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coronary plaque burden

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https://www.readbyqxmd.com/read/28630603/elevated-il-37-levels-in-the-plasma-of-patients-with-severe-coronary-artery-calcification
#1
Meng Chai, Hai-Tao Zhang, Yu-Jie Zhou, Qing-Wei Ji, Qing Yang, Yu-Yang Liu, Ying-Xin Zhao, Dong-Mei Shi, Wei Liu, Li-Xia Yang, Lin-Lin Zhang, Jing Liang
BACKGROUND: Coronary artery calcification (CAC) is a predictor of cardiovascular events and plaque burden and is closely associated with chronic inflammation. Interleukin (IL)-37 is a newly discovered member of the IL-1 family and is considered an anti-inflammatory cytokine. Our recent study on mice indicated that IL-37 could attenuate atherosclerosis and vascular calcification, which suggests that IL-37 could be associated with the development of atherosclerosis and related diseases...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28629625/what-exactly-regression-of-atherosclerosis-or-foreign-body-reaction-with-hyaline-arteriosclerosis-drives-transient-scaffolding-of-coronary-arteries-a-pooled-analysis-of-observational-absorb-studies-with-a-serial-multimodality-imaging-substudy-of-absorb-cohort
#2
Alexander N Kharlamov, John A Feinstein, John A Cramer, John A Boothroyd
OBJECTIVES: We aimed to estimate the trends of the artery remodeling after transient scaffolding. BACKGROUND: At least 2.62% reduction of the per cent atheroma volume (PAV) or plaque burden (PB) performed in ABSORB B trial at 60months. METHODS: The detailed multiple serial imaging evaluation was performed by intravascular ultrasound (IVUS) in comparison with quantitative coronary angiography (QCA), multislice CT (MSCT) and optical coherence tomography (OCT) thru 24months in the ABSORB cohort B1 trial (n=45) with the pooled analysis in ABSORB A and B trials (n=131)...
June 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28606882/the-effect-of-coronary-bifurcation-and-blood-flow-modelling-in-prediction-of-atherosclerotic-plaque-development-a-serial-computed-tomographic-coronary-angiographic-study
#3
Antonis Sakellarios, Christos V Bourantas, Stella-Lida Papadopoulou, Pieter H Kitslaar, Chrysafios Girasis, Gregg W Stone, Johan H C Reiber, Lampros K Michalis, Patrick W Serruys, Pim J de Feyter, Hector M Garcia-Garcia, Dimitrios I Fotiadis
AIMS: Examine the effect of the daughter branches to the haemodynamics and the potential prediction of atherosclerotic plaque development as well as the best flow division model for accurate blood flow modelling. METHODS AND RESULTS: In this study, we analysed computed tomographic coronary angiography retrospective data portraying 17 coronary artery bifurcations in 15 patients recruited in the PROSPECT MSCT study. The baseline and three year follow-up imaging data were used to reconstruct coronary artery anatomy and in the baseline models blood flow simulations was performed using three flow division approaches: stress-free, Murray's law and Doriot's law...
June 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28592134/circulating-annexin-a5-levels-are-associated-with-carotid-intima-media-thickness-but-not-coronary-plaque-composition
#4
Mathias Burgmaier, Sebastian Reith, Leon Schurgers, Florian Kahles, Nikolaus Marx, Chris Reutelingsperger
BACKGROUND: Annexin A5 (anxA5) is involved in processes which are crucial in atherogenesis. However, anxA5's relationship with atherosclerotic lesion extension and plaque composition in high-risk patients with type 2 diabetes remains unclear. Thus, we characterized the association between circulating anxA5 levels with atherosclerotic burden and coronary plaque composition in diabetes mellitus patients. METHODS: Intima-media thickness was determined in 96 diabetes mellitus patients with stable coronary artery disease...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28591063/a-new-technique-for-lipid-core-plaque-detection-by-optical-coherence-tomography-for-prevention-of-peri-procedural-myocardial-infarction-a-case-report
#5
Yongcheol Kim, Muthukaruppan Gnanadesigan, Gijs van Soest, Thomas W Johnson
RATIONALE: Percutaneous coronary intervention (PCI) provides effective revascularization of atherosclerotic coronary arteries but the invasive nature of treatment can result in complications. PATIENT CONCERNS: A 53-year old man underwent coronary angiography due to chest pain with minimal ST-segment elevation in the inferior leads of the electrocardiogram. DIAGNOSIS: We proceeded directly to coronary angiography and delineated a moderate stenosis with haziness in the mid right coronary artery (RCA)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28585034/myocardial-perfusion-imaging-in-women-for-the-evaluation-of-stable-ischemic-heart-disease-state-of-the-evidence-and-clinical-recommendations
#6
Viviany R Taqueti, Sharmila Dorbala, David Wolinsky, Brian Abbott, Gary V Heller, Timothy M Bateman, Jennifer H Mieres, Lawrence M Phillips, Nanette K Wenger, Leslee J Shaw
This document from the American Society of Nuclear Cardiology represents an updated consensus statement on the evidence base of stress myocardial perfusion imaging (MPI), emphasizing new developments in single-photon emission tomography (SPECT) and positron emission tomography (PET) in the clinical evaluation of women presenting with symptoms of stable ischemic heart disease (SIHD). The clinical evaluation of symptomatic women is challenging due to their varying clinical presentation, clinical risk factor burden, high degree of comorbidity, and increased risk of major ischemic heart disease events...
