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https://www.readbyqxmd.com/read/29052706/association-of-an-electroencephalography-based-risk-score-with-seizure-probability-in-hospitalized-patients
#1
Aaron F Struck, Berk Ustun, Andres Rodriguez Ruiz, Jong Woo Lee, Suzette M LaRoche, Lawrence J Hirsch, Emily J Gilmore, Jan Vlachy, Hiba Arif Haider, Cynthia Rudin, M Brandon Westover
Importance: Continuous electroencephalography (EEG) use in critically ill patients is expanding. There is no validated method to combine risk factors and guide clinicians in assessing seizure risk. Objective: To use seizure risk factors from EEG and clinical history to create a simple scoring system associated with the probability of seizures in patients with acute illness. Design, Setting, and Participants: We used a prospective multicenter (Emory University Hospital, Brigham and Women's Hospital, and Yale University Hospital) database containing clinical and electrographic variables on 5427 continuous EEG sessions from eligible patients if they had continuous EEG for clinical indications, excluding epilepsy monitoring unit admissions...
October 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29050063/-update-in-obstetric-anesthesia-tried-and-trusted-methods-controversies-and-new-perspectives-part-1
#2
Peter Kranke, Thorsten Annecke, Dorothee H Bremerich, Daniel Chappell, Thierry Girard, Wiebke Gogarten, Robert Hanß, Lutz Kaufner, Sophie Neuhaus, Tobias Ninke, Thomas Standl, Stefan Weber, Yvonne Jelting, Thomas Volk
Since 1975, a plethora of lectures within the context of annual meetings relevant for the clinical care has been summarized in "what's new in obstetric anesthesia" by the Society for Obstetric Anesthesia and Perinatology which can be recommended to everyone interested in anaesthesiology in the delivery room. After the death of Gerard W. Ostheimer, Professor of Anaesthesiology at Brigham and Women's Hospital in Boston, Massachusetts, it became renamed the Gerard W. Ostheimer "what's new in obstetric anesthesia" lecture to honor his contributions to regional anesthesia and obstetric anaesthesia...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29043945/merging-technology-and-emotions-introduction-to-affective-computing
#3
Tara J Brigham
Affective computing technologies are designed to sense and respond based on human emotions. This technology allows a computer system to process the information gathered from various sensors to assess the emotional state of an individual. The system then offers a distinct response based on what it "felt." While this is completely unlike how most people interact with electronics today, this technology is likely to trickle into future everyday life. This column will explain what affective computing is, some of its benefits, and concerns with its adoption...
October 2017: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/28993005/adalimumab-for-nail-psoriasis-efficacy-and-safety-from-the-first-26%C3%A2-weeks-of-a-phase-3-randomized-placebo-controlled-trial
#4
Boni E Elewski, Martin M Okun, Kim Papp, Christopher S Baker, Jeffrey J Crowley, Gérard Guillet, Murali Sundaram, Yves Poulin, Yihua Gu, Ziqian Geng, David A Williams, Phoebe A Rich
BACKGROUND: Previous clinical trials have not evaluated improvement in nail psoriasis as a primary end point. OBJECTIVE: This phase 3 trial evaluated the safety and efficacy of adalimumab in patients with moderate-to-severe fingernail psoriasis and moderate-to-severe plaque psoriasis. METHODS: Patients were randomized 1:1 to 40 mg adalimumab every other week or placebo. The primary efficacy end point was at least 75% improvement in total-fingernail modified Nail Psoriasis Severity Index (NAPSI75) response rate at week 26...
October 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28988432/impact-of-flow-gradient-and-left-ventricular-function-on-outcomes-after-transcatheter-aortic-valve-replacement
#5
Edward T Carreras, Tsuyoshi Kaneko, Fernando Ramirez-Del Val, Marc P Pelletier, Piotr S Sobieszczyk, Deepak L Bhatt, Pinak B Shah
OBJECTIVES: To assess the impact of low flow with and without preserved left ventricular ejection fraction (LVEF) on outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: Prior studies have shown that patients with low flow, AVG, and LVEF have worse outcomes after TAVR. It is unclear whether low AVG and LVEF remain prognostic after adjusting for flow, and how the outcomes of patients with low flow with and without preserved LVEF compare after TAVR...
