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coronary plaque burden

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https://www.readbyqxmd.com/read/29135482/long-term-darapladib-use-does-not-affect-coronary-plaque-composition-assessed-using-multimodality-intravascular-imaging-modalities-a-randomized-controlled-study
#1
Woong Gil Choi, Megha Prasad, Ryan Lennon, Rajiv Gulati, Abhiram Prasad, Lilach O Lerman, Amir Lerman
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. PATIENTS AND METHODS: This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment...
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29133478/clinical-relevance-of-18-f-sodium-fluoride-positron-emission-tomography-in-noninvasive-identification-of-high-risk-plaque-in-patients-with-coronary-artery-disease
#2
Joo Myung Lee, Ji-In Bang, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Tong Yaliang, Minseok Suh, Jin Chul Paeng, Yasutsugu Shiono, Takashi Kubo, Takashi Akasaka
BACKGROUND: (18)F-sodium fluoride ((18)F-NaF) positron-emission tomography has been introduced as a potential noninvasive imaging tool to identify plaques with high-risk characteristics in patients with coronary artery disease. We sought to evaluate the clinical relevance of (18)F-NaF uptake using optical coherence tomography (OCT), intravascular ultrasound (IVUS), and coronary computed tomography angiography in patients with coronary artery disease. METHODS AND RESULTS: The target population consisted of 51 prospectively enrolled patients (93 stenoses) who underwent (18)F-NaF positron-emission tomography before invasive coronary angiography...
November 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29119262/role-of-cardiac-pet-in-clinical-practice
#3
REVIEW
Brian M Salata, Parmanand Singh
Early identification of atherosclerosis and at-risk lesions plays a critical role in reducing the burden of cardiovascular disease. While invasive coronary angiography serves as the gold standard for diagnosing coronary artery disease, non-invasive imaging techniques provide visualization of both anatomical and functional atherosclerotic processes prior to clinical presentation. The development of cardiac positron emission tomography (PET) has greatly enhanced our capability to diagnose and treat patients with early stages of atherosclerosis...
November 9, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29100114/wall-based-measurement-features-provides-an-improved-ivus-coronary-artery-risk-assessment-when-fused-with-plaque-texture-based-features-during-machine-learning-paradigm
#4
Sumit K Banchhor, Narendra D Londhe, Tadashi Araki, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
BACKGROUND: Planning of percutaneous interventional procedures involves a pre-screening and risk stratification of the coronary artery disease. Current screening tools use stand-alone plaque texture-based features and therefore lack the ability to stratify the risk. METHOD: This IRB approved study presents a novel strategy for coronary artery disease risk stratification using an amalgamation of IVUS plaque texture-based and wall-based measurement features. Due to common genetic plaque makeup, carotid plaque burden was chosen as a gold standard for risk labels during training-phase of machine learning (ML) paradigm...
October 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29059296/carotid-plaque-thickness-and-carotid-plaque-burden-predict-future-cardiovascular-events-in-asymptomatic-adult-americans
#5
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt, Usman Baber, Roxana Mehran, Valentin Fuster
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size: carotid plaque thickness and carotid and intima-media thickness (IMT). Methods and results: A total of 6102 asymptomatic persons underwent assessment of conventional risk factors and imaging by carotid ultrasound. Carotid plaque burden (cPB) and maximum carotid plaque thickness (cPTmax) were measured from 'cross-sectional sweep' video acquisition of the carotid artery...
October 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29036197/morphometric-measurements-of-systemic-atherosclerosis-and-visceral-fat-evidence-from-an-autopsy-study
#6
Aline Nishizawa, Claudia K Suemoto, Daniela S Farias-Itao, Fernanda M Campos, Karen C S Silva, Marcio S Bittencourt, Lea T Grinberg, Renata E P Leite, Renata E L Ferretti-Rebustini, Jose M Farfel, Wilson Jacob-Filho, Carlos A Pasqualucci
BACKGROUND: Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies. However, the few autopsy studies that have investigated the association of visceral fat with atherosclerosis had small sample sizes and focused on coronary arteries of young or middle-aged White subjects. We aimed to investigate the association of pericardial fat (PF) and abdominal visceral fat (AVF) with atherosclerosis in the aorta, coronary, carotid, and cerebral arteries in a large autopsy study...
2017: PloS One
https://www.readbyqxmd.com/read/29032716/prediction-of-coronary-plaque-progression-using-biomechanical-factors-and-vascular-characteristics-based-on-computed-tomography-angiography
#7
Xiujian Liu, Guanghui Wu, Chuangye Xu, Yuna He, Lixia Shu, Yuyang Liu, Nan Zhang, Changyan Lin
OBJECTIVES: Coronary atherosclerotic plaques progress in a highly individual manner. Accurately predicting plaque progression will promote clinical management of atherosclerosis. The purpose of this study was to investigate the role of local biomechanics factors and vascular characteristics in coronary plaque progression and arterial remodeling. METHODS: Computed tomography angiography-based three-dimensional reconstruction of the native right coronary artery was performed in vivo in twelve patients with acute coronary syndrome at baseline and 12-month follow-up...
