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IGFBP-1

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https://www.readbyqxmd.com/read/28710882/mid-trimester-preterm-premature-rupture-of-membranes-pprom-etiology-diagnosis-classification-international-recommendations-of-treatment-options-and-outcome
#1
REVIEW
Michael Tchirikov, Natalia Schlabritz-Loutsevitch, James Maher, Jörg Buchmann, Yuri Naberezhnev, Andreas S Winarno, Gregor Seliger
Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal membranes prior to 28 weeks of gestation, complicates approximately 0.4%-0.7% of all pregnancies. This condition is associated with a very high neonatal mortality rate as well as an increased risk of long- and short-term severe neonatal morbidity. The causes of the mid-trimester PPROM are multifactorial. Altered membrane morphology including marked swelling and disruption of the collagen network which is seen with PPROM can be triggered by bacterial products or/and pro-inflammatory cytokines...
July 15, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28688245/the-timing-of-administration-of-exogenous-glucocorticoid-affects-24hour-growth-hormone-secretion-in-children
#2
Ole D Wolthers, Nilani Ramshanker, Carsten Heuck, Jan Frystyk
Exogenous glucocorticoids may suppress linear growth by affecting the diurnal secretory rhythm of GH. OBJECTIVE: To assess whether the timing of exogenous glucocorticoid administration affects GH secretion in children. DESIGN: Four girls and four boys aged 10.6 to 15.8 (mean 13.2) years with normal weight and height and pubertal stages I-IV were studied in an open randomized 2-period cross-over trial, with a 1-day un-in, and two 4-day periods of 5mg prednisolone in the morning or in the evening, respectively, separated by a 3-week washout period...
July 1, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28666856/production-of-recombinant-salmon-insulin-like-growth-factor-binding-protein-1-subtypes
#3
Hanae Tanaka, Gakuto Oishi, Yusuke Nakano, Hiroko Mizuta, Yuta Nagano, Naoshi Hiramatsu, Hironori Ando, Munetaka Shimizu
Insulin-like growth factor (IGF)-I is a growth promoting hormone that exerts its actions through endocrine, paracrine and autocrine modes. Local IGF-I is essential for normal growth, whereas circulating IGF-I plays a crucial role in regulating the production and secretion of growth hormone (GH) by the pituitary gland. These actions of IGF-I are modulated by six insulin-like growth factor binding proteins (IGFBPs). In teleosts, two subtypes of each IGFBP are present due to an extra round of whole-genome duplication...
June 27, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28617951/altered-expression-of-igf-i-system-in-neurons-of-the-inflamed-spinal-cord-during-acute-experimental-autoimmune-encephalomyelitis
#4
Azita Parvaneh Tafreshi, Farideh Talebi, Samira Ghorbani, Claude Bernard, Farshid Noorbakhsh
BACKGROUND: There is growing evidence that the impaired IGF-I system contributes to neurodegeneration. OBJECTIVES: In this study, we examined the spinal cords of the EAE, the animal model of multiple sclerosis, to see if the expression of the IGF-I system is altered. METHODS: To induce EAE, C57/BL6 mice were immunized with the Hooke lab MOG kit, sacrificed at the peak of the disease and their spinal cords were examined for the immunoreactivities (ir) of the IGF-I, IGF binding protein-1 (IGFBP-1) and glycogen synthase kinase 3β (GSK3β), as one major downstream molecule in the IGF-I signaling...
