keyword
MENU ▼
Read by QxMD icon Read
search

Positive remodeling

keyword
https://www.readbyqxmd.com/read/28916915/inflammatory-diseases-and-bone-fragility
#1
REVIEW
K Briot, P Geusens, I Em Bultink, W F Lems, C Roux
Systemic osteoporosis and increased fracture rates have been described in chronic inflammatory diseases such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, inflammatory bowel diseases, and chronic obstructive pulmonary disease. Most of these patients receive glucocorticoids, which have their own deleterious effects on bone. However, the other main determinant of bone fragility is the inflammation itself, as shown by the interactions between the inflammatory mediators, the actors of the immune system, and the bone remodelling...
September 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28903999/cdc42-regulates-junctional-actin-but-not-cell-polarization-in-the-caenorhabditis-elegans-epidermis
#2
Yuliya Zilberman, Joshua Abrams, Dorian C Anderson, Jeremy Nance
During morphogenesis, adherens junctions (AJs) remodel to allow changes in cell shape and position while preserving adhesion. Here, we examine the function of Rho guanosine triphosphatase CDC-42 in AJ formation and regulation during Caenorhabditis elegans embryo elongation, a process driven by asymmetric epidermal cell shape changes. cdc-42 mutant embryos arrest during elongation with epidermal ruptures. Unexpectedly, we find using time-lapse fluorescence imaging that cdc-42 is not required for epidermal cell polarization or junction assembly, but rather is needed for proper junctional actin regulation during elongation...
September 13, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28902902/multiscale-biphasic-modelling-of-peritumoural-collagen-microstructure-the-effect-of-tumour-growth-on-permeability-and-fluid-flow
#3
Peter A Wijeratne, John H Hipwell, David J Hawkes, Triantafyllos Stylianopoulos, Vasileios Vavourakis
We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour-host environment. The model is specified to in-vitro data, facilitating biophysically realistic simulations of tumour spheroid growth into a dense collagen hydrogel. We use the model to first confirm that passive mechanical remodelling of collagen fibres at the tumour boundary is driven by solid stress, and not fluid pressure. The model is then used to demonstrate the influence of collagen microstructure on peritumoural permeability and interstitial fluid flow...
2017: PloS One
https://www.readbyqxmd.com/read/28901438/lysyl-oxidase-is-involved-in-synovial-hyperplasia-and-angiogenesis-in-rats-with-collagen%C3%A2-induced-arthritis
#4
Fan Wang, Juan Wan, Qiuyan Li, Mingzhu Zhang, Qiaofeng Wan, Chen Ji, Haibo Li, Rongqing Liu, Mei Han
Lysyl oxidase (LOX) serves an important role in remodeling the extracellular matrix and angiogenesis in various types of cancer; however, whether LOX is involved in the pathogenesis of rheumatoid arthritis remains unknown. In order to investigate this in the present study, β‑aminopropionitrile, an inhibitor of LOX, was injected intraperitoneally into rats with type II collagen‑induced arthritis (CIA). Subsequently, synovial hyperplasia was examined by hematoxyl in and eosin staining, and the microvascular density (MVD) and expression levels of LOX, matrix metalloproteinase (MMP)‑2 and MMP‑9 in the synovial membrane and fluid were determined by immunohistochemistry and ELISA, respectively...
September 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899819/information-content-of-dendritic-spines-after-motor-learning
#5
Davide Viggiano, Luisa Speranza, Marianna Crispino, Gian Carlo Bellenchi, Umberto di Porzio, Attilio Iemolo, Elvira De Leonibus, Floriana Volpicelli, Carla Perrone-Capano
Dendritic spines, small protrusions emerging from the dendrites of most excitatory synapses in the mammalian brain, are highly dynamic structures and their shape and number is continuously modulated by memory formation and other adaptive changes of the brain. In this study, using a behavioral paradigm of motor learning, we applied the non-linear analysis of dendritic spines to study spine complexity along dendrites of cortical and subcortical neural systems, such as the basal ganglia, that sustain important motor learning processes...
