enrolled. Platelet aggregation was measured using the Multiplate analyser. Baseline characteristics, in-hospital outcomes and 1 year outcomes were collected...
August 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28832257/survey-of-the-occurrence-and-human-infective-potential-of-giardia-duodenalis-and-cryptosporidium-spp-in-wastewater-and-different-surface-water-sources-of-western-romania
#19
Kálmán Imre, Adriana Morar, Marius S Ilie, Judit Plutzer, Mirela Imre, Tîrziu Emil, Mihai V Herbei, Gheorghe Dărăbuș
From the group of parasitic protozoa, Giardia and Cryptosporidium are the most common pathogens spread in surface water sources, representing a continuous threat to public health and water authorities. The aim of this survey was to assess the occurrence and human infective potential of these pathogens in treated wastewaters and different surface water sources. A total of 76 western Romanian water bodies in four counties (Arad, Bihor, Caraș-Severin and Timiș) were investigated, including the effluents of wastewater treatment plants (n = 11) and brooks (n = 19), irrigation channels (n = 8), lakes (n = 16), and ponds (n = 22)...
August 23, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28826799/high-sensitivity-c-reactive-protein-and-long-term-reperfusion-success-of-primary-percutaneous-intervention-in-st-elevation-myocardial-infarction
#20
Hilde E Groot, Jacco C Karper, Erik Lipsic, Dirk J van Veldhuisen, Iwan C C van der Horst, Pim van der Harst
AIMS: In STEMI patients, success of reperfusion of primary PCI predicts cardiac remodeling and clinical outcome. This success may depend on inflammation. We aimed to investigate the association between inflammation and reperfusion success, left ventricular function and long-term mortality in STEMI patients. METHODS: In 376 consecutive STEMI patients of the GIPS-III trial hs-CRP levels were measured at baseline, 2weeks, 7weeks and 4months post-PCI. Myocardial blush grade was used to determine success of myocardial reperfusion...
December 1, 2017: International Journal of Cardiology
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