keyword
https://read.qxmd.com/read/38405736/disease-progression-strikingly-differs-in-research-and-real-world-parkinson-s-populations
#21
Brett Beaulieu-Jones, Francesca Frau, Sylvie Bozzi, Karen J Chandross, M Judith Peterschmitt, Caroline Cohen, Catherine Coulovrat, Dinesh Kumar, Mark J Kruger, Scott L Lipnick, Lane Fitzsimmons, Isaac Kohane, Clemens Scherzer
Characterization of Parkinson's disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability of real-world data and recent advances in natural language processing, particularly large language models, allow for a more granular comparison of populations and the methods of data collection describing these populations than previously possible. This study includes two research populations and two real-world data derived (RWD) populations...
February 18, 2024: medRxiv
https://read.qxmd.com/read/38403015/evaluating-the-utility-of-repeat-ct-scans-in-patients-with-isolated-mild-traumatic-subarachnoid-hemorrhage
#22
JOURNAL ARTICLE
Noah L A Nawabi, John L Kilgallon, Jack J McNulty, Brittany M Stopa, Jakob V E Gerstl, Timothy R Smith
BACKGROUND AND OBJECTIVES: Traumatic subarachnoid hemorrhage (tSAH) is a common consequence of head trauma. Treatment of tSAH patients commonly involves serial CT imaging to assess for expansile hemorrhage. However, growing evidence suggests that these patients rarely deteriorate or require neurosurgical intervention. We assessed the utility of repeat CT imaging in adult patients with isolated tSAH and an intact initial neurologic exam. METHODS: Patients presenting to Mass General Brigham Hospitals with tSAH between 2000 and 2021 were eligible for inclusion in this retrospective cohort study...
February 23, 2024: World Neurosurgery
https://read.qxmd.com/read/38384433/substandard-housing-and-the-risk-of-covid-19-infection-and-disease-severity-a-retrospective-cohort-study
#23
JOURNAL ARTICLE
Katharine Robb, Rowana Ahmed, John Wong, Elissa Ladd, Jorrit de Jong
In this study we examine associations between substandard housing and the risk of COVID-19 infection and severity during the first year of the pandemic by linking individual-level housing and clinical datasets. Residents of Chelsea, Massachusetts who were tested for COVID-19 at any Mass General Brigham testing site and who lived at a property that had received a city housing inspection were included (N = 2873). Chelsea is a densely populated city with a high prevalence of substandard housing. Inspected properties with housing code violations were considered substandard; inspected properties without violations were considered adequate...
March 2024: SSM—Population Health
https://read.qxmd.com/read/38370813/benzodiazepine-initiation-and-the-risk-of-falls-or-fall-related-injuries-in-older-adults-following-acute-ischemic-stroke
#24
Shuo Sun, Victor Lomachinsky, Louisa H Smith, Joseph P Newhouse, M Brandon Westover, Deborah Blacker, Lee Schwamm, Sebastien Haneuse, Lidia M V R Moura
BACKGROUND: Benzodiazepine use in older adults following acute ischemic stroke (AIS) is common, yet short-term safety concerning falls or fall-related injuries remains unexplored. METHODS: We emulated a hypothetical randomized trial of benzodiazepine use during the acute post stroke recovery period to assess incidence of falls or fall related injuries in older adults. Using linked data from the Get With the Guidelines Registry and Mass General Brigham's electronic health records, we selected patients aged 65 and older admitted for Acute Ischemic Stroke (AIS) between 2014 and 2021 with no documented prior stroke and no benzodiazepine prescriptions in the previous 3 months...