June 15, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28609475/increase-in-insulin-like-growth-factor-1-igf-1-and-insulin-like-growth-factor-binding-protein-1-after-supplementation-with-selenium-and-coenzyme-q10-a-prospective-randomized-double-blind-placebo-controlled-trial-among-elderly-swedish-citizens
#5
Urban Alehagen, Peter Johansson, Jan Aaseth, Jan Alexander, Kerstin Brismar
BACKGROUND: Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 decrease with age and during inflammation. As selenium and coenzyme Q10 are involved in both the antioxidative defense and the inflammatory response, the present study aimed to examine the effects of supplementation with selenium and coenzyme Q10 on concentrations of IGF-1 and its binding protein IGFBP-1 in a population showing reduced cardiovascular mortality following such supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/28593921/hyperandrogenism-in-adolescent-girls-relationship-with-the-somatotrophic-axis
#6
María Isabel Hernandez, Patricia López, Ximena Gaete, Claudio Villarroel, Gabriel Cavada, Alejandra Avila, German Iñiguez, Fernando Cassorla
BACKGROUND: During puberty there is a physiologic increase in adrenal and ovarian androgens. It has been suggested that the somatotrophic axis may be related to the development of hyperandrogenism and anovulation in non-obese adult women with polycystic ovarian syndrome (PCOS). The objective of the study was to investigate whether ovarian androgen secretion in young postmenarchal girls is related to the function of their somatotropic axis. METHODS: This was a cross-sectional study of adolescent girls...
May 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28468523/non-essential-and-branched-chain-amino-acids-differentially-regulate-insulin-like-growth-factor-binding-protein-1-production-and-phosphorylation-in-hepg2-cells
#7
Kei Tanaka, Keiji Sakai, Miho Matsushima, Yukiko Matsuzawa, Tomoko Izawa, Yoichi Kobayashi, Mitsutoshi Iwashita
Deprivation of branched-chain amino acids (BCAAs) induces insulin-like growth factor binding protein-1 (IGFBP-1) production in HepG2 cells, while the role of non-essential amino acids (NEAAs) remains unknown. We investigated changes in IGFBP-1 production and phosphorylation induced by NEAAs and also examined its significance on IGF-I activity in HepG2 cells. We demonstrated that decreased BCAAs and increased NEAAs stimulated phosphorylated IGFBP-1 secretion. We also revealed that decreased BCAA-to-NEAA ratios enhanced phosphorylated IGFBP-1 secretion, while changes in the total amount of amino acids (AAs) had no effect...
February 2017: Growth Factors
https://www.readbyqxmd.com/read/28449068/development-of-a-novel-human-recellularized-endometrium-that-responds-to-a-28-day-hormone-treatment
#8
Susan A Olalekan, Joanna E Burdette, Spiro Getsios, Teresa K Woodruff, J Julie Kim
Three dimensional (3D) in vitro models have been established to study the physiology and pathophysiology of the endometrium. With emerging evidence that the native extracellular matrix (ECM) provides appropriate cues and growth factors essential for tissue homeostasis, we describe, a novel 3D endometrium in vitro model developed from decellularized human endometrial tissue repopulated with primary endometrial cells. Analysis of the decellularized endometrium using mass spectrometry analysis revealed an enrichment of cell adhesion molecules, cytoskeletal proteins and ECM proteins such as Collagen IV and Laminin...
April 25, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28443632/erratum-loss-of-mir-542-3p-enhances-igfbp-1-expression-in-decidualizing-human-endometrial-stromal-cells
#9
Hideno Tochigi, Takeshi Kajihara, Yosuke Mizuno, Yumi Mizuno, Shunsuke Tamaru, Yoshimasa Kamei, Yasushi Okazaki, Jan J Brosens, Osamu Ishihara
No abstract text is available yet for this article.
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435049/exposure-of-decidualized-hiesc-to-low-oxygen-tension-and-leucine-deprivation-results-in-increased-igfbp-1-phosphorylation-and-reduced-igf-i-bioactivity
#10
Majida Abu Shehab, Kyle Biggar, Sahil Sagar Singal, Karen Nygard, Shawn Shun-Cheng Li, Thomas Jansson, Madhulika B Gupta
Phosphorylation of decidual IGFBP-1 enhances binding of IGF-I, limiting the bioavailability of this growth factor which may contribute to reduced placental and fetal growth. The mechanisms regulating decidual IGFBP-1 phosphorylation are incompletely understood. Using decidualized human immortalized endometrial stromal cells we tested the hypothesis that low oxygen tension or reduced leucine availability, believed to be common in placental insufficiency, increase the phosphorylation of decidual IGFBP-1. Multiple reaction monitoring-MS (MRM-MS) was used to quantify IGFBP-1 phosphorylation...
