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psoriasis vascular inflammation pet ct

Robert Bissonnette
No abstract text is available yet for this article.
June 23, 2017: Journal of Investigative Dermatology
Kasper Fjellhaugen Hjuler, Lars Christian Gormsen, Lars Iversen
No abstract text is available yet for this article.
June 23, 2017: Journal of Investigative Dermatology
Amit K Dey, Aditya A Joshi, Abhishek Chaturvedi, Joseph B Lerman, Tsion M Aberra, Justin A Rodante, Heather L Teague, Charlotte L Harrington, Joshua P Rivers, Jonathan H Chung, Mohammad Tarek Kabbany, Balaji Natarajan, Joanna I Silverman, Qimin Ng, Gregory E Sanda, Alexander V Sorokin, Yvonne Baumer, Emily Gerson, Ronald B Prussick, Alison Ehrlich, Lawrence J Green, Benjamin N Lockshin, Mark A Ahlman, Martin P Playford, Joel M Gelfand, Nehal N Mehta
Importance: Inflammation is critical in the development of atherosclerosis. Psoriasis is a chronic inflammatory skin disease that is associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography in vivo and future cardiovascular events. It provides a human model to understand the effect of treating inflammation in a target organ (eg, the skin) on vascular diseases. Objective: To investigate the association between change in skin disease severity and change in vascular inflammation at 1 year and to characterize the impact of 1 year of anti-tumor necrosis factor therapy on vascular inflammation...
May 31, 2017: JAMA Cardiology
Robert Bissonnette, François Harel, James G Krueger, Marie-Claude Guertin, Malorie Chabot-Blanchet, Juana Gonzalez, Catherine Maari, Isabelle Delorme, Charles W Lynde, Jean-Claude Tardif
Vascular inflammation is increased in patients with psoriasis. This randomized, double-blind, multicenter study evaluated the effects of tumor necrosis factor-α antagonist adalimumab on vascular inflammation in patients with psoriasis. A total of 107 patients were randomized (1:1) to receive adalimumab for 52 weeks or placebo for 16 weeks followed by adalimumab for 52 weeks. Vascular inflammation was assessed with positron emission tomography-computed tomography. There were no differences in the change from baseline in vessel wall target-to-background ratio (TBR) from the ascending aorta (primary endpoint) (adalimumab: TBR = 0...
March 9, 2017: Journal of Investigative Dermatology
Charlotte L Harrington, Amit K Dey, Raza Yunus, Aditya A Joshi, Nehal N Mehta
Inflammation is known to play a significant role in the process of atherogenesis and cardiovascular disease (CVD). Indeed, patients with chronic inflammatory diseases are at increased risk for cardiovascular events. However, the mechanisms linking chronic inflammation and CVD remain poorly understood. Psoriasis, a chronic inflammatory skin disease associated with a greater risk of early cardiovascular events, provides a suitable human model to study the pathophysiology of inflammatory atherogenesis in humans...
May 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
K F Hjuler, L C Gormsen, M H Vendelbo, A Egeberg, J Nielsen, L Iversen
BACKGROUND: Psoriasis is associated with cardiovascular disease; it has been proposed that increased cardiovascular risk is caused by low-grade systemic inflammation involving organs and tissues other than the skin and joints. OBJECTIVES: To investigate signs of vascular inflammation in untreated patients with moderate-to-severe psoriasis assessed by (18) F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography. A secondary objective was to assess signs of subcutaneous adipose tissue inflammation...
March 2017: British Journal of Dermatology
Tsion M Aberra, Aditya A Joshi, Joseph B Lerman, Justin A Rodante, Asha K Dahiya, Heather L Teague, Qimin Ng, Joanna I Silverman, Alexander V Sorokin, Taufiq Salahuddin, Benjamin N Lockshin, Mark A Ahlman, Martin P Playford, Marcus Y Chen, Joel M Gelfand, Nehal N Mehta
BACKGROUND AND AIMS: Psoriasis is a chronic inflammatory disorder associated with vascular inflammation, measured by 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), and an increased risk of myocardial infarction. Patients with psoriasis are also more likely to suffer from comorbid depression. Whether depression accelerates the development of subclinical atherosclerosis in psoriasis is unknown. METHODS: Patients were selected from within a larger psoriasis cohort...
