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https://www.readbyqxmd.com/read/29122394/scientific-notebook-software-applications-for-academic-radiology
#1
Michael L Richardson, Behrang Amini
OBJECTIVES: The goal of this article is to introduce the concept of scientific notebook software, and to illustrate how it can be used to document a research project, to perform image analysis and to create interactive teaching tools. METHODS: We describe the installation of scientific notebook software known as Project Jupyter, which is free, open-source and available for the Macintosh, Windows and Linux operating systems. RESULTS: We have created 2 scientific notebooks that demonstrate applications germane to radiologists, particularly those in academic radiology...
September 18, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29115689/learning-a-variational-network-for-reconstruction-of-accelerated-mri-data
#2
Kerstin Hammernik, Teresa Klatzer, Erich Kobler, Michael P Recht, Daniel K Sodickson, Thomas Pock, Florian Knoll
PURPOSE: To allow fast and high-quality reconstruction of clinical accelerated multi-coil MR data by learning a variational network that combines the mathematical structure of variational models with deep learning. THEORY AND METHODS: Generalized compressed sensing reconstruction formulated as a variational model is embedded in an unrolled gradient descent scheme. All parameters of this formulation, including the prior model defined by filter kernels and activation functions as well as the data term weights, are learned during an offline training procedure...
November 8, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29114747/annals-graphic-medicine-the-problem-list
#3
Kyle Burch
No abstract text is available yet for this article.
November 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29112749/pgg-population-a-database-for-understanding-the-genomic-diversity-and-genetic-ancestry-of-human-populations
#4
Chao Zhang, Yang Gao, Jiaojiao Liu, Zhe Xue, Yan Lu, Lian Deng, Lei Tian, Qidi Feng, Shuhua Xu
There are a growing number of studies focusing on delineating genetic variations that are associated with complex human traits and diseases due to recent advances in next-generation sequencing technologies. However, identifying and prioritizing disease-associated causal variants relies on understanding the distribution of genetic variations within and among populations. The PGG.Population database documents 7122 genomes representing 356 global populations from 107 countries and provides essential information for researchers to understand human genomic diversity and genetic ancestry...
November 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29090328/human-pluripotent-stem-cells-to-engineer-blood-vessels
#5
Xin Yi Chan, Morgan B Elliott, Bria Macklin, Sharon Gerecht
Development of pluripotent stem cells (PSCs) is a remarkable scientific advancement that allows scientists to harness the power of regenerative medicine for potential treatment of disease using unaffected cells. PSCs provide a unique opportunity to study and combat cardiovascular diseases, which continue to claim the lives of thousands each day. Here, we discuss the differentiation of PSCs into vascular cells, investigation of the functional capabilities of the derived cells, and their utilization to engineer microvascular beds or vascular grafts for clinical application...
November 1, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29071403/specific-cell-re-programming-approaches-and-perspectives
#6
Frauke Hausburg, Julia Jeannine Jung, Robert David
Many disorders are manifested by dysfunction of key cell types or their disturbed integration in complex organs. Thereby, adult organ systems often bear restricted self-renewal potential and are incapable of achieving functional regeneration. This underlies the need for novel strategies in the field of cell (re-)programming-based regenerative medicine as well as for drug development in vitro. The regenerative field has been hampered by restricted availability of adult stem cells and the potentially hazardous features of pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
October 26, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29058806/an-epidemic-of-multiple-sclerosis-and-falling-infection-rates-reflecting-on-comparisons-made-and-the-rising-ms-incidence-in-bach-s-nejm-2002-figure
#7
Helen Tremlett, Robyn Lucas
Myths are common in science and research. Findings from a publication in a high impact, influential journal, can be accepted as fact, with an assumption that the peer review process ensures study validity. Repeated presentation of graphical representations or summary statements at scientific meetings and through citation in publications can cement the findings such that they guide 'understanding' of science and future research directions. Such may be the case with the multiple sclerosis (MS) related epidemiology presented within a wider review article published in 2002 in the New England Journal of Medicine (NEJM)...
