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coronary plaque burden

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https://www.readbyqxmd.com/read/28804537/an-integrated-approach-to-coronary-heart-disease-diagnosis-and-clinical-management
#1
REVIEW
Teresa Infante, Ernesto Forte, Concetta Schiano, Carlo Cavaliere, Carlo Tedeschi, Andrea Soricelli, Marco Salvatore, Claudio Napoli
The major issue in coronary heart disease (CHD) diagnosis and management is that symptoms onset in an advanced state of disease. Despite the availability of several clinical risk scores, the prediction of cardiovascular events is lacking, and many patients at risk are not well stratified according to the canonical risk factors alone. Therefore, adequate risk assessment remains the most challenging issue. Recently, the integration of imaging data with biochemical markers in a radiogenomic framework has been proposed in many fields of medicine as well as in cardiology...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803421/quantitative-coronary-plaque-analysis-predicts-high-risk-plaque-morphology-on-coronary-computed-tomography-angiography-results-from-the-romicat-ii-trial
#2
Ting Liu, Pál Maurovich-Horvat, Thomas Mayrhofer, Stefan B Puchner, Michael T Lu, Khristine Ghemigian, Pieter H Kitslaar, Alexander Broersen, Amit Pursnani, Udo Hoffmann, Maros Ferencik
Semi-automated software can provide quantitative assessment of atherosclerotic plaques on coronary CT angiography (CTA). The relationship between established qualitative high-risk plaque features and quantitative plaque measurements has not been studied. We analyzed the association between quantitative plaque measurements and qualitative high-risk plaque features on coronary CTA. We included 260 patients with plaque who underwent coronary CTA in the Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography (ROMICAT) II trial...
August 12, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28740456/carotid-artery-stiffness-digital-endothelial-function-and-coronary-calcium-in-patients-with-essential-thrombocytosis-free-of-overt-atherosclerotic-disease
#3
Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel, Ales Blinc
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects. PATIENTS AND METHODS: 40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28734913/uncovered-culprit-plaque-ruptures-in-patients-with-st-segment-elevation-myocardial-infarction-assessed-by-optical-coherence-tomography-and-intravascular-ultrasound-with-imap
#4
Mikkel Hougaard, Henrik Steen Hansen, Per Thayssen, Lisbeth Antonsen, Lisette Okkels Jensen
OBJECTIVES: This study assessed the incidence and course of healing of uncovered plaque ruptures (PR) following primary percutaneous coronary intervention. BACKGROUND: The infarct-related occlusion is frequently located at the lesion site with maximum thrombus burden, whereas the culprit PR may be situated more proximally or distally. METHODS: Uncovered PR in segments adjacent to the stent were identified by optical coherence tomography and intravascular ultrasound using iMap (Boston Scientific, Marlborough, Massachusetts) within 48 h and after 12 months...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734077/integrative-studies-implicate-matrix-metalloproteinase-12-as-a-culprit-gene-for-large-artery-atherosclerotic-stroke
#5
Hovsep Mahdessian, Ljubica Perisic Matic, Mariette Lengquist, Karl Gertow, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E Humphries, Rainer Rauramaa, Ulf de Faire, Andries J Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Elena Tremoli, Anders Hamsten, Per Eriksson, Ulf Hedin, Anders Mälarstig
BACKGROUND: Ischemic stroke and coronary heart disease are important contributors to the global disease burden and share atherosclerosis as the main underlying cause. Recent evidence from a genome-wide association study (GWAS) suggested that single nucleotide polymorphisms (SNP) near the MMP12 gene at chromosome 11q22.3 were associated with large-vessel ischemic stroke. Here we evaluated and extended these results by examining the relationship between MMP12 and atherosclerosis in clinical and experimental studies...
