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IGFBP-1

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https://www.readbyqxmd.com/read/29325466/the-correlation-between-birth-weight-and-insulin-like-growth-factor-binding-protein-1-igfbp-1-kisspeptin-1-kiss-1-and-three-dimensional-fetal-volume
#1
Gunsu Kimyon Comert, Sertac Esin, Gamze Sinem Caglar, Bulent Yirci, Sedat Ozdemir, Selda Demirtas, Omer Kandemir
PURPOSE: This study aimed to determine the relationship between birth weight, and maternal serum insulin-like growth factor binding protein-1 (IGFBP-1) and kisspeptin-1 (KISS-1) levels, and first-trimester fetal volume (FV) based on three-dimensional ultrasonography. MATERIALS AND METHODS: The study included 142 pregnant women at gestational week 110-136. All fetuses were imaged ultrasonographically by the same physician. Maternal blood samples were collected at the time of ultrasonographic evaluation and analyzed for IGFBP-1 and KISS-1 levels via enzyme-linked immunosorbent assay (ELISA)...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29285144/icaritin-inhibits-decidualization-of-endometrial-stromal-cells
#2
Aiwen Le, Zhong Hai Wang, Xiao Yun Dai, Tian Hui Xiao, Rong Zhuo, Baozhen Zhang, Zhonglin Xiao, Xiujun Fan
The aim of the present study was to investigate the effects of Icaritin on the proliferation and decidualization of endometrial stromal cells (ESCs). A total of 20 specimens of endometrium were collected during hysterectomy at the Gynecology Department of Shenzhen Nanshan People's Hospital (Shenzhen, China) between August 2014 and December 2015. The endometrium was digested with high concentrations of collagenase and DNase and filtered with meshes, and then the glandular epithelial and stromal cells were separated by the adhesion purification method...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29278514/maternal-serum-placental-growth-hormone-insulin-like-growth-factors-and-their-binding-proteins-at-20-weeks-gestation-in-pregnancies-complicated-by-gestational-diabetes-mellitus
#3
Shutan Liao, Mark H Vickers, Rennae S Taylor, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by gestational diabetes mellitus (GDM). METHOD: In a nested case-control study, GDM cases (n=28) and matched controls (n=28) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20 weeks of gestation were determined by enzyme-linked immunosorbent assay (ELISA)...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29260199/systemic-inflammation-associated-proteins-and-retinopathy-of-prematurity-in-infants-born-before-the-28th-week-of-gestation
#4
Mari Holm, Tora S Morken, Raina N Fichorova, Deborah K VanderVeen, Elizabeth N Allred, Olaf Dammann, Alan Leviton
Purpose: To assess the association between systemic levels of inflammation-associated proteins and severe retinopathy of prematurity (ROP) in extremely preterm infants. Methods: We collected whole blood on filter paper on postnatal days 1, 7, 14, 21, and 28 from 1205 infants born before the 28th week of gestation, and measured the concentrations of 27 inflammation-associated, angiogenic, and neurotrophic proteins. We calculated odds ratios with 95% confidence intervals for the association between top quartile concentrations of each protein and prethreshold ROP...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29259466/overexpression-of-microrna-542-3p-attenuates-the-differentiating-capacity-of-endometriotic-stromal-cells
#5
Shamima Sultana, Takeshi Kajihara, Yumi Mizuno, Tomomi Sato, Tatsuo Oguro, Machiko Kimura, Masumi Akita, Osamu Ishihara
Aim: Endometriosis is defined as the presence of endometrial glandular and stromal cells outside of the uterine cavity. A previous study reported that microRNA (miR)-542-3p plays a critical role in eutopic endometrial decidualization. This study aims to clarify the potential role of miR-542-3p and the target gene, IGFBP-1 (insulin-like growth factor-binding protein 1), in the impairment of the decidualizing capacity of human ectopic endometrial stromal cells (HEcESCs). Methods: In vitro analysis of primary undifferentiated and decidualizing human eutopic endometrial stromal cells (HEuESCs) and HEcESCs was conducted...
April 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29250665/the-correlation-between-insulin-like-growth-factor-with-glycemic-control-glomerular-filtration-rate-blood-pressure-hematological-changes-or-body-mass-index-in-patients-with-type-2-diabetes-mellitus
#6
Marius Cristian NeamŢu, Elena Taina Avramescu, Iulia Rahela Marcu, Adina Turcu-Ştiolică, Mihail Virgil Boldeanu, Oana Maria NeamŢu, Ştefania Tudorache, Rucsandra Elena Dănciulescu Miulescu
Insulin-like growth factor (IGF) family is made up of two polypeptides, IGF-I and IGF-II, six specific binding proteins (IGFBPs 1-6) and specific receptors. IGF-I is involved in the regulation of growth and cellular proliferation and has a similar structure to insulin. The major IGF transport function is attributed to IGFBP-3. Some studies have highlighted the association between IGF and diabetes. The aims of this study were to analyze the correlation between IGF with glycemic control, glomerular filtration rate (GFR), blood pressure, hematological changes or body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM)...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29165552/what-happened-to-the-igf-binding-proteins
#7
Leon A Bach
Insulin-like growth factor binding proteins (IGFBPs) 1-6 are high affinity regulators of IGF activity. They generally inhibit IGF actions by preventing binding to the IGF-I receptor but may also enhance their actions under some conditions. Post-translational modifications such as glycosylation and phosphorylation modulate IGFBP properties, and IGFBP proteolysis results in IGF release. IGFBPs have more recently been shown to have IGF-independent actions. A number of mechanisms are involved, including modulation of other growth factor pathways, nuclear localization and transcriptional regulation, interaction with the sphingolipid pathway, and binding to non-IGF biomolecules in the extracellular space and matrix, on the cell surface and intracellularly...
