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IGFBP-1

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https://www.readbyqxmd.com/read/28468523/non-essential-and-branched-chain-amino-acids-differentially-regulate-insulin-like-growth-factor-binding-protein-1-production-and-phosphorylation-in-hepg2-cells
#1
Kei Tanaka, Keiji Sakai, Miho Matsushima, Yukiko Matsuzawa, Tomoko Izawa, Yoichi Kobayashi, Mitsutoshi Iwashita
Deprivation of branched-chain amino acids (BCAAs) induces insulin-like growth factor binding protein-1 (IGFBP-1) production in HepG2 cells, while the role of non-essential amino acids (NEAAs) remains unknown. We investigated changes in IGFBP-1 production and phosphorylation induced by NEAAs and also examined its significance on IGF-I activity in HepG2 cells. We demonstrated that decreased BCAAs and increased NEAAs stimulated phosphorylated IGFBP-1 secretion. We also revealed that decreased BCAA-to-NEAA ratios enhanced phosphorylated IGFBP-1 secretion, while changes in the total amount of amino acids (AAs) had no effect...
May 4, 2017: Growth Factors
https://www.readbyqxmd.com/read/28449068/development-of-a-novel-human-recellularized-endometrium-that-responds-to-a-28-day-hormone-treatment
#2
Susan A Olalekan, Joanna E Burdette, Spiro Getsios, Teresa K Woodruff, J Julie Kim
Three dimensional (3D) in vitro models have been established to study the physiology and pathophysiology of the endometrium. With emerging evidence that the native extracellular matrix (ECM) provides appropriate cues and growth factors essential for tissue homeostasis, we describe, a novel 3D endometrium in vitro model developed from decellularized human endometrial tissue repopulated with primary endometrial cells. Analysis of the decellularized endometrium using mass spectrometry analysis revealed an enrichment of cell adhesion molecules, cytoskeletal proteins and ECM proteins such as Collagen IV and Laminin...
April 25, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28443632/erratum-loss-of-mir-542-3p-enhances-igfbp-1-expression-in-decidualizing-human-endometrial-stromal-cells
#3
Hideno Tochigi, Takeshi Kajihara, Yosuke Mizuno, Yumi Mizuno, Shunsuke Tamaru, Yoshimasa Kamei, Yasushi Okazaki, Jan J Brosens, Osamu Ishihara
No abstract text is available yet for this article.
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435049/exposure-of-decidualized-hiesc-to-low-oxygen-tension-and-leucine-deprivation-results-in-increased-igfbp-1-phosphorylation-and-reduced-igf-i-bioactivity
#4
Majida Abu Shehab, Kyle Biggar, Sahil Sagar Singal, Karen Nygard, Shawn Shun-Cheng Li, Thomas Jansson, Madhulika B Gupta
Phosphorylation of decidual IGFBP-1 enhances binding of IGF-I, limiting the bioavailability of this growth factor which may contribute to reduced placental and fetal growth. The mechanisms regulating decidual IGFBP-1 phosphorylation are incompletely understood. Using decidualized human immortalized endometrial stromal cell () we tested the hypothesis that low oxygen tension or reduced leucine availability, believed to be common in placental insufficiency, increase the phosphorylation of decidual IGFBP-1. Multiple reaction monitoring-MS (MRM-MS) was used to identify/quantify IGFBP-1 phosphorylation...
