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Hanaa Alkharobi, Aishah Alhodhodi, Yousef Hawsawi, Hasanain Alkafaji, Deirdre Devine, Reem El-Gendy, James Beattie
Human dental pulp cells (DPCs), which are known to contain a subset of stem cells capable of reforming a dentin and pulp-like complex upon in vivo transplantation, were isolated from third molars of three healthy donors and differentiated to a matrix mineralisation phenotype using by culture in dexamethasone and l-ascorbic acid. qRT-PCR analysis of insulin-like growth factor ( IGF) axis gene expression indicated that all genes, except insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein-1 ( IGFBP-1), were expressed in DPCs...
September 24, 2016: Stem Cell Research
A Szeremeta, A Jura-Półtorak, K Komosińska-Vassev, A Zoń-Giebel, D Kapołka, K Olczyk
OBJECTIVES: To assess the association between plasma levels of the insulin-like growth factor (IGF) system including IGF-1, IGF-binding proteins (IGFBPs) including IGFBP-1, total (t-)IGFBP-3 and functional (f-)IGFBP-3, and the carboxyterminal propeptide of type I procollagen (PICP) in pre- and postmenopausal women with rheumatoid arthritis (RA). METHOD: Plasma concentrations of IGF-1, IGFBP-1, t-IGFBP-3, f-IGFBP-3, and PICP were measured by immunoassay. RESULTS: No significant difference was observed in plasma IGF-1 levels between pre- and postmenopausal subjects...
October 24, 2016: Scandinavian Journal of Rheumatology
Michael J Redd, Jay R Hoffman, Yftach Gepner, Jeffrey R Stout, Mattan W Hoffman, Daniel Ben-Dov, Shany Funk, David D Church, Guy Avital, Yacov Chen, Hagai Frankel, Ishay Ostfeld
OBJECTIVE: Insulin-like growth factor-I (IGF-I) is a metabolic and anabolic biomarker that has been proposed to reflect physiological adaptations resulting from multistressor environments. The bioactivity of IGF-I is regulated by seven different insulin-like growth factor binding proteins (IGFBPs) which act not only as carriers of IGF-1, but also function as a modulator of IGF-I availability and activity. Supplementing with β-hydroxy-β-methylbutyrate (HMB) has been shown to enhance physiological outcomes associated with intense training, and has been reported to augment the IGF-1 response...
October 5, 2016: Growth Hormone & IGF Research
Ying Li, Zhen-Long Kang, Na Qiao, Lian-Mei Hu, Yong-Jiang Ma, Xiao-Huan Liang, Ji-Long Liu, Zeng-Ming Yang
The aim of this study was to investigate the effects of copper ions on decidualization of human endometrial stromal cells (HESCs) cultured in vitro. Firstly, non-toxic concentrations of copper D-gluconate were screened in HESCs based on cell activity. Then, the effects of non-toxic concentrations of copper ions (0~250 μM) were examined on decidualization of human endometrial stromal cells. Our data demonstrated that the mRNA expressions of insulin-like growth factor binding protein (IGFBP-1), prolactin (PRL), Mn-SOD, and FOXO1were down-regulated during decidualization following the treatments with 100 or 250 μM copper ions...
October 10, 2016: Biological Trace Element Research
Matthew W Brunke, Christopher W Frye, Corri B Levine, Cristina Hansen, Joseph J Wakshlag
The objective of this study was to investigate the effects of running a 1000-mile (1600 km) endurance sled dog race on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins 1 and 3 (IGFBP-1 and IGFBP-3). Serum was examined from 12 sled dogs prior to the race, at midrace (approximately 690 km), and again at the finish. IGF-1, IGFBP-1, and IGFBP-3 were assessed using radioimmunoassay or enzyme linked immune-absorbance assays. Mean prerace concentrations were significantly higher than midrace and end-race concentrations at 215...
2016: TheScientificWorldJournal
Dominika Majchrzak-Baczmańska, Andrzej Malinowski
Insulin-like growth factor 1 (IGF-1) is a mitogen which plays a key role in regulating cell proliferation, differentiation, and apoptosis. It belongs to the family of proteins also composed of insulin-like growth factor 2 (IGF-2), two types of membrane receptors (IGF-1R and IGF-2R), 6 binding proteins (IGFBP 1-6), hydrolyzing proteases, and reactive molecules binding proteins, which regulate the activity of growth factors. Disturbances in the functioning of IGFBP/IGF/1GF1R can lead to induction of carcinogenesis, which has been demonstrated in breast, prostate or colon cancers...