April 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28422393/accuracy-and-response-time-of-dual-biomarker-model-of-insulin-like-growth-factor-binding-protein-1-alpha-fetoprotein-amnioquick-duo-in-comparison-to-placental-alpha-microglobulin-1-test-in-diagnosis-of-premature-rupture-of-membranes
#11
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Joseph Ifeanyichukwu Ikechebelu, Chukwuemeka Okwudili Ezeama, Ifeanyichukwu Uzoma Ezebialu, Nnabuike Okechukwu Ojiegbe, Chukwudi Celestine Obiora, Charles Ikechukwu Okafor, Gerald Okanandu Udigwe, Betrand Obi Nwosu, Frank O Ezugwu
AIM: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). METHODS: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28420208/serum-insulin-like-growth-factor-axis-and-the-risk-of-pancreatic-cancer-systematic-review-and-meta-analysis
#12
Yuanfeng Gong, Bingyi Zhang, Yadi Liao, Yunqiang Tang, Cong Mai, Tiejun Chen, Hui Tang
OBJECTIVE: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). METHODS: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of original studies and review articles on this topic. A summary of relative risks with 95% confidence intervals (CI) was calculated using a random-effects model. The heterogeneity between studies was assessed using Cochran Q and I² statistics...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28361446/does-milk-intake-promote-prostate-cancer-initiation-or-progression-via-effects-on-insulin-like-growth-factors-igfs-a-systematic-review-and-meta-analysis
#13
REVIEW
Sean Harrison, Rosie Lennon, Jeff Holly, Julian P T Higgins, Mike Gardner, Claire Perks, Tom Gaunt, Vanessa Tan, Cath Borwick, Pauline Emmet, Mona Jeffreys, Kate Northstone, Sabina Rinaldi, Stephen Thomas, Suzanne D Turner, Anna Pease, Vicky Vilenchick, Richard M Martin, Sarah J Lewis
PURPOSE: To establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3). METHODS: Systematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28259137/chronic-endometritis-modifies-decidualization-in-human-endometrial-stromal-cells
#14
Di Wu, Fuminori Kimura, Luyi Zheng, Mitsuaki Ishida, Yoko Niwa, Kimiko Hirata, Akie Takebayashi, Akiko Takashima, Kentaro Takahashi, Ryoji Kushima, Guangmei Zhang, Takashi Murakami
BACKGROUND: Chronic endometritis (CE) is a continuous inflammation of uterine endometrium, and it is usually symptomless. As CE has been thought not to affect the reproductive status and general health of affected women, its significance has not been explored. However, recent studies have shown that CE is related with repeated implantation failures after in vitro fertilization-embryo transfer, unexplained infertility, and recurrent miscarriages. As decidua differentiates to support the implantation process and maintains the pregnancy, we hypothesized that CE may influence the process of decidualization...
March 4, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28257428/dietary-protein-induced-hepatic-igf-1-secretion-mediated-by-ppar%C3%AE-activation
#15
Xiaojuan Wan, Songbo Wang, Jingren Xu, Lu Zhuang, Kongping Xing, Mengyuan Zhang, Xiaotong Zhu, Lina Wang, Ping Gao, Qianyun Xi, Jiajie Sun, Yongliang Zhang, Tiejun Li, Gang Shu, Qingyan Jiang
Dietary protein or amino acid (AA) is a crucial nutritional factor to regulate hepatic insulin-like growth factor-1 (IGF-1) expression and secretion. However, the underlying intracellular mechanism by which dietary protein or AA induces IGF-1 expression remains unknown. We compared the IGF-1 gene expression and plasma IGF-1 level of pigs fed with normal crude protein (CP, 20%) and low-protein levels (LP, 14%). RNA sequencing (RNA-seq) was performed to detect transcript expression in the liver in response to dietary protein...
