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coronary plaque burden

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https://www.readbyqxmd.com/read/28427383/is-ischemia-the-only-factor-predicting-cardiovascular-outcomes-in-all-diabetes-mellitus-patients
#1
REVIEW
Mark W Kennedy, Enrico Fabris, Harry Suryapranata, Elvin Kedhi
Diabetes mellitus (DM) is associated with an excess in cardiovascular morbidity and mortality, and is characterized by increased rates of coronary artery disease. Furthermore, once atherosclerosis is established, this is associated with an increased extent, complexity and a more rapid progression than seen in non-DM patients. Ischemia is the single most important predictor of future hard cardiac events and ischemia correction remains the cornerstone of current revascularization strategies. However recent data suggests that, in DM patients, coronary atherosclerosis despite the absence of ischemia, detected by either invasive or non-invasive methods, may not be associated with the same low risk of future cardiac events as seen in non-DM patients...
April 20, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28420816/coronary-atherosclerotic-plaque-characteristics-and-cardiovascular-risk-factors%C3%A3-insights-from-an-optical-coherence-tomography-study
#2
Roberta De Rosa, Mariuca Vasa-Nicotera, David M Leistner, Sophia M Reis, Claudia E Thome, Jes-Niels Boeckel, Stephan Fichtlscherer, Andreas M Zeiher
BACKGROUND: The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged. Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.Methods and Results:We assessed coronary atherosclerotic plaque characteristics by optical coherence tomography in 67 patients with stable coronary artery disease undergoing coronary angiography...
April 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28412430/incremental-prognostic-value-of-stress-echocardiography-with-carotid-ultrasound-for-suspected-cad
#3
Shahram Ahmadvazir, Benoy N Shah, Konstantinos Zacharias, Roxy Senior
OBJECTIVES: This study hypothesized that ischemia and atherosclerosis assessment by ultrasound (US) may provide incremental prognostic information in patients with new-onset chest pain who do not have coronary artery disease (CAD). BACKGROUND: The clinical significance of atherosclerosis assessment by carotid US in patients undergoing stress echocardiography (SE) in such patients is unknown. METHODS: Consecutive patients with suspected angina but no history of CAD underwent simultaneous SE and US prospectively to assess myocardial ischemia and carotid plaque burden (CPB), respectively...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28385496/angptl3-deficiency-and-protection-against-coronary-artery-disease
#4
Nathan O Stitziel, Amit V Khera, Xiao Wang, Andrew J Bierhals, A Christina Vourakis, Alexandra E Sperry, Pradeep Natarajan, Derek Klarin, Connor A Emdin, Seyedeh M Zekavat, Akihiro Nomura, Jeanette Erdmann, Heribert Schunkert, Nilesh J Samani, William E Kraus, Svati H Shah, Bing Yu, Eric Boerwinkle, Daniel J Rader, Namrata Gupta, Philippe M Frossard, Asif Rasheed, John Danesh, Eric S Lander, Stacey Gabriel, Danish Saleheen, Kiran Musunuru, Sekar Kathiresan
BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknown. OBJECTIVES: The study goal was to leverage 3 distinct lines of evidence-a family that included individuals with complete (compound heterozygote) ANGPTL3 deficiency, a population based-study of humans with partial (heterozygote) ANGPTL3 deficiency, and biomarker levels in patients with myocardial infarction (MI)-to test whether ANGPTL3 deficiency is associated with lower risk for CAD...
March 29, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28385391/prognostic-implications-of-coronary-artery-calcium-in-the-absence-of-coronary-artery-luminal-narrowing
#5
Iksung Cho, Bríain Ó Hartaigh, Heidi Gransar, Valentina Valenti, Fay Y Lin, Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin J W Chow, Allison M Dunning, Augustin DeLago, Todd C Villines, Martin Hadamitzky, Joerg Hausleiter, Jonathon Leipsic, Leslee J Shaw, Philipp A Kaufmann, Ricardo C Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, James K Min
BACKGROUND AND AIMS: Coronary artery calcium (CAC) scoring is a predictor of future adverse clinical events, and a surrogate measure of overall coronary artery plaque burden. Coronary computed tomographic angiography (CCTA) is a contrast-enhanced method that allows for visualization of plaque as well as whether that plaque causes luminal narrowing. To date, the prognosis of individuals with CAC but without stenosis has not been reported. We explored the prevalence of CAC>0 and its prognostic utility for future mortality for patients without luminal narrowing by CCTA...