October 8, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28975467/salvage-re-irradiation-for-recurrent-high-grade-glioma-and-comparison-to-bevacizumab-alone
#6
Nils D Arvold, Diana D Shi, Ayal A Aizer, Andrew D Norden, David A Reardon, Eudocia Q Lee, Lakshmi Nayak, Ian F Dunn, Alexandra J Golby, Mark D Johnson, Elizabeth B Claus, E Antonio Chiocca, Keith L Ligon, Patrick Y Wen, Brian M Alexander
While salvage re-irradiation is often used for recurrent high-grade glioma (HGG), there have been few comparisons between various re-radiation dose/fractionation schedules or with bevacizumab alone. We analyzed patients with recurrent HGG who received re-irradiation at Dana-Farber Cancer Institute and Brigham and Women's Hospital from 2010 to 2014 (n = 67), as well as those who received bevacizumab alone (n = 177). Cox proportional hazards modeling was used to examine factors associated with overall survival (OS)...
October 3, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28958850/catalyzing-healthcare-transformation-with-digital-health-performance-indicators-and-lessons-learned-from-a-digital-health-innovation-group
#7
Jocelyn Tseng, Sonia Samagh, Donna Fraser, Adam B Landman
Despite considerable investment in digital health (DH) companies and a growing DH ecosystem, there are multiple challenges to testing and implementing innovative solutions. Health systems have recognized the potential of DH and have formed DH innovation centers. However, limited information is available on DH innovation center processes, best practices, or outcomes. This case report describes a DH innovation center process that can be replicated across health systems and defines and benchmarks process indicators to assess DH innovation center performance...
September 25, 2017: Healthcare
https://www.readbyqxmd.com/read/28953953/contaminants-of-emerging-concern-in-tributaries-to-the-laurentian-great-lakes-ii-biological-consequences-of-exposure
#8
Linnea M Thomas, Zachary G Jorgenson, Mark E Brigham, Steven J Choy, Jeremy N Moore, Jo A Banda, Daniel J Gefell, Thomas A Minarik, Heiko L Schoenfuss
The Laurentian Great Lakes contain one fifth of the world's surface freshwater and have been impacted by human activity since the Industrial Revolution. In addition to legacy contaminants, nitrification and invasive species, this aquatic ecosystem is also the recipient of Contaminants of Emerging Concern (CECs) with poorly understood biological consequences. In the current study, we documented the presence, concentrations, and biological effects of CECs across 27 field sites in six Great Lakes tributaries by examining over 2250 resident and caged sunfish (Lepomis ssp...
2017: PloS One
https://www.readbyqxmd.com/read/28953889/contaminants-of-emerging-concern-in-tributaries-to-the-laurentian-great-lakes-i-patterns-of-occurrence
#9
Sarah M Elliott, Mark E Brigham, Kathy E Lee, Jo A Banda, Steven J Choy, Daniel J Gefell, Thomas A Minarik, Jeremy N Moore, Zachary G Jorgenson
Human activities introduce a variety of chemicals to the Laurentian Great Lakes including pesticides, pharmaceuticals, flame retardants, plasticizers, and solvents (collectively referred to as contaminants of emerging concern or CECs) potentially threatening the vitality of these valuable ecosystems. We conducted a basin-wide study to identify the presence of CECs and other chemicals of interest in 12 U.S. tributaries to the Laurentian Great Lakes during 2013 and 2014. A total of 292 surface-water and 80 sediment samples were collected and analyzed for approximately 200 chemicals...
