keyword
https://read.qxmd.com/read/38534473/a-comparison-of-the-impact-of-pharmacological-treatments-on-cardioversion-rate-control-and-mortality-in-data-driven-atrial-fibrillation-phenotypes-in-critical-care
#1
JOURNAL ARTICLE
Alexander Lacki, Antonio Martinez-Millana
Critical care physicians are commonly faced with patients exhibiting atrial fibrillation (AF), a cardiac arrhythmia with multifaceted origins. Recent investigations shed light on the heterogeneity among AF patients by uncovering unique AF phenotypes, characterized by differing treatment strategies and clinical outcomes. In this retrospective study encompassing 9401 AF patients in an intensive care cohort, we sought to identify differences in average treatment effects (ATEs) across different patient groups. We extract data from the MIMIC-III database, use hierarchical agglomerative clustering to identify patients' phenotypes, and assign them to treatment groups based on their initial drug administration during AF episodes...
February 20, 2024: Bioengineering
https://read.qxmd.com/read/38487153/frequency-of-cardiac-valvulopathies-in-patients-with-marfan-syndrome-a-systematic-review-and-meta-analysis
#2
REVIEW
Carlson Sama, Noah T Fongwen, Muchi Ditah Chobufo, Ademola Ajibade, Melissa Roberts, Mark Greathouse, Anthony Lyonga Ngonge, Ayowumi Adekolu, Yasmin S Hamirani
Marfan syndrome (MFS) is a progressive connective tissue disease with a broad range of clinical manifestations. We sought to establish the spectrum of structural valvular abnormalities as cardiovascular involvement has been identified as the most life-threatening aspect of the syndrome. This was a systematic review with a meta-analysis of studies indexed in Medline from the inception of the database to November 7, 2022. Using the random-effects model, separate Forest and Galbraith plots were generated for each valvular abnormality assessed...
February 2024: Curēus
https://read.qxmd.com/read/38355045/mitral-valve-repair-of-the-anterior-leaflet-are-we-there-yet
#3
REVIEW
Pegah Bahiraie, Hamidreza Soleimani, Narges Heydari, Kimia Najafi, Angelos Karlas, Dimitrios V Avgerinos, Georgios Samanidis, Toshiki Kuno, Ilias P Doulamis, Iakovou Ioannis, Nikolaos Spilias, Kaveh Hosseini, Polydoros N Kampaktsis
Mitral regurgitation is one of the most prevalent valvulopathies with a disease burden that incurs significant healthcare costs globally. Surgical repair of the posterior mitral valve leaflet is a standard treatment but approaches for repairing the anterior mitral valve leaflet are not widely established. Since anterior leaflet involvement is less common and more difficult to repair, fewer studies have investigated its natural history and treatment options. In this review, we discuss surgical techniques for repairing the anterior leaflet and their outcomes including survival, reoperation, and recurrence of regurgitation...
February 12, 2024: Hellenic Journal of Cardiology: HJC
https://read.qxmd.com/read/38349103/-not-available
#4
JOURNAL ARTICLE
Joshua Ravindran, Eirik Hornes Halvorsen, Andreas Kongsvik, Sigurd Birkeland, Einar Gude, Alessandro Müller De Bortoli
BACKGROUND: Ventricular septal rupture (VSR) following acute myocardial infarction is rare in the modern revascularisation era. Nevertheless, clinical awareness is paramount, as presentation may vary. CASE PRESENTATION: A middle-aged male with no history of cardiovascular disease developed progressive heart failure symptoms while travelling abroad. Initial workup revealed a prominent systolic murmur, but findings were inconsistent with acute coronary syndrome. Transthoracic echocardiogram showed a small hypokinetic area in the basal septum, preserved left ventricular function and no significant valvulopathy...
February 13, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://read.qxmd.com/read/38332441/tropheryma-whipplei-endocarditis-presenting-as-valvulopathy-and-multiple-septic-emboli
#5
JOURNAL ARTICLE
Ralph Akiki, Nazli Begum Ozturk, Reenal Patel, Kurt Bernacki, Francisco Davila
A 63-year-old man was admitted to the hospital for nausea, vomiting, and right flank pain. He was found to have septic emboli in multiple organs secondary to aortic valve endocarditis. He was started on broad-spectrum antibiotics and underwent valve replacement. Blood cultures from admission were negative, but a blood polymerase chain reaction (PCR) test for fastidious difficult-to-culture pathogens showed a positive result for Tropheryma whipplei. Valve histopathological evaluation confirmed Tropheryma whipplei endocarditis...
