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Graphic medicine

Herbert L Fred, Hendrik A van Dijk
The column in this issue is supplied by Herbert L. Fred, M.D., M.A.C.P., and Hendrik A. van Dijk, both from McGovern Medical School-UT Health, Houston, Texas. Dr. Fred is emeritus professor of medicine and a well-known medical educator and diagnostician. A graduate of Johns Hopkins University School of Medicine, he has authored just under 500 publications including six books. Mr. van Dijk, former director of the University of Texas Health Science Center Medical School's Graphic Communications Group, has devoted 50 years to biomedical communications and is a national expert in that field...
October 2017: Methodist DeBakey Cardiovascular Journal
Nika Marđetko, Mitja Kos
AIM: To assess the impact of the generic reference pricing (GRP) system on the prices and cost of medicines in Slovenia approximately 8 years after its introduction in 2003 and before the implementation of the therapeutic reference pricing system. METHODS: A retrospective study of all medicines (N=789) included in the GRP system on January 31, 2012 was performed. Medicine prices and cost were analyzed between January 31, 2012 and December 31, 2013 after every update (N=11) of the maximum reimbursable price (MRP) and were compared to the price and cost on January 31, 2012 (index date)...
April 30, 2018: Croatian Medical Journal
Konstantinos Sechidis, Konstantinos Papangelou, Paul D Metcalfe, David Svensson, James Weatherall, Gavin Brown
Motivation: The identification of biomarkers to support decision-making is central to personalised medicine, in both clinical and research scenarios. The challenge can be seen in two halves: identifying predictive markers, which guide the development/use of tailored therapies; and identifying prognostic markers, which guide other aspects of care and clinical trial planning, i.e. prognostic markers can be considered as covariates for stratification. Mistakenly assuming a biomarker to be predictive, when it is in fact largely prognostic (and vice-versa) is highly undesirable, and can result in financial, ethical and personal consequences...
May 2, 2018: Bioinformatics
Francesco Ortuso, Donatella Bagetta, Annalisa Maruca, Carmine Talarico, Maria L Bolognesi, Norbert Haider, Fernanda Borges, Sharon Bryant, Thierry Langer, Hanoch Senderowitz, Stefano Alcaro
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optimal pharmacological profile. However, some poorly active or even inactive compounds could live a second life if tested against other targets. Thus, new therapeutic opportunities could emerge and synergistic activities could be identified and exploited for existing compounds by sharing information between researchers who are working on different targets...
2018: Frontiers in Chemistry
Jade R Blue
No abstract text is available yet for this article.
May 1, 2018: Annals of Internal Medicine
Wei Ren, Lingyu Han, Mengyi Luo, Baolin Bian, Ming Guan, Hui Yang, Chao Han, Na Li, Tuo Li, Shilei Li, Yangyang Zhang, Zhenwen Zhao, Haiyu Zhao
Traditional Chinese medicines (TCMs) are undoubtedly treasured natural resources for discovering effective medicines in treating and preventing various diseases. However, it is still extremely difficult for screening the bioactive compounds due to the tremendous constituents in TCMs. In this work, the chemical composition of toad venom was comprehensively analyzed using ultra-high performance liquid chromatography (UPLC) coupled with high-resolution LTQ-Orbitrap mass spectrometry and 93 compounds were detected...
April 28, 2018: Analytical and Bioanalytical Chemistry
Pan Li, Zhiyong Yang, Shan Jiang
Image-guided robot-assisted minimally invasive surgery is an important medicine procedure used for biopsy or local target therapy. In order to reach the target region not accessible using traditional techniques, long and thin flexible needles are inserted into the soft tissue which has large deformation and nonlinear characteristics. However, the detection results and therapeutic effect are directly influenced by the targeting accuracy of needle steering. For this reason, the needle-tissue interactive mechanism, path planning, and steering control are investigated in this review by searching literatures in the last 10 years, which results in a comprehensive overview of the existing techniques with the main accomplishments, limitations, and recommendations...
April 21, 2018: Medical & Biological Engineering & Computing
Michael Koerner, Eliza Fredette, Trudy A Watt, Peter Lloyd Jones
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
Raúl García-Calvo, J L Guisado, Fernando Diaz-Del-Rio, Antonio Córdoba, Francisco Jiménez-Morales
Understanding the regulation of gene expression is one of the key problems in current biology. A promising method for that purpose is the determination of the temporal dynamics between known initial and ending network states, by using simple acting rules. The huge amount of rule combinations and the nonlinear inherent nature of the problem make genetic algorithms an excellent candidate for finding optimal solutions. As this is a computationally intensive problem that needs long runtimes in conventional architectures for realistic network sizes, it is fundamental to accelerate this task...