November 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/29163706/igfbp-4-expression-is-adversely-associated-with-lung-cancer-prognosis
#8
Yang Xiao, Shan Zhu, Wen Yin, Xiaofan Liu, Yi Hu
Insulin-like growth factor binding protein-4 (IGFBP-4) was reported to be associated with prognosis in several types of cancer; however, to the best of our knowledge, whether it is correlated with lung cancer has yet to be reported. In the present study, 102 pairs of lung cancer tissues and surrounding non-cancerous tissues (SNCTs) were collected. The IGFBP-4 levels in tissues were detected with immunohistochemistry. The relevance of IGFBP-4 to the survival of patients was assessed. The IGFBP-4 gene was knocked down, and its function in the proliferation of lung cancer cells was measured...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29160429/reduction-of-venous-pressure-during-the-resection-of-liver-metastases-compromises-enteric-blood-flow-igfbp-1-as-a-novel-biomarker-of-intestinal-barrier-injury
#9
Hermes Vieira Barbeiro, Marcel Autran César Machado, Heraldo Possolo de Souza, Fabiano Pinheiro da Silva, Marcel Cerqueira César Machado
OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage. METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection. RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed...
October 2017: Clinics
https://www.readbyqxmd.com/read/29153669/maternal-serum-igf-1-igfbp-1-and-3-and-placental-growth-hormone-at-20weeks-gestation-in-pregnancies-complicated-by-preeclampsia
#10
Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by later preeclampsia (PE). STUDY DESIGN: In a nested case-control study, PE cases (n=71) and matched controls (n=71) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20weeks of gestation were determined by ELISA...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29150385/igf-1r-mrna-expression-is-increased-in-obese-children
#11
Rafaela Cristina Ricco, Rubens Garcia Ricco, Mariangela Carletti Queluz, Mariana Teresa Sarti de Paula, Patricia Volpon Atique, Rodrigo José Custódio, Hugo Tourinho Filho, Raphael Del Roio Liberatori, Carlos Eduardo Martinelli
OBJECTIVES: Obese children are often taller than age-matched subjects. Reports on GH and IGF-I levels in obese individuals are controversial, with normal and reduced GH-IGF-I levels having been reported in this group of patients. Thus, the aim of this study was to analyse insulin-like growth factor type 1 receptor (IGF-IR) mRNA expression in obese children. METHODS: Forty-seven pre-pubertal children were included in this study: 29 were obese and taller than their target height, and 18 were normal eutrophic controls...
November 11, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29051031/inflammatory-molecules-and-neurotrophic-factors-as-biomarkers-of-neuropsychomotor-development-in-preterm-neonates-a-systematic-review
#12
REVIEW
Rafael C Magalhães, Letícia P Pimenta, Izabela G Barbosa, Janaina M Moreira, João L V M de Barros, Antônio L Teixeira, Ana C Simões E Silva
OBJECTIVE: To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. DATA SOURCE: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth...
October 16, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29037858/co-localization-of-insulin-like-growth-factor-binding-protein-1-casein-kinase-2%C3%AE-and-mechanistic-target-of-rapamycin-in-human-hepatocellular-carcinoma-cells-as-demonstrated-by-dual-immunofluorescence-and-in-situ-proximity-ligation-assay
#13
Sahil S Singal, Karen Nygard, Manthan R Dhruv, Kyle Biggar, Majida Abu Shehab, Shawn Shun-Cheng Li, Thomas Jansson, Madhulika B Gupta
Insulin-like growth factor binding protein (IGFBP)-1 influences fetal growth by modifying insulin-like growth factor-1 bioavailability. IGFBP-1 phosphorylation is regulated by mechanistic target of rapamycin (mTOR) and casein kinase (CSNK)-2. However, the underlying molecular mechanisms remain unknown. We examined the cellular localization and potential interactions of IGFBP-1, CSNK-2β, and mTOR as a prerequisite for protein-protein interaction. Analysis of dual immunofluorescence images indicated a potential perinuclear co-localization between IGFBP-1 and CSNK-2β and a nuclear co-localization between CSNK-2β and mTOR...
