keyword
MENU ▼
Read by QxMD icon Read
search

coronary plaque burden

keyword
https://www.readbyqxmd.com/read/27908890/pathology-of-human-coronary-and-carotid-artery-atherosclerosis-and-vascular-calcification-in-diabetes-mellitus
#1
Kazuyuki Yahagi, Frank D Kolodgie, Christoph Lutter, Hiroyoshi Mori, Maria E Romero, Aloke V Finn, Renu Virmani
The continuing increase in the prevalence of diabetes mellitus in the general population is predicted to result in a higher incidence of cardiovascular disease. Although the mechanisms of diabetes mellitus-associated progression of atherosclerosis are not fully understood, at clinical and pathological levels, there is an appreciation of increased disease burden and higher levels of arterial calcification in these subjects. Plaques within the coronary arteries of patients with diabetes mellitus generally exhibit larger necrotic cores and significantly greater inflammation consisting mainly of macrophages and T lymphocytes relative to patients without diabetes mellitus...
December 1, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27886161/cardiac-ct-in-the-emergency-department-in-the-era-of-highly-sensitive-troponins-is-there-still-a-role
#2
Admir Dedic, Koen Nieman, Udo Hoffmann, Maros Ferencik
INTRODUCTION: Physicians practicing cardiovascular medicine are every day confronted with patients presenting with symptoms suggestive of an acute coronary syndrome (ACS). Over the years, there have been substantial technical advances, such as the introduction of new non-invasive imaging techniques and the introduction of new highly sensitive cardiac biomarkers. EVIDENCE ACQUISITION AND SYNTHESIS: Physicians have adopted these new assets and have become more experienced with them thus improving medical care...
November 25, 2016: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27876264/intravascular-ultrasound-and-near-infrared-spectroscopic-characterization-of-thin-cap-fibroatheroma
#3
Shinji Inaba, Gary S Mintz, Allen P Burke, Gregg W Stone, Renu Virmani, Mitsuaki Matsumura, Rupa Parvataneni, Rishi Puri, Stephen J Nicholls, Akiko Maehara
Thin-cap fibroatheromas (TCFAs) are considered precursors for plaque rupture and subsequent acute coronary events. We investigated intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) characteristics of lesions that were histopathologic TCFAs. IVUS, NIRS, and histopathology were performed in 271 atherosclerotic lesions from 107 fresh coronary arteries from 54 patients at necropsy. The plaque burden and remodeling index calculated by IVUS and maximum lipid core burden index within any 4-mm segment (maxLCBI4mm) calculated by NIRS were compared among each plaque type based on histopathologic classifications but focusing on TCFA...
October 31, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27870948/hba1c-increase-is-associated-with-higher-coronary-and-peripheral-atherosclerotic-burden-in-non-diabetic-patients
#4
Roberto Scicali, Philippe Giral, Antonio Gallo, Antonino Di Pino, Agata Maria Rabuazzo, Francesco Purrello, Philippe Cluzel, Alban Redheuil, Eric Bruckert, David Rosenbaum
BACKGROUND AND AIMS: Prediabetes is associated with an increased risk of developing diabetes and cardiovascular disease. Our objective was to examine the cardiovascular (CV) risk profile of non-diabetic patients with and without prediabetes according to HbA1c, using macroangiopathic imaging biomarkers. METHODS: Our population consisted of 272 non diabetic patients aged between 40 and 70 years, with a normal fasting plasma glucose (FPG <5.6 mmol/L) and at least 1 CV risk factor...