2018: Evolutionary Bioinformatics Online
J W Qu, X Q Lv, Z M Liu, Y Liao, P H Sun, B Wang, Z Tang
OBJECTIVE: To establish a compact and efficient hypergraph representation and a graph-similarity-based retrieval method of molecules to achieve effective and efficient medicine information retrieval. METHODS: Chemical structural formula (CSF) was a primary search target as a unique and precise identifier for each compound at the molecular level in the research field of medicine information retrieval. To retrieve medicine information effectively and efficiently, a complete workflow of the graph-based CSF retrieval system was introduced...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Milan Grkovski, Karem Gharzeddine, Peter Sawan, Heiko Schoder, Laure Michaud, Wolfgang Andreas Weber, John Laurence Humm
The aim of this study was to investigate the value of pharmacokinetic modeling for quantifying11 C-choline uptake in patients with recurrent prostate cancer. Methods: 194 patients with clinical suspicion of recurrent prostate cancer underwent11 C-choline dynamic PET over the pelvic region (0-8-min), followed by 6 min static acquisition at ~25 min post-injection. Regions of interest (ROIs) were drawn over sites of disease identified by a radiologist with experience in nuclear medicine.11 C-choline uptake and pharmacokinetics were evaluated by standardized uptake value (SUV), graphical analysis (Patlak plot; KiP) and 1- and 2-compartment pharmacokinetic models (K1, K1/k2, k3, k4 and macro-parameter KiC)...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Ashajyothi C, Harish K Handral, Chandrakanth Kelmani R
During the present time, anti-microbial features of copper (Cu) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used to combat the growth of pathogenic microbes. CuNPs and ZnONPs are recurrently used in cosmetics, medicine and food additives, and their potential for toxic impacts on human and ecosystem is of high concern. In this study, the fate and toxicity of 16- to 96-nm-ranged biosynthesized copper (Bio-CuNPs) and zinc oxide (Bio-ZnONPs) was assessed in male Wistar rats. In vivo exposures of the two nanoparticles are achieved through two different administration routes namely, intraperitoneal (i/p) and intravenous (i/v) injections...
April 3, 2018: Nanoscale Research Letters
Caroline Shooner
No abstract text is available yet for this article.
April 3, 2018: Annals of Internal Medicine
Hongmei Liu, Yunxia Luan, Anxiang Lu, Bingru Li, Meihua Yang, JiHua Wang
The article describes an aptamer affinity column for selective solid-phase extraction of aflatoxin B2 (AFB2 ). Amino-modified aptamer against AFB2 was immobilized on CNBr-activated Sepharose through a covalent bond. The effects of oligosorbents based on 3'- or 5'-amino-modified sequences with a C6 or a C7 spacer arm were evaluated by UV spectroscopy at 260 nm. The extraction recovery was evaluated by HPLC with fluorometric detection. The extraction of AFB2 was optimized. Under the optimum conditions, the aptamer affinity column has a linear response to AFB2 in the range of 0...
December 20, 2017: Mikrochimica Acta
Shastri Vandana, Singh Shubnum, Kole Tamorish
BACKGROUND: There is a considerable paucity with regards to the research available on the quality and quantity of clinical teaching in the national emergency department (ED) setups. With the onset of the age of modern medicine, the outlook towards to the time worn tradition of triage and detailed medical evaluation must be revoked. Despite the variety of programs being conducted in the country, a comparable entity common to all is patients' clinical outcomes which can be measured using simple parameters which can be easily acquired compiling hospital registry entries...
2018: World Journal of Emergency Medicine
Marta O Soares, Simon Walker, Stephen J Palmer, Mark J Sculpher
In recent years, Health Technology Assessment (HTA) processes specific to diagnostics and prognostic tests have been created in response to the increased pressure on health systems to decide not only which tests should be used in practice but also the best way to proceed, clinically, from the information they provide. These technologies differ in the way value is accrued to the population of users, depending critically on the value of downstream health care choices. This paper defines an analytical framework for establishing the value of diagnostic and prognostic tests for HTA in a way that is consistent with methods used for the evaluation of other health care technologies...
May 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
Traci A Wolbrink, Lucy Rubin, Jeffrey P Burns, Barry Markovitz
INTRODUCTION: The number of websites for the critical care provider is rapidly growing, including websites that are part of the Free Open Access Med(ical ed)ucation (FOAM) movement. With this rapidly expanding number of websites, critical appraisal is needed to identify quality websites. The last major review of critical care websites was published in 2011, and thus a new review of the websites relevant to the critical care clinician is necessary. METHODS: A new assessment tool for evaluating critical care medicine education websites, the Critical Care Medical Education Website Quality Evaluation Tool (CCMEWQET), was modified from existing tools...
January 1, 2018: Journal of Intensive Care Medicine
Bethany Ober Mannon
The field of narrative medicine holds that personal narratives about illness have the potential to give illness meaning and to create order out of disparate facets of experience, thereby aiding a patient's treatment and resisting universalizing medical discourse. Two narratives of bipolar disorder, Kay Redfield Jamison's prose memoir An Unquiet Mind (1995) and Ellen Forney's graphic memoir Marbles (2012) challenge these ideas. These writers demonstrate that one result of bipolar disorder is a rupture to their sense of identity, making straightforward and verbal forms of narrative impossible...
March 6, 2018: Journal of Medical Humanities
William J Doan
No abstract text is available yet for this article.
March 6, 2018: Annals of Internal Medicine
Sajan Patel, Alvin Rajkomar, James D Harrison, Priya A Prasad, Victoria Valencia, Sumant R Ranji, Michelle Mourad
BACKGROUND: Audit and feedback improves clinical care by highlighting the gap between current and ideal practice. We combined best practices of audit and feedback with continuously generated electronic health record data to improve performance on quality metrics in an inpatient setting. METHODS: We conducted a cluster randomised control trial comparing intensive audit and feedback with usual audit and feedback from February 2016 to June 2016. The study subjects were internal medicine teams on the teaching service at an urban tertiary care hospital...
March 5, 2018: BMJ Quality & Safety
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