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28568890/myocardial-mass-contributes-to-the-discrepancy-between-anatomic-stenosis-severity-assessed-by-intravascular-ultrasound-and-fractional-flow-reserve-in-intermediate-lesions-of-the-coronary-artery
#7
Myeong-Ho Yoon, Seung-Jea Tahk, Hong-Seok Lim, Hyoung-Mo Yang, Kyoung-Woo Seo, Byoung-Joo Choi, So-Yeon Choi, Gyo-Seung Hwang, Jin-Sun Park, Joon-Han Shin
OBJECTIVES: The present study investigated the major contributors to the discrepancy between the minimal lumen area (MLA) and fractional flow reserve (FFR). BACKGROUND: There was considerable discrepancy between MLA or diameter stenosis (DS) and FFR. METHODS: We enrolled 744 patients with intermediate stenoses of the left anterior descending artery (LAD). Summed epicardial coronary artery length distal to the target stenosis was obtained from each longest view of the vessels on the coronary angiograms...
June 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28567351/regression-of-coronary-atherosclerosis-with-infusions-of-the-high-density-lipoprotein-mimetic-cer-001-in-patients-with-more-extensive-plaque-burden
#8
Yu Kataoka, Jordan Andrews, MyNgan Duong, Tracy Nguyen, Nisha Schwarz, Jessica Fendler, Rishi Puri, Julie Butters, Constance Keyserling, John F Paolini, Jean-Louis Dasseux, Stephen J Nicholls
BACKGROUND: CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol. Infusion of CER-001 3 mg/kg exhibited a potentially favorable effect on plaque burden in the CHI-SQUARE (Can HDL Infusions Significantly Quicken Atherosclerosis Regression) study. Since baseline atheroma burden has been shown as a determinant for the efficacy of HDL infusions, the degree of baseline atheroma burden might influence the effect of CER-001. METHODS: CHI-SQUARE compared the effect of 6 weekly infusions of CER-001 (3, 6 and 12 mg/kg) vs...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28543093/relationship-between-carotid-atherosclerosis-and-coronary-artery-calcification-in-asymptomatic-diabetic-patients-a-prospective-multicenter-study
#9
Anand Jeevarethinam, Shreenidhi Venuraju, Alain Dumo, Sherezade Ruano, Vishal S Mehta, Miranda Rosenthal, Devaki Nair, Mark Cohen, Daniel Darko, Avijit Lahiri, Roby Rakhit
BACKGROUND: The value of screening sub-clinical atherosclerosis in asymptomatic patients with type 2 diabetes mellitus (T2DM) remains controversial. HYPOTHESIS: An integrated model incorporating carotid intima-media thickness (CIMT) and carotid plaque with traditional risk factors can be used to predict prevalence and severity of coronary artery calcification in asymptomatic T2DM patients. METHODS: A cohort of 262 asymptomatic T2DM patients were prospectively studied with carotid ultrasound to evaluate CIMT and carotid plaque and also a computed tomography coronary artery calcium (CT-CAC) scan...
May 25, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28542516/evaluation-of-the-systemic-micro-and-macrovasculature-in-stable-angina-a-case-control-study
#10
Ulf Neisius, Erin Olson, Sabrina H Rossi, Hagar A Ibrahim, Gemma Currie, Anna F Dominiczak, Christian Delles
AIMS: The diagnosis of stable angina involves the use of probability estimates based on clinical presentation, age, gender and cardiovascular risk factors. In view of the link between the cardiac and systemic vasculature we tested whether non-invasive measures of systemic micro- and macrovascular structure and function differentiate between individuals with flow-limiting coronary artery disease (CAD) and those with normal coronary arteries (NCA). METHODS AND RESULTS: We recruited 84 patients undergoing elective coronary angiography for investigation of symptoms of stable angina...
