Nikos Papadimitriou, Conghui Qu, Tabitha A Harrison, Alaina M Bever, Richard M Martin, Konstantinos K Tsilidis, Polly A Newcomb, Stephen N Thibodeau, Christina C Newton, Caroline Y Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J Pellatt, Robert E Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D Buchanan, Brigid M Lynch, Stephen B Gruber, Yin Cao, Li Hsu, Jeroen R Huyghe, Yi Lin, Robert S Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H Zaidi, Amanda E Toland, Sonja I Berndt, Wen-Yi Huang, Elom K Aglago, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A Nowak, Claire E Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A Jenkins, Marc J Gunter, Peter T Campbell, Ulrike Peters, Mingyang Song, Amanda I Phipps, Neil Murphy
BACKGROUND: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. METHODS: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations)...
February 12, 2024: EBioMedicine