October 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29058218/ontology-based-vaccine-adverse-event-representation-and-analysis
#8
Jiangan Xie, Yongqun He
Vaccine is the one of the greatest inventions of modern medicine that has contributed most to the relief of human misery and the exciting increase in life expectancy. In 1796, an English country physician, Edward Jenner, discovered that inoculating mankind with cowpox can protect them from smallpox (Riedel S, Edward Jenner and the history of smallpox and vaccination. Proceedings (Baylor University. Medical Center) 18(1):21, 2005). Based on the vaccination worldwide, we finally succeeded in the eradication of smallpox in 1977 (Henderson, Vaccine 29:D7-D9, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29054263/nmsbuilder-freeware-to-create-subject-specific-musculoskeletal-models-for-opensim
#9
Giordano Valente, Gianluigi Crimi, Nicola Vanella, Enrico Schileo, Fulvia Taddei
BACKGROUND AND OBJECTIVE: Musculoskeletal modeling and simulations of movement have been increasingly used in orthopedic and neurological scenarios, with increased attention to subject-specific applications. In general, musculoskeletal modeling applications have been facilitated by the development of dedicated software tools; however, subject-specific studies have been limited also by time-consuming modeling workflows and high skilled expertise required. In addition, no reference tools exist to standardize the process of musculoskeletal model creation and make it more efficient...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29044753/development-of-a-quantitative-intracranial-vascular-features-extraction-tool-on-3d-mra-using-semiautomated-open-curve-active-contour-vessel-tracing
#10
Li Chen, Mahmud Mossa-Basha, Niranjan Balu, Gador Canton, Jie Sun, Kristi Pimentel, Thomas S Hatsukami, Jenq-Neng Hwang, Chun Yuan
PURPOSE: To develop a quantitative intracranial artery measurement technique to extract comprehensive artery features from time-of-flight MR angiography (MRA). METHODS: By semiautomatically tracing arteries based on an open-curve active contour model in a graphical user interface, 12 basic morphometric features and 16 basic intensity features for each artery were identified. Arteries were then classified as one of 24 types using prediction from a probability model...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29042301/towards-a-first-implementation-of-the-wlimes-approach-in-living-system-studies-advancing-the-diagnostics-and-therapy-in-personalized-medicine
#11
Plamen L Simeonov
The goal of this paper is to advance an extensible theory of living systems using an approach to biomathematics and biocomputation that suitably addresses self-organized, self-referential and anticipatory systems with multi-temporal multi-agents. Our first step is to provide foundations for modelling of emergent and evolving dynamic multi-level organic complexes and their sustentative processes in artificial and natural life systems. Main applications are in life sciences, medicine, ecology and astrobiology, as well as robotics, industrial automation, man-machine interface and creative design...
October 16, 2017: Bio Systems
https://www.readbyqxmd.com/read/29026954/selective-extraction-and-determination-of-chlorogenic-acids-as-combined-quality-markers-in-herbal-medicines-using-molecularly-imprinted-polymers-based-on-a-mimic-template
#12
Wenhua Ji, Mingming Zhang, Huijiao Yan, Hengqiang Zhao, Yan Mu, Lanping Guo, Xiao Wang
We describe a solid-phase extraction adsorbent based on molecularly imprinted polymers (MIPs), prepared with use of a mimic template. The MIPs were used for the selective extraction and determination of three chlorogenic acids as combined quality markers for Lonicera japonica and Lianhua qingwen granules. The morphologies and surface groups of the MIPs were assessed by scanning electron microscopy, Brunauer-Emmett-Teller surface area analysis, and Fourier transform infrared spectroscopy. The adsorption isotherms, kinetics, and selectivity of the MIPs were systematically compared with those of non-molecularly imprinted polymers...
October 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29026940/advanced-bioanalytics-for-precision-medicine
#13
Aldo Roda, Elisa Michelini, Cristiana Caliceti, Massimo Guardigli, Mara Mirasoli, Patrizia Simoni
Precision medicine is a new paradigm that combines diagnostic, imaging, and analytical tools to produce accurate diagnoses and therapeutic interventions tailored to the individual patient. This approach stands in contrast to the traditional "one size fits all" concept, according to which researchers develop disease treatments and preventions for an "average" patient without considering individual differences. The "one size fits all" concept has led to many ineffective or inappropriate treatments, especially for pathologies such as Alzheimer's disease and cancer...