December 3, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28369752/vascular-inflammation-and-low-density-lipoproteins-is-cholesterol-the-link-a-lesson-from-the-clinical-trials
#6
REVIEW
Alberico Luigi Catapano, Angela Pirillo, Giuseppe Danilo Norata
For long time the role of LDL and inflammation in the pathogenesis of atherosclerosis have been studied independently from each other and only more recently a common platform has been suggested. Accumulation of excess cholesterol due to the presence of increased circulating LDL promotes endothelium dysfunction and activation, which is associated with increased production of pro-inflammatory cytokines, overexpression of adhesion molecules, chemokines and C-reactive protein (CRP), increased generation of reactive oxygen species and reduction of nitric oxide levels and bioavailability...
March 30, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28349887/atherosclerotic-plaque-metabolism-in-high-cardiovascular-risk-subjects-a-subclinical-atherosclerosis-imaging-study-with-18-f-naf-pet-ct
#7
Manuel de Oliveira-Santos, Miguel Castelo-Branco, Rodolfo Silva, Andreia Gomes, Nuno Chichorro, Antero Abrunhosa, Paulo Donato, João Pedroso de Lima, Mariano Pego, Lino Gonçalves, Maria João Ferreira
BACKGROUND AND AIMS: Atherosclerotic plaque molecular imaging with (18)F-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) provides potential discrimination between active unstable microcalcification and established dormant calcification. We aimed to study (18)F-NaF atherosclerotic plaque uptake in high cardiovascular (CV) risk participants and its associations with CV risk factors, coronary calcium score and thoracic fat volume. METHODS: High CV risk hypertensive individuals from a single centre were prospectively scanned with (18)F-NaF-PET-CT in the coronary, aortic and carotideal arteries...
March 10, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28343599/presence-characteristics-and-volumes-of-coronary-plaque-determined-by-computed-tomography-angiography-in-young-type-2-diabetes-mellitus
#8
Negin Nezarat, Matthew J Budoff, Yanting Luo, Sirous Darabian, Rine Nakanishi, Dong Li, Nasim Sheidaee, Michael Kim, Anas Alani, Suguru Matsumoto, Sina Rahmani, Mitsuru Kanisawa, Indre Ceponiene, Kazuhiro Osawa, Hong Qi, Sajad Hamal, Pieter Kitslaar, Alexander Broersen, Ferdinand Flores, Eli Ipp, Bahram Khazai
Prevention and management of coronary artery disease (CAD) is of great concern in patients with diabetes mellitus. Although the impact of coronary atherosclerosis is described well for subjects older than 40 years, the prevalence and types of coronary atherosclerosis in young patients are not well known. The aim of this study was to evaluate the prevalence, extent, severity, and volumes of coronary plaque in type 2 diabetes mellitus (T2DM) population younger than of 40 years. This prospective study enrolled 181 subjects (25-40 year old) undergoing coronary computed tomography angiography, with 86 T2DM and 95 nondiabetic age/gender-matched subjects...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28335787/risk-factors-of-atherosclerotic-tissue-types-in-single-vessel-and-intermediate-coronary-lesions-a-cross-sectional-study
#9
Xianjin Wang, Qun Chen, Yu Xu, Yanqing Wang, Yang Yang, Ming Gu, Haihua Xu, Yanfang Zhao
BACKGROUND: Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in patients with single-vessel and intermediate coronary lesions. METHODS: One hundred and ninety-two patients with single-vessel and intermediate coronary lesions were enrolled in a cross-sectional study and divided into two groups: stable angina pectoris (SAP) and acute coronary syndrome (ACS) groups...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28325524/current-status-of-lipid-management-in-acute-coronary-syndrome
#10
REVIEW
Koichiro Fujisue, Kenichi Tsujita
The development of coronary revascularization has dramatically improved early cardiovascular outcomes in patients with acute coronary syndrome (ACS). However, patients who have experienced myocardial infarction (MI) are at high risk of recurrence of cardiovascular events compared with those who are healthy or have stable coronary artery disease. Acute coronary events induce further inflammatory responses and plaque vulnerability in either a coronary culprit or whole vessels. The majority of data have supported the importance of coronary risk management to prevent secondary events...