2017: PloS One
https://www.readbyqxmd.com/read/28540216/impact-of-plaque-characteristics-on-the-degree-of-functional-stenosis
#11
REVIEW
Pedro de Araújo Gonçalves, Alexandre Hideo-Kajita, Hector Manuel Garcia-Garcia
Coronary CT angiography (CCTA) is mainly regarded as a gatekeeper for invasive coronary angiography, in face of its widely recognized value to noninvasively rule out significant coronary stenosis. Nevertheless, it is also increasingly recognized that this noninvasive modality can depict several atherosclerotic plaque features and quantify total coronary plaque burden. This opens a new field for cardiac CT, since these atherosclerotic features beyond stenosis severity have been correlated with the degree of functional significance, and are the focus of the present manuscript...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28540143/association-between-coronary-artery-disease-and-microrna-literature-review-and-clinical-perspective
#12
Rehan Malik, Raja S Mushtaque, Usman A Siddiqui, Adnan Younus, Muhammad A Aziz, Choudhry Humayun, Kanaan Mansoor, Muhammad A Latif, Salman Waheed, Salman Assad, Idrees Khan, Syed M Bukhari, Daniel DelCampo, Ali Adus, Swetha Gannarapu
BACKGROUND: Until recently, circulating micro-RNAs (miRNAs) have attracted major interest as novel biomarkers for the early diagnosis of coronary artery disease (CAD). This review article summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD in an adult population. METHODS: A systematic literature analysis and retrieval online systems Public/Publisher MEDLINE/ Excerpta Medica Database /Medical Literature Analysis and Retrieval System Online,(PUBMED/EMBASE/MEDLINE) search were conducted for relevant information...
April 23, 2017: Curēus
https://www.readbyqxmd.com/read/28533317/cardiovascular-toxicity-of-illicit-anabolic-androgenic-steroid-use
#13
Aaron L Baggish, Rory B Weiner, Gen Kanayama, James I Hudson, Michael T Lu, Udo Hoffmann, Harrison G Pope
BACKGROUND: Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain incompletely understood. METHODS: Using a cross-sectional cohort design, we recruited 140 experienced male weightlifters 34 to 54 years of age, comprising 86 men reporting ≥2 years of cumulative lifetime AAS use and 54 nonusing men. Using transthoracic echocardiography and coronary computed tomography angiography, we assessed 3 primary outcome measures: left ventricular (LV) systolic function (left ventricular ejection fraction), LV diastolic function (early relaxation velocity), and coronary atherosclerosis (coronary artery plaque volume)...
May 23, 2017: Circulation
https://www.readbyqxmd.com/read/28531282/near-infrared-spectroscopy-derived-lipid-core-burden-index-predicts-adverse-cardiovascular-outcome-in-patients-with-coronary-artery-disease-during-long-term-follow-up
#14
Anne-Sophie Schuurman, Maxime Vroegindewey, Isabella Kardys, Rohit M Oemrawsingh, Jin M Cheng, Sanneke de Boer, Hector M Garcia-Garcia, Robert-Jan van Geuns, Evelyn S Regar, Joost Daemen, Nicolas M van Mieghem, Patrick W Serruys, Eric Boersma, K Martijn Akkerhuis
Aims: Near-infrared spectroscopy (NIRS) is able to quantify cholesterol within coronary arteries by the lipid core burden index (LCBI). We studied the prognostic value of NIRS-derived LCBI in patients with coronary artery disease (CAD) for adverse cardiac outcome during long-term follow-up. Methods and results: During 2009-2013, NIRS was performed in a non-culprit artery of 275 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina...
May 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28528743/-18-f-sodium-fluoride-positron-emission-tomography-for-molecular-imaging-of-coronary-atherosclerosis-based-on-computed-tomography-analysis
#15
Toshiro Kitagawa, Hideya Yamamoto, Shinya Toshimitsu, Ko Sasaki, Atsuhiro Senoo, Yumiko Kubo, Fuminari Tatsugami, Kazuo Awai, Yutaka Hirokawa, Yasuki Kihara
BACKGROUND AND AIMS: We aimed at evaluating the relation of (18)F-sodium fluoride ((18)F-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT). METHODS: Thirty-two patients with one or more coronary atherosclerotic lesions detected on cardiac CT underwent (18)F-NaF PET/CT. Each coronary atherosclerotic lesion was evaluated on CT angiography for plaque types (calcified plaque [CP], non-calcified plaque [NCP], partially calcified plaque [PCP]), and the presence of CT-based high-risk features (minimum CT density <30 Hounsfield units and vascular remodeling index >1...