November 4, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27867141/sex-differences-in-plaque-characteristics-by-intravascular-imaging-in-patients-with-coronary-artery-disease
#5
Monique E Ten Haaf, Melissa Rijndertse, Jin M Cheng, Sanneke P de Boer, Hector M Garcia Garcia, Robert-Jan M van Geuns, Evelyn Regar, Mattie J Lenzen, Yolande Appelman, Eric Boersma
AIMS: We aimed to study sex differences in coronary plaque burden and plaque composition in patients with coronary artery disease (CAD). METHODS AND RESULTS: Virtual histology intravascular ultrasound (VH-IVUS) and near-infrared spectroscopy (NIRS) imaging of a non-culprit coronary artery was performed in 178 (23.5%) women and 581 men who underwent invasive management of stable angina pectoris (SAP) or acute coronary syndrome (ACS). Women were older and had a worse cardiovascular risk profile than men, but less extended angiographic coronary disease...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27837151/atrial-fibrillation-progression-of-coronary-atherosclerosis-and-myocardial-infarction
#6
Ozgur Bayturan, Rishi Puri, E Murat Tuzcu, Mingyuan Shao, Kathy Wolski, Paul Schoenhagen, Samir Kapadia, Steven E Nissen, Prashanthan Sanders, Stephen J Nicholls
BACKGROUND: Despite atrial fibrillation representing an established risk factor for stroke, the association between atrial fibrillation and both progression of coronary atherosclerosis and major adverse cardiovascular events is not well characterized. We assessed the serial measures of coronary atheroma burden and cardiovascular outcomes in patients with and without atrial fibrillation. METHODS: Data were analyzed from nine clinical trials involving 4966 patients with coronary artery disease undergoing serial intravascular ultrasonography at 18-24 month intervals to assess changes in percent atheroma volume (PAV)...
November 11, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27834690/rac2-modulates-atherosclerotic-calcification-by-regulating-macrophage-interleukin-1%C3%AE-production
#7
Nicolle Ceneri, Lina Zhao, Bryan D Young, Abigail Healy, Suleyman Coskun, Hema Vasavada, Timur O Yarovinsky, Kenneth Ike, Ruggero Pardi, Lingfen Qin, Li Qin, George Tellides, Karen Hirschi, Judith Meadows, Robert Soufer, Hyung J Chun, Mehran Sadeghi, Jeffrey R Bender, Alan R Morrison
OBJECTIVE: The calcium composition of atherosclerotic plaque is thought to be associated with increased risk for cardiovascular events, but whether plaque calcium itself is predictive of worsening clinical outcomes remains highly controversial. Inflammation is likely a key mediator of vascular calcification, but immune signaling mechanisms that promote this process are minimally understood. APPROACH AND RESULTS: Here, we identify Rac2 as a major inflammatory regulator of signaling that directs plaque osteogenesis...
November 10, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27818473/plasma-lipoprotein-associated-phospholipase-a2-level-is-an-independent-predictor-of-high-thrombus-burden-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#8
Xiangqi Wu, Yingqiang Zhang, Zhiming Wu, Wei You, Fengshuo Liang, Fei Ye, Shaoliang Chen
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for plaque rupture and atherothrombotic events. However, the associations between serum Lp-PLA2 level and thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients remain unknown.We consecutively enrolled 351 STEMI patients who underwent primary percutaneous coronary intervention (pPCI). Patients were assigned to a high thrombus burden (HTB) group (n = 230) and a low thrombus burden (LTB) group (n = 121). Baseline data were recorded during hospital admission...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27806099/plaque-vulnerability-as-assessed-by-radiofrequency-intravascular-ultrasound-in-patients-with-valvular-calcification
#9
Nagendra Boopathy Senguttuvan, Sharath Kumar, Wang-Soo Lee, Sundeep Mishra, Jun Hwan Cho, Jee Eun Kwon, Seong Hyeop Hyeon, Yun Sang Jeong, Hoyoun Won, Seung Yong Shin, Kwang Je Lee, Tae Ho Kim, Chee Jeong Kim, Sang-Wook Kim
BACKGROUND: Cardiac valvular calcification is associated with the overall coronary plaque burden and considered an independent cardiovascular risk and prognostic factor. The purpose of this study was to evaluate the relationship between the presence of valvular calcification and plaque morphology and/or vulnerability. METHODS: Transthoracic echocardiography was used to assess valvular calcification in 280 patients with coronary artery disease who underwent radiofrequency intravascular ultrasound (Virtual Histology IVUS, VH-IVUS)...
