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https://www.readbyqxmd.com/read/28894750/factor-xiii-subunit-a-in-the-skin-applications-in-diagnosis-and-treatment
#1
REVIEW
Lilla Paragh, Daniel Törőcsik
The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28878836/newborn-skin-common-skin-problems
#2
Zekayi Kutlubay, Ali Tanakol, Burhan Engýn, Cristina Onel, Ersin Sýmsek, Server Serdaroglu, Yalçýn Tuzun, Erkan Yilmaz, Bülent Eren
The newborn skin can be separated from adult's skin in several ways. In dermatologic examination it can be easily observed that it is thinner, less hairy and has less sweat and sebaceous gland secretions. These differentiations present especially in preterm newborns. Their skin is exposed to mechanical trauma, bacteria and weather, heat alterations. At birth, newborn skin is protected by the coverage of vernix caseosa, which has lubricating and antibacterial features and its pH ranges from 6.7 to 7.4. Beneath the vernix caseosa the skin has a pH of 5...
January 2017: Mædica
https://www.readbyqxmd.com/read/28878204/analysis-of-antineutrophil-cytoplasm-antibody-from-118-730-patients-in-tertiary-hospitals-in-jiangxi-province-china
#3
Liming Tan, Anjun Jiao, Juanjuan Chen, Xiaojing Feng, Liuyue Xu, Siqi He, Fuyan Tan, Yongqing Jiang, Heng Luo, Hua Li, Yang Wu, Yongjian Tian, Tingting Zeng, Jianlin Yu, Liping Cao, Jianfeng Zheng, Hui Xu, Ming Wei, Wen Gan, Weihua Peng, Yanming Liu, Jing Hou, Jiangxia Xu, LiHua Shuai, Wenzhi Huang, Junyun Huang, Yan Lin, Jianrong Liu
BACKGROUND The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA. MATERIAL AND METHODS ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively...
September 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28866648/consensus-based-recommendations-for-the-use-of-biosimilars-to-treat-rheumatological-diseases
#4
Jonathan Kay, Monika M Schoels, Thomas Dörner, Paul Emery, Tore K Kvien, Josef S Smolen, Ferdinand C Breedveld
The study aimed to develop evidence-based recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases. The task force comprised an expert group of specialists in rheumatology, dermatology and gastroenterology, and pharmacologists, patients and a regulator from ten countries. Four key topics regarding biosimilars were identified through a process of discussion and consensus. Using a Delphi process, specific questions were then formulated to guide a systematic literature review...
September 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28831428/considerations-for-dermatologists-when-treating-u-s-military-service-members
#5
C G Kels, L H Kels
Civilian dermatologists sometimes provide care to military service members. This article provides an overview of special considerations that are relevant to the dermatologic treatment of members of the U.S. Armed Forces. We provide a review of the potential implications of certain conditions and treatments for medical retention standards and discuss how service-connected disabilities due to skin conditions are rated and compensated. Understanding service members' circumstances and priorities can help guide discussions and decisions about their care...
September 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28796657/microneedling-a-review-and-practical-guide
#6
Tina S Alster, Paul M Graham
BACKGROUND: Microneedling is a relatively new treatment option in dermatology and has been touted for a broad range of applications including skin rejuvenation, acne scarring, rhytides, surgical scars, dyschromia, melasma, enlarged pores, and transdermal drug delivery. The significant increase in minimally invasive procedures that has been reported over the past several years suggest that microneedling may occupy a specific niche for patients who desire measurable clinical results from treatments with little to no recovery...
August 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28735616/research-techniques-made-simple-an-introduction-to%C3%A2-use-and-analysis-of-big-data-in-dermatology
#7
REVIEW
Mackenzie R Wehner, Katherine A Levandoski, Martin Kulldorff, Maryam M Asgari
Big data is a term used for any collection of datasets whose size and complexity exceeds the capabilities of traditional data processing applications. Big data repositories, including those for molecular, clinical, and epidemiology data, offer unprecedented research opportunities to help guide scientific advancement. Advantages of big data can include ease and low cost of collection, ability to approach prospectively and retrospectively, utility for hypothesis generation in addition to hypothesis testing, and the promise of precision medicine...