February 8, 2024: medRxiv
https://read.qxmd.com/read/38370718/associations-of-a-multidimensional-polygenic-sleep-health-score-and-a-sleep-lifestyle-index-on-health-outcomes-and-their-interaction-in-a-clinical-biobank
#25
Valentina Paz, Hannah Wilcox, Matthew Goodman, Heming Wang, Victoria Garfield, Richa Saxena, Hassan S Dashti
Sleep is a complex behavior regulated by genetic and environmental factors, and is known to influence health outcomes. However, the effect of multidimensional sleep encompassing several sleep dimensions on diseases has yet to be fully elucidated. Using the Mass General Brigham Biobank, we aimed to examine the association of multidimensional sleep with health outcomes and investigate whether sleep behaviors modulate genetic predisposition to unfavorable sleep on mental health outcomes. First, we generated a Polygenic Sleep Health Score using previously identified single nucleotide polymorphisms for sleep health and constructed a Sleep Lifestyle Index using data from self-reported sleep questions and electronic health records; second, we performed phenome-wide association analyses between these indexes and clinical phenotypes; and third, we analyzed the interaction between the indexes on prevalent mental health outcomes...
February 7, 2024: medRxiv
https://read.qxmd.com/read/38368741/evolution-of-her2-expression-between-pre-treatment-biopsy-and-residual-disease-after-neoadjuvant-therapy-for-breast-cancer
#26
JOURNAL ARTICLE
Paolo Tarantino, Ogheneochuko Ajari, Noah Graham, Julie Vincuilla, Tonia Parker, Melissa E Hughes, Nabihah Tayob, Ana C Garrido-Castro, Stefania Morganti, Tari A King, Elizabeth A Mittendorf, Giuseppe Curigliano, Nancy U Lin, Sara M Tolaney
INTRODUCTION: We have previously found that HER2 expression is dynamic, and can change from the primary breast tumor to matched recurrences. With this work, we aimed to assess the dynamics of HER2 during neoadjuvant treatment.(NAT). METHODS: We reviewed HER2 expression in pre- and post-treatment samples from consecutive patients with early-stage breast cancer that received NAT and underwent surgery at Dana-Farber Brigham Cancer Center between 01/2016-08/2022. The primary outcome was evolution of HER2 expression from pre- to post-NAT specimens in patients with residual disease...
February 10, 2024: European Journal of Cancer
https://read.qxmd.com/read/38366637/cancer-type-and-histology-influence-cutaneous-immunotherapy-toxicities-a-multi-institutional-cohort-study
#27
JOURNAL ARTICLE
Guihong Wan, Sara Khattab, Bonnie W Leung, Shijia Zhang, Nga Nguyen, Matthew Tran, Chuck Lin, Crystal Chang, Nora Alexander, Ruple Jairath, Jordan Phillipps, Kimberly Tang, Ahmad Rajeh, Leyre Zubiri, Steven T Chen, Shadmehr Demehri, Kun-Hsing Yu, Alexander Gusev, Shawn G Kwatra, Nicole R LeBoeuf, Kerry L Reynolds, Yevgeniy R Semenov
BACKGROUND: Cutaneous immune-related adverse events (cirAEs) are the most common toxicities to occur in the setting of immune checkpoint inhibitor (ICI) therapy. Identifying patients who are at increased risk of developing cirAEs may improve quality of life and outcomes. OBJECTIVE: To investigate the influence of cancer type and histology on the development of cirAEs in the setting of ICI therapy and survival outcomes. METHODS: This retrospective cohort study included patients between December 1, 2011, and October 30, 2020...