2017: PloS One
https://www.readbyqxmd.com/read/28947285/risk-of-developing-pyoderma-gangrenosum-after-procedures-in-patients-with-a-known-history-of-pyoderma-gangrenosum-a-retrospective-analysis
#10
Fan Di Xia, Kristina Liu, Stephen Lockwood, Daniel Butler, William G Tsiaras, Cara Joyce, Arash Mostaghimi
BACKGROUND: The risk of postoperative pyoderma gangrenosum (PG) in patients with a known history of PG is unknown. OBJECTIVE: To quantify risk and identify patient/procedure-related risk factors for postsurgical PG recurrence/exacerbation in patients with known history of PG. METHODS: We retrospectively evaluated the likelihood of postsurgical PG recurrence/exacerbation for all patients with a confirmed diagnosis of PG at Brigham & Women's Hospital and Massachusetts General Hospital from 2000-2015...
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28942086/validation-of-a-52-gene-risk-profile-for-outcome-prediction-in-patients-with-idiopathic-pulmonary-fibrosis-an-international-multicentre-cohort-study
#11
Jose D Herazo-Maya, Jiehuan Sun, Philip L Molyneaux, Qin Li, Julian A Villalba, Argyrios Tzouvelekis, Heather Lynn, Brenda M Juan-Guardela, Cristobal Risquez, Juan C Osorio, Xiting Yan, George Michel, Nachelle Aurelien, Kathleen O Lindell, Melinda J Klesen, Miriam F Moffatt, William O Cookson, Yingze Zhang, Joe G N Garcia, Imre Noth, Antje Prasse, Ziv Bar-Joseph, Kevin F Gibson, Hongyu Zhao, Erica L Herzog, Ivan O Rosas, Toby M Maher, Naftali Kaminski
BACKGROUND: The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable. Clinical prediction tools are not accurate enough to predict disease outcomes. METHODS: We enrolled patients with IPF diagnosis in a six-cohort study at Yale University (New Haven, CT, USA), Imperial College London (London, UK), University of Chicago (Chicago, IL, USA), University of Pittsburgh (Pittsburgh, PA, USA), University of Freiburg (Freiburg im Breisgau, Germany), and Brigham and Women's Hospital-Harvard Medical School (Boston, MA, USA)...
September 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#12
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28918634/engineered-probiotic-for-the-inhibition-of-salmonella-via-tetrathionate-induced-production-of-microcin-h47
#13
Jacob D Palmer, Emma Piattelli, Beth A McCormick, Mark W Silby, Christopher J Brigham, Vanni Bucci
Complications arising from antibiotic-resistant bacteria are becoming one of the key issues in modern medicine. Members of drug-resistant Enterobacteriaceae spp. include opportunistic pathogens (e.g., Salmonella spp.) that are among the leading causes of morbidity and mortality worldwide. Overgrowth of these bacteria is considered a hallmark of intestinal dysbiosis. Microcins (small antimicrobial peptides) produced by some gut commensals can potentially cure these conditions by inhibiting these pathogens and have been proposed as a viable alternative to antibiotic treatment...
September 20, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28914352/impact-of-physical-activity-on-reporting-of-childhood-asthma-symptoms
#14
Benedicta Nneoma Nnodum, Meredith C McCormack, Nirupama Putcha, Seungyoung Hwang, Laura M Paulin, Emily P Brigham, Ashraf Fawzy, Karina Romero, Gregory B Diette, Nadia N Hansel
This study aims to determine the impact of physical activity on asthma symptom reporting among children living in an inner city. Among 147 children aged 5-12 years with physician-diagnosed asthma, we assessed asthma symptoms using twice-daily diaries and physical activity using the physical activity questionnaire for children during three 8-day periods (baseline, 3 and 6 months). Linear, logistic, and quasi-poisson regression models were used to determine the association between physical activity and asthma symptoms; adjusting for age, sex, race, BMI, caregiver's education, asthma severity, medication use, and season...