August 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28731005/preparing-medical-students-with-congenital-colour-vision-deficiency-for-safe-practice
#8
Rajat Dhingra, Jolly Rohatgi, Upreet Dhaliwal
BACKGROUND: Colour vision of candidates is tested in many medical colleges in India at the time of admission to undergraduate courses; however, there are no guidelines, and therefore no counselling, on how students with congenital colour vision deficiency (CCVD) should negotiate the medical course, and how best they can practise safely after graduation. Problems in interpreting coloured signs may lead to misdiagnosis. This study aimed to explore difficulties during clinical work that requires colour discrimination, and to offer suggestions on safe practice based on the findings and a review of the literature...
January 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28701207/development-of-a-core-outcome-set-for-clinical-trials-in-squamous-cell-carcinoma-study-protocol-for-a-systematic-review-of-the-literature-and-identification-of-a-core-outcome-set-using-a-delphi-survey
#9
Daniel I Schlessinger, Sanjana Iyengar, Arianna F Yanes, Sarah G Chiren, Victoria Godinez-Puig, Brian R Chen, Anastasia O Kurta, Jochen Schmitt, Stefanie Deckert, Karina C Furlan, Emily Poon, Todd V Cartee, Ian A Maher, Murad Alam, Joseph F Sobanko
BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the outcomes reported are highly variable, omitted, or clinically irrelevant. The outcome heterogeneity and reporting bias of these studies leave clinicians unable to accurately compare studies. Core outcome sets (COSs) are an agreed minimum set of outcomes recommended to be measured and reported in all clinical trials of a given condition or disease...
July 12, 2017: Trials
https://www.readbyqxmd.com/read/28697221/hair-loss-myths
#10
Gabriella DiMarco, Amy McMichael
<p>INTRODUCTION: Hair loss is a common complaint seen in dermatology clinics. From frustration and attempts at self-help, patients with hair loss may present to the dermatologist with false beliefs, or myths, about the causes of their condition and what treatments are effective.</p> <p>METHODS: We identified 12 common myths about hair loss, categorized as myths about minoxidil treatment, vitamin and mineral supplements, natural topical treatments, and hair care practices. We performed a PubMed search to find evidence to support or refute each myth...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28695565/dental-patch-testing-in-patients-with-undifferentiated-oral-lichen-planus
#11
Shevya M Tiwari, Kurt Gebauer, Agnieszka M Frydrych, Sally Burrows
BACKGROUND/OBJECTIVES: Distinguishing between oral lichen planus (LP) and lichenoid reactions to dental restorations can be impossible on clinical and histopathological grounds. Epicutaneous patch testing is an investigation that may guide patients and physicians in making timely and costly decisions to replace or cover existing dental restorations. This study aimed to assess the role of epicutaneous patch testing with a battery of dental allergens in patients with undifferentiated oral LP...
July 11, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28667573/urologic-dermatology-a-review
#12
REVIEW
Andrew W Stamm, Kathleen C Kobashi, Ksenija B Stefanovic
PURPOSE OF REVIEW: Genital dermatology represents a challenge to many providers. Though dermatologic lesions involving the genitalia may present to any of a number of practices, ranging from primary care to urology, gynecology, and dermatology, few training programs provide significant training regarding the diagnosis and management of genital dermatologic lesions. The purpose of this review is to provide urologists with an overview of common genital dermatological lesions that may be encountered in a clinic...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28631812/identification-of-allergens-by-ige-specific-testing-improves-outcomes-in-atopic-dermatitis
#13
Brett M Will, Richard Severino, Douglas W Johnson
INTRODUCTION: IgE quantitative assaying of allergens (IgEQAA) has long been implemented by allergists in determining patients' reactivities for allergic rhinitis and asthma, two of the three diagnoses in atopic syndrome. This test operates by measuring the patient's IgE response to different allergens and can identify potential triggers for a patient's symptoms. Despite this, IgEQAA has yet to see the same widespread use in the field of dermatology, specifically in the treatment of patients with atopic dermatitis (AD)...