February 15, 2024: British Journal of Dermatology
https://read.qxmd.com/read/38356571/knowledge-mapping-of-digital-medicine-in-cardiovascular-diseases-from-2004-to-2022-a-bibliometric-analysis
#28
REVIEW
Ying Chen, Xiang Xiao, Qing He, Rui-Qi Yao, Gao-Yu Zhang, Jia-Rong Fan, Chong-Xiang Xue, Li Huang
OBJECTIVE: To review studies on digital medicine in cardiovascular diseases (CVD), discuss its development process, knowledge structure and research hotspots, and provide a perspective for researchers in this field. METHODS: The relevant literature in recent 20 years (January 2004 to October 2022) were retrieved from the Web of Science Core Collection (WoSCC). CiteSpace was used to demonstrate our knowledge of keywords, co-references and speculative frontiers. VOSviewer was used to chart the contributions of authors, institutions and countries and incorporates their link strength into the table...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38350331/body-size-and-risk-of-colorectal-cancer-molecular-defined-subtypes-and-pathways-mendelian-randomization-analyses
#29
JOURNAL ARTICLE
Nikos Papadimitriou, Conghui Qu, Tabitha A Harrison, Alaina M Bever, Richard M Martin, Konstantinos K Tsilidis, Polly A Newcomb, Stephen N Thibodeau, Christina C Newton, Caroline Y Um, Mireia Obón-Santacana, Victor Moreno, Hermann Brenner, Marko Mandic, Jenny Chang-Claude, Michael Hoffmeister, Andrew J Pellatt, Robert E Schoen, Sophia Harlid, Shuji Ogino, Tomotaka Ugai, Daniel D Buchanan, Brigid M Lynch, Stephen B Gruber, Yin Cao, Li Hsu, Jeroen R Huyghe, Yi Lin, Robert S Steinfelder, Wei Sun, Bethany Van Guelpen, Syed H Zaidi, Amanda E Toland, Sonja I Berndt, Wen-Yi Huang, Elom K Aglago, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Meredith Hullar, Johnathan A Nowak, Claire E Thomas, Loic Le Marchand, Iona Cheng, Steven Gallinger, Mark A Jenkins, Marc J Gunter, Peter T Campbell, Ulrike Peters, Mingyang Song, Amanda I Phipps, Neil Murphy
BACKGROUND: Obesity has been positively associated with most molecular subtypes of colorectal cancer (CRC); however, the magnitude and the causality of these associations is uncertain. METHODS: We used Mendelian randomization (MR) to examine potential causal relationships between body size traits (body mass index [BMI], waist circumference, and body fat percentage) with risks of Jass classification types and individual subtypes of CRC (microsatellite instability [MSI] status, CpG island methylator phenotype [CIMP] status, BRAF and KRAS mutations)...
February 12, 2024: EBioMedicine
https://read.qxmd.com/read/38349732/identifying-functional-status-impairment-in-people-living-with-dementia-through-natural-language-processing-of-clinical-documents-cross-sectional-study
#30
JOURNAL ARTICLE
John Laurentiev, Dae Hyun Kim, Mufaddal Mahesri, Kuan-Yuan Wang, Lily G Bessette, Cassandra York, Heidi Zakoul, Su Been Lee, Li Zhou, Kueiyu Joshua Lin
BACKGROUND: Assessment of activities of daily living (ADLs) and instrumental ADLs (iADLs) is key to determining the severity of dementia and care needs among older adults. However, such information is often only documented in free-text clinical notes within the electronic health record and can be challenging to find. OBJECTIVE: This study aims to develop and validate machine learning models to determine the status of ADL and iADL impairments based on clinical notes...
February 13, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38345720/elevated-risk-of-recurrence-and-retreatment-for-silent-pituitary-adenomas
#31
JOURNAL ARTICLE
Saksham Gupta, Samantha E Hoffman, Neel H Mehta, Blake Hauser, Marcelle Altshuler, Joshua D Bernstock, Timothy R Smith, Omar Arnaout, Edward R Laws
PURPOSE: Pituitary adenomas are the most common tumor of the pituitary gland and comprise nearly 15% of all intracranial masses. These tumors are stratified into functional or silent categories based on their pattern of hormone expression and secretion. Preliminary evidence supports differential clinical outcomes between some functional pituitary adenoma (FPA) subtypes and silent pituitary adenoma (SPA) subtypes. METHODS: We collected and analyzed the medical records of all patients undergoing resection of SPAs or FPAs from a single high-volume neurosurgeon between 2007 and 2018 at Brigham and Women's Hospital...
