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https://www.readbyqxmd.com/read/28340057/long-term-outcome-of-pulmonary-vein-isolation-in-patients-with-paroxysmal-atrial-fibrillation-and-brugada-syndrome
#1
Giacomo Mugnai, Burak Hünük, Erwin Ströker, Diego Ruggiero, Hugo Enrique Coutino-Moreno, Ken Takarada, Valentina De Regibus, Rajin Choudhury, Juan Pablo Abugattas de Torres, Darragh Moran, Saverio Iacopino, Pasquale Filannino, Giulio Conte, Juan Sieira, Jan Poelaert, Stefan Beckers, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
Aims: The therapeutical management of atrial fibrillation (AF) in the setting of Brugada syndrome (BS) might be challenging as many antiarrhythmic drugs (AADs) with sodium channel blocking properties might lead to to the development of ventricular arrhythmias. This study sought to evaluate the clinical outcome in a consecutive series of patients with BS having undergone pulmonary vein (PV) isolation by means of radiofrequency (RF) or cryoballoon (CB) ablation and the efficacy of catheter ablation for preventing inappropriate interventions delivered by implantable cardioverter defibrillators (ICD) on a 3-year follow up...
March 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28338440/a-study-of-cognitive-function-in-treatment-refractory-obsessive-compulsive-disorder-treated-with-capsulotomy
#2
Feilong Gong, Peng Li, Bin Li, Shizhen Zhang, Xinjie Zhang, Sen Yang, Hongbin Liu, Wei Wang
OBJECTIVE Anterior capsulotomy (AC) is sometimes used as a last resort for treatment-refractory obsessive-compulsive disorder (OCD). Previous studies assessing neuropsychological outcomes in patients with OCD have identified several forms of cognitive dysfunction that are associated with the disease, but few have focused on changes in cognitive function in OCD patients who have undergone surgery. In the present study, the authors investigated the effects of AC on the cognitive function of patients with treatment-refractory OCD...
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28337995/cigarette-smoke-impairs-a2a-adenosine-receptor-mediated-wound-repair-through-up-regulation-of-duox-1-expression
#3
Zhi Tian, Hui Zhang, Jendayi Dixon, Nicole Traphagen, Todd A Wyatt, Kusum Kharbanda, Samantha Simet Chadwick, Narasaiah Kolliputi, Diane S Allen-Gipson
Cigarette smoke (CS) exposure and intrinsic factors such as the NADPH oxidases produce high levels of reactive oxygen species (ROS), ensuing inflammatory tissue injury. We previously demonstrated that CS-generated ROS, particularly hydrogen peroxide (H2O2), impaired adenosine stimulated wound repair. We hypothesized that CS exposure modulates expression of Dual oxidase 1 (Duox-1), a NADPH oxidases known to generate H2O2. To test this hypothesis, we used human bronchial epithelial cell line Nuli-1 and C57BL/6 mice...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28335415/time-modulated-arrays-from-their-origin-to-their-utilization-in-wireless-communication-systems
#4
REVIEW
Roberto Maneiro-Catoira, Julio Brégains, José A García-Naya, Luis Castedo
Time-modulated arrays (TMAs) are electromagnetic systems whose radiated power pattern is controlled by the application of variable-width periodical pulses to the individual elements. The nonlinear nature of the array operation causes the appearance of radiation patterns at the harmonic frequencies of such periodic pulses. The technique can be used for improving the side-lobe level (SLL) topology of the radiation pattern at the central frequency and/or to profitably exploit the harmonic patterns in order to supply smart antenna capabilities...