September 15, 2017: Lung
https://www.readbyqxmd.com/read/28902465/a-modified-reporting-approach-for-thyroid-fna-in-the-niftp-era-a-1-year-institutional-experience
#15
Jeffrey K Mito, Erik K Alexander, Trevor E Angell, Justine A Barletta, Matthew A Nehs, Edmund S Cibas, Jeffrey F Krane
BACKGROUND: The reclassification of noninvasive follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has created diagnostic and management issues for thyroid fine-needle aspiration (FNA). In response to these challenges, the authors' laboratory adopted a NIFTP policy including 1) stringent criteria (requiring pseudo-inclusions, papillae, and/or psammoma bodies) for a malignant diagnosis of papillary carcinoma to limit false-positive results due to NIFTP and 2) the use of explanatory notes in cases with cytomorphologic features suggestive of possible NIFTP to encourage lobectomy over thyroidectomy...
September 13, 2017: Cancer
https://www.readbyqxmd.com/read/28895835/massachusetts-what-universal-coverage-could-look-like
#16
Joseph Burns
The lowest rate of uninsured, but costs are a concern. That's due, in part, to the clout of the state's large prestigious health care systems, especially Partners Healthcare in Boston, which includes Harvard-affiliated Massachusetts General Hospital, and Brigham and Women's hospitals.
July 2017: Managed Care
https://www.readbyqxmd.com/read/28877483/dysregulation-of-mirna-9-in-a-subset-of-schizophrenia-patient-derived-neural-progenitor-cells
#17
Aaron Topol, Shijia Zhu, Brigham J Hartley, Jane English, Mads E Hauberg, Ngoc Tran, Chelsea Ann Rittenhouse, Anthony Simone, Douglas M Ruderfer, Jessica Johnson, Ben Readhead, Yoav Hadas, Peter A Gochman, Ying-Chih Wang, Hardik Shah, Gerard Cagney, Judith Rapoport, Fred H Gage, Joel T Dudley, Pamela Sklar, Manuel Mattheisen, David Cotter, Gang Fang, Kristen J Brennand
No abstract text is available yet for this article.
September 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/28855408/association-of-intracranial-aneurysm-rupture-with-smoking-duration-intensity-and-cessation
#18
Anil Can, Victor M Castro, Yildirim H Ozdemir, Sarajune Dagen, Sheng Yu, Dmitriy Dligach, Sean Finan, Vivian Gainer, Nancy A Shadick, Shawn Murphy, Tianxi Cai, Guergana Savova, Ruben Dammers, Scott T Weiss, Rose Du
OBJECTIVE: Although smoking is a known risk factor for intracranial aneurysm (IA) rupture, the exact relationship between IA rupture and smoking intensity and duration, as well as duration of smoking cessation, remains unknown. METHODS: In this case-control study, we analyzed 4,701 patients with 6,411 IAs diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016. We divided individuals into patients with ruptured aneurysms and controls with unruptured aneurysms...
September 26, 2017: Neurology
https://www.readbyqxmd.com/read/28837409/use-of-a-gc-ms-organic-aerosol-monitor-for-in-field-detection-of-fine-particulate-organic-compounds-in-source-apportionment
#19
Paul M Cropper, Delbert J Eatough, Devon K Overson, Jaron C Hansen, Fern Caka, Robert A Cary
A study was conducted on the Brigham Young University campus during January and February 2015 to identify winter-time sources of fine particulate material in Utah Valley, Utah. Fine particulate mass and components and related gas phase species were all measured on an hourly average basis. Light scattering was also measured during the study. Included in the sampling was the first-time source apportionment application of a new monitoring instrument for the measurement of fine particulate organic marker compounds on an hourly average basis...
August 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28833385/empiric-vancomycin-dosing-in-pediatric-patients-with-congenital-heart-disease-and-the-impact-of-cardiopulmonary-bypass-on-trough-concentrations
#20
Christopher A Thomas, Amy Picone, Sharad Menon, Brigham C Willis
OBJECTIVES: To determine the optimal vancomycin dosing regimen to achieve empiric goal trough concentrations in pediatric patients with congenital heart disease and to examine the impact of cardiopulmonary bypass on vancomycin dosing requirements. METHODS: Patients younger than 18 years of age admitted to the pediatric cardiovascular intensive care unit (CVICU) at our institution from 10/1/2012 - 12/31/2014 who received at least one dose of vancomycin were retrospectively reviewed...
August 22, 2017: Pharmacotherapy
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