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https://www.readbyqxmd.com/read/28091784/recognition-of-d-penicillamine-using-schiff-base-centered-fluorescent-organic-nanoparticles-and-application-to-medicine-analysis
#1
Prasad G Mahajan, Govind B Kolekar, Shivajirao R Patil
Schiff base centered fluorescent organic compound 1,1'-[(1E,2E)-hydrazine-1,2-diylidenedi(E)methylylidene]- dinaphthalen-2-ol (HN) was synthesized followed by spectral characterization viz., NMR, IR and Mass spectroscopy. The fluorescent nanoparticles of HN prepared using reprecipitation method shows red shifted aggregation induced enhanced emission (AIEE) with respect to HN solution in acetone. The average particle size of nanoparticles (HNNPs) is of 67.2 nm shows sphere shape morphology. The surfactant cetyltrimethyl ammonium bromide (CTAB) used to stabilize HNNPs induces positive charge surface with zeta potential of 11...
January 14, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28091714/comparison-of-potential-higher-order-reference-methods-for-total-haemoglobin-quantification-an-interlaboratory-study
#2
Claudia Frank, Christine Brauckmann, Marie Palos, Cristian G Arsene, Joerg Neukammer, Maria Estela Del Castillo Busto, Sabine Zakel, Claudia Swart, Bernd Güttler, Rainer Stosch
The total haemoglobin (Hb) concentration in blood is one of the most frequently measured analytes in clinical medicine because of its significance for evaluating the health state of a human. The spectrophotometric cyanmethaemoglobin (HiCN) method is the internationally accepted conventional reference method to determine this biomarker. It is frequently used in clinical routine diagnostics but is not traceable to the International System of Units and thus does not meet highest metrological demands. A further critical issue is the toxicity of the necessary potassium cyanide...
January 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28076183/markov-influence-diagrams
#3
Francisco J Díez, Mar Yebra, Iñigo Bermejo, Miguel A Palacios-Alonso, Manuel Arias Calleja, Manuel Luque, Jorge Pérez-Martín
Markov influence diagrams (MIDs) are a new type of probabilistic graphical model that extends influence diagrams in the same way that Markov decision trees extend decision trees. They have been designed to build state-transition models, mainly in medicine, and perform cost-effectiveness analyses. Using a causal graph that may contain several variables per cycle, MIDs can model various patient characteristics without multiplying the number of states; in particular, they can represent the history of the patient without using tunnel states...
February 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28048357/su-f-r-05-multidimensional-imaging-radiomics-geodesics-a-novel-manifold-learning-based-automatic-feature-extraction-method-for-diagnostic-prediction-in-multiparametric-imaging
#4
V Parekh, M A Jacobs
PURPOSE: Multiparametric radiological imaging is used for diagnosis in patients. Potentially extracting useful features specific to a patient's pathology would be crucial step towards personalized medicine and assessing treatment options. In order to automatically extract features directly from multiparametric radiological imaging datasets, we developed an advanced unsupervised machine learning algorithm called the multidimensional imaging radiomics-geodesics(MIRaGe). METHODS: Seventy-six breast tumor patients underwent 3T MRI breast imaging were used for this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035644/dft-and-tddft-investigation-of-the-schiff-base-formed-by-tacrine-and-saccharin
#5
Nursel Acar, Cenk Selçuki, Emine Coşkun
Schiff bases have many chemical and biological applications in medicine and pharmaceuticals due to the presence of an imine group (-C=N-). These bases are used in many different fields of technology, and in photochemistry because of their photochromic properties. Here, the structural and electronic properties of the Schiff base formed by tacrine and saccharin (TacSac) were explored using density functional theory with the B3LYP, M06-2X, M06L, and ωB97XD functionals in combination with the 6-311++G(d,p) basis set...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28032246/identification-and-characterization-of-diploid-and-tetraploid-in-platycodon-grandiflorum
#6
Jeoung-Hwa Shin, Yun Gyong Ahn, Ju-Hee Jung, Sun-Hee Woo, Hag-Hyun Kim, Shela Gorinstein, Hee-Ock Boo
Platycodon grandiflorum (PG), a species of herbaceous flowering perennial plant of the family Campanulaceae, has been used as a traditional oriental medicine for bronchitis, asthma, pulmonary tuberculosis, diabetes, hepatic fibrosis, bone disorders and many others similar diseases and as a food supplement. For the primary profiling of PG gas chromatography coupled with high resolution - time of flight mass spectrometry (GC/HR-TOF MS) was used as an analytical tool. A comparison of optimal extraction of metabolites was carried out with a number of solvents [hexane, methylene chloride, methanol, ethanol, methanol: ethanol (70:30, v:v)]...