March 14, 2017: Sensors
https://www.readbyqxmd.com/read/28334937/dynamically-and-epigenetically-coordinated-gata-ets-sox-transcription-factor-expression-is-indispensable-for-endothelial-cell-differentiation
#5
Yasuharu Kanki, Ryo Nakaki, Teppei Shimamura, Taichi Matsunaga, Kohei Yamamizu, Shiori Katayama, Jun-Ichi Suehiro, Tsuyoshi Osawa, Hiroyuki Aburatani, Tatsuhiko Kodama, Youichiro Wada, Jun K Yamashita, Takashi Minami
Although studies of the differentiation from mouse embryonic stem (ES) cells to vascular endothelial cells (ECs) provide an excellent model for investigating the molecular mechanisms underlying vascular development, temporal dynamics of gene expression and chromatin modifications have not been well studied. Herein, using transcriptomic and epigenomic analyses based on H3K4me3 and H3K27me3 modifications at a genome-wide scale, we analysed the EC differentiation steps from ES cells and crucial epigenetic modifications unique to ECs...
March 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334688/preparation-of-poly-n-isopropylacrylamide-block-acrylic-acid-encapsulated-proteinaceous-microbubbles-for-delivery-of-doxorubicin
#6
Xiaochen Ma, Qingxia Liu
Inspired by theranostic technologies, we electrostatically loaded proteinaceous microbubbles (MBs) with a model drug, doxorubicin (Dox) to couple their utilizations in diagnostic imaging with drug loading. A temperature-sensitive polymer, poly(N-isopropylacrylamide-block-acrylic acid) (poly(NIPAM-b-AAc)) was used to encapsulate the Dox-loaded MBs to prevent premature release and to control the Dox release thermally. An LCST of 39°C, slightly higher than normal body temperatures, enables the release of Dox through a conformational change of the polymer shell upon moderate heating...
March 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28334507/comparative-study-of-cytotoxicity-and-genotoxicity-of-commercial-jeffamines%C3%A2-and-polyethylenimine-in-cho-k1-cells
#7
Leniher Castan, Cristiano José da Silva, Eduardo Ferreira Molina, Raquel Alves Dos Santos
Jeffamines(®) are a family of polymers containing primary amine groups attached to the extremities of polyether backbone which can be used as biomaterials. They have been used in combination with polyethylenimine (PEI) to improve biocompatibility in drug and gene delivery systems. Despite these facts, very few studies have been done on cytotoxicity and genotoxicity of pure Jeffamines(®) or compared with PEI. The present study aimed to evaluate and compare the cytotoxic and genotoxic effects of Jeffamines(®) and PEI in CHO-K1 cells...
March 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28334367/modeling-of-stiffness-and-strength-of-bone-at-nanoscale
#8
Diab W Abueidda, Fereshteh A Sabet, Iwona M Jasiuk
Two distinct geometrical models of bone at nanoscale (collagen fibril and mineral platelets) are analyzed computationally. In the first model (Model I) minerals are periodically distributed in a staggered manner in a collagen matrix while in the second model (Model II) minerals form continuous layers outside the collagen fibril. Elastic modulus and strength of bone at the nanoscale, represented by these two models, are studied using a finite element software Abaqus. The analysis employs a traction-separation law (cohesive surface modeling) at various interfaces in the models to account for interfacial delaminations...
March 23, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28333092/impact-of-coagulant-and-flocculant-addition-to-an-anaerobic-dynamic-membrane-bioreactor-andmbr-treating-waste-activated-sludge
#9
Guido Kooijman, Wilton Lopes, Zhongbo Zhou, Hongxiao Guo, Merle de Kreuk, Henri Spanjers, Jules van Lier
In this work, we investigated the effects of flocculation aid (FA) addition to an anaerobic dynamic membrane bioreactor (AnDMBR) (7 L, 35 °C) treating waste-activated sludge (WAS). The experiment consisted of three distinct periods. In period 1 (day 1-86), the reactor was operated as a conventional anaerobic digester with a solids retention time (SRT) and hydraulic retention time (HRT) of 24 days. In period 2 (day 86-303), the HRT was lowered to 18 days with the application of a dynamic membrane while the SRT was kept the same...
