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REVIEW
Sofia Fatima Giuseppina Colombo, Chiara Nava, Francesca Castoldi, Valentina Fabiano, Fabio Meneghin, Gianluca Lista, Francesco Cavigioli
The aim of this scoping review was to investigate and synthesize existing evidence on the airway microbiome of preterm infants to outline the prognostic and therapeutic significance of these microbiomes within the preterm population and identify gaps in current knowledge, proposing avenues for future research. We performed a scoping review of the literature following the Arskey and O'Malley framework. In accordance with our inclusion criteria and the intended purpose of this scoping review, we identified a total of 21 articles...
February 6, 2024: Nutrients
#2
RANDOMIZED CONTROLLED TRIAL
Abhijit Duggal, Steven A Conrad, Nicholas A Barrett, Mohamed Saad, Tariq Cheema, Sonal Pannu, Ramiro Saavedra Romero, Laurent Brochard, Stefano Nava, V Marco Ranieri, Alexandra May, Daniel Brodie, Nicholas S Hill
Rationale: It is unclear whether extracorporeal CO2 removal (ECCO2 R) can reduce the rate of intubation or the total time on invasive mechanical ventilation (IMV) in adults experiencing an exacerbation of chronic obstructive pulmonary disease (COPD). Objectives: To determine whether ECCO2 R increases the number of ventilator-free days within the first 5 days postrandomization (VFD-5) in exacerbation of COPD in patients who are either failing noninvasive ventilation (NIV) or who are failing to wean from IMV...
March 1, 2024: American Journal of Respiratory and Critical Care Medicine
#3
JOURNAL ARTICLE
Daniel H Arellano, Roberto Brito, Caio C A Morais, Pablo Ruiz-Rudolph, Abraham I J Gajardo, Dannette V Guiñez, Marioli T Lazo, Ivan Ramirez, Verónica A Rojas, María A Cerda, Juan N Medel, Victor Illanes, Nivia R Estuardo, Alejandro R Bruhn, Laurent J Brochard, Marcelo B P Amato, Rodrigo A Cornejo
BACKGROUND: Internal redistribution of gas, referred to as pendelluft, is a new potential mechanism of effort-dependent lung injury. Neurally-adjusted ventilatory assist (NAVA) and proportional assist ventilation (PAV +) follow the patient's respiratory effort and improve synchrony compared with pressure support ventilation (PSV). Whether these modes could prevent the development of pendelluft compared with PSV is unknown. We aimed to compare pendelluft magnitude during PAV + and NAVA versus PSV in patients with resolving acute respiratory distress syndrome (ARDS)...
December 20, 2023: Annals of Intensive Care
#4
JOURNAL ARTICLE
Alex Lepage-Farrell, Laurence Tabone, Virginie Plante, Atsushi Kawaguchi, Joshua Feder, Sally Al Omar, Guillaume Emeriaud
OBJECTIVES: To describe our experience of using noninvasive neurally adjusted ventilatory assist (NIV-NAVA) in infants with bronchiolitis, its association with the evolution of respiratory effort, and PICU outcomes. DESIGN: Retrospective analysis of a prospectively curated, high-frequency electronic database. SETTING: A PICU in a university-affiliated maternal-child health center in Canada. PATIENTS: Patients younger than 2 years old who were admitted with a diagnosis of acute bronchiolitis and treated with NIV-NAVA from October 2016 to June 2018...
March 1, 2024: Pediatric Critical Care Medicine
#5
REVIEW
Yuliang Sheng, Wei Shao, Yuhao Wang, Xiuwen Kang, Rong Hu
Mechanical ventilation has, since its introduction into clinical practice, undergone a major evolution from controlled ventilation to diverse modes of assisted ventilation. Conventional mechanical ventilators depend on flow sensors and pneumatic pressure and controllers to complete the respiratory cycle. Neurally adjusted ventilatory assist (NAVA) is a new form of assisted ventilation in recent years, which monitors the electrical activity of the diaphragm (EAdi) to provide an appropriately level of pressure support...