October 16, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29032450/association-between-coronary-artery-disease-severity-and-overactive-bladder-in-geriatric-patients
#8
Muhammet Fatih Kilinc, Erdogan Yasar, Halil Ibrahim Aydin, Yildiray Yildiz, Omer Gokhan Doluoglu
PURPOSE: To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS: The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of OAB was documented using the self-administered OAB-V8 questionnaire. Formal stratification of the coronary vessels plaque burden was assessed by calculation of a Gensini score for each patient...
October 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29020908/cardiac-society-of-australia-and-new-zealand-position-statement-executive-summary-coronary-artery-calcium-scoring
#9
Christian R Hamilton-Craig, Clara K Chow, John F Younger, V M Jelinek, Jonathan Chan, Gary Yh Liew
Introduction This article summarises the Cardiac Society of Australia and New Zealand position statement on coronary artery calcium (CAC) scoring. CAC scoring is a non-invasive method for quantifying coronary artery calcification using computed tomography. It is a marker of atherosclerotic plaque burden and the strongest independent predictor of future myocardial infarction and mortality. CAC scoring provides incremental risk information beyond traditional risk calculators such as the Framingham Risk Score...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28993120/coronary-lumen-volume-to-myocardial-mass-ratio-in-primary-microvascular-angina
#10
Rominder Grover, Jonathon A Leipsic, John Mooney, Shaw-Hua Kueh, Mickael Ohana, Bjarne L Nᴓrgaard, Ashkan Eftekhari, Jeroen J Bax, Darra T Murphy, Cameron J Hague, Michael A Seidman, Philipp Blanke, Tara Sedlak, Stephanie L Sellers
BACKGROUND: Microvascular angina (MVA) is an incompletely understood clinical entity. Computational analysis of coronary Computed Tomography Angiography (CTA) has shown an association between low coronary lumen volume to myocardial mass (V/M) ratio and lower Fractional Flow Reserve values, independent of plaque measures. We hypothesized that low V/M ratio may be present in patients with MVA. METHODS: A retrospective case-control analysis was performed using patients fulfilling guideline criteria for MVA with controls matched for age, gender, coronary risk factors and atherosclerotic plaque burden...
September 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28984758/expression-of-matrix-metalloproteinases-12-in-st-segment-elevation-myocardial-infarction-a-case-control-study
#11
Jing Wang, Guoqing Wei, Wei Hu, Linhua Li, Yujia Ye, Huawei Wang, Wen Wan, Rui Li, Longjun Li, Linling Ma, Zhaohui Meng
Matrix metalloproteinases-12 (MMP12) can lead to degradation of elastin resulting in plaque destabilization and rupture. MMP12 also facilitates platelet aggregation, adhesion, and granule secretion. However, evidence in the literature related to the function of MMP12 in ST-segment elevation myocardial infarction (STEMI) is little. This study investigated the expression of MMP12 in human coronary thrombus and examined the relationship between plasma MMP12 and STEMI.Arterial plasma was obtained from 46 STEMI patients and 52 stable angina pectoris (SAP) patients and 30 controls with angiographically normal coronary arteries...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982648/high-risk-coronary-atherosclerosis-is-it-the-plaque-burden-the-calcium-the-lipid-or-something-else
#12
EDITORIAL
Akiko Maehara, Gregg W Stone
No abstract text is available yet for this article.
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28982647/multimodality-intracoronary-imaging-with-near-infrared-spectroscopy-and-intravascular-ultrasound-in-asymptomatic-individuals-with-high-calcium-scores
#13
Ryan D Madder, Stacie VanOosterhout, David Klungle, Abbey Mulder, Matthew Elmore, Jeffrey M Decker, David Langholz, Thomas F Boyden, Jessica Parker, James E Muller
BACKGROUND: This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS: Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS ≥300 Agatston units...
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28979905/the-role-of-intracoronary-imaging-in-acute-coronary-syndromes-oct-in-focus
#14
REVIEW
Ahmad Samir, Ahmed ElGuindy
Optical coherence tomography (OCT) has emerged as a powerful intravascular imaging modality in recent years. The introduction of frequency-domain OCT has simplified the procedure and enabled its safe utilisation in different clinical settings including acute coronary syndromes, where it can determine the mechanism of plaque disruption, thrombus burden, and guide percutaneous coronary intervention. In patients presenting with stent failure (stent thrombosis and instent restenosis), OCT can also be very useful in determining the underlying mechanism and guiding therapy thereafter...