March 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28321013/cystatin-c-adiponectin-complex-in-plasma-associates-with-coronary-plaque-instability
#11
Akane Matsumoto, Hiroyasu Yamamoto, Tetsuro Matsuoka, Kento Kayama, Sumire Onishi, Natsumi Matsuo, Shinji Kihara
AIM: Adiponectin (APN) is an adipocyte-derived bioactive molecule with antiatherogenic properties. We previously reported that cystatin C (CysC) abolished the anti-atherogenic effects of APN. We aimed to elucidate the clinical significance of CysC-APN complex in patients with coronary artery disease (CAD). METHODS: We enrolled 43 stable CAD male patients to examine the relationship between CysC-APN complex and coronary plaque characteristics. Serum was immunoprecipitated by the anti-APN antibody and immunoblotted by the anti-CysC antibody to demonstrate the presence of CysC-APN complexes in vivo...
March 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28318137/plaque-erosion-delays-vascular-healing-after-drug-eluting-stent-implantation-in-patients-with-acute-coronary-syndrome-an-in-vivo-optical-coherence-tomography-study
#12
COMPARATIVE STUDY
Sining Hu, Chao Wang, Chunyang Zhe, Yinchun Zhu, Taishi Yonetsu, Haibo Jia, Jingbo Hou, Shaosong Zhang, Ik-Kyung Jang, Bo Yu
OBJECTIVES: To compare vascular healing after drug-eluting stent (DES) implantation between plaque rupture (PR) and plaque erosion (PE). BACKGROUND: Vascular response after stent implantation in patients with PR has been extensively studied. Little is known about vascular healing after stent implantation in PE. METHODS: Sixty-five ACS patients who received optical coherence tomography (OCT) imaging of the culprit lesions both before and after stent implantation at baseline as well as at 6 months were included in this study...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28299809/bedside-screening-with-the-use-of-pocket-size-imaging-device-can-be-useful-for-ruling-out-carotid-artery-stenosis-in-patients-scheduled-for-cardiac-surgery
#13
Dominika Filipiak-Strzecka, Jarosław D Kasprzak, Ewa Szymczyk, Paulina Wejner-Mik, Piotr Lipiec
BACKGROUND: Patients (pts) scheduled for coronary artery bypass grafting, burdened with high risk of carotid stenosis, are recommended to undergo duplex ultrasonography (DUS) of carotid arteries. PURPOSE: To validate pocket-size imaging device (PSID) equipped with linear probe as an easily accessible tool enabling bedside screening for carotid artery stenosis (CAS). METHODS: A total of 100 pts (60 men, mean age 69±11 years) with multivessel coronary artery disease underwent bedside DUS of carotid arteries with the use of PSID performed by a cardiology resident trained in DUS...
March 16, 2017: Echocardiography
https://www.readbyqxmd.com/read/28292864/coronary-artery-plaque-burden-nomograms-are-they-ready-for-use
#14
EDITORIAL
Paolo Raggi, Nikolaos Alexopoulos
No abstract text is available yet for this article.
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28292858/predictive-value-of-age-and-sex-specific-nomograms-of-global-plaque-burden-on-coronary-computed-tomography-angiography-for-major-cardiac-events
#15
Christopher Naoum, Daniel S Berman, Amir Ahmadi, Philipp Blanke, Heidi Gransar, Jagat Narula, Leslee J Shaw, Leonard Kritharides, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin Chow, Ricardo C Cury, Augustin DeLago, Allison Dunning, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Erica Maffei, Hugo Marquez, Gianluca Pontone, Gilbert Raff, Ronen Rubinshtein, Todd C Villines, James Min, Jonathon Leipsic
BACKGROUND: Age-adjusted coronary artery disease (CAD) burden identified on coronary computed tomography angiography predicts major adverse cardiovascular event (MACE) risk; however, it seldom contributes to clinical decision making because of a lack of nomographic data. We aimed to develop clinically pragmatic age- and sex-specific nomograms of CAD burden using coronary computed tomography angiography and to validate their prognostic use. METHODS AND RESULTS: Patients prospectively enrolled in phase I of the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes) were included (derivation cohort: n=21,132; 46% female) to develop CAD nomograms based on age-sex percentiles of segment involvement score (SIS) at each year of life (40-79 years)...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28290832/-computed-tomography-in-the-evaluation-of-coronary-atherosclerotic-plaques-comparison-with-intravascular-ultrasound
#16
T N Veselova, M S Shabanova, V M Mironov, I N Merkulova, S K Ternovoy
PURPOSE: Determination of computed tomography angiography (CTA) informativeness in assessment of state of atherosclerotic coronary plaque (ACP) and identification of signs of its instability compared with intravascular ultrasound (IVUS). MATERIALS AND METHODS: Coronary CTA was carried out in 52 patients with clinical presentation of non-ST elevation (NSTE) acute coronary syndrome on the first day of hospitalization. ACPs were identified in 32 of 52 patients (61...