December 28, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28030666/annals-graphic-medicine-breach-of-confidentiality
#7
Caroline Shooner
No abstract text is available yet for this article.
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28027346/graphic-medicine-the-best-of-2016
#8
Michael J Green, M K Czerwiec
No abstract text is available yet for this article.
27, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27994638/platelet-12-lipoxygenase-targeting-via-a-newly-synthesized-curcumin-derivative-radiolabeled-with-technetium-99m
#9
Reem Ibrahim Al-Wabli, Tamer Mostafa Mohamed Hafez Sakr, Mohammed Abdou Khedr, Adly Abdallah Selim, Mohamed Abd El-Motaleb Abd El-Rahman, Wafaa Abdou Zaghary
BACKGROUND: One of the most popular techniques for cancer detection is the nuclear medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) as a promising target for treating and radio-imaging tumor tissues. Curcumin was reported to inhibit this enzyme via binding to its active site. RESULTS: A novel curcumin derivative was successfully synthesized and characterized with yield of 74%. It was radiolabeled with the diagnostic radioisotope technetium-99m with 84% radiochemical yield and in vitro stability up to 6 h...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27941006/constructing-diagnostic-likelihood-clinical-decisions-using-subjective-versus-statistical-probability
#10
John Kinnear, Ruth Jackson
BACKGROUND: Although physicians are highly trained in the application of evidence-based medicine, and are assumed to make rational decisions, there is evidence that their decision making is prone to biases. One of the biases that has been shown to affect accuracy of judgements is that of representativeness and base-rate neglect, where the saliency of a person's features leads to overestimation of their likelihood of belonging to a group. This results in the substitution of 'subjective' probability for statistical probability...
December 9, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27928425/synthesis-of-acyl-oleanolic-acid-uracil-conjugates-and-their-anti-tumor-activity
#11
Wei-Bin Mo, Chun-Hua Su, Jia-Yan Huang, Jun Liu, Zhen-Feng Chen, Ke-Guang Cheng
BACKGROUND: Oleanolic acid, which can be isolated from many foods and medicinal plants, has been reported to possess diverse biological activities. It has been found that the acylation of the hydroxyl groups of the A-ring in the triterpene skeleton of oleanolic acid could be favorable for biological activities. The pyrimidinyl group has been constructed in many new compounds in various anti-tumor studies. RESULTS: Five acyl oleanolic acid-uracil conjugates were synthesized...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27919219/ston-exploring-biological-pathways-using-the-sbgn-standard-and-graph-databases
#12
Vasundra Touré, Alexander Mazein, Dagmar Waltemath, Irina Balaur, Mansoor Saqi, Ron Henkel, Johann Pellet, Charles Auffray
BACKGROUND: When modeling in Systems Biology and Systems Medicine, the data is often extensive, complex and heterogeneous. Graphs are a natural way of representing biological networks. Graph databases enable efficient storage and processing of the encoded biological relationships. They furthermore support queries on the structure of biological networks. RESULTS: We present the Java-based framework STON (SBGN TO Neo4j). STON imports and translates metabolic, signalling and gene regulatory pathways represented in the Systems Biology Graphical Notation into a graph-oriented format compatible with the Neo4j graph database...
December 5, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27919083/annals-graphic-medicine-the-physiology-of-panic-or-all-systems-go
#13
William J Doan
No abstract text is available yet for this article.
December 6, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27909780/interrogating-the-variation-of-element-masses-and-distribution-patterns-in-single-cells-using-icp-ms-with-a-high-efficiency-cell-introduction-system
#14
Hailong Wang, Meng Wang, Bing Wang, Lingna Zheng, Hanqing Chen, Zhifang Chai, Weiyue Feng
Cellular heterogeneity is an inherent condition of cell populations, which results from stochastic expression of genes, proteins, and metabolites. The heterogeneity of individual cells can dramatically influence cellular decision-making and cell fate. So far, our knowledge about how the variation of endogenous metals and non-metals in individual eukaryotic cells is limited. In this study, ICP-MS equipped with a high efficiency cell introduction system (HECIS) was developed as a method of single-cell ICP-MS (SC-ICP-MS)...
