Alvaro Gonzalez-Cantero, Meron Teklu, Alexander V Sorokin, Ronald Prussick, Jorge González-Cantero, Jose Luis Martin-Rodriguez, Nidhi Patel, Philip M Parel, Grigory A Manyak, Heather L Teague, Justin A Rodante, Andrew Keel, Cristina Pérez-Hortet, Ana I Sanchéz-Moya, Natalia Jiménez, Asunción Ballester, Jorge Solis, Leticia Fernandez-Friera, María G Barderas, Jorge L Gonzalez-Calvin, Pedro Jaen, Martin P Playford, Amit K Dey, Joel M Gelfand, Nehal N Mehta
Psoriasis is associated with a higher risk of liver diseases. We investigated the impact of hepatic steatosis (European cohort) and hepatic inflammation (United States cohort) on subclinical atherosclerosis. In the European cohort (n=76 psoriasis participants and 76 controls), non-alcoholic fatty liver disease (NAFLD), assessed by the sonographic hepatorenal index (SHRI), was more prevalent in psoriasis than controls (61% vs 45%; p=.04). Psoriasis participants with NAFLD had a higher prevalence of subclinical atherosclerosis (ultrasonographic presence of plaque in femoral or carotid arteries) than psoriasis without NAFLD (61% vs 23%; p=...
July 19, 2021: Journal of Investigative Dermatology