February 8, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38315124/evaluating-fenfluramine-hydrochloride-as-an-oral-solution-for-the-treatment-of-seizures-associated-with-lennox-gastaut-syndrome
#6
REVIEW
Frank M C Besag, Michael J Vasey, Richard F M Chin
INTRODUCTION: Lennox-Gastaut syndrome (LGS) is a severe childhood-onset developmental and epileptic encephalopathy characterized by treatment-refractory seizures, including tonic/atonic 'drop' seizures, and intellectual impairment and slow spike-wave discharges on the electroencephalogram. Fenfluramine, previously prescribed as a weight-loss drug but then withdrawn, has recently been approved in the US, EU, and UK for the adjunct treatment of seizures associated with LGS. AREAS COVERED: The authors review the efficacy and safety findings from clinical trials of fenfluramine in LGS...
February 5, 2024: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/38276788/the-impact-of-comorbidities-and-demographic-factors-on-ejection-fraction
#7
JOURNAL ARTICLE
Cezara Andreea Soysaler, Cătălina Liliana Andrei, Octavian Ceban, Crina Julieta Sinescu
Heart failure (HF) presents an increasingly significant problem as the population ages. The cause of HF plays a significant role in determining treatment options and outcomes. It is worth noting that several studies have identified gender disparities in both morbidity and mortality, which may suggest differing causes of HF. The purpose of this research is to investigate the influence of various factors, including demographics and comorbidities, on ejection fraction (EF). The objectives of this study involve implementing preventive measures, ensuring timely diagnosis, and implementing interventions that target risk factors and specific comorbidities...
December 19, 2023: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/38214279/microdosing-psychedelics-and-the-risk-of-cardiac-fibrosis-and-valvulopathy-comparison-to-known-cardiotoxins
#8
REVIEW
Antonin Rouaud, Abigail E Calder, Gregor Hasler
Though microdosing psychedelics has become increasingly popular, its long-term effects on cardiac health remain unknown. Microdosing most commonly involves ingesting sub-threshold doses of lysergic acid diethylamide (LSD), psilocybin, or other psychedelic drugs 2-4 times a week for at least several weeks, but potentially months or years. Concerningly, both LSD and psilocybin share structural similarities with medications which raise the risk of cardiac fibrosis and valvulopathy when taken regularly, including methysergide, pergolide, and fenfluramine...
January 12, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38173783/association-of-endomyocardial-fibrosis-and-minor-myocarditis-sequelae-with-intracardiac-thrombus-and-ebstein-like-valvulopathy-in-a-patient-with-beh%C3%A3-et-disease-a-case-report
#9
Hélène Ceruti, Philippe van de Borne, Daniela-Corina Mirica
BACKGROUND: Cardiac complications occur in 1-6% of cases of Behçet disease (BD) with intracardiac thrombus being the most frequent complication. Endomyocardial fibrosis, less common and occasionally associated with intracardiac thrombus, is reported in <20 case reports of BD, among which, three cases are described to mimic Ebstein disease based on echocardiography. We present the first case in the literature of a 34-year-old man with BD diagnosed with multiple cardiovascular complications, highlighting the challenging diagnosis and treatment of this pathology, especially regarding anticoagulation therapy...
January 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38156485/right-ventricular-function-in-surgical-treatment-of-left-heart
#10
JOURNAL ARTICLE
I V Slivneva, I Yu Farulova, I I Skopin, Yu D Pirushkina, D V Murysova, D I Marapov, E Z Golukhova
Aim    The aim of this study was to evaluate right ventricular (RV) function during left chamber surgery.Material and methods    This was a single-site prospective cohort study. The study included 197 patients with valvular pathology of heart left chambers. Mean age of patients was 58 [47; 65] years. Precordial echocardiography was performed preoperatively and within one week after surgery.Results    Decreased parameters of the right ventricular (RV) longitudinal function and global contractile function were observed postoperatively in the majority of patients...