April 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28422393/accuracy-and-response-time-of-dual-biomarker-model-of-insulin-like-growth-factor-binding-protein-1-alpha-fetoprotein-amnioquick-duo-in-comparison-to-placental-alpha-microglobulin-1-test-in-diagnosis-of-premature-rupture-of-membranes
#5
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Joseph Ifeanyichukwu Ikechebelu, Chukwuemeka Okwudili Ezeama, Ifeanyichukwu Uzoma Ezebialu, Nnabuike Okechukwu Ojiegbe, Chukwudi Celestine Obiora, Charles Ikechukwu Okafor, Gerald Okanandu Udigwe, Betrand Obi Nwosu, Frank O Ezugwu
AIM: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). METHODS: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28420208/serum-insulin-like-growth-factor-axis-and-the-risk-of-pancreatic-cancer-systematic-review-and-meta-analysis
#6
Yuanfeng Gong, Bingyi Zhang, Yadi Liao, Yunqiang Tang, Cong Mai, Tiejun Chen, Hui Tang
OBJECTIVE: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). METHODS: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of original studies and review articles on this topic. A summary of relative risks with 95% confidence intervals (CI) was calculated using a random-effects model. The heterogeneity between studies was assessed using Cochran Q and I² statistics...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28361446/does-milk-intake-promote-prostate-cancer-initiation-or-progression-via-effects-on-insulin-like-growth-factors-igfs-a-systematic-review-and-meta-analysis
#7
REVIEW
Sean Harrison, Rosie Lennon, Jeff Holly, Julian P T Higgins, Mike Gardner, Claire Perks, Tom Gaunt, Vanessa Tan, Cath Borwick, Pauline Emmet, Mona Jeffreys, Kate Northstone, Sabina Rinaldi, Stephen Thomas, Suzanne D Turner, Anna Pease, Vicky Vilenchick, Richard M Martin, Sarah J Lewis
PURPOSE: To establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3). METHODS: Systematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28259137/chronic-endometritis-modifies-decidualization-in-human-endometrial-stromal-cells
#8
Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang, Takashi Murakami
BACKGROUND: Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, its significance has not been explored. However, recent studies have shown that CE is related with repeated implantation failures after in vitro fertilization-embryo transfer, unexplained infertility, and recurrent miscarriages. As decidua differentiates to support the implantation process and maintains the pregnancy, we hypothesized that CE may influence the process of decidualization...
March 4, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28257428/dietary-protein-induced-hepatic-igf-1-secretion-mediated-by-ppar%C3%AE-activation
#9
Xiaojuan Wan, Songbo Wang, Jingren Xu, Lu Zhuang, Kongping Xing, Mengyuan Zhang, Xiaotong Zhu, Lina Wang, Ping Gao, Qianyun Xi, Jiajie Sun, Yongliang Zhang, Tiejun Li, Gang Shu, Qingyan Jiang
Dietary protein or amino acid (AA) is a crucial nutritional factor to regulate hepatic insulin-like growth factor-1 (IGF-1) expression and secretion. However, the underlying intracellular mechanism by which dietary protein or AA induces IGF-1 expression remains unknown. We compared the IGF-1 gene expression and plasma IGF-1 level of pigs fed with normal crude protein (CP, 20%) and low-protein levels (LP, 14%). RNA sequencing (RNA-seq) was performed to detect transcript expression in the liver in response to dietary protein...
2017: PloS One
https://www.readbyqxmd.com/read/28245469/decidualization-is-impaired-in-endometrial-stromal-cells-from-uterine-rudiments-in-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#10
Sara Y Brucker, Simone Eisenbeis, Juliana König, Melanie Lamy, Madhuri S Salker, Ni Zeng, Harald Seeger, Melanie Henes, Dorit Schöller, Birgitt Schönfisch, Annette Staebler, Florin-Andrei Taran, Diethelm Wallwiener, Katharina Rall
BACKGROUND/AIMS: Uterine rudiments from patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) contain all tissues typically found in the uterus. Endometrium from the rudiments predominantly exhibits basalis-like features, and endometrial proliferative capacity in patients' epithelium and stroma is significantly lower. METHODS: This single-center, prospective study conducted at a major German university hospital compared in-vitro decidualization in cultured ESCs from MRKHS patients and hysterectomy controls...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28236632/accuracy-of-a-combined-insulin-like-growth-factor-binding-protein-1-interleukin-6-test-premaquick-in-predicting-delivery-in-women-with-threatened-preterm-labor
#11
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Lydia Ijeoma Eleje, Joseph Ifeanyichukwu Ikechebelu, Ifeanyichukwu Uzoma Ezebialu, Chukwudi Celestine Obiora, Betrand Obi Nwosu, Chukwuemeka Okwudili Ezeama, Gerald Okanandu Udigwe, Charles Ikechukwu Okafor, Frank Okechukwu Ezugwu
PURPOSE: To determine values of combinations of interleukin-6 (IL-6)/cervical native insulin-like growth factor-binding protein-1 (IGFBP-1)/total IGFBP-1 (Premaquick©) in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in women with threatened preterm labor. METHODS: Women with singleton pregnancies between gestation age (GA) of 24 weeks and 36 weeks and 6 days with preterm labor were recruited during a prospective multicenter study...