November 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
#6
REVIEW
Saikiran Mandyam, Muhammad Qureshi, Yamini Katamreddy, Devam Parghi, Priyanka Patel, Vidhi Patel, Fnu Anshul
Mechanical ventilation serves as crucial life support for critically ill patients. Although it is life-saving prolonged ventilation carries risks and complications like barotrauma, Ventilator-associated pneumonia, sepsis, and many others. Optimizing patient-ventilator interactions and facilitating early weaning is necessary for improved intensive care unit (ICU) outcomes. Traditionally Pressure support ventilation (PSV) mode is widely used for weaning patients who are intubated and mechanically ventilated. Neurally adjusted ventilatory assist (NAVA) mode of the ventilator is an emerging ventilator mode that delivers pressure depending on the patient's respiratory drive, which in turn prevents over-inflation and improves the patient's ventilator interactions...
November 15, 2023: Journal of Intensive Care Medicine
#7
JOURNAL ARTICLE
Prateek Sehgal, Dominique Piquette, Michael Detsky, Nava Maham, Maria Jogova, David Hall, Hannah Wozniak, Margaret Herridge
No abstract text is available yet for this article.
October 12, 2023: American Journal of Respiratory and Critical Care Medicine
#8
JOURNAL ARTICLE
Ignacio Martin-Loeches, Luis Felipe Reyes, Saad Nseir, Otavio Ranzani, Pedro Povoa, Emili Diaz, Marcus J Schultz, Alejandro H Rodríguez, Cristian C Serrano-Mayorga, Gennaro De Pascale, Paolo Navalesi, Mauro Panigada, Luis Miguel Coelho, Szymon Skoczynski, Mariano Esperatti, Andrea Cortegiani, Stefano Aliberti, Anselmo Caricato, Helmut J F Salzer, Adrian Ceccato, Rok Civljak, Paolo Maurizio Soave, Charles-Edouard Luyt, Pervin Korkmaz Ekren, Fernando Rios, Joan Ramon Masclans, Judith Marin, Silvia Iglesias-Moles, Stefano Nava, Davide Chiumello, Lieuwe D Bos, Antoni Artigas, Filipe Froes, David Grimaldi, Fabio Silvio Taccone, Massimo Antonelli, Antoni Torres
PURPOSE: Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to the intensive care unit (ICU). We aim to report the clinical characteristics of ICU-admitted patients due to nosocomial LRTI and to describe their microbiology and clinical outcomes. METHODS: A prospective observational study was conducted in 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics and outcomes of ventilator-associated pneumonia (VAP), ventilator-associated tracheobronchitis (VAT), ICU hospital-acquired pneumonia (ICU-HAP), HAP that required invasive ventilation (VHAP), and HAP in patients transferred to the ICU without invasive mechanical ventilation were collected...
October 2023: Intensive Care Medicine
#9
JOURNAL ARTICLE
Ling Liu, Hong-Liang Li, Cong Lu, Purab Patel, Danqiong Wang, Jennifer Beck, Christer Sinderby
BACKGROUND: Mechanical ventilation is applied to unload the respiratory muscles, but knowledge about transpulmonary driving pressure (ΔPL ) is important to minimize lung injury. We propose a method to estimate ΔPL during neurally synchronized assisted ventilation, with a simple intervention of lowering the assist for one breath ("lower assist maneuver", LAM). METHODS: In 24 rabbits breathing spontaneously with imposed loads, titrations of increasing assist were performed, with two neurally synchronized modes: neurally adjusted ventilatory assist (NAVA) and neurally triggered pressure support (NPS)...
August 25, 2023: Critical Care: the Official Journal of the Critical Care Forum
#10
REVIEW
Irene Prediletto, Gilda Giancotti, Stefano Nava
Chronic obstructive pulmonary disease (COPD) is one of the major causes of morbidity and mortality worldwide. Hospitalization due to acute exacerbations of COPD (AECOPD) is a relevant health problem both for its impact on disease outcomes and on health system resources. Severe AECOPD causing acute respiratory failure (ARF) often requires admission to an intensive care unit (ICU) with endotracheal intubation and invasive mechanical ventilation. AECOPD also acts as comorbidity in critically ill patients; this condition is associated with poorer prognoses...