March 23, 2017: Membranes
https://www.readbyqxmd.com/read/28331443/pacemaker-use-following-heart-transplantation
#10
Hari R Mallidi, Michael Bates
BACKGROUND: The incidence of permanent pacemaker implantation after orthotopic heart transplantation has been reported to be 2%-24%. Transplanted hearts usually exhibit sinus rhythm in the operating room following reperfusion, and most patients do not exhibit significant arrhythmias during the postoperative period. However, among the patients who do exhibit abnormalities, pacemakers may be implanted for early sinus node dysfunction but are rarely used after 6 months. Permanent pacing is often required for atrioventricular block...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28331377/management-of-systemic-lupus-erythematosus-during-pregnancy-challenges-and-solutions
#11
REVIEW
Caroline L Knight, Catherine Nelson-Piercy
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal-neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28330886/preclinical-diagnosis-predicting-its-ability-to-improve-control-of-farm-to-farm-foot-and-mouth-disease-transmission-in-cattle
#12
Noel Nelson, David J Paton, Simon Gubbins, Claire Colenutt, Emma Brown, Sophia Hodgson, Jose L Gonzales
Foot-and-mouth disease (FMD) can cause large disruptive epidemics in livestock. Current eradication measures rely on the rapid clinical detection and removal of infected herds. Here, we have evaluated the potential for preclinical diagnosis during reactive surveillance to reduce the risk of between farm transmission. We used data from transmission experiments in cattle where both individual animal samples, such as blood, probang, saliva or nasal swabs, and herd level samples, such as air samples, were taken daily during the course of infection...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28330510/an-integrated-environmental-improvement-of-marshlands-impact-on-control-and-elimination-of-schistosomiasis-in-marshland-regions-along-the-yangtze-river-china
#13
Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Zheng-Qiu Zhang, Qing-Biao Hong, Guo-Jing Yang, Hong-Ru Zhu, You-Sheng Liang, Hai-Tao Yang
BACKGROUND: Schistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core regions endemic for Schistosoma japonicum are mainly located in the marshland and lake regions along the Yangtze River basin. METHODS: During the period from 2001 through 2015, an integrated environmental improvement of the marshlands was carried out through the implementation of industrial, agricultural and resources development projects in Yizheng County along the Yangtze River...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28328519/a-framework-for-mixed-type-multi-outcome-prediction-with-applications-in-healthcare
#14
Budhaditya Saha, Sunil Gupta, Dinh Phung, Svetha Venkatesh
Health analysis often involves prediction of multiple outcomes of mixed-type. Existing work is restrictive to either a limited number or specific outcome types. We propose a framework for mixed-type multi-outcome prediction. Our proposed framework proposes a cumulative loss function composed of a specific loss function for each outcome type - as an example, least square (continuous outcome), hinge (binary outcome), poisson (count outcome) and exponential (non-negative outcome). To model these outcomes jointly, we impose a commonality across the prediction parameters through a common matrix-Normal prior...
March 16, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28323387/induction-of-tumor-regression-by-intratumoral-sting-agonists-combined-with-anti-programmed-death-l1-blocking-antibody-in-a-preclinical-squamous-cell-carcinoma-model
#15
Shekhar K Gadkaree, Juan Fu, Rupashree Sen, Michael J Korrer, Clint Allen, Young J Kim
BACKGROUND: Cyclic dinucleotides (CDNs) are bacterial intracellular messengers that have demonstrated antitumor activity in melanoma and breast tumors, although their role in immunotherapy of head and neck squamous cell cancers (HNSCCs) has not been well investigated. METHODS: We measured primary tumor growth rates, mechanism of antitumor activity, and efficacy of programmed death-L1 blockade combinatorial therapy in SCCFVII tumor-bearing C3H/HeOUJ mice undergoing intratumoral injections with RR-cyclic-di-guanine (synthetic CDG), CDG (natural cyclic-di-guanine), R848 (TLR 7/8 agonist), or phosphate buffered saline (PBS, control)...