February 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28179448/the-igf-system-in-patients-with-type-2-diabetes-associations-with-markers-of-cardiovascular-target-organ-damage
#12
Rikke Hjortebjerg, Esben Laugesen, Pernille Høyem, Claus Oxvig, Brian Stausbøl-Grøn, Søren T Knudsen, Won Y Kim, Per L Poulsen, Troels K Hansen, Mette Bjerre, Jan Frystyk
OBJECTIVE: Perturbations in the insulin-like growth factor (IGF) system may contribute to the accelerated cardiovascular disease (CVD) that occurs in patients with type 2 diabetes (T2D). However, it remains unknown whether the IGF system is also involved in the development of early, subclinical CVD. We characterised the IGF system in T2D patients and matched controls and examined the associations with markers of subclinical target organ damage. METHODS: The study included 99 patients with recently diagnosed T2D and 99 age- and sex-matched controls...
May 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28178340/sputum-biomarkers-in-ipf-evidence-for-raised-gene-expression-and-protein-level-of-igfbp-2-il-8-and-mmp-7
#13
J Guiot, M Henket, J L Corhay, C Moermans, R Louis
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease of unknown origin leading rapidly to death. This paper addresses the issue of whether sputum induction is a suitable tool to study respiratory tract inflammation and potential biomarkers in IPF compared to COPD, a fibrosing airway wall disease. METHODS: In a cross-sectional analysis, 15 IPF patients, 32 COPD and 30 healthy subjects underwent sputum induction. Total sputum cell counts and the amount of TGF- β, IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, IL-8, IL-13, MMP-7, MMP-9, YKL-40, TNF-α and KL-6 in sputum supernatant were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/28143425/higher-igfbp-1-to-igf-1-serum-ratio-predicts-unfavourable-survival-in-patients-with-nasopharyngeal-carcinoma
#14
Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu, Ge Zhang
BACKGROUND: The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopathological significance and prognostic value in nasopharyngeal carcinoma (NPC). METHODS: IGF system components (IGF-1, IGF-2, IGF-1SR, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-6) were quantified from the plasma of NPC patients and healthy individuals using the RayBio Human Cytokine Antibody Array...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28130434/selective-progesterone-receptor-modulator-sprm-ulipristal-acetate-upa-and-its-effects-on-the-human-endometrium
#15
L H R Whitaker, A A Murray, R Matthews, G Shaw, A R W Williams, P T K Saunders, H O D Critchley
STUDY QUESTION: What is the impact of administration of the selective progesterone receptor modulator (SPRM), ulipristal acetate (UPA) on the endometrium of women with fibroids? SUMMARY ANSWER: UPA administration altered expression of sex-steroid receptors and progesterone-regulated genes and was associated with low levels of glandular and stromal cell proliferation. WHAT IS KNOWN ALREADY: Administration of all SPRM class members results in PAEC (progesterone receptor modulator associated endometrial changes)...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28122472/human-placental-growth-hormone-is-increased-in-maternal-serum-at-20-weeks-of-gestation-in-pregnancies-with-large-for-gestational-age-babies
#16
Shutan Liao, Mark H Vickers, Rennae S Taylor, Beatrix Jones, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA...
