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coronary plaque burden

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https://www.readbyqxmd.com/read/29781836/relationship-between-left-main-coronary-artery-plaque-burden-and-nonleft-main-coronary-atherosclerosis-results-from-the-prospect-study
#1
Takehisa Shimizu, Gary S Mintz, Bernard De Bruyne, Naim Z Farhat, Shinji Inaba, Yang Cao, Steven P Marso, Giora Weisz, Patrick W Serruys, Gregg W Stone, Akiko Maehara
OBJECTIVES: Whether the severity of left main coronary artery (LMCA) disease reflects LMCA and overall coronary atherosclerotic burden is not known. We aimed to assess nonculprit LMCA disease characteristics and the relationship with atherosclerosis in the rest of the coronary arteries as well as patient outcomes. PATIENTS AND METHODS: In the PROSPECT study, 697 patients with acute coronary syndromes underwent three-vessel gray-scale and radiofrequency intravascular ultrasound after percutaneous coronary intervention...
May 17, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29778853/natural-history-of-diabetic-coronary-atherosclerosis-by-quantitative-measurement-of-serial-coronary-computed-tomographic-angiography-results-of-the-paradigm-study-progression-of-atherosclerotic-plaque-determined-by-computed-tomographic-angiography-imaging
#2
Ung Kim, Jonathon A Leipsic, Stephanie L Sellers, Michael Shao, Philipp Blanke, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J Budoff, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Peter H Stone, Daniel S Berman, Jagat Narula, Leslee J Shaw, Jeroen J Bax, James K Min, Hyuk-Jae Chang
OBJECTIVES: This study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM). BACKGROUND: The natural history of coronary PP in patients with DM is not well established. METHODS: A total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and analyzed from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) trial...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29754669/comparison-of-fractional-flow-reserve-and-intravascular-ultrasound-guided-intervention-strategy-for-clinical-outcomes-in-patients-with-intermediate-stenosis-flavour-rationale-and-design-of-a-randomized-clinical-trial
#3
Jeehoon Kang, Bon-Kwon Koo, Xinyang Hu, Joo Myung Lee, Joo-Yong Hahn, Hyoung-Mo Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Chul Ahn, JianAn Wang, Seung-Jae Tahk
BACKGROUND: Coronary angiography has limitations in defining the ischemia-causing stenotic lesion, especially in cases with intermediate coronary stenosis. Fractional flow reserve (FFR) is a current standard method to define the presence of ischemia, and intravascular ultrasound (IVUS) is the most commonly used invasive imaging tool that can provide the lesion geometry and can provide the information on plaque vulnerability. The primary aim of this study is to compare the safety and efficacy of FFR-guided and IVUS-guided percutaneous coronary intervention (PCI) strategies in patients with intermediate coronary stenosis...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29747829/local-low-shear-stress-and-endothelial-dysfunction-in-patients-with-nonobstructive-coronary-atherosclerosis
#4
Gerasimos Siasos, Jaskanwal D Sara, Marina Zaromytidou, Kyoung H Park, Ahmet Umit Coskun, Lilach O Lerman, Evangelos Oikonomou, Charles C Maynard, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Charles Feldman, Amir Lerman, Peter H Stone
BACKGROUND: Local hemodynamic factors are important determinants of atherosclerotic plaque development and progression. OBJECTIVES: The goal of this study was to determine the association between low endothelial shear stress (ESS) and microvascular and epicardial endothelial dysfunction in patients with early atherosclerosis. METHODS: Sixty-five patients (mean age 52 ± 11 years) with nonobstructive coronary atherosclerosis (luminal diameter stenosis <30%) were included...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29743417/impact-of-indoxyl-sulfate-on-coronary-plaques-in-patients-on-hemodialysis
#5
Masahiko Asami, Kengo Tanabe, Shunsuke Ito, Eri Yoshida, Jiro Aoki, Shuzou Tanimoto, Yu Horiuchi, Masayuki Yoshida
Serum indoxyl sulfate (IS; a uremic toxin) levels, which are significantly higher in patients with chronic kidney disease, including those undergoing hemodialysis, than in the robust, are associated with both cardiovascular disease (CVD) and CVD-related mortality. Furthermore, coronary artery calcium (CAC) is an independent predictor of cardiovascular events in patients undergoing hemodialysis. This study aimed to interpret the association between serum IS levels and coronary plaque burden (CPB) or CAC.A total of 30 consecutive patients on hemodialysis, who underwent 320-row coronary multidetector computed tomography (MDCT) angiography for suspected coronary artery disease, were enrolled in this prospective study...