September 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28899730/a-green-tea-polyphenol-epigallocatechin-3-gallate-enhances-neuroregeneration-after-spinal-cord-injury-by-altering-levels-of-inflammatory-cytokines
#6
Lucia Machova Urdzikova, Jiri Ruzicka, Kristyna Karova, Anna Kloudova, Barbora Svobodova, Anubhav Amin, Jana Dubisova, Meic Schmidt, Sarka Kubinova, Meena Jhanwar-Uniyal, Pavla Jendelova
Spinal cord injury (SCI) is a debilitating condition which is characterized by an extended secondary injury due to the presence of inflammatory local milieu. Epigallocatechin gallate (EGCG) appears to possess strong neuroprotective properties. Here, we evaluated the beneficial effect of EGCG on recovery from SCI. Male Wistar rats were given either EGCG or saline directly to the injured spinal cord and thereafter a daily IP injection. Behavior recovery was monitored by BBB, plantar, rotarod and flat-beam tests...
September 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28898813/insight-into-the-modulation-of-intestinal-proteome-of-juvenile-common-carp-cyprinus-carpio-l-after-dietary-exposure-to-zno-nanoparticles
#7
Latifeh Chupani, Hamid Niksirat, Vanessa Lünsmann, Sven-Bastiaan Haange, Martin von Bergen, Nico Jehmlich, Eliska Zuskova
ZnO nanoparticles (NPs) are widely used in industrial and consumer products. Therefore understanding their interaction with biological systems is key to their safe application. Proteomics was applied to assess the sub-lethal effects of dietary ZnO NPs on two parts of carp intestine, the intestinal folds and the muscular parts. A commercial carp feed containing 500mgkg(-1) of ZnO NPs was fed to fish for six weeks. The abundances of 32 proteins in the treated intestinal folds were significantly changed and in addition, 28 proteins were significantly changed in the muscular parts...
September 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28895584/effects-of-lobeglitazone-a-novel-thiazolidinedione-on-adipose-tissue-remodeling-and-brown-and-beige-adipose-tissue-development-in-db-db-mice
#8
G Kim, Y-H Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
BACKGROUND/OBJECTIVES: We investigated the effect of long-term treatment with lobeglitazone, a novel thiazolidinedione-based activator of PPARγ, on adipose tissue (AT), focusing on its effects on insulin resistance in obese db/db mice. METHODS: Seven-week-old male db/db mice were assigned to either a vehicle-treated (n=8) or lobeglitazone-treated (n=8) group. Lobeglitazone (1 mg/kg daily) was injected intraperitoneally for 20 weeks. RESULTS: Lobeglitazone treatment for 20 weeks resulted in a remarkably improved glycemic index, including significantly decreased glucose levels, enhanced insulin sensitivity, and preserved pancreatic beta cells...
September 12, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28894604/new-generation-bioresorbable-scaffold-technologies-an-update-on-novel-devices-and-clinical-results
#9
REVIEW
Damiano Regazzoli, Pier Pasquale Leone, Antonio Colombo, Azeem Latib
Bioresorbable scaffolds (BRS) represent a novel horizon in interventional cardiology and may lead to some potential long-term advantages including the restoration of vasomotion, positive remodeling and a reduced incidence of late and very-late scaffold thrombosis (ScT). This technology, introduced to overcome limitations of current metallic drug-eluting stents (DES), is constantly and rapidly evolving with many companies working on bioresorbable devices. The aim of this review is to present an update on the most promising scaffolds that are under development...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28893706/hypertension-acute-stent-thrombosis-and-paraplegia-6-months-after-tevar-for-blunt-thoracic-aortic-injury-in-a-22-year-old-patient
#10
O Martinelli, F Faccenna, A Malaj, J Jabbour, S Venosi, R Gattuso, B Gossetti, L Irace
TEVAR is a less invasive option for managing traumatic injuries of the descending aorta in polytraumatized patients. Concerns arise when treating young patients with TEVAR. A 22-year old male was admitted to the Emergency Department following a high-impact road traffic collision. Whole body CT scan documented multiple injuries, including rupture of descending thoracic aorta just below the isthmus. There was no evidence of paraplegia or stroke. We decided to treat him in an endovascular fashion with a Zenith Cook (Cook Incorporated, Bloomington, IN) endograft...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28892740/human-ogg1-activity-in-nucleosomes-is-facilitated-by-transient-unwrapping-of-dna-and-is-influenced-by-the-local-histone-environment
#11
Katharina Bilotti, Erin E Kennedy, Chuxuan Li, Sarah Delaney
If unrepaired, damage to genomic DNA can cause mutations and/or be cytotoxic. Single base lesions are repaired via the base excision repair (BER) pathway. The first step in BER is the recognition and removal of the nucleobase lesion by a glycosylase enzyme. For example, human oxoguanine glycosylase 1 (hOGG1) is responsible for removal of the prototypic oxidatively damaged nucleobase, 8-oxo-7,8-dihydroguanine (8-oxoG). To date, most studies of glycosylases have used free duplex DNA substrates. However, cellular DNA is packaged as repeating nucleosome units, with 145 base pair segments of DNA wrapped around histone protein octamers...