April 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28522312/intravascular-imaging-in-cardiovascular-ageing
#16
REVIEW
Christos V Bourantas, Tom Crake, Yao-Jun Zhang, Mick Ozkor, Javed Ahmed, Hector M Garcia-Garcia, Patrick W Serruys
Ageing is related to complex molecular, inflammatory and biochemical changes that affect coronary pathology and often lead to coronary artery disease and cardiovascular events. Intravascular imaging is considered as the ideal technique to study coronary plaque morphology and assess its burden. Over the recent years several studies have been performed that investigated the association between pathophysiological mechanisms that promote vascular ageing and plaque morphology. In addition, several reports have compared plaque pathology in different age groups and a few studies included serial intravascular imaging to assess changes in the atheroma burden and compositional characteristics of the plaque...
May 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28521932/discordance-between-fractional-flow-reserve-and-coronary-flow-reserve-insights-from-intracoronary-imaging-and-physiological%C3%A2-assessment
#17
Sung Gyun Ahn, Jon Suh, Olivia Y Hung, Hee Su Lee, Yasir H Bouchi, Wenjie Zeng, Rounak Gandhi, Parham Eshtehardi, Bill D Gogas, Habib Samady
OBJECTIVES: The aim of this study was to investigate the epicardial and microvascular substrates associated with discordances between fractional flow reserve (FFR) and coronary flow reserve (CFR) values. BACKGROUND: Discordances between FFR and CFR remain poorly characterized. METHODS: FFR, hyperemic stenosis resistance (HSR), and intravascular ultrasound were performed as indexes of epicardial function and CFR and hyperemic microvascular resistance (HMR) as measures of microvascular function in 94 patients with moderate coronary stenosis...
May 22, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28515369/effect-of-reverse-vessel-remodeling-on-regression-of-coronary-atherosclerosis-in-patients-treated-with-aggressive-lipid-and-blood-pressure-lowering-therapy%C3%A3-insight-from-million-study
#18
Tadatsugu Gamou, Kenji Sakata, Hayato Tada, Tetsuo Konno, Kenshi Hayashi, Hidekazu Ino, Masakazu Yamagishi, Masa-Aki Kawashiri
BACKGROUND: The MILLION study, a prospective randomized multicenter study, revealed that lipid and blood pressure (BP)-lowering therapy resulted in regression of coronary plaque as determined by intravascular ultrasound (IVUS). In the present study we performed additional analysis to investigate the associated factors with regression of coronary plaque.Methods and Results:We investigated serial 3D IVUS images from 68 patients in the MILLION study. Standard IVUS parameters were assessed at both baseline and follow-up (18-24 months)...
May 17, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28492564/-heart-rate-as-a-therapeutic-target-after-acute-coronary-syndrome-and-in-chronic-coronary-heart-disease
#19
Marco Ambrosetti, Giuseppe Scardina, Giuseppe Favretto, Pier Luigi Temporelli, Pompilio Massimo Faggiano, Cesare Greco, Roberto Franco Pedretti
For patients with stable coronary artery disease (SCAD), either after hospitalization for acute cardiac events or in the chronic phase, comprehensive treatment programs should be devoted to: (i) reducing mortality and major adverse cardiovascular events, (ii) reducing the ischemic burden and related symptoms, and (iii) increasing exercise capacity and quality of life.Heart rate (HR) has demonstrated to have prognostic value and patients beyond the limit of 70 bpm display increased risk of all the above adverse outcomes, even after adjustment for parameters such as the extension of myocardial infarction and the presence of heart failure...
March 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28487327/resistant-atherosclerosis-the-need-for-monitoring-of-plaque-burden
#20
J David Spence, Karla Solo
BACKGROUND AND PURPOSE: Recent studies indicate that patients with lower levels of low-density lipoprotein cholesterol (LDL-C) have greater regression of coronary plaque. In 2002, we found that carotid plaque progression doubled cardiovascular risk. In 2003, we therefore implemented a new approach, treating arteries instead of risk factors. Since then, we have seen many patients with carotid plaque progression despite very low levels of LDL-C, suggesting other causes of atherosclerosis...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
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