December 30, 2016: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28965166/comparative-assessment-of-three-drug-eluting-stents-with-different-platforms-but-with-the-same-biodegradable-polymer-and-the-drug-based-on-quantitative-coronary-angiography-and-optical-coherence-tomography-at-12-month-follow-up
#15
Robert J Gil, Jacek Bil, Jacek Legutko, Tomasz Pawłowski, Katarzyna E Gil, Dariusz Dudek, Ricardo A Costa
The aim of this study was to compare neointima proliferation in three drug-eluting stents (DES) produced by the same company (Balton, Poland) which are covered with a biodegradable polymer and elute sirolimus (concentration: 1.0 and 1.2 µg/mm(2)), but have different stent platforms and strut thickness: stainless steel Prolim(®) (115 µm) and BiOSS LIM(®) (120 µm) and cobalt-chromium Alex(®) (70 µm). We analyzed data of patients with quantitative coronary angiography (QCA) and optical coherence tomography (OCT) at 12 months from BiOSS LIM Registry, Prolim Registry and Alex OCT clinical trial...
September 30, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28963687/prognostic-value-of-coronary-atherosclerosis-progression-evaluated-by-coronary-ct-angiography-in-patients-with-stable-angina
#16
Hui Gu, Yang Gao, Zhihui Hou, U Joseph Schoepf, Alan N Snyder, Taylor M Duguay, Ximing Wang, Bin Lu
OBJECTIVES: To investigate the progression of coronary atherosclerosis burden by coronary CT angiography (CCTA) and to demonstrate its association with the incidence of major adverse cardiac events (MACE). METHODS: We retrospectively studied patients with stable angina who had undergone repeat CCTA due to recurrent or worsening symptoms. Lipid-rich, fibrous, calcified and total plaque burden as well as coronary diameter stenosis were quantitatively analysed. The incidence of MACE during follow-up was determined...
September 29, 2017: European Radiology
https://www.readbyqxmd.com/read/28950315/quantitative-global-plaque-characteristics-from-coronary-computed-tomography-angiography-for-the-prediction-of-future-cardiac-mortality-during-long-term-follow-up
#17
Michaela M Hell, Manish Motwani, Yuka Otaki, Sebastien Cadet, Heidi Gransar, Romalisa Miranda-Peats, Jacob Valk, Piotr J Slomka, Victor Y Cheng, Alan Rozanski, Balaji K Tamarappoo, Sean Hayes, Stephan Achenbach, Daniel S Berman, Damini Dey
Aims: Adverse plaque characteristics determined by coronary computed tomography angiography (CTA) have been associated with future cardiac events. Our aim was to investigate whether quantitative global per-patient plaque characteristics from coronary CTA can predict subsequent cardiac death during long-term follow-up. Methods and results: Out of 2748 patients without prior history of coronary artery disease undergoing CTA with dual-source CT, 32 patients suffered cardiac death (mean follow-up of 5 ± 2 years)...
December 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28947310/assessments-of-carotid-artery-plaque-burden-in-patients-with-familial-hypercholesterolemia
#18
Hayato Tada, Masa-Aki Kawashiri, Hirofumi Okada, Takuya Nakahashi, Kenji Sakata, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi
Although both carotid intima-media thickness (cIMT) and carotid plaque score (cPS) determined by carotid ultrasonography reflect the severity of coronary atherosclerosis, there are few reports on direct comparisons of their clinical utilities in patients with familial hypercholesterolemia (FH). We aimed (1) to compare the clinical utilities of these measurements and (2) to estimate the onset and progression of carotid atherosclerosis in patients with FH. We examined 225 patients with FH (126 males; mean age, 51 ± 18 years) who underwent carotid ultrasonography...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28923811/coronary-artery-calcium-progression-is-associated-with-cardiovascular-events-among-asymptomatic-individuals-from-the-north-texas-primary-care-practice-based-research-network-nortex-pbrn
#19
Roberto Cardarelli, Alexandria Hall, Wade Rankin
BACKGROUND: Although incidental coronary artery calcium (CAC) has been established as a surrogate measure for atherosclerotic plaque burden, little is known about its progression and the associated risks. This study looks at the association of select cardiovascular risk factors with the progression of CAC over a 2-year period and the relationship between CAC progression and experiencing a composite cardiovascular disease (CVD) event. METHODS: Repeated CAC measurements were obtained for 311 asymptomatic participants aged >44 years, who were recruited from a collaborative network of primary care clinics...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28917684/role-of-low-endothelial-shear-stress-and-plaque-characteristics-in-the-prediction-of-nonculprit-major-adverse-cardiac-events-the-prospect-study
#20
Peter H Stone, Akiko Maehara, Ahmet Umit Coskun, Charles C Maynard, Marina Zaromytidou, Gerasimos Siasos, Ioannis Andreou, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Alexandra J Lansky, Gary S Mintz, Patrick W Serruys, Charles L Feldman, Gregg W Stone
OBJECTIVES: This study sought to determine whether low endothelial shear stress (ESS) adds independent prognostication for future major adverse cardiac events (MACE) in coronary lesions in patients with high-risk acute coronary syndrome (ACS) from the United States and Europe. BACKGROUND: Low ESS is a proinflammatory, proatherogenic stimulus associated with coronary plaque development, progression, and destabilization in human-like animal models and in humans. Previous natural history studies including baseline ESS characterization investigated low-risk patients...
September 18, 2017: JACC. Cardiovascular Imaging
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