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coronary plaque burden

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https://www.readbyqxmd.com/read/28209562/vinexin-%C3%AE-ablation-inhibits-atherosclerosis-in-apolipoprotein-e-deficient-mice-by-inactivating-the-akt-nuclear-factor-%C3%AE%C2%BAb-inflammatory-axis
#1
Hongjing Guan, Wen-Lin Cheng, Junhong Guo, Meng-Lin Chao, Yan Zhang, Jun Gong, Xue-Yong Zhu, Zhi-Gang She, Zan Huang, Hongliang Li
BACKGROUND: Vinexin β is a novel adaptor protein that regulates cellular adhesion, cytoskeletal reorganization, signal transduction, and transcription; however, the exact role that vinexin β plays in atherosclerosis remains unknown. METHODS AND RESULTS: Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining...
February 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28196817/comparison-of-carotid-plaque-score-and-coronary-artery-calcium-score-for-predicting-cardiovascular-disease-events-the-multi-ethnic-study-of-atherosclerosis
#2
Adam D Gepner, Rebekah Young, Joseph A Delaney, Matthew J Budoff, Joseph F Polak, Michael J Blaha, Wendy S Post, Erin D Michos, Joel Kaufman, James H Stein
BACKGROUND: Coronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown. METHODS AND RESULTS: CVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound-detected plaques in the common, bifurcation, and internal carotid artery segments...
February 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28191713/tissue-characterization-and-phenotype-classification-in-patients-presenting-with-acute-myocardial-infarction-insights-from-the-iwonder-study
#3
Cristiano F Souza, Akiko Maehara, Gary S Mintz, Mitsuaki Matsumura, Claudia M R Alves, Antonio Carlos Carvalho, Adriano Caixeta
OBJECTIVES: We sought to assess a new modality of radiofrequency intravascular ultrasound (IVUS) called iMAP-IVUS (Boston Scientific, Santa Clara, California) during the evaluation of patients presenting with high-risk acute coronary syndromes. BACKGROUND: There are limited data on plaque tissue characterization and phenotype classification using iMAP-IVUS. METHODS: In the iWonder study patients presenting with ST-elevation myocardial infarction (STEMI) or non-STEMI underwent three-vessel grayscale IVUS and iMAP-IVUS tissue characterization prior to percutaneous intervention...
February 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28177655/iterative-image-reconstruction-improves-the-accuracy-of-automated-plaque-burden-assessment-in-coronary-ct-angiography-a-comparison-with-intravascular-ultrasound
#4
Stefan B Puchner, Maros Ferencik, Akiko Maehara, Paul Stolzmann, Shixin Ma, Synho Do, Hans-Ulrich Kauczor, Gary S Mintz, Udo Hoffmann, Christopher L Schlett
OBJECTIVE: The purpose of this study was to determine whether use of iterative image reconstruction algorithms improves the accuracy of coronary CT angiography (CCTA) compared with intravascular ultrasound (IVUS) in semiautomated plaque burden assessment. MATERIALS AND METHODS: CCTA and IVUS images of seven coronary arteries were acquired ex vivo. CT images were reconstructed with filtered back projection (FBP) and adaptive statistical (ASIR) and model-based (MBIR) iterative reconstruction algorithms...
February 8, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28164672/circulating-endothelial-progenitor-cells-were-increased-in-patients-with-thin-cap-fibroatheroma
#5
Qiang Tan, Qingsheng Wang, Shuangyue Zhang, Ximing Qi, Yang Li
BACKGROUND: We used virtual histology-intravascular ultrasound (VH-IVUS) to evaluate the relationship between circulating endothelial progenitor cells (EPC) and thin-cap fibroatheroma (TCFA). METHODS: This study included 52 patients with unstable angina who underwent coronary angiography and IVUS examination. Patients were divided into a TCFA group (n = 21) or a non-TCFA group (n = 31) based on VH-IVUS performance. Before angiography, peripheral blood levels of EPC were measured by flow cytometry...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28150280/galectin-3-is-associated-with-coronary-plaque-burden-and-obstructive-sleep-apnea-syndrome-severity
#6
Hamdi Pusuroglu, Umut Somuncu, Ismail Bolat, Ozgur Akgul, Vesile Ornek, Hayriye Ak Yıldırım, Emre Akkaya, Huseyin Karakurt, Aydın Yıldırım, Ayfer Utku Savaş
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is reported to be associated with hypertension, coronary artery disease, atrial fibrillation, and heart failure. Galectin-3 plays an important role in the regulation of inflammation, development of cardiac fibrosis and remodeling. A significant relationship between galectin-3 and the total number of coronary plaques and the macrocalcified plaque structures of patients with type 2 DM has been reported. AIM: The aim of this study was to investigate the association between galectin-3 level and coronary plaque burden as well as OSAS severity in patients with obstructive sleep apnea syndrome...