May 9, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29703635/differences-in-the-association-of-total-versus-local-coronary-artery-calcium-with-acute-coronary-syndrome-and-culprit-lesions-in-patients-with-acute-chest-pain-the-coronary-calcium-paradox
#6
Stefan B Puchner, Thomas Mayrhofer, Jakob Park, Michael T Lu, Ting Liu, Pal Maurovich-Horvat, Khristine Ghemigian, Daniel O Bittner, Jerome L Fleg, James E Udelson, Quynh A Truong, Udo Hoffmann, Maros Ferencik
BACKGROUND AND AIMS: Total coronary artery calcium (CAC) burden is associated with an increased cardiovascular risk, while local CAC may represent stable plaques. We determined differences in relationship of total CAC with acute coronary syndrome (ACS) and local CAC with culprit lesions in patients with suspected ACS. METHODS: We performed computed tomography (CT) for CAC and CT angiography to assess the presence of significant stenosis and high-risk plaque (positive remodeling, low CT attenuation, napkin-ring sign, spotty calcium) in 37 patients with ACS and 223 controls...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29703054/impact-of-von-willebrand-factor-on-coronary-plaque-burden-in-coronary-artery-disease-patients-treated-with-statins
#7
Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin'ichiro Yasunaga, Keijiro Saku, Shin-Ichiro Miura
High von Willebrand factor (VWF) levels have been reported to be associated with an increased risk of cardiovascular events. However, the relationship between VWF levels and coronary atherosclerosis in patients with coronary artery disease (CAD) who have already received stain treatment is still unclear. We examined the association between VWF levels and coronary plaque as assessed by intravascular ultrasound (IVUS) in CAD patients treated with statins. Ninety-one CAD patients who underwent percutaneous coronary intervention under IVUS guidance, and who were already receiving statin treatment based on Japanese guidelines, were included...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29695169/association-of-prediabetes-with-higher-coronary-atherosclerotic-burden-among-patients-with-first-diagnosed-acute-coronary-syndrome
#8
Burak Açar, Ozcan Ozeke, Mustafa Karakurt, Yasin Ozen, Mustafa Bilal Özbay, Sefa Unal, Mustafa Karanfil, Cagri Yayla, Serkan Cay, Orhan Maden, Serkan Topaloğlu, Dursun Aras, Zehra Golbasi, Sinan Aydogdu
Diabetes mellitus (DM) is associated with more extensive coronary atherosclerosis and more vulnerable plaque phenotypes. However, DM should not be considered a homogeneous and purely binary entity in terms of risk assessment. We evaluated the impact of prediabetic status on coronary atherosclerosis burden in patients with first-time acute coronary syndrome (ACS) who underwent urgent coronary angiography. The patients were divided into DM, prediabetes, and control groups. The 3-vessel disease (TVD) rates and SYNTAX and Gensini scoring systems for defining atherosclerotic burden were compared...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29685695/advanced-analyses-of-computed-tomography-coronary-angiography-can-help-discriminate-ischemic-lesions
#9
Jun-Mei Zhang, Dongsi Shuang, Lohendran Baskaran, Weijun Wu, Soo-Kng Teo, Weimin Huang, Like Gobeawan, John Carson Allen, Ru San Tan, Xi Su, Nasrul Bin Ismail, Min Wan, Boyang Su, Hua Zou, Ris Low, Xiaodan Zhao, Yanling Chi, Jiayin Zhou, Yi Su, Aileen Mae Lomarda, Chee Yang Chin, Jiang Ming Fam, Felix Yung Jih Keng, Aaron Sung Lung Wong, Jack Wei Chieh Tan, Khung Keong Yeo, Philip En Hou Wong, Chee Tang Chin, Kay Woon Ho, Jonathan Yap, Ghassan S Kassab, Terrance Chua, Tian Hai Koh, Swee Yaw Tan, Soo Teik Lim, Liang Zhong
BACKGROUND: Computed tomography coronary angiography (CTCA) image analysis enables plaque characterization and non-invasive fractional flow reserve (FFR) calculation. We analyzed various parameters derived from CTCA images and evaluated their associations with ischemia. METHODS: 49 (61 lesions) patients underwent CTCA and invasive FFR. Lesions with diameter stenosis (DS) ≥ 50% were considered obstructive. CTCA image processing incorporating analytical and numerical methods were used to quantify anatomical parameters of lesion length (LL) and minimum lumen area (MLA); plaque characteristic parameters of plaque volume, low attenuation plaque (LAP) volume, dense calcium volume (DCV), normalized plaque volume (NP Vol), plaque burden, eccentricity index and napkin-ring (NR) sign; and hemodynamic parameters of resistance index, stenosis flow reserve (SFR) and FFRB ...
