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psoriasis vascular inflammation

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https://www.readbyqxmd.com/read/29663878/role-of-angiogenenic-growth-factors-in-psoriasis-a-review
#1
Tahseena Akhtar, Willayat Yousuf Wani, Mohammad A Kamal, Rajinder Kaur
BACKGROUND: Psoriasis is a chronic inflammatory disease, involving autoimmune mechanism wherein immune system, autoantigens and various environmental triggers all interact to create the systemically diseased state. It is a multifactorial skin disease of complex nature characterized by infiltration of multiple immune cells, kerationcyte proliferation, and increased dermal vascularity. Among all factors, vascular alterations present a significant feature of the disease and angiogenesis seems to have an important role in giving rise to psoriasis phenotype...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29605673/high-fat-diet-exacerbates-early-psoriatic-skin-inflammation-independent-of-obesity-saturated-fatty-acids-as-key-players
#2
Diana Herbert, Sandra Franz, Yulia Popkova, Ulf Anderegg, Jürgen Schiller, Katharina Schwede, Axel Lorz, Jan C Simon, Anja Saalbach
In obesity, hypertrophic adipocytes secret high amounts of adipocytokines resulting in low-grade inflammation- amplified by infiltrating pro-inflammatory macrophages, oxidative stress, hypoxia and lipolysis. It is known, that these chronic pro-inflammatory conditions support the development of type II diabetes and cardio vascular diseases, while mechanisms of obesity-related exacerbation of inflammatory skin disorders like psoriasis are unclear. In this study, we uncover nutritional saturated fatty acids (SFAs) as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters, like fat mass extension, adipocytokines and glucose homeostasis...
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29559399/ustekinumab-treatment-is-associated-with-decreased-systemic-and-vascular-inflammation-in-patients-with-moderate-to-severe-psoriasis-feasibility-study-using-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#3
Byung-Soo Kim, Won-Ku Lee, Kyoungjune Pak, Junhee Han, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Seong-Jang Kim
BACKGROUND: Evidence suggests that psoriasis may be associated with metabolic syndrome and an increased risk of cardiovascular disease. OBJECTIVE: To determine whether ustekinumab reduces systemic and vascular inflammation associated with metabolic syndrome and cardiovascular disease, measured using 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT). METHODS: Patients with psoriasis and healthy controls underwent baseline 18 F-FDG PET/CT imaging...
March 17, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29431216/mast-cell-neural-interactions-contribute-to-pain-and-itch
#4
REVIEW
Kalpna Gupta, Ilkka T Harvima
Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a "power house" by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29382533/topical-sunitinib-ointment-alleviates-psoriasis-like-inflammation-by-inhibiting-the-proliferation-and-apoptosis-of-keratinocytes
#5
Ye-Hong Kuang, Yan Lu, Ying-Ke Liu, Li-Qiu Liao, Xing-Chen Zhou, Qun-Shi Qin, Xue-Kun Jia, Li-Sha Wu, Wu Zhu, Xiang Chen
Psoriasis is a chronic auto-immune inflammation disease with skin lesions and abnormal keratinocyte proliferation. Sunitinib, a multi-targeted tyrosine kinase inhibitor, is known to selectively inhibit several growth factor receptors, including vascular endothelial growth factor receptor, platelet-derived growth factor receptor and stem cell factor. It was reported that a patient with renal cell carcinoma (RCC) whose psoriatic lesion was resolved dramatically during treatment with Sunitinib, however, the mechanism is still unclear...
April 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29321372/chronic-skin-inflammation-accelerates-macrophage-cholesterol-crystal-formation-and-atherosclerosis
#6
Yvonne Baumer, Qimin Ng, Gregory E Sanda, Amit K Dey, Heather L Teague, Alexander V Sorokin, Pradeep K Dagur, Joanna I Silverman, Charlotte L Harrington, Justin A Rodante, Shawn M Rose, Nevin J Varghese, Agastya D Belur, Aditya Goyal, Joel M Gelfand, Danielle A Springer, Christopher Ke Bleck, Crystal L Thomas, Zu-Xi Yu, Mårten Cg Winge, Howard S Kruth, M Peter Marinkovich, Aditya A Joshi, Martin P Playford, Nehal N Mehta
Inflammation is critical to atherogenesis. Psoriasis is a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides a compelling model to understand potential pathways linking these diseases. A murine model capturing the vascular and metabolic diseases in psoriasis would accelerate our understanding and provide a platform to test emerging therapies. We aimed to characterize a new murine model of skin inflammation (Rac1V12) from a cardiovascular standpoint to identify novel atherosclerotic signaling pathways modulated in chronic skin inflammation...