July 22, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28712815/asymptomatic-carotid-stenosis-is-associated-with-cognitive%C3%A2-impairment
#6
Brajesh K Lal, Moira C Dux, Siddhartha Sikdar, Carly Goldstein, Amir A Khan, John Yokemick, Limin Zhao
BACKGROUND: Cerebrovascular risk factors (eg, hypertension, coronary artery disease) and stroke can lead to vascular cognitive impairment. The Asymptomatic Carotid Stenosis and Cognitive Function study evaluated the isolated impact of asymptomatic carotid stenosis (no prior ipsilateral or contralateral stroke or transient ischemic attack) on cognitive function. Cerebrovascular hemodynamic and carotid plaque characteristics were analyzed to elucidate potential mechanisms affecting cognition...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28708548/predicting-locations-of-high-risk-plaques-in-coronary-arteries-in-patients-receiving-statin-therapy
#7
Ling Zhang, Andreas Wahle, Zhi Chen, John J Lopez, Tomas Kovarnik, Milan Sonka
Features of high-risk coronary artery plaques prone to major adverse cardiac events (MACE) were identified by intravascular ultrasound (IVUS) virtual histology (VH). These plaque features are: Thin-cap fibroatheroma (TCFA), plaque burden PB≥70%, or minimal luminal area MLA≤4mm². Identification of arterial locations likely to later develop such high-risk plaques may help prevent MACE. We report a machine learning method for prediction of future high-risk coronary plaque locations and types in patients under statin therapy...
July 11, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28708039/comparison-of-endothelial-function-in-healthy-chronic-periodontitis-and-myocardial-infarction-patients
#8
Anahita Punj, Santhosh B Shenoy, Subramanyam K
BACKGROUND: The inflammatory burden as a result of severe periodontal disease acts as an insult to the endothelium. This disruption in the function of the endothelium, predisposes it towards formation of atherosclerotic plaque, which may be a subsequent risk for coronary artery disease. The aim of this study was to estimate and compare endothelial function via flow mediated dilation (FMD) assessment in periodontal health and disease. MATERIAL AND METHODS: A total of 120 patients were selected and categorized equally into three groups of healthy, chronic periodontitis and myocardial infarction patients...
July 14, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28707263/delivery-of-viral-vectors-for-gene-therapy-in-intimal-hyperplasia-and-restenosis-in-atherosclerotic-swine
#9
REVIEW
Sannette Hall, Devendra K Agrawal
Cardiovascular diseases including atherosclerosis are a major financial and health burden globally. Inflammation associated with atherosclerosis results in the development of plaques that can rupture causing thrombosis, stroke, or death. The most widely used treatment for the removal of atherosclerotic plaques is percutaneous transluminal coronary angioplasty (PTCA) with or without stenting. Although this is a safer and minimally invasive method, restenosis and intimal hyperplasia after interventional procedure remains a major hurdle and more refined approaches are needed...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28682809/mechanisms-of-erosion-of-atherosclerotic-plaques
#10
Thibaut Quillard, Grégory Franck, Thomas Mawson, Eduardo Folco, Peter Libby
PURPOSE OF REVIEW: The present review explores the mechanisms of superficial intimal erosion, a common cause of thrombotic complications of atherosclerosis. RECENT FINDINGS: Human coronary artery atheroma that give rise to thrombosis because of erosion differ diametrically from those associated with fibrous cap rupture. Eroded lesions characteristically contain few inflammatory cells, abundant extracellular matrix, and neutrophil extracellular traps (NETs). Innate immune mechanisms such as engagement of Toll-like receptor 2 (TLR2) on cultured endothelial cells can impair their viability, attachment, and ability to recover a wound...
July 5, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28664826/differences-in-vascular-response-between-balloon-overstretch-and-stent-overexpansion-in-nonatherosclerotic-porcine-coronary-arteries
#11
Yoshiaki Mitsutake, Jörg Reifart, Wook Bum Pyun, Jennifer K Lyons, Tobias Deuse, Sonja Schrepfer, Fumiaki Ikeno
Which preclinical models are best suited for restenosis research remains uncertain. Here we compared the restenotic responsesafter balloon or stent overstretch injury in a porcine coronary artery. A total of 30 coronary lesions in 5 pigs were treated by balloon overdilatation or oversized stent implantation at various balloon-to-artery (B:A) ratios. Four weeks later, the lesions were examined in vivo by using coronary angiography, intravascular ultrasound, and optical coherence tomography (OCT). At follow-up, the lumen area stenosis and plaque burden at the minimal lumen area site were greater in stented sites than in balloon injury site (lumen area stenosis, 21...