April 20, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#10
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29680968/an-increased-waist-to-hip-ratio-is-a-key-determinant-of-atherosclerotic-burden-in-overweight-subjects
#11
Roberto Scicali, David Rosenbaum, Antonino Di Pino, Philippe Giral, Philippe Cluzel, Alban Redheuil, Salvatore Piro, Agata Maria Rabuazzo, Francesco Purrello, Eric Bruckert, Antonio Gallo
AIMS: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR). METHODS: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25-29.9 kg/m2 and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease...
April 21, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29680699/the-additive-effect-of-adherence-to-multiple-healthy-lifestyles-on-subclinical-atherosclerosis-insights-from-the-awhs
#12
Irina Uzhova, Rocio Mateo-Gallego, Belén Moreno-Franco, Esther Molina-Montes, Montserrat Leon-Latre, José A Casasnovas Lenguas, Fernando Civeira, José L Peñalvo
BACKGROUND: Public health strategies targeting multiple healthy behaviors, rather than individual factors, have been proposed as more efficient strategies to promote cardiovascular health. However, the additive effect of multiple targets on primary prevention has not been fully characterized. OBJECTIVE: To examine how adherence to multiple healthy behaviors is associated with the presence of subclinical atherosclerosis, a measure of early cardiovascular disease...
March 28, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29669944/neutrophil-subsets-and-their-gene-signature-associate-with-vascular-inflammation-and-coronary-atherosclerosis-in-lupus
#13
Philip M Carlucci, Monica M Purmalek, Amit K Dey, Yenealem Temesgen-Oyelakin, Simantini Sakhardande, Aditya A Joshi, Joseph B Lerman, Alice Fike, Michael Davis, Jonathan H Chung, Martin P Playford, Mohammad Naqi, Pragnesh Mistry, Gustavo Gutierrez-Cruz, Stefania Dell'Orso, Faiza Naz, Taufiq Salahuddin, Balaji Natarajan, Zerai Manna, Wanxia L Tsai, Sarthak Gupta, Peter Grayson, Heather Teague, Marcus Y Chen, Hong-Wei Sun, Sarfaraz Hasni, Nehal N Mehta, Mariana J Kaplan
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular dysfunction and inflammation and coronary plaque. METHODS: SLE subjects and healthy controls underwent multimodal phenotyping of vascular disease by quantifying vascular inflammation (18F-fluorodeoxyglucose-PET/CT [18F-FDG-PET/CT]), arterial dysfunction (EndoPAT and cardio-ankle vascular index), and coronary plaque burden (coronary CT angiography)...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29643815/mechanical-characterization-of-the-vessel-wall-by-data-assimilation-of-intravascular-ultrasound-studies
#14
Gonzalo D Maso Talou, Pablo J Blanco, Gonzalo D Ares, Cristiano Guedes Bezerra, Pedro A Lemos, Raúl A Feijóo
Atherosclerotic plaque rupture and erosion are the most important mechanisms underlying the sudden plaque growth, responsible for acute coronary syndromes and even fatal cardiac events. Advances in the understanding of the culprit plaque structure and composition are already reported in the literature, however, there is still much work to be done toward in-vivo plaque visualization and mechanical characterization to assess plaque stability, patient risk, diagnosis and treatment prognosis. In this work, a methodology for the mechanical characterization of the vessel wall plaque and tissues is proposed based on the combination of intravascular ultrasound (IVUS) imaging processing, data assimilation and continuum mechanics models within a high performance computing (HPC) environment...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29622563/noncanonical-matrix-metalloprotease-1-protease-activated-receptor-1-signaling-drives-progression-of-atherosclerosis
#15
Rajashree Rana, Tianfang Huang, Georgios Koukos, Elizabeth K Fletcher, Susan E Turner, Andrew Shearer, Paul A Gurbel, Jeffrey J Rade, Carey D Kimmelstiel, Kevin P Bliden, Lidija Covic, Athan Kuliopulos
OBJECTIVE: Protease-activated receptor-1 (PAR1) is classically activated by thrombin and is critical in controlling the balance of hemostasis and thrombosis. More recently, it has been shown that noncanonical activation of PAR1 by matrix metalloprotease-1 (MMP1) contributes to arterial thrombosis. However, the role of PAR1 in long-term development of atherosclerosis is unknown, regardless of the protease agonist. APPROACH AND RESULTS: We found that plasma MMP1 was significantly correlated ( R =0...