February 2, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28130645/subclinical-atherosclerosis-detected-by-coronary-computed-tomographic-angiography-in-qatar-a-comparison-between-qataris-and-south-asian-migrants
#7
Joshua Schulman-Marcus, Ran Heo, Heidi Gransar, Jassim Al Suwaidi, Maryam Alkuwari, Kimberly Elmore, Mille J Gomez, Amin Jayyousi, Mahmoud Zirie, James K Min, Jessica M Peña
PURPOSE: There are limited data regarding subclinical atherosclerosis in Middle Eastern countries. We aimed to describe and compare coronary computed tomographic angiography (CCTA) findings in Qatari native and South Asian migrants at increased risk of coronary artery disease (CAD). METHODS: We performed CCTA in 251 consecutive volunteers (126 South Asian, 125 Qatari, mean age 50.0 ± 7.3 years, 27.1% female) at increased risk of cardiovascular disease. Given differences in baseline risk factors, we employed propensity score matching to create a cohort of 162 subjects for comparative analyses...
January 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28118185/comparison-of-plaque-morphology-between-peripheral-and-coronary-artery-disease-from-the-clarity-and-adapt-des-ivus-substudies
#8
Da Yin, Mitsuaki Matsumura, John Rundback, Jason A Yoho, Bernhard Witzenbichler, Gregg W Stone, Gary S Mintz, Akiko Maehara
OBJECTIVE: The aim of this study was to help understand the different outcomes when treating peripheral arterial disease (PAD) versus coronary artery disease (CAD). We compared plaque morphology between PAD and CAD using intravascular ultrasound. METHODS: Complete Lesion Assessment with ffR and IVUS TechnologY (CLARITY) was a prospective, multicenter trial that enrolled 50 PAD patients with a lower extremity wound fed by a tibial or a peroneal artery with diameter stenosis more than 50%...
January 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28110570/-computer-tomography-examination-of-the-coronary-system-national-plaque-registry-and-database-hungary
#9
Zsolt Bagyura, Márton Kolossváry, Béla Merkely, Pál Maurovich-Horvat
INTRODUCTION AND AIM: Coronary computer tomography angiography is a unique non-invasive imaging technique with the capability to provide information regarding plaque quantity, burden and structure. A reliable registry is required to use the data of these examinations in research projects. The difficulty is that registries need double data entry simultaneously to the hospital information system. METHOD: Our registry solves this problem through a structured reporting tool, which generates clinical report and stores all data simultaneously...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28109934/coronary-plaque-burden-and-adverse-plaque-characteristics-are-increased-in-healthy-relatives-of-patients-with-early-onset-coronary-artery-disease
#10
Morten K Christiansen, Jesper M Jensen, Bjarne L Nørgaard, Damini Dey, Hans Erik Bøtker, Henrik K Jensen
OBJECTIVES: This study characterized and quantified subclinical atherosclerosis by coronary computed tomography angiography (CTA) in first-degree relatives of patients with early onset coronary artery disease (CAD). BACKGROUND: A strong family history of CAD is an important risk factor for adverse cardiovascular events. Whether predisposed individuals suffer an increased burden of coronary atherosclerosis and adverse plaque features is not known. METHODS: We included 88 healthy middle-aged first-degree relatives from 59 families with early onset CAD...
