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https://www.readbyqxmd.com/read/29667359/predicting-responses-to-mechanical-ventilation-for-preterm-infants-with-acute-respiratory-illness-using-artificial-neural-networks
#1
Katharine Brigham, Samir Gupta, John C Brigham
Infants born prematurely are particularly susceptible to respiratory illness due to underdeveloped lungs, which can often result in fatality. Preterm infants in acute stages of respiratory illness typically require mechanical ventilation assistance, and the efficacy of the type of mechanical ventilation and its delivery has been the subject of a number clinical studies. With recent advances in machine learning approaches, particularly deep learning, it may be possible to estimate future responses to mechanical ventilation in real-time, based on ventilation monitoring up to the point of analysis...
April 17, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29650485/providing-transthoracic-echocardiography-training-for-intensive-care-unit-trainees-an-educational-improvement-initiative
#2
Catherine M Kuza, M Tariq Hanifi, Melissa Koç, Matthias Stopfkuchen-Evans
OBJECTIVE: Transthoracic echocardiography (TTE) is important in the management of critically ill patients, yet it has not been incorporated into many residency programs' curricula. Our objective is to determine if trainees undergoing a 60-minute training session on TTE have improved knowledge, ultrasound skills, and increases the utilization of TTE during their rotation in the intensive care unit (ICU). We will also compare the results of participants with prior TTE exposure to TTE-naïve trainees...
April 9, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29645325/crowd-sourcing-as-an-analytical-method-metrology-of-smartphone-measurements-in-heritage-science
#3
Rosie Brigham, Josep Grau-Bove, Anna Rudnicka, May Cassar, Matija Strlic
This research assesses the precision, repeatability and accuracy of crowd-sourced scientific measurements, and whether their quality is sufficient to provide usable results. Measurements of colour and area were chosen because of the possibility of producing them with smartphone cameras. The quality of measurements was estimated experimentally by comparing data contributed by anonymous participants in heritage sites with reference measurements of known accuracy and precision. Participants performed the measurements by taking photographs with their smartphones, from which colour and dimensional data could be extracted...
April 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29643259/cerebrovascular-accidents-during-mechanical-circulatory-support-new-predictors-of-ischemic-and-hemorrhagic-strokes-and-outcome
#4
Saef Izzy, Daniel B Rubin, Firas S Ahmed, Feras Akbik, Simone Renault, Katelyn W Sylvester, Henrikas Vaitkevicius, Jennifer A Smallwood, Michael M Givertz, Steven K Feske
BACKGROUND AND PURPOSE: Left ventricular assist devices (LVADs) have emerged as an effective treatment for patients with advanced heart failure refractory to medical therapy. Post-LVAD strokes are an important cause of morbidity and reduced quality of life. Data on risks that distinguish between ischemic and hemorrhagic post-LVAD strokes are limited. The aim of this study was to determine the incidence of post-LVAD ischemic and hemorrhagic strokes, their association with stroke risk factors, and their effect on mortality...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29627826/meibomian-gland-dysfunction-in-primary-and-secondary-sj%C3%A3-gren-syndrome
#5
David A Sullivan, Reza Dana, Rose M Sullivan, Kathleen L Krenzer, Afsun Sahin, Beril Arica, Yang Liu, Wendy R Kam, Athena S Papas, Jennifer M Cermak
PURPOSE: We hypothesized that women with primary (pSS) and secondary Sjögren syndrome (sSS; with systemic lupus erythematosus [SLE] or rheumatoid arthritis [RA]) have meibomian gland dysfunction (MGD). We sought to test our hypothesis. METHODS: Subjects with pSS, sSS + SLE, sSS + RA, and non-SS-related MGD were recruited from the Sjögren's Syndrome Foundation or outpatient clinics at Tufts University School of Dental Medicine or Brigham and Women's Hospital. The control population was recruited from the Greater Boston area...
April 6, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29622625/lipid-lowering-agents-and-high-hdl-high-density-lipoprotein-are-inversely-associated-with-intracranial-aneurysm-rupture
#6
Anil Can, Victor M Castro, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T Weiss, Rose Du
BACKGROUND AND PURPOSE: Growing evidence from experimental animal models and clinical studies suggests the protective effect of statin use against rupture of intracranial aneurysms; however, results from large studies detailing the relationship between intracranial aneurysm rupture and total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and lipid-lowering agent use are lacking. METHODS: The medical records of 4701 patients with 6411 intracranial aneurysms diagnosed at the Massachusetts General Hospital and the Brigham and Women's Hospital between 1990 and 2016 were reviewed and analyzed...