June 29, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28658167/loss-of-nighttime-blood-pressure-dipping-as-a-risk-factor-for-coronary-artery-calcification-in-nondialysis-chronic-kidney-disease
#12
Hoon Young Choi, Chan Joo Lee, Jung Eun Lee, Hyun Su Yang, Ha Yan Kim, Hyeong Cheon Park, Hyeon Chang Kim, Hyuk-Jae Chang, Sung-Ha Park, Beom Seok Kim
Diurnal variations in blood pressure (BP) loss are closely associated with target organ damage and cardiovascular events. The quantity of coronary artery calcification (CAC) correlates with the atherosclerotic plaque burden, and an increased quantity indicates a substantially increased risk of cardiovascular events. This study investigated the nighttime diurnal variation in BP loss associated with CAC in patients with chronic kidney disease (CKD).Of the 1958 participants, we enrolled 722 participants with CKD without a history of acute coronary syndrome or symptomatic coronary artery disease...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28657444/bridging-the-gap-for-lipid-lowering-therapy-plaque-regression-coronary-computed-tomographic-angiography-and-imaging-guided-personalized-medicine
#13
Alan C Kwan, Konstantinos N Aronis, Veit Sandfort, Roger S Blumenthal, David A Bluemke
Lipid-lowering therapy effectively decreases cardiovascular risk on a population level, but it remains difficult to identify an individual patient's personal risk reduction while following guideline directed medical therapy, leading to overtreatment in some patients and cardiovascular events in others. Recent improvements in cardiac CT technology provide the ability to directly assess an individual's atherosclerotic disease burden, which has the potential to personalize risk assessment for lipid-lowering therapy...
July 6, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28657113/high-burden-of-coronary-atherosclerosis-in-patients-with-cirrhosis
#14
Konstantin Kazankov, Kim Munk, Kristian Altern Øvrehus, Jesper Møller Jensen, Cecilie Brøckner Siggaard, Henning Grønbaek, Bjarne Linde Nørgaard, Hendrik Vilstrup
BACKGROUND: Population studies report increased cardiovascular mortality in patients with cirrhosis. Coronary artery disease may be a trait of end-stage liver disease, but whether it is frequent or extensive in cirrhosis in general is unknown. Thus, we aimed to assess the prevalence and extent of coronary artery disease in unselected cirrhosis patients. MATERIALS AND METHODS: Using coronary computed tomography angiography, we investigated 52 patients from all Child-Pugh classes and aetiologies of cirrhosis without known cardiac disease for presence and severity of coronary artery disease in a cross-sectional design...
June 28, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28637783/paradoxical-suppression-of-atherosclerosis-in-the-absence-of-microrna-146a
#15
Henry S Cheng, Rickvinder Besla, Angela Li, Zhiqi Chen, Eric A Shikatani, Maliheh Nazari-Jahantigh, Adel Hammoutène, My-Anh Nguyen, Michele Geoffrion, Lei Cai, Nadiya Khyzha, Tong Li, Sonya A MacParland, Mansoor Husain, Myron I Cybulsky, Chantal M Boulanger, Ryan E Temel, Andreas Schober, Katey J Rayner, Clinton S Robbins, Jason E Fish
RATIONALE: Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a) has been identified as a critical brake on proinflammatory nuclear factor κ light chain enhancer of activated B cells signaling in several cell types, including endothelial cells and bone marrow (BM)-derived cells. Importantly, miR-146a expression is elevated in human atherosclerotic plaques, and polymorphisms in the miR-146a precursor have been associated with risk of coronary artery disease. OBJECTIVE: To define the role of endogenous miR-146a during atherogenesis...