May 9, 2023: Journal of Clinical Medicine
#11
JOURNAL ARTICLE
Arsenio De La Vega Sánchez, Ana Navas Pérez, Marcos Pérez-Carrasco, María Torrens Sonet, Yolanda Diaz Buendia, Patricia Ortiz Ballujera, Miguel Rodríguez López, Joan Sabater Riera, Aitor Olmo-Isasmendi, Ester Vendrell Torra, María Álvarez García-Pumarino, Mercedes Ibarz Villamayor, Rosa María Catalán Ibars, Iban Oliva Zelaya, Javier Pardos Chica, Conxita Rovira Anglès, Teresa M Tomasa-Irriguible, Anna Baró Serra, Edward J Casanova, Francisco J González De Molina
This study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during the first pandemic wave. We performed a prospective, observational, multicenter study of confirmed COVID-19 patients admitted to 19 intensive care units (ICUs) in Catalonia (Spain). Data regarding demographics, comorbidities, drug and medical treatment, physiological and laboratory results, AKI development, need for renal replacement therapy (RRT) and clinical outcomes were collected. Descriptive statistics and logistic regression analysis for AKI development and mortality were used...
2023: PloS One
#12
JOURNAL ARTICLE
Kui Wang, Yun Tang, Xiubin Tao, Mengke Jiang, Yunyou Dou, Wei Zhang, Tao Yu, Guiliang Wang, Zhen Fan, Nianlong Wu
OBJECTIVE: To explore the prognostic effect and safety of neurally adjusted ventilatory assist (NAVA) mode on the patients with severe neurological cerebrovascular disease undergoing mechanical ventilation. METHODS: A prospective study was conducted. Fifty-four patients with cerebrovascular disease undergoing mechanical ventilation admitted to the neurosurgery intensive care unit (NSICU) of the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital) from December 2020 to May 2022 were enrolled...
February 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
#13
JOURNAL ARTICLE
Antonio Piralla, Francesco Mojoli, Laura Pellegrinelli, Ferruccio Ceriotti, Antonia Valzano, Giacomo Grasselli, Maria Rita Gismondo, Valeria Micheli, Antonio Castelli, Claudio Farina, Marco Arosio, Ferdinando Luca Lorini, Diana Fanti, Andrea Busni, Matteo Laratta, Fabrizio Maggi, Federica Novazzi, Luca Cabrini, Anna Paola Callegaro, Roberto Keim, Giuseppe Remuzzi, Annalisa Cavallero, Sergio Maria Ivano Malandrin, Roberto Rona, Federica Giardina, Guglielmo Ferrari, Federica Zavaglio, Piera D'angelo, Cristina Galli, Laura Bubba, Sandro Binda, Massimo Oggioni, Sara Colonia Uceda Renteria, Patrizia Bono, Andreina Baj, Francesca Drago Ferrante, Davide Guarneri, Marco Tonelli, Gavino Napolitano, Alice Nava, Lorenzo Romeo, Elena Nicolini, Rea Valaperta, Ludovica Varisano, Caterina Mele, Lucia Liguori, Monica Raggi, Silvia Mongodi, Michele Pagani, Paolo Severgnini, Dario Gasberti, Ezio Bonanomi, Paolo Gritti, Francesco Marrazzo, Ilaria Giovannini, Noemi Sacchi, Orlando Sagliocco, Danilo Cereda, Sabrina Buoro, Fausto Baldanti, Elena Pariani
This multicenter observational study included 171 COVID-19 adult patients hospitalized in the ICUs of nine hospitals in Lombardy (Northern Italy) from December, 1st 2021, to February, 9th 2022. During the study period, the Delta/Omicron variant ratio of cases decreased with a delay of two weeks in ICU patients compared to that in the community; a higher proportion of COVID-19 unvaccinated patients was infected by Delta than by Omicron whereas a higher rate of COVID-19 boosted patients was Omicron-infected. A higher number of comorbidities and a higher comorbidity score in ICU critically COVID-19 inpatients was positively associated with the Omicron infection as well in vaccinated individuals...
March 3, 2023: Respiratory medicine and research
#14
JOURNAL ARTICLE
Davide Ottolina, Beatrice Cairo, Tommaso Fossali, Claudio Mazzucco, Antonio Castelli, Roberto Rech, Emanuele Catena, Alberto Porta, Riccardo Colombo
Respiration and cardiac activity are strictly interconnected with reciprocal influences. They act as weakly coupled oscillators showing varying degrees of phase synchronization and their interactions are affected by mechanical ventilation. The study aims at differentiating the impact of three ventilatory modes on the cardiorespiratory phase coupling in critically ill patients. The coupling between respiration and heartbeat was studied through cardiorespiratory phase synchronization analysis carried out via synchrogram during pressure control ventilation (PCV), pressure support ventilation (PSV), and neurally adjusted ventilatory assist (NAVA) in critically ill patients...
