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https://www.readbyqxmd.com/read/27909780/interrogating-the-variation-of-element-masses-and-distribution-patterns-in-single-cells-using-icp-ms-with-a-high-efficiency-cell-introduction-system
#1
Hailong Wang, Meng Wang, Bing Wang, Lingna Zheng, Hanqing Chen, Zhifang Chai, Weiyue Feng
Cellular heterogeneity is an inherent condition of cell populations, which results from stochastic expression of genes, proteins, and metabolites. The heterogeneity of individual cells can dramatically influence cellular decision-making and cell fate. So far, our knowledge about how the variation of endogenous metals and non-metals in individual eukaryotic cells is limited. In this study, ICP-MS equipped with a high efficiency cell introduction system (HECIS) was developed as a method of single-cell ICP-MS (SC-ICP-MS)...
December 1, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27900356/graphical-dataset-on-important-medicinal-plants-used-for-curing-dental-issues-in-manoor-valley-mansehra-pakistan
#2
Inayat Ur Rahman, Farhana Ijaz, Aftab Afzal, Zafar Iqbal, Niaz Ali, Muhammad Azhar Khan, Muhammad Afzal, Said Muhammad, Ghulam Qadir, Muhammad Asif
The graphical dataset in this paper is related to the research article entitled "A novel survey of the ethno medicinal knowledge of dental problems in Manoor Valley (Northern Himalaya), Pakistan" (I.U. Rahman, F. Ijaz, Z. Iqbal, A. Afzal, N. Ali, M. Afzal, M.A. Khan, S. Muhammad, G. Qadir, M. Asif, 2016) [1]. This article describes how the local community of Manoor Valley practices cultural / traditional knowledge for dental problems. For the recorded data of 25 medicinal plants, six quantitative ethnomedicinal statistical approaches / equations were used...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27896724/genomic-database-searching
#3
James R A Hutchins
The availability of reference genome sequences for virtually all species under active research has revolutionized biology. Analyses of genomic variations in many organisms have provided insights into phenotypic traits, evolution and disease, and are transforming medicine. All genomic data from publicly funded projects are freely available in Internet-based databases, for download or searching via genome browsers such as Ensembl, Vega, NCBI's Map Viewer, and the UCSC Genome Browser. These online tools generate interactive graphical outputs of relevant chromosomal regions, showing genes, transcripts, and other genomic landmarks, and epigenetic features mapped by projects such as ENCODE...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27888946/difficult-doctors-difficult-patients-building-empathy
#4
Patricia F Anderson, Elise Wescom, Ruth C Carlos
Effective doctor-patient communication facilitates the therapeutic relationship, promotes patient physical and mental health, and improves physician satisfaction. Methods of teaching effective communication use a range of techniques, typically combining didactic instruction with simulated communication encounters and reflective discussion. Rarely are patients and physicians exposed to these instructions as colearners. The evidence for the utility of graphic stories, comics, and cartoons to improve patient comprehension and self-regulation is small but encouraging...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27862084/intra-and-inter-observer-reproducibility-and-generalizability-of-first-trimester-uterine-artery-pulsatility-index-by-transabdominal-and-transvaginal-ultrasound
#5
Laura Marchi, Eva Zwertbroek, Judith Snelder, Maaike Kloosterman, Caterina Maddalena Bilardo
OBJECTIVES: The primary aim of the study was to assess intra-observer and inter-observer reproducibility and generalizability (general reliability) of first trimester Doppler measurements of uterine arteries (UtA) performed both transabdominally (TA) and transvaginally (TV). Secondary aims were to investigate whether maternal BMI and acquisition modality (transabdominal or transvaginal) affect feasibility and reliability of UtA Doppler evaluation. METHODS: Singleton pregnancies between 11(+0) and 13(+6) weeks underwent TA and TV Doppler measurements of UtA prospectively, blindly and independently by Fetal Medicine Foundation-accredited operators...
November 16, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27845763/the-chemistry-and-pharmacology-of-citrus-limonoids
#6
REVIEW
Roberta Gualdani, Maria Maddalena Cavalluzzi, Giovanni Lentini, Solomon Habtemariam
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach...