2017: PloS One
https://www.readbyqxmd.com/read/28245469/decidualization-is-impaired-in-endometrial-stromal-cells-from-uterine-rudiments-in-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome
#16
Sara Y Brucker, Simone Eisenbeis, Juliana König, Melanie Lamy, Madhuri S Salker, Ni Zeng, Harald Seeger, Melanie Henes, Dorit Schöller, Birgitt Schönfisch, Annette Staebler, Florin-Andrei Taran, Diethelm Wallwiener, Katharina Rall
BACKGROUND/AIMS: Uterine rudiments from patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) contain all tissues typically found in the uterus. Endometrium from the rudiments predominantly exhibits basalis-like features, and endometrial proliferative capacity in patients' epithelium and stroma is significantly lower. METHODS: This single-center, prospective study conducted at a major German university hospital compared in-vitro decidualization in cultured ESCs from MRKHS patients and hysterectomy controls...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28236632/accuracy-of-a-combined-insulin-like-growth-factor-binding-protein-1-interleukin-6-test-premaquick-in-predicting-delivery-in-women-with-threatened-preterm-labor
#17
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Lydia Ijeoma Eleje, Joseph Ifeanyichukwu Ikechebelu, Ifeanyichukwu Uzoma Ezebialu, Chukwudi Celestine Obiora, Betrand Obi Nwosu, Chukwuemeka Okwudili Ezeama, Gerald Okanandu Udigwe, Charles Ikechukwu Okafor, Frank Okechukwu Ezugwu
PURPOSE: To determine values of combinations of interleukin-6 (IL-6)/cervical native insulin-like growth factor-binding protein-1 (IGFBP-1)/total IGFBP-1 (Premaquick©) in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in women with threatened preterm labor. METHODS: Women with singleton pregnancies between gestation age (GA) of 24 weeks and 36 weeks and 6 days with preterm labor were recruited during a prospective multicenter study...
February 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28179448/the-igf-system-in-patients-with-type-2-diabetes-associations-with-markers-of-cardiovascular-target-organ-damage
#18
Rikke Hjortebjerg, Esben Laugesen, Pernille Høyem, Claus Oxvig, Brian Stausbøl-Grøn, Søren T Knudsen, Won Y Kim, Per L Poulsen, Troels K Hansen, Mette Bjerre, Jan Frystyk
OBJECTIVE: Perturbations in the insulin-like growth factor (IGF) system may contribute to the accelerated cardiovascular disease (CVD) that occurs in patients with type 2 diabetes (T2D). However, it remains unknown whether the IGF system is also involved in the development of early, subclinical CVD. We characterised the IGF system in T2D patients and matched controls and examined the associations with markers of subclinical target organ damage. METHODS: The study included 99 patients with recently diagnosed T2D and 99 age- and sex-matched controls...
May 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28178340/sputum-biomarkers-in-ipf-evidence-for-raised-gene-expression-and-protein-level-of-igfbp-2-il-8-and-mmp-7
#19
J Guiot, M Henket, J L Corhay, C Moermans, R Louis
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease of unknown origin leading rapidly to death. This paper addresses the issue of whether sputum induction is a suitable tool to study respiratory tract inflammation and potential biomarkers in IPF compared to COPD, a fibrosing airway wall disease. METHODS: In a cross-sectional analysis, 15 IPF patients, 32 COPD and 30 healthy subjects underwent sputum induction. Total sputum cell counts and the amount of TGF- β, IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, IL-8, IL-13, MMP-7, MMP-9, YKL-40, TNF-α and KL-6 in sputum supernatant were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/28143425/higher-igfbp-1-to-igf-1-serum-ratio-predicts-unfavourable-survival-in-patients-with-nasopharyngeal-carcinoma
#20
Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu, Ge Zhang
BACKGROUND: The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopathological significance and prognostic value in nasopharyngeal carcinoma (NPC). METHODS: IGF system components (IGF-1, IGF-2, IGF-1SR, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-6) were quantified from the plasma of NPC patients and healthy individuals using the RayBio Human Cytokine Antibody Array...
January 31, 2017: BMC Cancer
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