2016: PloS One
https://www.readbyqxmd.com/read/27798490/the-future-of-imaging-in-cardiovascular-disease-intervention-trials-2017-and-beyond
#10
Mhairi K Doris, Marc R Dweck, Zahi A Fayad
PURPOSE OF REVIEW: As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end points are expensive, leading to interest in phase II clinical trials with imaging-derived outcome measures. RECENT FINDINGS: Noninvasive imaging techniques that assess changes in both atherosclerotic disease burden and plaque composition in response to therapy are well established...
December 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27769663/influence-of-adaptive-statistical-iterative-reconstruction-on-coronary-plaque-analysis-in-coronary-computed-tomography-angiography
#11
Helle Precht, Pieter H Kitslaar, Alexander Broersen, Jouke Dijkstra, Oke Gerke, Jesper Thygesen, Kenneth Egstrup, Jess Lambrechtsen
PURPOSE: The purpose of this study was to study the effect of iterative reconstruction (IR) software on quantitative plaque measurements in coronary computed tomography angiography (CCTA). METHODS: Thirty patients with a three clinical risk factors for coronary artery disease (CAD) had one CCTA performed. Images were reconstructed using FBP, 30% and 60% adaptive statistical IR (ASIR). Coronary plaque analysis was performed as per patient and per vessel (LM, LAD, CX and RCA) measurements...
September 28, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27755007/fibrinogen-in-relation-to-degree-and-composition-of-coronary-plaque-on-intravascular-ultrasound-in-patients-undergoing-coronary-angiography
#12
Nermina Buljubasic, K Martijn Akkerhuis, Jin M Cheng, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Sanneke P M de Boer, Evelyn Regar, Robert-Jan M van Geuns, Patrick W J C Serruys, Eric Boersma, Isabella Kardys
OBJECTIVE: The aim of this study was to provide additional insight into the role of fibrinogen in coronary artery disease by investigating the associations between plasma fibrinogen with both degree and composition of coronary atherosclerosis as determined by virtual histology-intravascular ultrasound. PATIENTS AND METHODS: In 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina pectoris, preprocedural blood samples were drawn for fibrinogen, C-reactive protein (CRP), interleukin-6, and plasminogen activator inhibitor-1 measurements, and virtual histology-intravascular ultrasound of a nonculprit coronary artery was performed...
October 14, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27754070/os-18-02-antihypertensive-treatment-and-risk-of-brain-ischemia-due-to-carotid-stenosis-in-a-survey-of-hospitalised-patients-aged-90-years-and-older
#13
Jürgen Bohlender, Jürg Nussberger, Beate Bohlender
OBJECTIVE: In elderly hypertensive patients, systolic blood pressure (sBP) goals recommended by US and European guidelines (ESH) for the initiation of treatment are more liberal than in younger patients because of an increased risk of treatment-associated side-effects and hypotension. Carotid stenosis increases with age and poses a risk of brain ischemia if hypotension occurs. Its relevance for the routine care of elderly hypertensives, however, remains unclear. We analyzed data on precerebral artery morphology and BP evolution from a survey of aged hospitalized patients...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733980/comparison-of-coronary-plaque-coronary-artery-calcification-and-major-adverse-cardiac-events-in-chinese-outpatients-with-and-without-type-2-diabetes
#14
Lijie Zhu, Jingjing Liu, Chuanyu Gao, Wenli Zhao, Jing Que, Xianpei Wang, Datun Qi, Jun Liu, Wentao Xiao, Juanjuan Yan, Wentao Li, You Zhang, Honghui Yang
OBJECTIVE: Diabetes substantially increases the risk of cardiovascular disease (CAD) and is associated with an increased risk of CAD mortality. The purpose of this study was to investigate the differences in coronary artery plaque, coronary artery calcification (CAC) measured in outpatients with and without type 2 diabetes, and the occurrence rate of a major adverse cardiac event (MACE) throughout follow-up with the same patients. METHODS: Five hundred eighty-eight outpatients with suspected CAD comprising 208 diabetic and 380 non-diabetic patients were enrolled in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27692635/-is-regression-of-atherosclerotic-plaque-possible
#15
José A Páramo, Fernando Civeira
As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion ('angiographic paradox')...