April 5, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29622443/pericardial-and-visceral-but-not-total-body-fat-are-related-to-global-coronary-and-extra-coronary-atherosclerotic-plaque-burden
#16
Gaston A Rodriguez-Granillo, Exequiel Reynoso, Carlos Capunay, Jimena Carpio, Patricia Carrascosa
BACKGROUND: To explore the relationship between coronary and extra-coronary atherosclerotic plaque burden with total and regional fat depots among patients undergoing ECG-gated aortic computed tomography angiography (CTA). METHODS: The subjects of this study comprised a cohort of consecutive patients who underwent ECG-gated thoracoabdominal CTA. We assessed the number of coronary segments with plaques (segment-involvement score, SIS); and the extra-coronary atherosclerotic plaque burden, comprising the aorta and supra-aortic trunks, iliofemoral arteries, and visceral arteries (extra-coronary SS)...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29619417/nonalcoholic-fatty-liver-disease-contributes-to-subclinical-atherosclerosis-a-systematic-review-and-meta-analysis
#17
Yao-Yao Zhou, Xiao-Dong Zhou, Sheng-Jie Wu, Dan-Hong Fan, Sven Van Poucke, Yong-Ping Chen, Shen-Wen Fu, Ming-Hua Zheng
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of atherosclerotic cardiovascular disease. In our meta-analysis, we aimed to assess the correlation of NAFLD and four surrogate markers of subclinical atherosclerosis. PubMed, Embase, and the Cochrane Library were searched up until April 2017. Original studies investigating the association between NAFLD and subclinical atherosclerosis were included. The outcome data were extracted and pooled for the effect estimate by using a random-effects model...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29617981/impact-of-statin-therapy-on-coronary-plaque-burden-and-composition-assessed-by-coronary-computed-tomographic-angiography-a-systematic-review-and-meta-analysis
#18
Linn Andelius, Martin Bødtker Mortensen, Bjarne Linde Nørgaard, Jawdat Abdulla
Aim: To clarify the potential role of coronary computed tomographic angiography (CCTA) in assessing the remodelling impact of statin therapy on plaque burden and compositions. Methods and results: A systematic literature review and meta-analysis were conducted to examine the effect of statin therapy on different plaque volumes assessed by serial CCTA. Twelve studies were included with a mean (±standard deviation) follow-up period of 14.5 ± 9.5 months. Data on plaque volume were pooled using weighted mean difference method...
March 30, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29617001/personalized-statin-therapy-and-coronary-atherosclerotic-plaque-burden-in-asymptomatic-low-intermediate-risk-individuals
#19
Ranganath Muniyappa, Radwa A Noureldin, Khaled Z Abd-Elmoniem, Riham H El Khouli, Jatin Raj Matta, Ahmed Hamimi, Siri Ranganath, Colleen Hadigan, Lynnette K Nieman, Ahmed M Gharib
BACKGROUND: Current guidelines for the primary prevention of atherosclerotic cardiovascular disease are based on the estimation of a predicted 10-year cardiovascular disease risk and the average relative risk reduction estimates from statin trials. In the clinical setting, however, decision-making is better informed by the expected benefit for the individual patient, which is typically lacking. Consequently, a personalized statin benefit approach based on absolute risk reduction over 10 years (ARR10 benefit threshold ≥2...
March 26, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29616625/plaque-burden-influences-accurate-classification-of-fibrous-cap-atheroma-by-in-vivo-optical-coherence-tomography-in-a-porcine-model-of-advanced-coronary-atherosclerosis
#20
Christian B Poulsen, Ryan M Pedrigi, Nilesh Pareek, Ismail D Kilic, Niels Ramsing Holm, Jacob F Bentzon, Hans Erik Bøtker, Erling Falk, Rob Krams, Ranil de Silva
AIMS: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. METHODS AND RESULTS: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation...
April 3, 2018: EuroIntervention
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