January 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109718/lipid-core-burden-response-to-stent-implantation-assessed-with-near-infrared-spectroscopy-and-intravascular-ultrasound-evaluation-in-patients-with-myocardial-infarction
#11
Manijeh Noori, Per Thayssen, Karsten Tange Veien, Anders Junker, Knud Nørregaard Hansen, Henrik Steen Hansen, Lisette Okkels Jensen
INTRODUCTION: Near-infrared spectroscopy (NIRS) is a new method to identify lipid core plaque (LCP). The LCP and vascular response were assessed with NIRS to examine whether LCP was compressed or redistributed during percutaneous coronary intervention with stent implantation. METHODS: In 25 patients with non-ST segment elevation myocardial infarction (NSTEMI) NIRS acquisition was performed after predilation, stent implantation with nominal pressure and high-pressure post-dilation with a non-compliant balloon...
December 27, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28107355/assessment-of-inter-expert-variability-and-of-an-automated-segmentation-method-of-40-and-60-mhz-ivus-images-of-coronary-arteries
#12
François Destrempes, Marie-Hélène Roy Cardinal, Yoshifumi Saijo, Gérard Finet, Jean-Claude Tardif, Guy Cloutier
The objectives were to compare the performance of a segmentation algorithm, based on the minimization of an uncertainty function, to delineate contours of external elastic membrane and lumen of human coronary arteries imaged with 40 and 60 MHz IVUS, and to use values of this function to delineate portions of contours with highest uncertainty. For 8 patients, 40 and 60 MHz IVUS coronary data acquired pre- and post-interventions were used, for a total of 68,516 images. Manual segmentations of contours (on 2312 images) performed by experts at three core laboratories were the gold-standards...
2017: PloS One
https://www.readbyqxmd.com/read/28062170/an-artificial-neural-network-method-for-lumen-and-media-adventitia-border-detection-in-ivus
#13
Shengran Su, Zhenghui Hu, Qiang Lin, William Kongto Hau, Zhifan Gao, Heye Zhang
Intravascular ultrasound (IVUS) has been well recognized as one powerful imaging technique to evaluate the stenosis inside the coronary arteries. The detection of lumen border and media-adventitia (MA) border in IVUS images is the key procedure to determine the plaque burden inside the coronary arteries, but this detection could be burdensome to the doctor because of large volume of the IVUS images. In this paper, we use the artificial neural network (ANN) method as the feature learning algorithm for the detection of the lumen and MA borders in IVUS images...
November 17, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28060223/coronary-plaque-progression-and-regression-in-asymptomatic-african-american-chronic-cocaine-users-with-obstructive-coronary-stenoses-a-preliminary-study
#14
Veit Sandfort, David A Bluemke, Jose Vargas, Jeffrey A Brinker, Gary Gerstenblith, Thomas Kickler, Gang Zheng, Ji Li, Shaoguang Chen, Hong Lai, Elliot K Fishman, Shenghan Lai
OBJECTIVE: Although rapid progression of coronary atherosclerosis was observed in chronic cocaine users, it is unknown whether reduced cocaine use retards the progression of atherosclerosis. We investigated whether reduced cocaine use over a 12-month period was associated with coronary plaque regression in cocaine users. METHODS: Fifteen African American chronic cocaine users with previously coronary computed tomography angiography (CCTA)-confirmed >50% coronary stenosis in Baltimore, Maryland, were enrolled in a study to investigate whether reduced cocaine use is associated with changes in coronary plaque burden over a 12-month period of cash-based incentive intervention, which was implemented to systematically reinforce cocaine abstinence...
January 6, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28052860/increased-prevalence-of-coronary-plaque-in-patients-with-psoriatic-arthritis-without-prior-diagnosis-of-coronary-artery-disease
#15
Jiayun Shen, Ka-Tak Wong, Isaac T Cheng, Qing Shang, Edmund K Li, Priscilla Wong, Emily W Kun, Mei Yan Law, Ronald Yip, Isaac Yim, Shirley Ying, Martin Li, Tena K Li, Chun-Kwok Wong, Tracy Y Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVES: To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using coronary CT angiography (CCTA). METHODS: Ninety consecutive patients with PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls (male: 137(57.1%); 49.6±10.7 years) without known cardiovascular (CV) diseases who underwent CCTA due to chest pain and/or multiple CV risk factors were recruited for comparison. RESULTS: Patients with PsA and controls were matched in age, gender and traditional CV risk factors (all p>0...