2016: Ginekologia Polska
Louise A Kelly, E Todd Schroeder, Armando Loza, Xiao Lin, Alastair E Moody, Adrienne Hughes, Alison Kirk, Ann-Marie Knowles
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Liping Qiao, Jean-Sebastien Wattez, Samuel Lee, Zhuyu Guo, Jerome Schaack, William W Hay, Matteo Moretto Zita, Mana Parast, Jianhua Shao
AIMS/HYPOTHESIS: The main objective of this study was to investigate whether maternal adiponectin regulates fetal growth through the endocrine system in the fetal compartment. METHODS: Adiponectin knockout (Adipoq (-/-) ) mice and in vivo adenovirus-mediated reconstitution were used to study the regulatory effect of maternal adiponectin on fetal growth. Primary human trophoblast cells were treated with adiponectin and a specific peroxisome proliferator-activated receptor α (PPARα) agonist or antagonist to study the underlying mechanism through which adiponectin regulates fetal growth...
November 2016: Diabetologia
Troels Brynskov, Caroline Schmidt Laugesen, Andrea Karen Floyd, Jan Frystyk, Torben Lykke Sørensen
BACKGROUND: Laparoscopic gastric bypass (LGB) abruptly causes remission of type 2 diabetes (T2D). Such dramatic metabolic changes have previously been found to cause worsening of diabetic retinopathy (DR) and circulating insulin-like growth factor I (IGF-I) has been suggested as a causal mediator. We aimed to evaluate baseline imbalances in the circulating IGF-system and changes after LGB in patients with T2D. METHODS: Prospective ocular examinations and measurement of the IGF-axis before and 3 and 12 months after LGB...
July 27, 2016: Obesity Surgery
Jinhai Gou, Jia Jia, Juntao Feng, Xia Zhao, Tao Yi, Tao Cui, Zhengyu Li
The aim of the present study was to explore the potential mechanism underlying stathmin 1 (Stmn1) regulation of embryo implantation, as a continuation of previous proteomic research. Adult healthy female mice were mated naturally with fertile males. Murine uterine tissue was collected during the peri-implantation period. Local expression of Stmn1 during embryo implantation was detected by immunohistochemistry (IHC), which showed that Stmn1 was extensively expressed in endometrial glandular epithelium, vascular endothelium, luminal epithelium and the underlying stromal cells at the implantation site on Day 5...
July 26, 2016: Reproduction, Fertility, and Development
Larisa Mešić Ðogić, Dragana Mićić, Feđa Omeragić, Refka Kovač, Seid Fazlagić
Aim To establish a correlation between positive values of IGFBP-1(>10 mg/L, Actim Partus Test, APT) and premature cervical ripening in imminent preterm labor. Methods A prospective study was conducted in primary health care centers in Tuzla, Gynecology and Obstetrics Clinic of the University Clinical Centre in Tuzla and General Hospital Tešanj. The study included 50 women (singleton pregnancy, 28-37 week) with imminent preterm labor diagnosed by cervical biometry and modified Bishop score) (examinees) and 30 healthy pregnant women (control group)...
August 1, 2016: Medicinski Glasnik
Natsumi Taniyama, Nobuto Kaneko, Yu Inatani, Yasuyuki Miyakoshi, Munetaka Shimizu
Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1 and RNA/DNA ratio are endocrine and biochemical parameters used as growth indices in fish, however, they are subjected to environmental modulation. Chum salmon (Oncorhynchus keta) migrate from freshwater (FW) to seawater (SW) at fry/juvenile stage weighing around 1g and suffer growth-dependent mortality during the early phase of their marine life. In order to reveal environmental modulation of the IGF/IGFBP system and establish a reliable growth index for juvenile chum salmon, we examined effects of SW transfer and fasting on IGF-I, IGFBP-1 and RNA/DNA ratio, and correlated them to individual growth rate...
September 15, 2016: General and Comparative Endocrinology
Karin Bergen, Kerstin Brismar, Sara Tehrani
INTRODUCTION: Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 (IGFBP-1) play an important role in vascular health. Many patients with type 1 diabetes are medicated with HMG-CoA reductase inhibitors, statins, in order to prevent vascular complications. Yet little is known about the effect of statins on the IGF-1/IGFBP-1 axis in these patients. OBJECTIVES: The aim of this study was to evaluate the effect of atorvastatin treatment on IGF-1 and IGFBP-1 with regards to microvascular function...