June 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28628677/impact-of-a-31-gene-expression-profiling-test-for-cutaneous-melanoma-on-dermatologists-clinical-management-decisions
#14
Aaron S Farberg, Alex M Glazer, Richard White, Darrell S Rigel
<p>Importance: Current guidelines for cutaneous malignant melanoma (CMM) provide general recommendations regarding surveillance while indicating that management should be tailored to patients' individual probability of recurrence. A 31-gene expression profile (31-GEP) test to predict metastatic risk has been previously validated, and classifies patients as either Class 1 (low risk) or Class 2 (high risk).</p> <p>Objective: To determine the impact of the 31-GEP test's result on clinical decision-making...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28617750/skin-and-wound-care-in-lymphedema-patients-a-taxonomy-primer-and-literature-review
#15
Caroline E Fife, Wade Farrow, Adelaide A Hebert, Nathan C Armer, Bob R Stewart, Janice N Cormier, Jane M Armer
BACKGROUND: Lymphedema is a condition of localized protein-rich swelling from damaged or malfunctioning lymphatics. Because the immune system is compromised, there is a high risk of infection. Infection in patients with lymphedema may present in a variety of ways. OBJECTIVE: The goals of this review were to standardize the terminology of skin breakdown in the context of lymphedema, synthesize the available information to create best practice recommendations in support of the American Lymphedema Framework Project update to its Best Practices document, and create recommendations for further research...
July 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28562437/use-of-skin-biopsies-among-dermatologists
#16
David A Weinstein, Sasank Konda, Brett M Coldiron
BACKGROUND: Skin biopsies are essential to establish a diagnosis in many skin diseases. Utilization has been increasing rapidly and represents a significant health care cost. There are no benchmarks or baselines to guide the practice of skin biopsies. OBJECTIVE: To create a reference data set of biopsy behavior among dermatologists. METHODS: Five hundred eighty-eight dermatologists belonging to the American Dermatological Association (ADA) were surveyed...
May 25, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28534449/sweet-syndrome-presenting-as-a-febrile-rash-in-a-returning-traveller
#17
Alexander Hart, Katharina Plenk, David Carr
Sweet syndrome was discovered in 1964 and is now well described in the dermatology literature. Knowledge of this unique febrile and painful dermatosis is important for the emergency physician because the syndrome can be readily identified and is extremely responsive to oral steroid therapy. Early diagnosis can greatly improve patient satisfaction and avoid days of ineffective treatment. An accurate and timely diagnosis of Sweet syndrome is also important to guide investigation into a number of associated diseases...
May 23, 2017: CJEM
https://www.readbyqxmd.com/read/28533848/dermatology-in-ghana-a-retrospective-review-of-skin-disease-at-the-korle-bu-teaching-hospital-dermatology-clinic
#18
Brooke E Rosenbaum, Rebecca Klein, Paa Gyasi Hagan, Mark-Young Seadey, Naa Larteley Quarcoo, Rachel Hoffmann, Maria Robinson, Margaret Lartey, Marie C Leger
INTRODUCTION: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. METHODS: We conducted a chart review of new patients presenting to the Korle Bu Teaching Hospital dermatology clinic during 2014. RESULTS: Among the 529 patients studied, 700 discrete diagnoses were made...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28500693/the-clinical-spectrum-of-xanthomatous-lesions-of-the-eyelids
#19
REVIEW
Can Baykal, Algun Polat Ekinci, Kurtulus D Yazganoglu, Nesimi Buyukbabani
Yellowish papules, nodules, or plaques, namely "xanthomatous" lesions, may be seen on the eyelids in the course of various disorders. The prototype is "xanthelasma palpebrarum" (XP) that is localized only to the eyelids and may be associated with hyperlipidemia. On the other hand, different types of normolipemic disorders may also cause xanthomatous eyelid lesions. Among these, Langerhans cell histiocytosis, diffuse normolipemic xanthoma, and non-Langerhans cell histiocytoses (papular xanthoma, juvenile xanthogranuloma, xanthoma disseminatum, adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, and reticulohistiocytosis) can be listed...
May 13, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28492924/handheld-reflectance-confocal-microscopy-for-the-detection-of-recurrent-extramammary-paget-disease
#20
Oriol Yélamos, Brian P Hibler, Miguel Cordova, Travis J Hollmann, Kivanc Kose, Michael A Marchetti, Patricia L Myskowski, Melissa P Pulitzer, Milind Rajadhyaksha, Anthony M Rossi, Manu Jain
Importance: Extramammary Paget disease (EMPD) is commonly refractory to surgical and nonsurgical therapies. Identifying recurrent or persistent EMPD is challenging because the disease is multifocal, and multiple blind scouting biopsies are usually performed in this setting. Handheld reflectance confocal microscopy (HRCM) has been used to diagnose and map primary EMPD and therefore may be used to identify EMPD recurrences. Objective: To evaluate HRCM's diagnostic accuracy in the setting of recurrent or persistent EMPD as well as its potential diagnostic pitfalls...
July 1, 2017: JAMA Dermatology
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