January 11, 2018: JCI Insight
https://www.readbyqxmd.com/read/29193791/il-35-recombinant-protein-reverses-inflammatory-bowel-disease-and-psoriasis-through-regulation-of-inflammatory-cytokines-and-immune-cells
#7
Yuan Wang, Ying Mao, Junfeng Zhang, Gang Shi, Lin Cheng, Yi Lin, Yiming Li, Xiaomei Zhang, Yujing Zhang, Xiaolei Chen, Jie Deng, Xiaolan Su, Lei Dai, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei, Hongxin Deng
Interleukin-35 (IL-35), a member of the IL-12 family, functions as a new anti-inflammatory factor involved in arthritis, psoriasis, inflammatory bowel disease (IBD) and other immune diseases. Although IL-35 can significantly prevent the development of inflammation in many diseases, there have been no early studies accounting for the role of IL-35 recombinant protein in IBD and psoriasis. In this study, we assessed the therapeutic potential of IL-35 recombinant protein in three well-known mouse models: the dextransulfate sodium (DSS)-induced colitis mouse model, the keratin14 (K14)-vascular endothelial growth factor A (VEGF-A)-transgenic (Tg) psoriasis mouse model and the imiquimod (IMQ)-induced psoriasis mouse model...
February 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29078787/glyca-a-novel-biomarker-of-systemic-inflammation-and-cardiovascular-disease-risk
#8
REVIEW
Margery A Connelly, James D Otvos, Irina Shalaurova, Martin P Playford, Nehal N Mehta
BACKGROUND: GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases. GlycA is unique in its composite nature, reflecting both increased glycan complexity and circulating acute phase protein levels during local and systemic inflammation. Recent studies of GlycA from cross-sectional, observational and interventional studies have been highly informative, demonstrating that GlycA is elevated in acute and chronic inflammation, predicts death in healthy individuals and is associated with disease severity in patients with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and lupus...
October 27, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29062018/ifn-%C3%AE-and-tnf-%C3%AE-synergism-may-provide-a-link-between-psoriasis-and-inflammatory-atherogenesis
#9
Nehal N Mehta, Heather L Teague, William R Swindell, Yvonne Baumer, Nicole L Ward, Xianying Xing, Brooke Baugous, Andrew Johnston, Aditya A Joshi, Joanna Silverman, Drew H Barnes, Liza Wolterink, Rajan P Nair, Philip E Stuart, Martin Playford, John J Voorhees, Mrinal K Sarkar, James T Elder, Katherine Gallagher, Santhi K Ganesh, Johann E Gudjonsson
Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, a chronic inflammatory skin disease associated with increased susceptibility to atherosclerosis, provides a clinical human model that can be utilized to investigate the links between chronic inflammation and atherosclerosis development. We sought to investigate key biological processes in psoriasis skin and human vascular tissue to identify biological components that may promote atherosclerosis in chronic inflammatory conditions...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29055628/visceral-adiposity-in-psoriasis-is-associated-with-vascular-inflammation-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-beyond-cardiometabolic-disease-risk-factors-in-an-observational-cohort-study
#10
Joshua P Rivers, Tiffany M Powell-Wiley, Amit K Dey, Justin A Rodante, Jonathan H Chung, Aditya A Joshi, Balaji Natarajan, Aparna P Sajja, Abhishek Chaturvedi, Anshuma Rana, Charlotte L Harrington, Heather L Teague, Benjamin N Lockshin, Mark A Ahlman, Jianhua Yao, Martin P Playford, Joel M Gelfand, Nehal N Mehta
OBJECTIVES: The authors sought to examine the relationship between visceral adipose tissue (VAT) and vascular inflammation (VI) by 18 F-Fluorodeoxyglucose (18 F-FDG) positron-emission tomography (PET)/computed tomography (CT) in psoriasis (PSO). Furthermore, we evaluated whether treatment of PSO modulated VAT and VI. BACKGROUND: PSO, a chronic inflammatory skin disease, is associated with VI by 18 F-FDG PET/CT and increased cardiometabolic risk including adipose tissue dysregulation...