August 4, 2017: Circulation Research
https://www.readbyqxmd.com/read/28630603/elevated-il-37-levels-in-the-plasma-of-patients-with-severe-coronary-artery-calcification
#16
Meng Chai, Hai-Tao Zhang, Yu-Jie Zhou, Qing-Wei Ji, Qing Yang, Yu-Yang Liu, Ying-Xin Zhao, Dong-Mei Shi, Wei Liu, Li-Xia Yang, Lin-Lin Zhang, Jing Liang
BACKGROUND: Coronary artery calcification (CAC) is a predictor of cardiovascular events and plaque burden and is closely associated with chronic inflammation. Interleukin (IL)-37 is a newly discovered member of the IL-1 family and is considered an anti-inflammatory cytokine. Our recent study on mice indicated that IL-37 could attenuate atherosclerosis and vascular calcification, which suggests that IL-37 could be associated with the development of atherosclerosis and related diseases...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28629625/what-exactly-regression-of-atherosclerosis-or-foreign-body-reaction-with-hyaline-arteriosclerosis-drives-transient-scaffolding-of-coronary-arteries-a-pooled-analysis-of-observational-absorb-studies-with-a-serial-multimodality-imaging-substudy-of-absorb-cohort
#17
Alexander N Kharlamov, John A Feinstein, John A Cramer, John A Boothroyd
OBJECTIVES: We aimed to estimate the trends of the artery remodeling after transient scaffolding. BACKGROUND: At least 2.62% reduction of the per cent atheroma volume (PAV) or plaque burden (PB) performed in ABSORB B trial at 60months. METHODS: The detailed multiple serial imaging evaluation was performed by intravascular ultrasound (IVUS) in comparison with quantitative coronary angiography (QCA), multislice CT (MSCT) and optical coherence tomography (OCT) thru 24months in the ABSORB cohort B1 trial (n=45) with the pooled analysis in ABSORB A and B trials (n=131)...
June 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28606882/the-effect-of-coronary-bifurcation-and-blood-flow-modelling-in-prediction-of-atherosclerotic-plaque-development-a-serial-computed-tomographic-coronary-angiographic-study
#18
Antonis Sakellarios, Christos V Bourantas, Stella-Lida Papadopoulou, Pieter H Kitslaar, Chrysafios Girasis, Gregg W Stone, Johan H C Reiber, Lampros K Michalis, Patrick W Serruys, Pim J de Feyter, Hector M Garcia-Garcia, Dimitrios I Fotiadis
AIMS: Examine the effect of the daughter branches to the haemodynamics and the potential prediction of atherosclerotic plaque development as well as the best flow division model for accurate blood flow modelling. METHODS AND RESULTS: In this study, we analysed computed tomographic coronary angiography retrospective data portraying 17 coronary artery bifurcations in 15 patients recruited in the PROSPECT MSCT study. The baseline and three year follow-up imaging data were used to reconstruct coronary artery anatomy and in the baseline models blood flow simulations was performed using three flow division approaches: stress-free, Murray's law and Doriot's law...
June 13, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28592134/circulating-annexin-a5-levels-are-associated-with-carotid-intima-media-thickness-but-not-coronary-plaque-composition
#19
Mathias Burgmaier, Sebastian Reith, Leon Schurgers, Florian Kahles, Nikolaus Marx, Chris Reutelingsperger
BACKGROUND: Annexin A5 (anxA5) is involved in processes which are crucial in atherogenesis. However, anxA5's relationship with atherosclerotic lesion extension and plaque composition in high-risk patients with type 2 diabetes remains unclear. Thus, we characterized the association between circulating anxA5 levels with atherosclerotic burden and coronary plaque composition in diabetes mellitus patients. METHODS: Intima-media thickness was determined in 96 diabetes mellitus patients with stable coronary artery disease...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28591063/a-new-technique-for-lipid-core-plaque-detection-by-optical-coherence-tomography-for-prevention-of-peri-procedural-myocardial-infarction-a-case-report
#20
Yongcheol Kim, Muthukaruppan Gnanadesigan, Gijs van Soest, Thomas W Johnson
RATIONALE: Percutaneous coronary intervention (PCI) provides effective revascularization of atherosclerotic coronary arteries but the invasive nature of treatment can result in complications. PATIENT CONCERNS: A 53-year old man underwent coronary angiography due to chest pain with minimal ST-segment elevation in the inferior leads of the electrocardiogram. DIAGNOSIS: We proceeded directly to coronary angiography and delineated a moderate stenosis with haziness in the mid right coronary artery (RCA)...
June 2017: Medicine (Baltimore)
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