January 4, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28040277/microparticles-and-their-role-in-coronary-artery-disease
#16
REVIEW
Sudheer Koganti, Despina Eleftheriou, Paul A Brogan, Tushar Kotecha, Ying Hong, Roby D Rakhit
Despite significant advances in prevention, medical and interventional management, coronary artery disease (CAD) remains the leading cause of death worldwide. Although the number of people being diagnosed with CAD has plateaued in the western world, it is projected to increase significantly in the developing world reaching epidemic proportions, particularly in South Asia. To better stratify the risk of developing and suffering a cardiovascular event due to CAD, not only plasma biomarkers relating to disease burden but also disease activity in CAD are needed; this will allow targeting of appropriate management to high-risk patients for acute events...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28025263/quantitative-plaque-features-from-coronary-computed-tomography-angiography-to-identify-regional-ischemia-by-myocardial-perfusion-imaging
#17
Mariana Diaz-Zamudio, Tobias A Fuchs, Piotr Slomka, Yuka Otaki, Reza Arsanjani, Heidi Gransar, Guido Germano, Daniel S Berman, Philipp A Kaufmann, Damini Dey
AIMS: We aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND RESULTS: Hundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state (99m)Tc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion)...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28024655/prevalence-by-computed-tomographic-angiography-of-coronary-plaques-in-south-asian-and-white-patients-with-type-2-diabetes-mellitus-at-low-and-high-risk-using-four-cardiovascular-risk-scores-ukpds-frs-ascvd-and-jbs3
#18
Sanjay N Gobardhan, Aukelien C Dimitriu-Leen, Alexander R van Rosendael, Erik W van Zwet, Cornelis J Roos, Pranobe V Oemrawsingh, Aan V Kharagjitsingh, J Wouter Jukema, Victoria Delgado, Martin J Schalij, Jeroen J Bax, Arthur J H A Scholte
The aim of this study was to explore the association between various cardiovascular (CV) risk scores and coronary atherosclerotic burden on coronary computed tomography angiography (CTA) in South Asians with type 2 diabetes mellitus and matched whites. Asymptomatic type 2 diabetic South Asians and whites were matched for age, gender, body mass index, hypertension, and hypercholesterolemia. Ten-year CV risk was estimated using different risk scores (United Kingdom Prospective Diabetes Study [UKPDS], Framingham Risk Score [FRS], AtheroSclerotic CardioVascular Disease [ASCVD], and Joint British Societies for the prevention of CVD [JBS3]) and categorized into low- and high-risk groups...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28024654/coronary-computed-tomography-angiography-derived-plaque-quantification-in-patients-with-acute-coronary%C3%A2-syndrome
#19
Christian Tesche, Damiano Caruso, Carlo N De Cecco, Darby C Shuler, Jess D Rames, Moritz H Albrecht, Taylor M Duguay, Akos Varga-Szemes, David Jochheim, Moritz Baquet, Richard R Bayer, Ullrich Ebersberger, Sheldon E Litwin, Salvatore A Chiaramida, Ellen Hoffmann, U Joseph Schoepf
This study investigated the discriminatory value of quantitative atherosclerotic plaque markers derived from coronary computed tomography angiography (cCTA) in patients with first acute coronary syndrome (ACS) compared with patients with stable coronary artery disease (CAD). Forty patients (56.9 ± 9.3 years, 55% men) admitted with their first ACS and Framingham risk score-matched controls with stable CAD were retrospectively analyzed. All patients had undergone cCTA followed by invasive coronary angiography...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28017925/intravascular-ultrasound-and-near-infrared-spectroscopic-features-of-coronary-lesions-with-intraplaque-haemorrhage
#20
Mitsuaki Matsumura, Gary S Mintz, Soo-Jin Kang, Stephen T Sum, Sean P Madden, Allen P Burke, James Goldstein, Rupa Parvataneni, Gregg W Stone, James E Muller, Renu Virmani, Akiko Maehara
AIMS: Intraplaque haemorrhage is considered a major contributor to lesion progression. We assessed coronary lesions with intraplaque haemorrhage using intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS). METHODS AND RESULTS: We evaluated coronary arteries from autopsy hearts using 40MHz IVUS and NIRS and compared the imaging findings to histopathology. A total of 2324 2-mm long histological segments from 101 coronary arteries from 56 autopsy hearts were included...
December 25, 2016: European Heart Journal Cardiovascular Imaging
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