December 27, 2023: Kardiologiia
https://read.qxmd.com/read/38113229/mediastinal-radiotherapy-induced-early-onset-valvulopathy-in-a-6-year-old-boy-with-hodgkin-lymphoma
#11
JOURNAL ARTICLE
Mustafa Doğan, Uğur Demirsoy, Eviç Zeynep Başar, Kadir Babaoğlu
Mediastinal radiotherapy for childhood cancers, particularly Hodgkin disease, has numerous potential adverse effects, including coronary artery disease, pericarditis, cardiomyopathy, valvular disease, and conduction abnormalities. The prevalence of valvular stenosis is relatively low, and regurgitation is more common. Mediastinal radiotherapy-induced valvular disease develops more than 10 years after radiotherapy. Here, we present a case of a 6-year-old boy with moderate to significant mitral stenosis + moderate mitral regurgitation and mild aortic regurgitation that appeared 1...
December 18, 2023: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38021698/a-rare-case-of-persistent-left-superior-vena-cava-coexisting-with-valvulopathies-and-complete-heart-block
#12
Sushil Paudyal, Amit K Thakur, Ahmed Z Abdelkarim, Faizan A Zakir
Persistent left superior vena cava (PLSVC) is a rare congenital vascular anomaly that is often detected incidentally during cardiovascular imaging or interventions. Coexisting PLSVC with mitral regurgitation (MR), aortic stenosis (AS), aortic regurgitation (AR), and complete heart block (CHB) are exceptionally rare and have not been reported in the literature to our knowledge. We present the case of a 50-year-old male with PLSVC coexisting with severe MR, mild AS/AR, and CHB who successfully underwent permanent pacemaker (PPM) implantation and mitral valve replacement...
October 2023: Curēus
https://read.qxmd.com/read/38021530/anesthetic-considerations-for-patients-with-mitral-stenosis-undergoing-orthotopic-liver-transplant
#13
Justin Mitchell, Amar Alnemer, Selina Deiparine, Erica Stein, Leonid Gorelik
A 70-year-old male presented for an orthotopic liver transplant (OLT) with co-existing moderate-severe mitral valve stenosis. The hemodynamic goals of managing mitral stenosis posed a significant additional challenge to this patient's care. Intraoperative transesophageal echocardiography (TEE) was critical in guiding volume status and resuscitation. In addition, the patient's valvulopathy guided our vasoactive medication selection and arrhythmia prevention. In this article, we describe the multidisciplinary discussions regarding preoperative valvular intervention as well as the intraoperative techniques used to preserve cardiac output while avoiding coagulopathy and arrhythmias...
October 2023: Curēus
https://read.qxmd.com/read/37992962/valve-sparing-aortic-root-replacement-long-term-variables-significantly-associated-with-mortality-and-morbidity
#14
JOURNAL ARTICLE
Varun J Sharma, Abbie Kangarajah, Amy Yang, Michelle Kim, Siven Seevayanagam, George Matalanis
OBJECTIVES: In aortic root surgery, Valve Sparing Aortic Root Replacement (VSARR) is an attractive alternative by mitigating the risks inherent to prosthetic valves, however little is known about the variables that impact its durability. We review our mid to long-term outcomes following VSARR and describe factors that impact survival and valve reintervention and insufficiency. METHODS: A retrospective review of 284 consecutive patients undergoing VSARR between November 1999 and January 2022 at Austin Health, Melbourne, Australia, was undertaken, with median follow-up of 6...
November 20, 2023: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37969488/arrhythmic-burden-of-adult-survivors-with-repaired-total-anomalous-pulmonary-venous-connection
#15
JOURNAL ARTICLE
Mariama Touray, Magalie Ladouceur, Judith Bouchardy, Markus Schwerzmann, Matthias Greutmann, Daniel Tobler, Reto Engel, Harald Gabriel, Etienne Pruvot, Coralie Blanche, Nicole Sekarski, Tobias Rutz
BACKGROUND: The long-term outcome of adults with repaired total anomalous pulmonary venous connection (TAPVC) is poorly documented. Therefore, the present study aims to provide current clinical data on adult survivors with repaired TAPVC focusing on arrhythmia. METHODS: Clinical and imaging data (prevalence and type of arrhythmias, symptoms, surgical and medical treatment, echocardiographic and cardiac magnetic resonance haemodynamic parameters) were retrospectively collected from 8 European centres and compared between patients with and without arrhythmias...