October 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29037141/analysis-of-four-circulating-complexes-of-insulin-like-growth-factor-binding-proteins-in-human-blood-during-aging
#14
O Nedić, M Šunderić, N Gligorijević, V Malenković, G Miljuš
The primary role of insulin-like growth factor binding proteins (IGFBPs) is to regulate availability of IGFs for interacting with receptors, but IGFBPs perform IGF-independent actions as well. The availability and activity of IGFBPs in the circulation is influenced primarily by their concentration and structural modifications, but possibly also by interaction with major plasma proteins such as transferrin, alpha-2-macroglobulin (α2M), and fibrinogen. Four types of circulating IGFBP complexes were examined in this study by immuno- and ligand-binding assays in adults of different age...
October 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28977591/novel-function-of-a-transcription-factor-wt1-in-regulating-decidualization-in-human-endometrial-stromal-cells-and-its-molecular-mechanism
#15
Isao Tamura, Yuichiro Shirafuta, Kousuke Jozaki, Takuya Kajimura, Masahiro Shinagawa, Ryo Maekawa, Toshiaki Taketani, Hiromi Asada, Shun Sato, Hiroshi Tamura, Norihiro Sugino
The Wilms tumor suppressor gene (WT1) encodes an essential transcription factor regulating mammalian urogenital development. However, the function of WT1 in human endometrium is still unclear. The current study examined the involvement of WT1 in the regulation of IGF-binding protein-1 (IGFBP-1) and prolactin (PRL), which are specific markers of decidualization, in human endometrial stromal cells (ESCs) undergoing decidualization. ESCs isolated from proliferative-phase endometrium were incubated with cyclic adenosine monophosphate (cAMP) to induce decidualization...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28945869/effects-of-prednisolone-on-serum-and-tissue-fluid-igf-i-receptor-activation-and-post-receptor-signaling-in-humans
#16
Nilani Ramshanker, Maiken Aagaard, Rikke Hjortebjerg, Thomas Schmidt Voss, Niels Møller, Jens Otto Lunde Jørgensen, Niels Jessen, Peter Bjerring, Nils Erik Magnusson, Mette Bjerre, Claus Oxvig, Jan Frystyk
Context: Short-term glucocorticoid exposure increases serum insulinlike growth factor I (IGF-I) concentrations but antagonizes IGF-I tissue signaling. The underlying mechanisms remain unknown. Objective: To identify at which levels glucocorticoid inhibits IGF-I signaling. Design and Methods: Nineteen healthy males received prednisolone (37.5 mg/d) and placebo for 5 days in a randomized, double-blinded, placebo-controlled crossover study. Serum was collected on days 1, 3, and 5, and abdominal skin suction blister fluid (SBF; ~interstitial fluid) was taken on day 5 (n = 9) together with muscle biopsy specimens (n = 19)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28927302/igfbp-1-and-igf-i-as-markers-for-advanced-fibrosis-in-nafld-a-pilot-study
#17
Hannes Hagström, Per Stål, Rolf Hultcrantz, Kerstin Brismar, Ishrath Ansurudeen
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease globally. Advanced fibrosis (stage 3-4) is the most robust marker for future mortality, but diagnosis requires liver biopsy. Current non-invasive scoring systems aimed to identify advanced fibrosis are imperfect. Insulin-like growth factor I (IGF-I) and its binding protein IGFBP-1 are liver derived proteins, that are involved in various liver disorders. The aim of this study was to examine the possible association between advanced fibrosis and IGF-I and IGFBP-1 in NAFLD...
September 19, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#18
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28911141/glucagon-decreases-igf-1-bioactivity-in-humans-independently-of-insulin-by-modulating-its-binding-proteins
#19
RANDOMIZED CONTROLLED TRIAL
Zeinab Sarem, Christiane Bumke-Vogt, Ayman M Mahmoud, Biruhalem Assefa, Martin O Weickert, Aikatarini Adamidou, Volker Bähr, Jan Frystyk, Matthias Möhlig, Joachim Spranger, Stefanie Lieske, Andreas L Birkenfeld, Andreas F H Pfeiffer, Ayman M Arafat
Context: Depending on its lipolytic activity, glucagon plays a promising role in obesity treatment. Glucagon-induced growth hormone (GH) release can promote its effect on lipid metabolism, although the underlying mechanisms have not been well-defined. Objective: The present study highlights the glucagon effect on the GH/insulinlike growth factor 1 (IGF-1)/IGF-binding protein (IGFBP) axis in vivo and in vitro, taking into consideration insulin as a confounding factor...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28886098/molecular-and-biochemical-responses-of-hypoxia-exposure-in-atlantic-croaker-collected-from-hypoxic-regions-in-the-northern-gulf-of-mexico
#20
Md Saydur Rahman, Peter Thomas
A major impact of global climate change has been the marked increase worldwide in the incidence of coastal hypoxia (dissolved oxygen, DO<2.0 mg l-1). However, the extent of hypoxia exposure to motile animals such as fish collected from hypoxic waters as well as their molecular and physiological responses to environmental hypoxia exposure are largely unknown. A suite of potential hypoxia exposure biomarkers was evaluated in Atlantic croaker collected from hypoxic and normoxic regions in the northern Gulf of Mexico (nGOM), and in croaker after laboratory exposure to hypoxia (DO: 1...
2017: PloS One
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