February 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28982338/thalidomide-improves-psoriasis-like-lesions-and-inhibits-cutaneous-vegf-expression-without-alteration-of-microvessel-density-in-imiquimod-induced-psoriatic-mouse-model
#11
Juan-Hua Liu, Hui-Hui Wu, Yu-Kun Zhao, Fang Wang, Qian Gao, Di-Qing Luo
Background Psoriasis is a chronic inflammatory skin disorder of unknown etiology. Increasing evidence suggests that psoriasis is probably an angiogenesis-dependent disease. Thalidomide has been reported being able to inhibit the effects of fibroblast growth factor 2 and vascular endothelial growth factor (VEGF), and inhibit tumour necrosis factor-alpha synthesis, and suppress tumour necrosis factor-induced nuclear factor-kappa B activation in Jurkat cells, resulting in suppression of proliferation inflammation, angiogenesis, and the immune system, which are related to the pathogenesis of psoriasis...
October 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28844939/lack-of-galanin-receptor-3-alleviates-psoriasis-by-altering-vascularization-immune-cell-infiltration-and-cytokine-expression
#12
Felix Locker, Silvia Vidali, Barbara S Holub, Julia Stockinger, Susanne M Brunner, Sabine Ebner, Andreas Koller, Andrea Trost, Herbert A Reitsamer, David Schwarzenbacher, Roland Lang, Barbara Kofler
The neuropeptide galanin is distributed in the central and peripheral nervous systems and in non-neuronal peripheral organs, including the skin. Galanin acts via three G protein-coupled receptors which, except galanin receptor 1, are expressed in various skin structures. The galanin system has been associated with inflammatory processes of the skin and of several other organs. Psoriasis is an inflammatory skin disease with increased neovascularization, keratinocyte hyperproliferation, a proinflammatory cytokine milieu, and immune cell infiltration...
January 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28826925/the-relationship-between-duration-of-psoriasis-vascular-inflammation-and-cardiovascular-events
#13
Alexander Egeberg, Lone Skov, Aditya A Joshi, Lotus Mallbris, Gunnar H Gislason, Jashin J Wu, Justin Rodante, Joseph B Lerman, Mark A Ahlman, Joel M Gelfand, Nehal N Mehta
BACKGROUND: Psoriasis is associated with risk of cardiovascular (CV) disease (CVD) and a major adverse CV event (MACE). Whether psoriasis duration affects risk of vascular inflammation and MACEs has not been well characterized. OBJECTIVES: We utilized two resources to understand the effect of psoriasis duration on vascular disease and CV events: (1) a human imaging study and (2) a population-based study of CVD events. METHODS: First, patients with psoriasis (N = 190) underwent fludeoxyglucose F 18 positron emission tomography/computed tomography (duration effect reported as a β-coefficient)...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28762474/adipokines-psoriasis-systemic-inflammation-and-endothelial-dysfunction
#14
REVIEW
Maeve Lynch, Tomas Ahern, Cheryl M Sweeney, Anna Malara, Anne-Marie Tobin, Donal O'Shea, Brian Kirby
Adipokines are secreted by white adipose tissue, an active endocrine organ, and play a role in the regulation of metabolic functions such as lipid metabolism, inflammation, and vascular homeostasis. Adipokines are secreted in excess in obesity and contribute to the development of associated comorbidities such as metabolic syndrome and atherosclerosis. Psoriasis, a chronic immune-mediated skin disease, is associated with obesity and increased cardiovascular risk. Understanding the role of adipokines in psoriasis may in part explain the association between psoriasis and cardiovascular disease...