October 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29019458/visualizing-the-geography-of-the-diseases-of-china-western-disease-maps-from-analytical-tools-to-tools-of-empire-sovereignty-and-public-health-propaganda-1878-1929
#14
Marta Hanson
Argument This article analyzes for the first time the earliest western maps of diseases in China spanning fifty years from the late 1870s to the end of the 1920s. The 24 featured disease maps present a visual history of the major transformations in modern medicine from medical geography to laboratory medicine wrought on Chinese soil. These medical transformations occurred within new political formations from the Qing dynasty (1644-1911) to colonialism in East Asia (Hong Kong, Taiwan, Manchuria, Korea) and hypercolonialism within China (Tianjin, Shanghai, Amoy) as well as the new Republican Chinese nation state (1912-49)...
September 2017: Science in Context
https://www.readbyqxmd.com/read/28984353/care-maps-for-children-with-medical-complexity
#15
Sherri Adams, David Nicholas, Sanjay Mahant, Natalie Weiser, Ronik Kanani, Katherine Boydell, Eyal Cohen
AIM: Children with medical complexity require multiple providers and services to keep them well and at home. A care map is a patient/family-created diagram that pictorially maps out this complex web of services. This study explored what care maps mean for families and healthcare providers to inform potential for clinical use. METHOD: Parents (n=15) created care maps (hand drawn n=10 and computer-generated n=5) and participated in semi-structured interviews about the process of developing care maps and their perceived impact...
October 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28975371/bithiophenic-maldi-matrices-as-valuable-leads-for-the-selective-detection-of-alkaloids
#16
Ali Jaber, Denis Seraphin, David Guilet, Junichi Osuga, Edmond Cheble, Ghassan Ibrahim, Pascal Richomme, Andreas Schinkovitz
Alkaloids represent a group of biologically most interesting compounds commonly used in modern medicines but also known for exhibiting severe toxic effects. Therefore, the detection of alkaloids is an important issue in quality control of plants, dietary supplements, and herbal pharmaceutical and mostly facilitated by methods such as GC or LC-MS. However, benefitting from the development of selective matrices as well as requiring very little sample preparation, MALDI-MS may also provide a valuable supplement to these standard analytical methods...
October 3, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28973216/annals-graphic-medicine-every-little-bit
#17
Allison K Weinstock
No abstract text is available yet for this article.
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28963670/development-of-an-lc-ms-ms-method-with-protein-g-purification-strategy-for-quantifying-bevacizumab-in-human-plasma
#18
Huai-Hsuan Chiu, I-Lin Tsai, Yen-Shen Lu, Ching-Hung Lin, Ching-Hua Kuo
Biopharmaceutical products such as protein drugs and monoclonal antibodies (mAb) are currently of great interest with monoclonal antibody drugs being one of the fastest growing categories of biopharmaceutical products. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has gained high interest for measuring mAb drugs in biological samples in recent years due to its high selectivity. Bevacizumab is a humanized immunoglobulin G (IgG) mAb drug against human vascular endothelial cell growth factor A (VEGF-A)...
September 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28961917/towards-clinically-more-relevant-dissection-of-patient-heterogeneity-via-survival-based-bayesian-clustering
#19
Ashar Ahmad, Holger Fröhlich
Motivation: Discovery of clinically relevant disease sub-types is of prime importance in personalized medicine. Disease sub-type identification has in the past often been explored in an unsupervised machine learning paradigm which involves clustering of patients based on available-omics data, such as gene expression. A follow-up analysis involves determining the clinical relevance of the molecular sub-types such as that reflected by comparing their disease progressions. The above methodology, however, fails to guarantee the separability of the sub-types based on their subtype-specific survival curves...
November 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28929446/new-imaging-tools-in-cardiovascular-medicine-computational-fluid-dynamics-and-4d-flow-mri
#20
Keiichi Itatani, Shohei Miyazaki, Tokoki Furusawa, Satoshi Numata, Sachiko Yamazaki, Kazuki Morimoto, Rina Makino, Hiroko Morichi, Teruyasu Nishino, Hitoshi Yaku
Blood flow imaging is a novel technology in cardiovascular medicine and surgery. Today, two types of blood flow imaging tools are available: measurement-based flow visualization including 4D flow MRI (or 3D cine phase-contrast magnetic resonance imaging), or echocardiography flow visualization software, and computer flow simulation modeling based on computational fluid dynamics (CFD). MRI and echocardiography flow visualization provide measured blood flow but have limitations in temporal and spatial resolution, whereas CFD flow calculates the flow according to assumptions instead of flow measurement, and it has sufficiently fine resolution up to the computer memory limit, and it enables even virtual surgery when combined with computer graphics...
November 2017: General Thoracic and Cardiovascular Surgery
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