January 25, 2017: Growth Factors
https://www.readbyqxmd.com/read/28108607/insulin-like-growth-factor-binding-protein-1-could-improve-glucose-regulation-and-insulin-sensitivity-through-its-rgd-domain
#17
Natalie J Haywood, Paul A Cordell, Kar Yeun Tang, Natallia Makova, Nadira Y Yuldasheva, Helen Imrie, Hema Viswambharan, Alexander F Bruns, Richard M Cubbon, Mark T Kearney, Stephen B Wheatcroft
Low circulating levels of insulin-like growth factor binding protein 1 (IGFBP-1) are associated with insulin resistance and predict the development of type 2 diabetes. IGFBP-1 can affect cellular functions independently of IGF binding through an Arg-Gly-Asp (RGD) integrin-binding motif. Whether causal mechanisms underlie the favorable association of high IGFBP-1 levels with insulin sensitivity and whether these could be exploited therapeutically remain unexplored. We used recombinant IGFBP-1 and a synthetic RGD-containing hexapeptide in complementary in vitro signaling assays and in vivo metabolic profiling in obese mice to investigate the effects of IGFBP-1 and its RGD domain on insulin sensitivity, insulin secretion, and whole-body glucose regulation...
February 2017: Diabetes
https://www.readbyqxmd.com/read/28096479/igf-1-receptor-modulates-foxo1-mediated-tamoxifen-response-in-breast-cancer-cells
#18
Ali Vaziri-Gohar, Yan Zheng, Kevin D Houston
Tamoxifen is a common adjuvant treatment for estrogen receptor (ER)α-positive patients with breast cancer; however, acquired resistance abrogates the efficacy of this therapeutic approach. We recently demonstrated that G protein-coupled estrogen receptor 1 (GPER1) mediates tamoxifen action in breast cancer cells by inducing insulin-like growth factor-binding protein-1 (IGFBP-1) to inhibit IGF-1-dependent signaling. To determine whether dysregulation of IGFBP-1 induction is associated with tamoxifen resistance, IGFBP-1 transcription was measured in tamoxifen-resistant MCF-7 cells (TamR) after tamoxifen (Tam) treatment...
April 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28089088/synovial-chondromatosis-of-the-temporomandibular-joint-immunohistochemical-examinations-regarding-the-role-of-insulin-like-growth-factors-and-their-binding-proteins-in-the-etiology-of-this-disease
#19
Christian T Wilms, Nils Heim, Marcus Teschke, Rudolf R Reich, Werner Götz
Synovial chondromatosis (SC) is a benign disease of the joints without a known cause. It sometimes affects the temporomandibular joint (TMJ) and is accompanied by pain, swelling, malocclusion, and crepitation. It has been divided into three stages by Milgram and is supposed to originate from the synovia and cartilage of a joint (Milgram, 1977b). The aim of this study was to examine an involvement of the insulin-like growth factors (IGF-I/-II) and their binding proteins (IGFBP-1 to -6) in the etiology of this disease...
December 14, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28051155/loss-of-mir-542-3p-enhances-igfbp-1-expression-in-decidualizing-human-endometrial-stromal-cells
#20
Hideno Tochigi, Takeshi Kajihara, Yosuke Mizuno, Yumi Mizuno, Shunsuke Tamaru, Yoshimasa Kamei, Yasushi Okazaki, Jan J Brosens, Osamu Ishihara
Endometrial decidualization represents an essential step for the successful implantation of the embryo; however, the molecular mechanism behind this differentiation process remains unclear. This study aimed to identify novel microRNAs (miRNAs) involved in the regulation of decidual gene expression in human endometrial stromal cells (HESCs). An in vitro analysis of primary undifferentiated and decidualizing HESCs was conducted. HESCs were isolated from hysterectomy specimens from normally cycling premenopausal women with uterine fibroids, who were not on hormonal treatment at the time of surgery...
January 4, 2017: Scientific Reports
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