December 1, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27900356/graphical-dataset-on-important-medicinal-plants-used-for-curing-dental-issues-in-manoor-valley-mansehra-pakistan
#15
Inayat Ur Rahman, Farhana Ijaz, Aftab Afzal, Zafar Iqbal, Niaz Ali, Muhammad Azhar Khan, Muhammad Afzal, Said Muhammad, Ghulam Qadir, Muhammad Asif
The graphical dataset in this paper is related to the research article entitled "A novel survey of the ethno medicinal knowledge of dental problems in Manoor Valley (Northern Himalaya), Pakistan" (I.U. Rahman, F. Ijaz, Z. Iqbal, A. Afzal, N. Ali, M. Afzal, M.A. Khan, S. Muhammad, G. Qadir, M. Asif, 2016) [1]. This article describes how the local community of Manoor Valley practices cultural / traditional knowledge for dental problems. For the recorded data of 25 medicinal plants, six quantitative ethnomedicinal statistical approaches / equations were used...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27896724/genomic-database-searching
#16
James R A Hutchins
The availability of reference genome sequences for virtually all species under active research has revolutionized biology. Analyses of genomic variations in many organisms have provided insights into phenotypic traits, evolution and disease, and are transforming medicine. All genomic data from publicly funded projects are freely available in Internet-based databases, for download or searching via genome browsers such as Ensembl, Vega, NCBI's Map Viewer, and the UCSC Genome Browser. These online tools generate interactive graphical outputs of relevant chromosomal regions, showing genes, transcripts, and other genomic landmarks, and epigenetic features mapped by projects such as ENCODE...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27888946/difficult-doctors-difficult-patients-building-empathy
#17
Patricia F Anderson, Elise Wescom, Ruth C Carlos
Effective doctor-patient communication facilitates the therapeutic relationship, promotes patient physical and mental health, and improves physician satisfaction. Methods of teaching effective communication use a range of techniques, typically combining didactic instruction with simulated communication encounters and reflective discussion. Rarely are patients and physicians exposed to these instructions as colearners. The evidence for the utility of graphic stories, comics, and cartoons to improve patient comprehension and self-regulation is small but encouraging...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27862084/intra-and-inter-observer-reproducibility-and-generalizability-of-first-trimester-uterine-artery-pulsatility-index-by-transabdominal-and-transvaginal-ultrasound
#18
Laura Marchi, Eva Zwertbroek, Judith Snelder, Maaike Kloosterman, Caterina Maddalena Bilardo
OBJECTIVES: The primary aim of the study was to assess intra-observer and inter-observer reproducibility and generalizability (general reliability) of first trimester Doppler measurements of uterine arteries (UtA) performed both transabdominally (TA) and transvaginally (TV). Secondary aims were to investigate whether maternal BMI and acquisition modality (transabdominal or transvaginal) affect feasibility and reliability of UtA Doppler evaluation. METHODS: Singleton pregnancies between 11(+0) and 13(+6) weeks underwent TA and TV Doppler measurements of UtA prospectively, blindly and independently by Fetal Medicine Foundation-accredited operators...
December 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27845763/the-chemistry-and-pharmacology-of-citrus-limonoids
#19
REVIEW
Roberta Gualdani, Maria Maddalena Cavalluzzi, Giovanni Lentini, Solomon Habtemariam
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach...
November 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27843438/a-decade-long-commitment-to-antimicrobial-resistance-surveillance-in-portugal
#20
REVIEW
Catarina M Marinho, Tiago Santos, Alexandre Gonçalves, Patrícia Poeta, Gilberto Igrejas
Antimicrobial resistance (AMR) is a worldwide problem with serious health and economic repercussions. Since the 1940s, underuse, overuse, and misuse of antibiotics have had a significant environmental downside. Large amounts of antibiotics not fully metabolized after use in human and veterinary medicine, and other applications, are annually released into the environment. The result has been the development and dissemination of antibiotic-resistant bacteria due to many years of selective pressure. Surveillance of AMR provides important information that helps in monitoring and understanding how resistance mechanisms develop and disseminate within different environments...
2016: Frontiers in Microbiology
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