August 2016: Atherosclerosis
Haley B Naik, Balaji Natarajan, Elena Stansky, Mark A Ahlman, Heather Teague, Taufiq Salahuddin, Qimin Ng, Aditya A Joshi, Parasuram Krishnamoorthy, Jenny Dave, Shawn M Rose, Julia Doveikis, Martin P Playford, Ronald B Prussick, Alison Ehrlich, Mariana J Kaplan, Benjamin N Lockshin, Joel M Gelfand, Nehal N Mehta
OBJECTIVE: To understand whether directly measured psoriasis severity is associated with vascular inflammation assessed by (18)F-fluorodeoxyglucose positron emission tomography computed tomography. APPROACH: In-depth cardiovascular and metabolic phenotyping was performed in adult psoriasis patients (n=60) and controls (n=20). Psoriasis severity was measured using psoriasis area severity index. Vascular inflammation was measured using average aortic target-to-background ratio using (18)F-fluorodeoxyglucose positron emission tomography computed tomography...
December 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
Søren Hess, Susanne H Hansson, Kasper T Pedersen, Sandip Basu, Poul Flemming Høilund-Carlsen
Nuclear medicine techniques have been an integral part of infection and inflammation imaging for decades; in recent years, fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has taken over many indications. This review provides a comprehensive overview of the current and potential applications for FDG-PET/CT in infectious and inflammatory diseases (ie, systemic infections, bone infections, vascular infection and inflammation, thoracic and abdominal inflammation) and potential novel applications in both infection and inflammation...
October 2014: PET Clinics
Sang Woong Youn, Seo Young Kang, Sung Ae Kim, Gyeong Yul Park, Won Woo Lee
Severe psoriasis is a systemic inflammatory disease involving major arteries and internal organs. The association between psoriasis and arterial inflammation, however, has been noted mostly in patients with moderate to severe psoriasis. Therefore, it is still not clear whether mild psoriasis also increases the arterial inflammation and cardiovascular disease. In this study, we aimed to investigate systemic inflammation using (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in patients with mild psoriasis...
June 2015: Journal of Dermatology
Shawn Rose, Jenny Dave, Corina Millo, Haley B Naik, Evan L Siegel, Nehal N Mehta
INTRODUCTION: Psoriasis and psoriatic arthritis (PsA) increase cardiovascular disease (CVD) risk, but surrogate markers for CVD in these disorders are inadequate. Because the presence of sacroiliitis may portend more severe PsA, we hypothesized that sacroiliitis defined by computed tomography (CT) would be associated with increased vascular inflammation defined by 18-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), which is an established measure of CVD...
July 30, 2014: Arthritis Research & Therapy
Shawn Rose, Nikhil H Sheth, Joshua F Baker, Alexis Ogdie, Anna Raper, Babak Saboury, Thomas J Werner, Preethi Thomas, Abby Vanvoorhees, Abass Alavi, Drew A Torigian, Joel M Gelfand, Nehal N Mehta
OBJECTIVE: Psoriasis (PSO) and rheumatoid arthritis (RA) increase cardiovascular diseases (CVD) beyond traditional risk factors. Vascular inflammation has previously been demonstrated to be present in PSO and RA using [18F]-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging. However, vascular inflammation has not been compared in these two disorders relative to a healthy reference population. Thus, vascular inflammation was quantitatively assessed in patients with PSO (n=10), RA (n=5), and healthy subjects (n=10) using FDG-PET/CT...
2013: American Journal of Cardiovascular Disease
Yiding Yu, Nikhil Sheth, Parasuram Krishnamoorthy, Babak Saboury, Anna Raper, Amanda Baer, Rachel Ochotony, Julia Doveikis, Stephanie Derohannessian, Abby S Van Voorhees, Drew A Torigian, Abass Alavi, Joel M Gelfand, Nehal N Mehta
Psoriasis is a model Th1-mediated inflammatory disease associated with increased incidence of stroke and cardiovascular disease (CVD). The mechanism behind these associations is unknown, however abnormal HDL particle composition measured by nuclear magnetic resonance (NMR) spectroscopy has been shown to be associated with CVD. Using [18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT), a validated surrogate marker of CVD, we assessed whether HDL particle size and concentration were associated with vascular inflammation in patients with psoriasis...
2012: American Journal of Cardiovascular Disease
Nehal N Mehta, YiDing Yu, Babak Saboury, Negar Foroughi, Parasuram Krishnamoorthy, Anna Raper, Amanda Baer, Jules Antigua, Abby S Van Voorhees, Drew A Torigian, Abass Alavi, Joel M Gelfand
OBJECTIVE: To evaluate the feasibility of using [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT) to detect and quantify systemic inflammation in patients with psoriasis. DESIGN: Case series with a nested case-control study. SETTING: Referral dermatology and preventive cardiology practices. PARTICIPANTS: Six patients with psoriasis affecting more than 10% of their body surface area and 4 controls age and sex matched to 4 of the patients with psoriasis for a nested case-control study...
September 2011: Archives of Dermatology
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