February 12, 2024: Pituitary
https://read.qxmd.com/read/38335710/predictors-of-relapsing-disease-course-following-index-event-in-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease-mogad
#32
JOURNAL ARTICLE
Negar Molazadeh, Philippe A Bilodeau, Rebecca Salky, Gauruv Bose, Itay Lotan, Gabriela Romanow, Monique R Anderson, Marcelo Matiello, Tanuja Chitnis, Michael Levy
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disease that can present as a monophasic or relapsing disease course. Here, we investigate the predictors of developing relapsing disease with a focus on the index event. METHODS: MOGAD patients followed at Massachusetts General Hospital and Brigham and Women's Hospital were included. Data on demographic, clinical, and laboratory features were collected. Time-to-event survival analysis was performed using a Cox proportional hazards model...
January 30, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38314479/effectiveness-of-immunotherapies-in-relapsing-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease
#33
JOURNAL ARTICLE
Philippe Antoine Bilodeau, Anastasia Vishnevetsky, Negar Molazadeh, Itay Lotan, Monique Anderson, Gabriela Romanow, Rebecca Salky, Brian C Healy, Marcelo Matiello, Tanuja Chitnis, Michael Levy
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) can cause optic neuritis, transverse myelitis, or acute disseminated encephalomyelitis (ADEM). Immunotherapy is often used for relapsing disease, but there is variability in treatment decisions. OBJECTIVE: The objective was to determine the annualized relapse rates (ARRs) and incidence rate ratios (IRRs) compared to pre-treatment and relapse-freedom probabilities among patients receiving steroids, B-cell depletion (BCD), intravenous immunoglobulin (IVIG), and mycophenolate mofetil (MMF)...
March 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38308819/utilization-of-electronic-health-record-sex-and-gender-demographic-fields-a-metadata-and-mixed-methods-analysis
#34
JOURNAL ARTICLE
Dinah Foer, David M Rubins, Vi Nguyen, Alex McDowell, Meg Quint, Mitchell Kellaway, Sari L Reisner, Li Zhou, David W Bates
OBJECTIVES: Despite federally mandated collection of sex and gender demographics in the electronic health record (EHR), longitudinal assessments are lacking. We assessed sex and gender demographic field utilization using EHR metadata. MATERIALS AND METHODS: Patients ≥18 years of age in the Mass General Brigham health system with a first Legal Sex entry (registration requirement) between January 8, 2018 and January 1, 2022 were included in this retrospective study...
February 2, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38307160/deep-learning-approach-for-automated-segmentation-of-myocardium-using-bone-scintigraphy-spect-ct-in-patients-with-suspected-cardiac-amyloidosis
#35
JOURNAL ARTICLE
Abhijit Bhattaru, Chaitanya Rojulpote, Mahesh Vidula, Jeffrey Duda, Matthew T Maclean, Sophia Swago, Elizabeth Thompson, James Gee, Janice Pieretti, Brian Drachman, Adam Cohen, Sharmila Dorbala, Paco E Bravo, Walter R Witschey
PURPOSE: We employed deep learning to automatically detect myocardial bone-seeking uptake, as a marker of transthyretin cardiac amyloid cardiomyopathy (ATTR-CM) in patients undergoing 99mTc-pyrophosphate (PYP) or hydroxydiphosphonate (HDP) single-photon emission computed tomography (SPECT)/computed tomography (CT). METHODS: We identified a primary cohort of 77 subjects at Brigham and Women's Hospital and a validation cohort of 93 consecutive patients imaged at the University of Pennsylvania who underwent SPECT/CT with PYP and HDP respectively for evaluation of ATTR-CM...
January 31, 2024: Journal of Nuclear Cardiology
https://read.qxmd.com/read/38300210/safety-and-efficacy-of-ultrasound-guided%C3%A2-sympathetic-blockade-by-proximal-intercostal-block-in%C3%A2-electrical%C3%A2-storm%C3%A2-patients
#36
JOURNAL ARTICLE
Uyanga Batnyam, Kamen V Vlassakov, Ahmad Halawa, Erica Seligson, Liting Chen, Brahim Redouane, David Janfaza, Usha B Tedrow
BACKGROUND: Electrical storm (ES) patients who fail standard therapies have a high mortality rate. Previous studies report effective management of ES with bedside, ultrasound-guided percutaneous stellate ganglion block (SGB). We report our experience with sympathetic blockade administered via a novel alternative approach: proximal intercostal block (PICB). Compared with SGB, this technique targets an area typically free of other catheters and support devices, and may pose less strict requirements for anticoagulation interruption, along with lower risk of focal neurological side effects...