September 1, 2017: DNA Repair
https://www.readbyqxmd.com/read/28891464/concentration-dependent-chromatin-states-induced-by-the-bicoid-morphogen-gradient
#12
Colleen E Hannon, Shelby A Blythe, Eric F Wieschaus
In Drosophila, graded expression of the maternal transcription factor Bicoid (Bcd) provides positional information to activate target genes at different positions along the anterior-posterior axis. We have measured the genome-wide binding profile of Bcd using ChIP-seq in embryos expressing single, uniform levels of Bcd protein, and grouped Bcd-bound targets into four classes based on occupancy at different concentrations. By measuring the biochemical affinity of target enhancers in these classes in vitro and genome-wide chromatin accessibility by ATAC-seq, we found that the occupancy of target sequences by Bcd is not primarily determined by Bcd binding sites, but by chromatin context...
September 11, 2017: ELife
https://www.readbyqxmd.com/read/28890470/circulating-angptl2-levels-increase-in-humans-and-mice-exhibiting-cardiac-dysfunction
#13
Zhe Tian, Keishi Miyata, Jun Morinaga, Haruki Horiguchi, Tsuyoshi Kadomatsu, Motoyoshi Endo, Jiabin Zhao, Shunshun Zhu, Taichi Sugizaki, Michio Sato, Kazutoyo Terada, Takahiro Okumura, Toyoaki Murohara, Yuichi Oike
BACKGROUND: Recently, it was reported that angiopoietin-like protein 2 (ANGPTL2) secreted from a pathologically stressed heart accelerates cardiac dysfunction in an autocrine/paracrine manner, and that suppression of ANGPTL2 production in the heart restored cardiac function and myocardial energy metabolism, thereby blocking heart failure (HF) development. Interestingly, circulating ANGPTL2 concentrations reportedly increase in HF patients, suggesting a possible endocrine effect on cardiac dysfunction...
September 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28890304/hemodynamic-parameters-that-may-predict-false-lumen-growth-in-type-b-aortic-dissection-after-endovascular-repair-a-preliminary-study-on-long-term-multiple-follow-ups
#14
Huanming Xu, Zhenfeng Li, Huiwu Dong, Yilun Zhang, Jianyong Wei, Paul N Watton, Wei Guo, Duanduan Chen, Jiang Xiong
Thoracic endovascular aortic repair (TEVAR) is commonly applied in type-B aortic dissection. For patients with dissection affects descending aorta and extends downward to involve abdominal aorta and possibly iliac arteries, false lumen (FL) expansion might occur post-TEVAR. Predictions of dissection development may assist in medical decision on re-intervention or surgery. In this study, two patients are selected with similar morphological features at initial presentation but with different long-term FL development post-TEVAR (stable and enlarged FL)...