August 2016: Growth Hormone & IGF Research
M Lappas, D Jinks, A Shub, J C Willcox, H M Georgiou, M Permezel
AIMS: Women with previous gestational diabetes mellitus (GDM) are at greater risk of developing type 2 diabetes. In the general population, the insulin-like growth factor (IGF) system has been implicated in the development of type 2 diabetes. The aim of this study was to determine if circulating IGF-I, IGF-II, IGFBP-1 and IGFBP-2 levels 12weeks following a GDM pregnancy are associated with an increased risk of developing type 2 diabetes. METHODS: IGF-I, IGF-II, IGFBP-1 and IGFBP-2 levels were measured in 98 normal glucose tolerant women, 12weeks following an index GDM pregnancy using enzyme immunoassay...
July 4, 2016: Diabetes & Metabolism
N J Menzies-Gow, P A Harris, J Elliott
BACKGROUND: Certain individuals appear predisposed to recurrent pasture-associated laminitis. Previous studies have predominantly investigated risk factors only after disease occurrence. OBJECTIVES: To investigate pasture-associated laminitis risk factors prior to disease occurrence. STUDY DESIGN: Prospective cohort study. METHODS: Non-laminitic ponies >7 years old were recruited. Body condition score (BCS), height, weight, crest height and thickness were measured and an overnight dexamethasone suppression test performed...
July 1, 2016: Equine Veterinary Journal
N Vallikkannu, W K Lam, S Z Omar, P C Tan
OBJECTIVE: To evaluate the tolerability of cervical insulin-like growth factor binding protein 1 (IGFBP-1) and its value as a predictor of successful labour induction, compared with Bishop score and transvaginal ultrasound (TVUS) cervical length. DESIGN: A prospective study. SETTING: A tertiary hospital in Malaysia. POPULATION: A cohort of 193 term nulliparous women with intact membranes. METHODS: Prior to labour induction, cervical fluid was obtained via a vaginal speculum and tested for IGFBP-1, followed by TVUS and finally Bishop score...
June 27, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Ulrika Ljung Faxén, Camilla Hage, Lina Benson, Stanislava Zabarovskaja, Anna Andreasson, Erwan Donal, Jean-Claude Daubert, Cecilia Linde, Kerstin Brismar, Lars H Lund
BACKGROUND: Anabolic drive is impaired in heart failure with reduced ejection fraction (HFrEF) but insufficiently studied in heart failure with preserved ejection fraction (HFpEF). Insulin-like growth factor 1 (IGF-1) mediates growth hormone effects and IGF binding protein 1 (IGFBP-1) regulates IGF-1 activity. We tested the hypothesis that HFpEF and HFrEF are similar with regard to IGF-1 and IGFBP-1. METHODS AND RESULTS: In patients with HFpEF (n = 79), HFrEF (n = 85), and controls (n = 136), we analyzed serum IGF-1 and IGFBP-1 concentrations, correlations, and associations with outcome...
June 17, 2016: Journal of Cardiac Failure
N Gligorijević, O Nedić
Fibrinogen is a plasma glycoprotein and one of the principle participants in blood coagulation. It interacts with many proteins during formation of a blood clot, including insulin-like growth factors (IGFs) and their binding proteins (IGFBP). Fibrinogen complexes were found as minor fractions in fibrinogen preparations independently of the coagulation process, and their presence influences the kinetics of polymerization. The idea of this work was to investigate whether fibrinogen in human plasma interacts with IGFBPs independently of the tissue injury or coagulation process...
February 2016: Biochemistry. Biokhimii︠a︡
S Jakobsdottir, I C van Nieuwpoort, C C van Bunderen, M B de Ruiter, J W R Twisk, J B Deijen, D J Veltman, M L Drent
OBJECTIVE: Early anthropometric and metabolic changes during a caloric restricted diet in obese postmenopausal women, and correlations between these factors with activity in brain areas involved in processing of visual food related stimuli, were investigated. SUBJECTS AND METHODS: An eight week prospective intervention study of 18 healthy postmenopausal women, with a BMI of 30-35 kg/m(2). The first two weeks subjects were on an isocaloric diet, four weeks on a 1000 kcal restricted diet followed by two weeks on an isocaloric diet...
May 24, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Hans Lundin, Maria Sääf, Lars-Erik Strender, Sven Nyren, Sven-Erik Johansson, Helena Salminen
High serum levels of IGFBP-1 are related both to low body mass index (BMI) and to low insulin-like growth factor 1 (IGF-I), which both in turn are related to low bone mineral density (BMD) and to increased fracture risk. However, we have found no previous prospective studies on IGFBP-1 and fracture risk. Despite its name, IGFBP-1 is not only just a binding protein but also has its own IGF-independent effects, e.g., stimulating osteoclast differentiation. IGFBP-1 might have an IGF-related and/or an IGF-independent association to fracture risk...
October 2016: Calcified Tissue International
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