November 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28679449/abatacept-reduces-synovial-regulatory-t-cell-expression-in-patients-with-psoriatic-arthritis
#15
Agnes Szentpetery, Eric Heffernan, Martina Gogarty, Lisa Mellerick, Janet McCormack, Muhammad Haroon, Musaab Elmamoun, Phil Gallagher, Genevieve Kelly, Aurelie Fabre, Brian Kirby, Oliver FitzGerald
BACKGROUND: The aim was to study changes in immunohistochemical expression markers of synovial and skin inflammation, clinical outcomes and magnetic resonance imaging (MRI) scores with abatacept treatment in patients with psoriatic arthritis (PsA). METHODS: Biological-treatment-naïve PsA patients with active disease including synovitis of a knee were enrolled in this single-centre, crossover study. Patients were randomised to receive intravenous abatacept 3 mg/kg of body weight or placebo infusion on day 1, 15 and 29; thereafter abatacept 10 mg/kg of body weight was administered every 28 days for 5 months...
July 5, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28652110/response-to-hjuler-et%C3%A2-al
#16
Robert Bissonnette, François Harel, James G Krueger, Marie-Claude Guertin, Malorie Chabot-Blanchet, Juana Gonzalez, Catherine Maari, Isabelle Delorme, Charles W Lynde, Jean-Claude Tardif
No abstract text is available yet for this article.
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652109/using-fdg-pet-ct-to-detect-vascular-inflammation-in-patients-with-psoriasis-where-to-look-and-for-what
#17
Kasper Fjellhaugen Hjuler, Lars Christian Gormsen, Lars Iversen
No abstract text is available yet for this article.
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28592257/clinical-safety-and-efficacy-of-vitamin-d3-analog-ointment-for-treatment-of-obstructive-meibomian-gland-dysfunction
#18
RANDOMIZED CONTROLLED TRIAL
Reiko Arita, Motoko Kawashima, Masataka Ito, Kazuo Tsubota
BACKGROUND: Hyperkeratinization is a major cause of obstructive meibomian gland dysfunction (oMGD) and results in degenerative gland dilation and atrophy without inflammation. Ointment containing 1,25-dihydroxy-22-oxavitamin D3 (maxacalcitol), a noncalcemic analog of the active form of vitamin D3, is applied for the treatment of hyperkeratotic cutaneous conditions such as psoriasis and ichtyosis because it suppresses the proliferation and promotes the differentiation of keratinocytes through interaction with the vitamin D receptor...
June 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28564678/association-between-skin-and-aortic-vascular-inflammation-in-patients-with-psoriasis-a-case-cohort-study-using-positron-emission-tomography-computed-tomography
#19
Amit K Dey, Aditya A Joshi, Abhishek Chaturvedi, Joseph B Lerman, Tsion M Aberra, Justin A Rodante, Heather L Teague, Charlotte L Harrington, Joshua P Rivers, Jonathan H Chung, Mohammad Tarek Kabbany, Balaji Natarajan, Joanna I Silverman, Qimin Ng, Gregory E Sanda, Alexander V Sorokin, Yvonne Baumer, Emily Gerson, Ronald B Prussick, Alison Ehrlich, Lawrence J Green, Benjamin N Lockshin, Mark A Ahlman, Martin P Playford, Joel M Gelfand, Nehal N Mehta
Importance: Inflammation is critical in the development of atherosclerosis. Psoriasis is a chronic inflammatory skin disease that is associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography in vivo and future cardiovascular events. It provides a human model to understand the effect of treating inflammation in a target organ (eg, the skin) on vascular diseases. Objective: To investigate the association between change in skin disease severity and change in vascular inflammation at 1 year and to characterize the impact of 1 year of anti-tumor necrosis factor therapy on vascular inflammation...
September 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28429105/increased-expression-of-upa-upar-and-pai-1-in-psoriatic-skin-and-in-basal-cell-carcinomas
#20
K A Rubina, V Yu Sysoeva, E I Zagorujko, Z I Tsokolaeva, M I Kurdina, Ye V Parfyonova, V A Tkachuk
There is substantial evidence implicating the urokinase system in tissue remodeling during neo-vascularization, inflammation, tumor invasion, and metastasis. Regulated degradation of the extracellular matrix at the leading edge of migrating cells, mediated by uPA and uPAR, is required for tissue remodeling, invasiveness, and angiogenesis. Psoriasis and basal cell carcinoma (BCC) are the most common skin diseases. Pathogenesis of both of them is associated with keratinocyte hyperproliferation, inflammatory cell migration, and angiogenesis-processes in which the plasminogen system (uPA, uPAR, tPA, and PAI-1) plays a crucial role...
August 2017: Archives of Dermatological Research
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