January 2017: Kardiologiia
https://www.readbyqxmd.com/read/28290345/first-experiences-with-model-based-iterative-reconstructions-influence-on-quantitative-plaque-volume-and-intensity-measurements-in-coronary-computed-tomography-angiography
#17
H Precht, P H Kitslaar, A Broersen, O Gerke, J Dijkstra, J Thygesen, K Egstrup, J Lambrechtsen
PURPOSE: Investigate the influence of adaptive statistical iterative reconstruction (ASIR) and the model-based IR (Veo) reconstruction algorithm in coronary computed tomography angiography (CCTA) images on quantitative measurements in coronary arteries for plaque volumes and intensities. METHODS: Three patients had three independent dose reduced CCTA performed and reconstructed with 30% ASIR (CTDIvol at 6.7 mGy), 60% ASIR (CTDIvol 4.3 mGy) and Veo (CTDIvol at 1...
February 2017: Radiography
https://www.readbyqxmd.com/read/28282560/genome-wide-meta-analysis-identifies-novel-loci-of-plaque-burden-in-carotid-artery
#18
Janne Pott, Ralph Burkhardt, Frank Beutner, Katrin Horn, Andrej Teren, Holger Kirsten, Lesca M Holdt, Gerhard Schuler, Daniel Teupser, Markus Loeffler, Joachim Thiery, Markus Scholz
BACKGROUND AND AIMS: Carotid artery plaque is an established marker of subclinical atherosclerosis and common patho-mechanisms with coronary artery disease (CAD) are hypothesized. We aimed to identify genetic variants associated with carotid plaque and to examine the potential shared genetic basis with CAD. METHODS: After investigating the reliability of plaque detection, we performed a genome-wide meta-association study in two independent cohorts (LIFE-Adult, n = 4037 and LIFE-Heart, n = 3152) for carotid plaque score (PS), defined as the sum of the plaque load of common carotid artery and carotid bulb...
April 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28279437/coronary-plaque-characteristics-in-hemodialysis-dependent-patients-as-assessed-by-optical%C3%A2-coherence-tomography
#19
Chee Yang Chin, Mitsuaki Matsumura, Akiko Maehara, Wenbin Zhang, Cheolmin Tetsumin Lee, Myong Hwa Yamamoto, Lei Song, Yasir Parviz, Nisha B Jhalani, Sumit Mohan, Lloyd E Ratner, David J Cohen, Ori Ben-Yehuda, Gregg W Stone, Richard A Shlofmitz, Tsunekazu Kakuta, Gary S Mintz, Ziad A Ali
Coronary arteries in patients with chronic kidney disease (CKD) have been shown to exhibit more extensive atherosclerosis and calcium. We aimed to assess characteristics of coronary plaque in hemodialysis (HD)-dependent patients using optical coherence tomography (OCT). This was a multicenter, retrospective study of 124 patients with stable angina who underwent OCT imaging. Sixty-two HD-dependent patients who underwent pre-intervention OCT for coronary artery disease were compared 1:1 with a cohort of patients without CKD, matched for age, diabetes mellitus, gender, and culprit vessel...
February 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28279371/carotid-plaque-lipid-content-and-fibrous-cap-status-predict-systemic-cv-outcomes-the-mri-substudy-in-aim-high
#20
Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Moni B Neradilek, Daniel A Isquith, Kiyofumi Yamada, Gádor Cantón, John R Crouse, Todd J Anderson, John Huston, Kevin O'Brien, Daniel S Hippe, Nayak L Polissar, Chun Yuan, Thomas S Hatsukami
OBJECTIVES: The aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease. BACKGROUND: Advancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden. METHODS: As part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features...
March 2017: JACC. Cardiovascular Imaging
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