April 5, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29606668/rituximab-in-the-treatment-of-interstitial-lung-disease-associated-with-antisynthetase-syndrome-a-multicenter-retrospective-case-review
#7
Tracy J Doyle, Namrata Dhillon, Rachna Madan, Fernanda Cabral, Elaine A Fletcher, Diane C Koontz, Rohit Aggarwal, Juan C Osorio, Ivan O Rosas, Chester V Oddis, Paul F Dellaripa
OBJECTIVE: To assess clinical outcomes including imaging findings on computed tomography (CT), pulmonary function testing (PFT), and glucocorticoid (GC) use in patients with the antisynthetase syndrome (AS) and interstitial lung disease (ILD) treated with rituximab (RTX). METHODS: We retrospectively identified all patients at 2 institutions with AS-ILD who were treated with RTX. Baseline demographics, PFT, and chest CT were assessed before and after RTX. Two radiologists independently evaluated CT using a standardized scoring system...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29572287/allergen-specific-immunotherapy-in-the-treatment-of-pediatric-asthma-a-systematic-review
#8
REVIEW
Jessica L Rice, Gregory B Diette, Catalina Suarez-Cuervo, Emily P Brigham, Sandra Y Lin, Murugappan Ramanathan, Karen A Robinson, Antoine Azar
CONTEXT: Treatment options for allergic asthma include allergen avoidance, pharmacotherapy, and allergen immunotherapy. OBJECTIVES: Summarize and update current evidence for the efficacy and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in pediatric allergic asthma. DATA SOURCES: PubMed, Embase, Cochrane Central Register of Controlled Trials (January 1, 2005, through May 8, 2017), ClinicalTrials.gov, and the US Food and Drug Administration Adverse Event Reporting System...
March 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29568560/life-as-an-early-career-researcher-interview-with-yu-shrike-zhang
#9
Yu Shrike Zhang
Yu Shrike Zhang talks to Francesca Lake, Head of Open Access Publishing: Yu Shrike Zhang received his BE degree in biomedical engineering in 2008 from Southeast University, PR China and PhD degree in biomedical engineering in 2013 from Georgia Institute of Technology. He is currently an Instructor of Medicine and Associate Bioengineer in the Division of Engineering in Medicine at the Brigham and Women's Hospital, Harvard Medical School. His research interests include organs-on-chips, biomaterials, bioprinting, biomedical devices, biomedical imaging and biosensing with a focus on innovating medical engineering technologies to recreate functional tissues and biomimetic tissue models...
March 2018: Future Science OA
https://www.readbyqxmd.com/read/29528696/the-responsible-inclusion-of-students-receiving-special-education-services-for-emotional-disturbance-unraveling-the-practice-to-research-gap
#10
John William McKenna, Michael Solis, Frederick Brigham, Reesha Adamson
The majority of students receiving special education services for emotional disturbance (ED) receive a significant amount of instruction in general education classrooms, which emphasizes curriculums based on college and career readiness standards. In turn, those teachers who provide instruction to students with ED in inclusive settings are responsible for using evidence-based practices (EBPs) for those teaching situations in which they exist to meet free appropriate public education (FAPE) mandates. However, the identification of EBPs is a necessary pre-condition to eventual school adoption and teacher use of such practices...
March 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29522115/prediction-of-pain-and-opioid-utilization-in-the-perioperative-period-in-patients-undergoing-primary-knee-arthroplasty-psychophysical-and-psychosocial-factors
#11
Christopher R Abrecht, Marise Cornelius, Albert Wu, Robert N Jamison, David Janfaza, Richard D Urman, Claudia Campbell, Michael Smith, Jennifer Haythornthwaite, Robert R Edwards, Kristin L Schreiber
Objective: To identify factors associated with pain severity and opioid consumption in the early perioperative period. Design: Prospective observational cohort study. Setting: Tertiary academic medical center. Subjects: Patients with osteoarthritis older than age 45 years undergoing primary total knee replacement at Brigham and Women's Hospital. A total of 126 patients enrolled. Methods: Preoperatively, pain questionnaires and quantitative sensory testing were performed on patients to develop a psychosocial and psychophysical profile...
March 7, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29521163/polygamy-piousness-and-the-practice-of-medicine-understanding-brigham-young-and-the-predominance-of-female-medical-providers-in-early-utah
#12
Samuel R Donnenfeld
The nineteenth century Mormon Prophet, Brigham Young, has long been lauded as progressive for sending dozens of Mormon women from the Utah territory to receive a formal medical education at The Women's Medical College of Pennsylvania. This manuscript comes to a contrary conclusion through close reading of diaries and journals created by these same women and the public speeches of the Prophet himself. These texts have historically been held up as evidence of Prophet Young's encouragement of women as physicians...
January 1, 2018: Journal of Medical Biography
https://www.readbyqxmd.com/read/29517523/about-politeness-face-and-feedback-exploring-resident-and-faculty-perceptions-of-how-institutional-feedback-culture-influences-feedback-practices
#13
Subha Ramani, Karen D Könings, Karen V Mann, Emily E Pisarski, Cees P M van der Vleuten
PURPOSE: To explore resident and faculty perspectives on what constitutes feedback culture, their perceptions of how institutional feedback culture (including politeness concepts) might influence the quality and impact of feedback, feedback seeking, receptivity, and readiness to engage in bidirectional feedback. METHOD: Using a constructivist grounded theory approach, five focus group discussions with internal medicine residents, three focus group discussions with general medicine faculty, and eight individual interviews with subspecialist faculty were conducted at Brigham and Women's Hospital between April and December 2016...