January 26, 2023: Medical & Biological Engineering & Computing
#15
JOURNAL ARTICLE
Bharath A Chhabria, Kuruswamy Thurai Prasad, Sahajal Dhooria, Valliappan Muthu, Ashutosh Nath Aggarwal, Ritesh Agarwal, Raghava Rao Gandra, Inderpaul Singh Sehgal
PURPOSE: No study has compared neurally adjusted ventilator assist (NAVA) with adaptive support ventilation (ASV) during non-invasive ventilation (NIV) in subjects with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). MATERIALS AND METHODS: In this randomized controlled trial, we compared NAVA-NIV with ASV-NIV for delivering NIV in consecutive subjects with AECOPD. The primary outcome was NIV failure rate (invasive mechanical ventilation). The key secondary outcomes were number of NIV manipulations, asynchrony index, and 90-day mortality...
January 19, 2023: Journal of Critical Care
#16
JOURNAL ARTICLE
Alessio Dell'Olio, Caterina Vocale, Alessandra Primavera, Lara Pisani, Salvatore Altavilla, Greta Roncarati, Fabio Tumietto, Pierluigi Viale, Maria Carla Re, Tiziana Lazzarotto, Stefano Nava, V Marco Ranieri, Tommaso Tonetti
BACKGROUND: Environmental contamination by SARS-CoV-2 from patients with COVID-19 undergoing noninvasive ventilation (NIV) in the ICU is still under investigation. This study set out to investigate the presence of SARS-CoV-2 on surfaces near subjects receiving NIV in the ICU under controlled conditions (ie, use of dual-limb circuits, filters, adequate room ventilation). METHODS: This was a single-center, prospective, observational study in the ICU of a tertiary teaching hospital...
November 15, 2022: Respiratory Care
#17
JOURNAL ARTICLE
Tommaso Tonetti, V Marco Ranieri, Paolo Navalesi, Stefano Nava, Arthur S Slutsky
No abstract text is available yet for this article.
May 12, 2022: American Journal of Respiratory and Critical Care Medicine
#18
María Jesús Valero, Jose L Muñoz-Blanco, Alejandro Garrido Sanchez, Gregorio Cuerpo, Javier Castrodeza, Paula Navas, Iago Sousa, Adolfo Villa, Francisco Fernández-Avilés, Manuel Martínez-Sellés
The information on heart transplantation (HT) in patients with Friedreich's Ataxia (FA) is scarce, and the few published case reports are limited to young patients with mild neurological manifestations. We present the case of a 58-year-old patient with advanced FA (Scale for the Assessment and Rating of Ataxia [SARA] score 30/40), wheelchair-bound for the last 16 years and had urinary incontinence, dysarthria, and neurosensorial deafness. The patient was admitted for a refractory arrhythmic storm and had previous hypertrophic cardiomyopathy that evolved to dilated cardiomyopathy with severely reduced left ventricular ejection fraction and recurrent ventricular arrhythmias...
March 9, 2022: Journal of Cardiovascular Development and Disease
#19
RANDOMIZED CONTROLLED TRIAL
Vijay Hadda, Sourabh Pahuja, Saurabh Mittal, Karan Madan, Maroof A Khan, Anant Mohan, Randeep Guleria
BACKGROUND: Better patient-ventilator interactions, during neurally adjusted ventilator assist (NAVA), are expected to result in lower rate of diaphragm dysfunction. OBJECTIVE: This study was planned to compare the rate of diaphragm dysfunction between the conventional modes of mechanical ventilation and NAVA. METHODS: Patients who were initiated on mechanical ventilation for acute respiratory failure were randomized to continue either conventional mode of mechanical ventilation or switched to NAVA...
May 2022: Heart & Lung: the Journal of Critical Care
#20
REVIEW
L C Song, L X Xie
In this review, we outlined the clinical studies in critical care field of pulmonary medicine from November 1, 2020 to September 30, 2021. A Chinese retrospective study for critically ill patients with COVID-19 showed that corticosteroid therapy was associated with a reduced 28-day mortality in patients with the hyperinflammatory phenotype. In hospitalized patients with COVID-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization, and early sedation with dexmedetomidine exhibited a high probability of reduced 90-day mortality in older patients regardless of operative or non-operative cluster status...
January 12, 2022: Chinese Journal of Tuberculosis and Respiratory Diseases
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