November 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27843438/a-decade-long-commitment-to-antimicrobial-resistance-surveillance-in-portugal
#7
REVIEW
Catarina M Marinho, Tiago Santos, Alexandre Gonçalves, Patrícia Poeta, Gilberto Igrejas
Antimicrobial resistance (AMR) is a worldwide problem with serious health and economic repercussions. Since the 1940s, underuse, overuse, and misuse of antibiotics have had a significant environmental downside. Large amounts of antibiotics not fully metabolized after use in human and veterinary medicine, and other applications, are annually released into the environment. The result has been the development and dissemination of antibiotic-resistant bacteria due to many years of selective pressure. Surveillance of AMR provides important information that helps in monitoring and understanding how resistance mechanisms develop and disseminate within different environments...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27815610/matrix-assisted-laser-desorption-ionization-imaging-mass-spectrometry-reveals-changes-of-phospholipid-distribution-in-induced-pluripotent-stem-cell-colony-differentiation
#8
Yasuo Shimizu, Motoyasu Satou, Keitaro Hayashi, Yusuke Nakamura, Mio Fujimaki, Yasuhiro Horibata, Hiromi Ando, Taiji Watanabe, Taichi Shiobara, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Naohiko Anzai, Yoshiki Ishii
Induced pluripotent stem cells (iPSCs) are opening up new possibilities for medicine. Understanding the regulation of iPSC biology is important when attempting to apply these cells to disease models or therapy. Changes of lipid metabolism in iPSCs were investigated by matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry (MALDI-TOF-IMS). Analysis revealed changes of the intensity and distribution of peaks at m/z 782.5 and 798.5 in iPSC colonies during spontaneous differentiation...
November 4, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27802459/annals-graphic-medicine-the-moment
#9
Lucia Briatore, Ilaria Pozzi
No abstract text is available yet for this article.
November 1, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27796454/strategy-for-non-target-ionic-analysis-by-capillary-electrophoresis-with-ultraviolet-detection
#10
Viktoria V Sursyakova, Galina V Burmakina, Anatoly I Rubaylo
A strategy for non-target analysis of samples with unknown composition by capillary electrophoresis (CE) with ultraviolet (UV) detection is suggested. The strategy is based on the preliminary identification of analytes and further optimization of the conditions for their separation using the developed computational tool set ElphoSeparation. It is shown that, in order to record electrophoretic peaks with the mobilities from the maximum to minimum possible values, the positive and negative voltage polarity and hydrodynamic pressure should be used...
October 28, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27790286/sol-gel-encapsulation-of-au-nanoparticles-in-hybrid-silica-improves-gold-oxidation-catalysis
#11
Rosaria Ciriminna, Valerica Pandarus, Riccardo Delisi, Antonino Scurria, Maria Pia Casaletto, Francesco Giordano, François Béland, Mario Pagliaro
BACKGROUND: The introduction of an heterogeneously catalyzed gold-based alcohol oxidation process of broad applicability using a clean primary oxidant would be highly desirable. Gold is non toxic and carbonyl and carboxyl compounds are widely used to produce medicines, plastics, colorants, paints, detergents, fragrances, flavors, and other valued functional products. RESULTS: The sol-gel entrapment of gold nanoparticles in hybrid silica improves gold-based oxidation catalysis applied to the selective oxidation of alcohols with aqueous hydrogen peroxide as eco-friendly primary oxidant...
2016: Chemistry Central Journal
https://www.readbyqxmd.com/read/27782287/graphical-presentation-of-patient-treatment-interaction-elucidated-by-continuous-biomarkers-current-practice-and-scope-for-improvement
#12
Yu-Ming Shen, Lien D Le, Rory Wilson, Ulrich Mansmann
BACKGROUND: Biomarkers providing evidence for patient-treatment interaction are key in the development and practice of personalized medicine. Knowledge that a patient with a specific feature - as demonstrated through a biomarker - would have an advantage under a given treatment vs. a competing treatment can aid immensely in medical decision-making. Statistical strategies to establish evidence of continuous biomarkers are complex and their formal results are thus not easy to communicate...
October 26, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27757513/parallel-single-cell-analysis-of-active-caspase-3-7-in-apoptotic-and-non-apoptotic-cells
#13
Vojtěch Ledvina, Eva Janečková, Eva Matalová, Karel Klepárník
Analysing the chemical content of individual cells has already been proven to reveal unique information on various biological processes. Single-cell analysis provides more accurate and reliable results for biology and medicine than analyses of extracts from cell populations, where a natural heterogeneity is averaged. To meet the requirements in the research of important biologically active molecules, such as caspases, we have developed a miniaturized device for simultaneous analyses of individual cells. A stainless steel body with a carousel holder enables high-sensitivity parallel detections in eight microvials...