September 7, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28890257/effects-of-pdgf-bb-delivery-from-heparinized-collagen-sutures-on-the-healing-of-lacerated-chicken-flexor-tendon-in-vivo
#15
Mousa Younesi, Derrick M Knapik, Jameson Cumsky, Baris Ozgur Donmez, Ping He, Anowarul Islam, Greg Learn, Philip McClellan, Michael Bohl, Robert J Gillespie, Ozan Akkus
Flexor tendon lacerations are traditionally repaired by using non-absorbable monofilament sutures. Recent investigations have explored to improve the healing process by growth factor delivery from the sutures. However, it is difficult to conjugate growth factors to nylon or other synthetic sutures. This study explores the performance of a novel electrochemically aligned collagen suture in a flexor tendon repair model with and without platelet derived growth factor following complete tendon laceration in vivo...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28878133/exome-capture-rna-sequencing-of-decade-old-breast-cancers-and-matched-decalcified-bone-metastases
#16
Nolan Priedigkeit, Rebecca J Watters, Peter C Lucas, Ahmed Basudan, Rohit Bhargava, William Horne, Jay K Kolls, Zhou Fang, Margaret Q Rosenzweig, Adam M Brufsky, Kurt R Weiss, Steffi Oesterreich, Adrian V Lee
Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen receptor-positive (ER-positive) breast cancer; yet, characterizations of human specimens are limited. In this study, exome-capture RNA sequencing (ecRNA-seq) on aged (8-12 years), formalin-fixed, paraffin-embedded (FFPE), and decalcified cancer specimens was evaluated. Gene expression values and ecRNA-seq quality metrics from FFPE or decalcified tumor RNA showed minimal differences when compared with matched flash-frozen or nondecalcified tumors...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28877394/her2-breast-cancer-cells-undergo-apoptosis-upon-exposure-to-tannic-acid-released-from-remodeled-crosslinked-collagen-type-i
#17
Lauren G Jordan, Brian W Booth
Tannic acid (TA) is a naturally occurring polyphenol that crosslinks collagen type I and possesses anti-cancer potential. In previous studies, we demonstrated the increased sensitivity of estrogen receptor-positive (ER(+) ) breast cancer cells to TA as opposed to triple negative breast cancer cells and normal human breast epithelial cells. In the current study, human pre-adipocytes and HER2+ breast cancer cells were grown on TA-crosslinked collagen type I beads. Cell attachment, growth, and proliferation of the cells result in remodeling of the collagen matrix and release of the crosslinking TA...
September 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28875528/transplantation-of-artificial-human-lymphatic-vascular-tissues-fabricated-using-a-cell-accumulation-technique-and-their-engraftment-in-mouse-tissue-with-vascular-remodeling
#18
Yoshiya Asano, Hiroshi Shimoda, Michiya Matsusaki, Mitsuru Akashi
Transplantation of engineered tissues with microvascular structure is advancing towards therapeutic application to improve the flow of blood and/or lymphatic fluids. In lymphatic disorders, transplantation of tissue-engineered lymphatic grafts can be an ideal treatment for draining excessive lymphatic fluid. In this study, we examined the transplantation of three-dimensional artificial human lymphatic network tissue (AHLT) fabricated by the cell accumulation technique into the subcutaneous tissue and fascia of mice...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28874564/endodermal-germ-layer-formation-through-active-actin-driven-migration-triggered-by-n-cadherin
#19
Florence A Giger, Nicolas B David
Germ-layer formation during gastrulation is both a fundamental step of development and a paradigm for tissue formation and remodeling. However, the cellular and molecular basis of germ-layer segregation is poorly understood, mostly because of the lack of direct in vivo observations. We used mosaic zebrafish embryos to investigate the formation of the endoderm. High-resolution live imaging and functional analyses revealed that endodermal cells reach their characteristic innermost position through an active, oriented, and actin-based migration dependent on Rac1, which contrasts with the previously proposed differential adhesion cell sorting...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28874462/%C3%AE-arrestin2-improves-post-myocardial-infarction-heart-failure-via-sarco-endo-plasmic-reticulum-ca-2-atpase-dependent-positive-inotropy-in-cardiomyocytes
#20
Katie A McCrink, Jennifer Maning, Angela Vu, Malika Jafferjee, Christine Marrero, Ava Brill, Ashley Bathgate-Siryk, Samalia Dabul, Walter J Koch, Anastasios Lymperopoulos
Heart failure is the leading cause of death in the Western world, and new and innovative treatments are needed. The GPCR (G protein-coupled receptor) adapter proteins βarr (β-arrestin)-1 and βarr-2 are functionally distinct in the heart. βarr1 is cardiotoxic, decreasing contractility by opposing β1AR (adrenergic receptor) signaling and promoting apoptosis/inflammation post-myocardial infarction (MI). Conversely, βarr2 inhibits apoptosis/inflammation post-MI but its effects on cardiac function are not well understood...
September 5, 2017: Hypertension
keyword
keyword
114296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"