March 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28321965/robust-presurgical-functional-mri-at-7-t-using-response-consistency
#16
Pedro Lima Cardoso, Florian Ph S Fischmeister, Barbara Dymerska, Alexander Geißler, Moritz Wurnig, Siegfried Trattnig, Roland Beisteiner, Simon Daniel Robinson
Functional MRI is valuable in presurgical planning due to its non-invasive nature, repeatability, and broad availability. Using ultra-high field MRI increases the specificity and sensitivity, increasing the localization reliability and reducing scan time. Ideally, fMRI analysis for this application should identify unreliable runs and work even if the patient deviates from the prescribed task timing or if there are changes to the hemodynamic response due to pathology. In this study, a model-free analysis method-UNBIASED-based on the consistency of fMRI responses over runs was applied, to ultra-high field fMRI localizations of the hand area...
March 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28319550/continuous-transversus-abdominis-plane-nerve-blocks-does-varying-local-anesthetic-delivery-method-automatic-repeated-bolus-versus-continuous-basal-infusion-influence-the-extent-of-sensation-to-cold-a-randomized-triple-masked-crossover-study-in-volunteers
#17
Bahareh Khatibi, Engy T Said, Jacklynn F Sztain, Amanda M Monahan, Rodney A Gabriel, Timothy J Furnish, Johnathan T Tran, Michael C Donohue, Brian M Ilfeld
BACKGROUND: It remains unknown whether continuous or scheduled intermittent bolus local anesthetic administration is preferable for transversus abdominis plane (TAP) catheters. We therefore tested the hypothesis that when using TAP catheters, providing local anesthetic in repeated bolus doses increases the cephalad-caudad cutaneous effects compared with a basal-only infusion. METHODS: Bilateral TAP catheters (posterior approach) were inserted in 24 healthy volunteers followed by ropivacaine 2 mg/mL administration for a total of 6 hours...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28318159/-meta-analysis-of-the-condylar-position-changes-produced-by-functional-appliances-in-class-%C3%A2-malocclusion
#18
Huang Xinqi, Cen Xiao, Liu Jun
OBJECTIVE: This study aimed to analyze the condylar position changes produced by functional appliances in class Ⅱ malocclusion by systematic review. METHODS: Electronic search was conducted using Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Medline, Embase, Pubmed, and Cochrane Central Register of Controlled Trials. Studies on condylar position changes produced by functional appliances in class Ⅱ malocclusion were included...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28316225/-the-clinical-impact-of-artery-first-approach-combined-with-vascular-resection-and-reconstruction-in-the-treatment-of-pancreatic-head-carcinoma
#19
J L Huang, W G Li, F Z Chen, Z J Su, F M Li, B Liu
Objective: To evaluate the application of artery first, combined vascular resection and reconstruction in the treatment of pancreatic head carcinoma. Methods: The clinical data of 13 patients with pancreatic head cancer were retrospectively analyzed from February 2014 to March 2016 in the Affiliated Hospital of Xiamen University. Preoperative computed tomography of high resolution layer or magnetic resonance imaging examination demonstrated pancreatic head carcinoma, as well as close adhesion, stenosis, compression or displacement of superior mesenteric vein or portal vein wall...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28316073/arrhythmic-effects-of-epac-mediated-ryanodine-receptor-activation-in-langendorff-perfused-murine-hearts-are-associated-with-reduced-conduction-velocity
#20
Mengye Li, Sandeep Hothi, Samantha C Salvage, Kamalan Jeevaratnam, Andrew A Grace, Christopher L-H Huang
Recent papers have attributed arrhythmic substrate in murine RyR2-P2328S hearts to reduced action potential (AP) conduction velocities (CV), reflecting acute functional inhibition and/or reduced expression of sodium channels. We explored for acute effects of direct Epac (exchange protein directly activated by cAMP)-mediated ryanodine receptor-2 (RyR2) activation on arrhythmic substrate and CV. Monophasic action potential recordings demonstrated that initial steady (8-Hz) extrinsic pacing elicited ventricular tachycardia (VT) in 0 of 18 Langendorff-perfused wild-type mouse ventricles before pharmacological intervention...
March 18, 2017: Clinical and Experimental Pharmacology & Physiology
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