October 18, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27730414/survey-of-non-rigid-registration-tools-in-medicine
#14
András P Keszei, Benjamin Berkels, Thomas M Deserno
We catalogue available software solutions for non-rigid image registration to support scientists in selecting suitable tools for specific medical registration purposes. Registration tools were identified using non-systematic search in Pubmed, Web of Science, IEEE Xplore® Digital Library, Google Scholar, and through references in identified sources (n = 22). Exclusions are due to unavailability or inappropriateness. The remaining (n = 18) tools were classified by (i) access and technology, (ii) interfaces and application, (iii) living community, (iv) supported file formats, and (v) types of registration methodologies emphasizing the similarity measures implemented...
October 11, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27702638/application-of-various-control-strategies-to-japanese-encephalitic-a-mathematical-study-with-human-pig-and-mosquito
#15
A De, K Maity, Soovoojeet Jana, M Maiti
Japanese encephalitis (JE) is a public health problem that threats the entire world today. Japanese Encephalitis virus (JEV) mostly became a threat due to the significant number of increase of susceptible mosquito vectors and vertebrate hosts in Asia by which around 70,000 cases and 10,000 deaths per year took place in children below 15 years of age. In this paper, a mathematical model of JE due to JEV from the vector source (infected mosquito) and two vertebrate hosts (infected human and infected pig) is formulated...
December 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27699402/annals-graphic-medicine-today-s-doctor-patient-relationship
#16
Kartik A Valluri
No abstract text is available yet for this article.
October 4, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27659817/volume-determination-of-irregularly-shaped-quasi-spherical-nanoparticles
#17
Ravi Kiran Attota, Eileen Cherry Liu
Nanoparticles (NPs) are widely used in diverse application areas, such as medicine, engineering, and cosmetics. The size (or volume) of NPs is one of the most important parameters for their successful application. It is relatively straightforward to determine the volume of regular NPs such as spheres and cubes from a one-dimensional or two-dimensional measurement. However, due to the three-dimensional nature of NPs, it is challenging to determine the proper physical size of many types of regularly and irregularly-shaped quasi-spherical NPs at high-throughput using a single tool...
November 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27627901/dna-barcoding-and-nmr-spectroscopy-based-assessment-of-species-adulteration-in-the-raw-herbal-trade-of-saraca-asoca-roxb-willd-an-important-medicinal-plant
#18
Santhosh Kumar Jayanthinagar Urumarudappa, Navdeep Gogna, Steven G Newmaster, Krishna Venkatarangaiah, Ragupathy Subramanyam, Seethapathy Gopalakrishnan Saroja, Ravikanth Gudasalamani, Kavita Dorai, Uma Shaanker Ramanan
Saraca asoca (Roxb.) Willd, commonly known as "Asoka" or "Ashoka," is one of the most important medicinal plants used in raw herbal trade in India. The bark extracts of the tree are used in the treatment of leucorrhea and other uterine disorders besides also having anti-inflammatory, anti-bacterial, anti-pyretic, anti-helminthic, and analgesic activity. The indiscriminate and rampant extraction of the wood to meet the ever-increasing market demand has led to a sharp decline in naturally occurring populations of the species in the country...
November 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27619921/evaluation-of-gallium-as-a-tracer-of-exogenous-hemoglobin-haptoglobin-complexes-for-targeted-drug-delivery-applications
#19
Shengsheng Xu, Igor A Kaltashov
Haptoglobin (Hp) is a plasma glycoprotein that generates significant interest in the drug delivery community because of its potential for delivery of antiretroviral medicines with high selectivity to macrophages and monocytes, the latent reservoirs of human immunodeficiency virus. As is the case with other therapies that exploit transport networks for targeted drug delivery, the success of the design and optimization of Hp-based therapies will critically depend on the ability to accurately localize and quantitate Hp-drug conjugates on the varying and unpredictable background of endogenous proteins having identical structure...
September 12, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27614587/the-effect-of-peer-review-on-the-quality-of-data-graphs-in-annals-of-emergency-medicine
#20
David L Schriger, Brian Raffetto, Claire Drolen, Richelle J Cooper
STUDY OBJECTIVE: We determine how peer review affects the quality of published data graphs and how the appointment of a graphics editor affects the quality of graphs in an academic medical journal. METHODS: We conducted an observational time-series analysis to quantify the qualities of data graphs in original manuscripts and published research articles in Annals of Emergency Medicine from 2006 to 2012. We retrospectively analyzed 3 distinct periods: before the use of a graphics editor, graph review after a manuscript's acceptance, and graph review just before the first request for revision...
September 7, 2016: Annals of Emergency Medicine
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