December 2022: CJC Pediatr Congenit Heart Dis
https://read.qxmd.com/read/37936601/identifying-mitral-valve-prolapse-at-risk-for-arrhythmias-and-fibrosis-from-electrocardiograms-using-deep-learning
#16
JOURNAL ARTICLE
Geoffrey H Tison, Sean Abreau, Joshua Barrios, Lisa J Lim, Michelle Yang, Valentina Crudo, Dipan J Shah, Thuy Nguyen, Gene Hu, Shalini Dixit, Gregory Nah, Farzin Arya, Dwight Bibby, Yoojin Lee, Francesca N Delling
BACKGROUND: Mitral valve prolapse (MVP) is a common valvulopathy, with a subset developing sudden cardiac death or cardiac arrest. Complex ventricular ectopy (ComVE) is a marker of arrhythmic risk associated with myocardial fibrosis and increased mortality in MVP. OBJECTIVES: The authors sought to evaluate whether electrocardiogram (ECG)-based machine learning can identify MVP at risk for ComVE, death and/or myocardial fibrosis on cardiac magnetic resonance (CMR) imaging...
August 2023: JACC Adv
https://read.qxmd.com/read/37900542/an-infrequently-encountered-cause-of-hemoptysis
#17
Prakash Banjade, Yasoda Rijal, Asmita Itani, Becky X Lou, Munish Sharma
Mitral stenosis (MS) is not a common entity in modern-day medicine, especially in developed countries, as the most common etiology is still rheumatic fever. MS can present mainly with a wide range of cardiac symptoms. However, infrequently, MS can cause extra-cardiac symptoms as well. We present a case report of a patient with severe bioprosthetic mitral valve stenosis with intermittent hemoptysis and cardiogenic shock. We aim to report this case to remind clinicians about this uncommon but significant cause of hemoptysis...
September 2023: Curēus
https://read.qxmd.com/read/37834923/progression-of-non-significant-mitral-and-tricuspid-regurgitation-after-surgical-aortic-valve-replacement-for-aortic-regurgitation
#18
JOURNAL ARTICLE
Shirit Kazum, Mordehay Vaturi, Idit Yedidya, Shmuel Schwartzenberg, Olga Morelli, Keren Skalsky, Hadas Ofek, Ram Sharony, Ran Kornowski, Yaron Shapira, Alon Shechter
Little is known about the natural history of non-significant mitral and tricuspid regurgitation (MR and TR) following surgical aortic valve replacement (SAVR) for aortic regurgitation (AR). We retrospectively analyzed 184 patients (median age 64 (IQR, 55-74) years, 76.6% males) who underwent SAVR for AR. Subjects with significant non-aortic valvulopathies, prior/concomitant valvular interventions, or congenital heart disease were excluded. The cohort was evaluated for MR/TR progression and, based on the latter's occurrence, for echocardiographic and clinical indices of heart failure and mortality...
September 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37763197/pulmonary-hypertension-in-left-ventricular-valvular-diseases-a-comprehensive-review-on-pathophysiology-and-prognostic-value
#19
REVIEW
Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P E Kadoglou
Left ventricular (LV) valvular diseases, make up one of the most common etiologies for pulmonary hypertension (PH), and it is not well understood how and at which degree it affects prognosis. The aim of the present study was a comprehensive review of the pathophysiologic mechanism of PH in patients with LV valvular diseases and the prognostic value of baseline and post-intervention PH in patients undergoing interventional treatment. The pathophysiology of PH in patients with LV valvular diseases involves gradual elevation of left ventricular filling pressure and left atrial pressure, which are passively transmitted to the pulmonary circulation and raise pulmonary artery systolic pressure (PASP)...
August 22, 2023: Life
https://read.qxmd.com/read/37734846/weill-marchesani-syndrome-natural-history-and-genotype-phenotype-correlations-from-18-news-cases-and-review-of-literature
#20
JOURNAL ARTICLE
Pauline Marzin, Sophie Rondeau, Jean-Luc Alessandri, Klaus Dieterich, Carine le Goff, Clémentine Mahaut, Sandra Mercier, Caroline Michot, Oana Moldovan, Gianmaria Miolo, Massimiliano Rossi, Julien Van-Gils, Christine Francannet, Matthieu Robert, Jean-Philippe Jaïs, Céline Huber, Valerie Cormier-Daire
BACKGROUND: Weill-Marchesani syndrome (WMS) belongs to the group of acromelic dysplasias, defined by short stature, brachydactyly and joint limitations. WMS is characterised by specific ophthalmological abnormalities, although cardiovascular defects have also been reported. Monoallelic variations in FBN1 are associated with a dominant form of WMS, while biallelic variations in ADAMTS10 , ADAMTS17 and LTBP2 are responsible for a recessive form of WMS. OBJECTIVE: Natural history description of WMS and genotype-phenotype correlation establishment...
September 21, 2023: Journal of Medical Genetics
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