September 27, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27680774/plasma-cystatin-c-and-neutrophil-gelatinase-associated-lipocalin-in-relation-to-coronary-atherosclerosis-on-intravascular-ultrasound-and-cardiovascular-outcome-impact-of-kidney-function-atheroremo-ivus-study
#16
Milos Brankovic, K Martijn Akkerhuis, Nermina Buljubasic, Jin M Cheng, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Evelyn Regar, Patrick W Serruys, Robert-Jan van Geuns, Eric Boersma, Isabella Kardys
BACKGROUND AND AIMS: We investigated whether plasma cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) are associated with intravascular ultrasound (IVUS)-derived characteristics of coronary atherosclerosis and 1-year adverse coronary events in patients with normal and mildly-to-moderately impaired kidney function. METHODS: Between 2008 and 2011, virtual histology (VH)-IVUS of a non-culprit coronary artery was performed in 581 patients undergoing coronary angiography...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27679600/evaluation-of-coronary-plaque-characteristics-with-coronary-computed-tomography-angiography-in-patients-with-non-obstructive-coronary-artery-disease-a-long-term-follow-up-study
#17
Edoardo Conte, Andrea Annoni, Gianluca Pontone, Saima Mushtaq, Marco Guglielmo, Andrea Baggiano, Valentina Volpato, Cecilia Agalbato, Alice Bonomi, Fabrizio Veglia, Alberto Formenti, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi, Daniele Andreini
AIMS: Recent studies suggested that even non-obstructive coronary artery disease (CAD) increases major cardiovascular adverse events (MACE) rate. Aim of this study was to evaluate whether coronary computed tomography angiography (CCTA) may detect specific plaque characteristics that may affect prognosis in patients with non-obstructive CAD. METHODS: We enrolled 245 patients who underwent CCTA between April 2004 and April 2007 for suspected CAD and were found to have non-obstructive CAD...
September 27, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27679596/utility-of-near-infrared-spectroscopy-for-detection-of-thin-cap-neoatherosclerosis
#18
Tomasz Roleder, Keyvan Karimi Galougahi, Chee Yang Chin, Navdeep K Bhatti, Emmanouil Brilakis, Tamim M Nazif, Ajay J Kirtane, Dimitri Karmpaliotis, Wojciech Wojakowski, Martin B Leon, Gary S Mintz, Akiko Maehara, Gregg W Stone, Ziad A Ali
AIMS: Near-infrared spectroscopy (NIRS) has been employed to assess the composition of the atherosclerotic plaques in native coronary arteries. However, little is known about the detection of neoatherosclerosis by NIRS in in-stent restenosis (ISR). The aim of the study was to assess the relationship between the distribution of lipid determined by NIRS and morphology of ISR on optical coherence tomography (OCT). METHODS AND RESULTS: We performed both NIRS and OCT in 39 drug-eluting stents with ISR...
September 27, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27677761/national-trends-among-radiologists-in-reporting-coronary-artery-calcium-in-non-gated-chest-computed-tomography
#19
Jacobo Kirsch, Felipe Martinez, David Lopez, Gian M Novaro, Craig R Asher
Coronary artery calcification (CAC) is a known risk factor for adverse outcomes in the general population and in patients with coronary artery disease. We performed a survey of United States radiologists to evaluate the trends in reporting the presence or absence of CAC on NCCT examinations. An 11 multiple-choice questionnaire was distributed to members of the American College of Radiology, and 530 members participated in the study. Eighty-seven percent of the analyzed group report the presence of CAC on standard CT scans of the chest, and approximately half them (52 %) use a qualitative modifier...
September 27, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27672369/intra-arterial-drug-and-light-delivery-for-photodynamic-therapy-using-visudyne%C3%A2-implication-for-atherosclerotic-plaque-treatment
#20
Manish Jain, Matthieu Zellweger, Aurélien Frobert, Jérémy Valentin, Hubert van den Bergh, Georges Wagnières, Stéphane Cook, Marie-Noelle Giraud
UNLABELLED: Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulation within the plaque with reduced systemic adverse effects. Thus, this "intra-arterial" PDT would be expected to have less side effects and due to the short time involved would be compatible with percutaneous coronary interventions...
2016: Frontiers in Physiology
keyword
keyword
114277
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"