March 6, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29516613/environmentally-relevant-chemical-mixtures-of-concern-in-waters-of-u-s-tributaries-to-the-great-lakes
#14
Sarah M Elliott, Mark E Brigham, Richard L Kiesling, Heiko L Schoenfuss, Zachary G Jorgenson
The North American Great Lakes are a vital natural resource that provide fish and wildlife habitat, as well as drinking water and waste assimilation services for millions of people. Tributaries to the Great Lakes receive chemical inputs from various point and non-point sources, and thus are expected to have complex mixtures of chemicals. However, our understanding of the co-occurrence of specific chemicals in complex mixtures is limited. To better understand the occurrence of specific chemical mixtures in the U...
March 8, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29516080/validating-4-staging-systems-for-cutaneous-squamous-cell-carcinoma-using-population-based-data-a-nested-case-control-study
#15
Ingrid Roscher, Ragnhild S Falk, Linda Vos, Ole P F Clausen, Per Helsing, Petter Gjersvik, Trude E Robsahm
Importance: Cutaneous squamous cell carcinoma (cSCC) has metastatic potential, but the prognostic value of current staging systems in nonselected patients is uncertain. Objective: To assess the effect of risk factors for metastasis and to evaluate validity and usefulness of 4 staging systems for cSCC using population-based data. Design, Setting, and Participants: This was a nationwide, population-based, nested case-control study. The Cancer Registry of Norway, which receives compulsory data on all cancers in the Norwegian population of approximately 5...
March 7, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29512054/peripartum-care-for-mothers-diagnosed-with-hepatitis-b-during-pregnancy-a-survey-of-provider-practices
#16
Allison J Kwong, Matthew S Chang, Ruth E Tuomala, Laura E Riley, Julian N Robinson, Muthoka L Mutinga, Karin L Andersson, Robert S Brown, Emily Oken, Chinweike Ukomadu, Anna E Rutherford
Objectives Hepatitis B (HBV) remains a significant public health burden, despite effective therapy. Routine HBV screening is recommended during pregnancy to reduce the risk of vertical transmission, but the rates of follow-up care peri-partum are low. The aim of this study was to evaluate physician practices and knowledge regarding HBV in women diagnosed perinatally. Methods A survey was distributed to obstetricians and midwives within the Partners HealthCare system at Brigham and Women's Hospital and Massachusetts General Hospital...
March 6, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29490887/facial-restoration-by-transplantation
#17
REVIEW
Branislav Kollar, Bohdan Pomahac
Hundred years ago, Sir Harold Gillies laid a foundation to the modern plastic surgery trying to reconstruct facial defects of severely disfigured soldiers of World War I. Some years later, Joseph Murray experimented with rejection of skin grafts aimed for treatment of burned patients who sustained their injuries on battlefields of World War II. In 1954, the acquired expertise and intensive research allowed him to perform the first successful kidney transplantation in the world at Peter Bent Brigham Hospital in Boston...
February 25, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29474284/pelvic-organ-prolapse-and-urinary-incontinence-in-women-after-bariatric-surgery-5-year-follow-up
#18
Iwona Gabriel, Ali Tavakkoli, Vatche A Minassian
OBJECTIVE: The objective of this study was to determine if weight loss surgery is associated with decreased prevalence of urinary incontinence (UI) and pelvic organ prolapse (POP) symptoms. METHODS: A survey was conducted among previously morbidly obese women who underwent bariatric surgery at Brigham and Women's Hospital, Boston from 2007 to 2015. In addition to the Pelvic Floor Distress Inventory 20, we collected demographic and clinical data including symptoms of and treatment for UI and POP before surgery...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29451069/arthritis-and-use-of-hydroxychloroquine-associated-with-a-decreased-risk-of-macrophage-activation-syndrome-among-adult-patients-hospitalized-with-systemic-lupus-erythematosus
#19
E M Cohen, K D'Silva, D Kreps, M B Son, K H Costenbader
Background Macrophage activation syndrome (MAS) is an uncommon but serious complication of systemic lupus erythematosus (SLE). We aimed to identify factors associated with MAS among adult hospitalized SLE patients. Methods Within the Brigham and Women's Hospital (BWH) Lupus Center Registry, we identified adult SLE patients > age 17 who had been hospitalized from 1970 to 2016, with either ferritin > 5000 ng/ml during admission or "macrophage activation syndrome" or "MAS" in discharge summary...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29450453/the-association-of-age-with-clinical-presentation-and-comorbidities-of-pyoderma-gangrenosum
#20
Hovik J Ashchyan, Daniel C Butler, Caroline A Nelson, Megan H Noe, William G Tsiaras, Stephen J Lockwood, William D James, Robert G Micheletti, Misha Rosenbach, Arash Mostaghimi
Importance: Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis. Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies. Objective: To evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum. Design, Setting, and Participants: This was a multicenter retrospective cohort study performed at tertiary academic referral centers in urban settings...
February 14, 2018: JAMA Dermatology
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