January 11, 2024: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/38291116/mismatch-between-subjective-and-objective-dysautonomia
#37
JOURNAL ARTICLE
Peter Novak, David M Systrom, Sadie P Marciano, Alexandra Knief, Donna Felsenstein, Matthew P Giannetti, Matthew J Hamilton, Jennifer Nicoloro-SantaBarbara, Tara V Saco, Mariana Castells, Khosro Farhad, David M Pilgrim, William J Mullally
Autonomic symptom questionnaires are frequently used to assess dysautonomia. It is unknown whether subjective dysautonomia obtained from autonomic questionnaires correlates with objective dysautonomia measured by quantitative autonomic testing. The objective of our study was to determine correlations between subjective and objective measures of dysautonomia. This was a retrospective cross-sectional study conducted at Brigham and Women's Faulkner Hospital Autonomic Laboratory between 2017 and 2023 evaluating the patients who completed autonomic testing...
January 30, 2024: Scientific Reports
https://read.qxmd.com/read/38285539/impact-of-as-needed-heparin-boluses-on-supratherapeutic-activated-partial-thromboplastin-time-in-patients-managed-with-extracorporeal-membrane-oxygenation
#38
JOURNAL ARTICLE
Delaney M Corcoran, Mary P Kovacevic, Heather Dell'Orfano, Katelyn W Sylvester, Jean M Connors
INTRODUCTION: Brigham and Women's Hospital (BWH) historically used titratable weight-based heparin nomograms with as needed boluses managed by extracorporeal membrane oxygenation (ECMO) specialists to achieve a pre-determined goal activated partial thromboplastin time (aPTT). Due to concern amongst providers that as needed boluses may lead to supratherapeutic aPTT's and subsequent bleeding, new nomograms without as needed boluses were implemented. The purpose of this retrospective observational analysis is to provide a comparison in safety and efficacy between the heparin nomograms with as needed boluses and the new nomograms without boluses...
January 30, 2024: Critical Pathways in Cardiology
https://read.qxmd.com/read/38283708/rare-causes-of-musculoskeletal-pain-thinking-beyond-common-rheumatologic-diseases
#39
Julia F Charles, Alan O Malabanan, Stan Krolczyk, Kathryn M Dahir
OBJECTIVES: Rare metabolic bone diseases can present with symptoms mimicking more common rheumatological conditions including spondyloarthritis, osteoarthritis, and fibromyalgia. Increasing awareness of these rare diseases within the rheumatology community is vital to ensure that affected patients are diagnosed and appropriately treated. The literature includes several reports of tumour-induced osteomalacia initially diagnosed as rheumatic disease, but other rare diseases such as X-linked hypophosphatemia (XLH) and hypophosphatasia (HPP) also deserve attention...
2024: Case Reports in Rheumatology
https://read.qxmd.com/read/38273887/dysanapsis-is-differentially-related-to-lung-function-trajectories-with-distinct-structural-and-functional-patterns-in-copd-and-variable-risk-for-adverse-outcomes
#40
JOURNAL ARTICLE
James C Ross, Raul San José Estépar, Sam Ash, Carrie Pistenmaa, MeiLan Han, Surya P Bhatt, Sandeep Bodduluri, David Sparrow, Jean-Paul Charbonnier, George R Washko, Alejandro A Diaz
BACKGROUND: Abnormal lung function trajectories are associated with increased risk of chronic obstructive pulmonary disease (COPD) and premature mortality; several risk factors for following these trajectories have been identified. Airway under-sizing dysanapsis (small airway lumens relative to lung size), is associated with an increased risk for COPD. The relationship between dysanapsis and lung function trajectories at risk for adverse outcomes of COPD is largely unexplored. We test the hypothesis that dysanapsis differentially affects distinct lung function trajectories associated with adverse outcomes of COPD...
February 2024: EClinicalMedicine
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