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coronary plaque burden

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https://www.readbyqxmd.com/read/29274686/fluid-structure-interaction-models-based-on-patient-specific-ivus-at-baseline-and-follow-up-for-prediction-of-coronary-plaque-progression-by-morphological-and-biomechanical-factors-a-preliminary-study
#1
Liang Wang, Dalin Tang, Akiko Maehara, Zheyang Wu, Chun Yang, David Muccigrosso, Jie Zheng, Richard Bach, Kristen L Billiar, Gary S Mintz
Plaque morphology and biomechanics are believed to be closely associated with plaque progression. In this paper, we test the hypothesis that integrating morphological and biomechanical risk factors would result in better predictive power for plaque progression prediction. A sample size of 374 intravascular ultrasound (IVUS) slices was obtained from 9 patients with IVUS follow-up data. 3D fluid-structure interaction models were constructed to obtain both structural stress/strain and fluid biomechanical conditions...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29259500/quantitative-evaluation-of-coronary-plaque-progression-by-computed-tomographic-angiography
#2
Xiujian Liu, Guanghui Wu, Chuangye Xu, Yuna He, Lixia Shu, Yuyang Liu, Nan Zhang, Changyan Lin
Understanding plaque formation in patients at risk for coronary artery disease-the leading cause of morbidity and death in the world-enables physicians to better determine whether and how to treat these individuals. We used computed tomographic angiography to quantitatively evaluate the progression of nonculprit coronary plaques along the full length of the right coronary artery in 21 patients with acute coronary syndrome. Each right coronary artery was analyzed in sequential, 3-mm-long segments, and the minimum luminal area, plaque burden, and plaque volume within each segment were evaluated at baseline and at 12-month follow-up...
October 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29226174/proprotein-convertase-subtilisin-kexin-9-levels-in-relation-to-systemic-immune-activation-and-subclinical-coronary-plaque-in-hiv
#3
Markella V Zanni, Lauren A Stone, Mabel Toribio, Dodie E Rimmelin, Jake Robinson, Tricia H Burdo, Kenneth Williams, Kathleen V Fitch, Janet Lo, Steven K Grinspoon
Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is known to mediate homeostasis of low-density lipoprotein cholesterol (LDL-c), but it may also participate in immune reactivity and atherogenesis. Methods: We compared circulating PCSK9 levels among asymptomatic individuals with and without HIV. Further, within each group, we assessed the relationship between PCSK9 levels, traditional cardiovascular disease risk factors, immune activation, and subclinical coronary atherosclerotic plaque...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29193860/higher-coronary-plaque-burden-in-psoriatic-arthritis-is-independent-of-metabolic-syndrome-and-associated-with-underlying-disease-severity
#4
Agnes Szentpetery, Gerard M Healy, Darragh Brady, Muhammad Haroon, Phil Gallagher, Ciaran E Redmond, Hannah Fleming, John Duignan, Jonathan D Dodd, Oliver FitzGerald
OBJECTIVES: To examine the effect of metabolic syndrome (Metsy) and psoriatic disease-related variables on coronary plaque burden in psoriatic arthritis (PsA) patients. METHODS: 50 PsA patients without symptoms of coronary artery disease (CAD) (25 with Metsy and 25 without (NMetsy)) and 50 age and sex-matched controls underwent 64-slice coronary CT angiography (CCTA). Plaque localisation, segment involvement score (SIS), stenosis severity score (SSS) and total plaque volume (TPV) were calculated...
November 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29176683/coronary-calcification-in-adults-with-turner-syndrome
#5
Marissa Schoepp, Fady Hannah-Shmouni, Jatin Matta, Ahmed M Ghanem, John A Hanover, Khaled Z Abd-Elmoniem, Ahmed M Gharib
PurposeAdults with Turner syndrome (TS) have an increased predisposition to ischemic heart disease. The quantitative relationship between coronary atherosclerosis and TS has yet to be established.MethodsA total of 128 females (62 with TS) participated in this prospective study. Coronary computed tomography angiography was performed to measure coronary calcified plaque burden, and prevalent noncalcified plaque burden. Regression analysis was used to study the effects of TS and traditional cardiovascular disease risk factors on coronary plaque burden...
October 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29175647/gamma-glutamyl-transferase-and-the-risk-of-atherosclerosis-and-coronary-heart-disease
#6
REVIEW
Gjin Ndrepepa, Roisin Colleran, Adnan Kastrati
Gamma-glutamyl transferase (GGT) is a ubiquitous cell surface enzyme that cleaves extracellular glutathione (G-SH) or other gamma-glutamyl compounds. GGT serves to increase the availability of amino acids, primarily cysteine, for intracellular G-SH synthesis and plays a crucial role in maintaining G-SH homeostasis and defense against oxidative stress in organisms. Measurement of circulating GGT activity is widely used for the diagnosis of liver and obstructive biliary diseases and as an indicator of alcohol consumption...
November 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29135482/long-term-darapladib-use-does-not-affect-coronary-plaque-composition-assessed-using-multimodality-intravascular-imaging-modalities-a-randomized-controlled-study
#7
Woong Gil Choi, Megha Prasad, Ryan Lennon, Rajiv Gulati, Abhiram Prasad, Lilach O Lerman, Amir Lerman
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. PATIENTS AND METHODS: This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment...
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29133478/clinical-relevance-of-18f-sodium-fluoride-positron-emission-tomography-in-noninvasive-identification-of-high-risk-plaque-in-patients-with-coronary-artery-disease
#8
COMPARATIVE STUDY
Joo Myung Lee, Ji-In Bang, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Tong Yaliang, Minseok Suh, Jin Chul Paeng, Yasutsugu Shiono, Takashi Kubo, Takashi Akasaka
BACKGROUND: 18F-sodium fluoride (18F-NaF) positron-emission tomography has been introduced as a potential noninvasive imaging tool to identify plaques with high-risk characteristics in patients with coronary artery disease. We sought to evaluate the clinical relevance of 18F-NaF uptake using optical coherence tomography (OCT), intravascular ultrasound (IVUS), and coronary computed tomography angiography in patients with coronary artery disease. METHODS AND RESULTS: The target population consisted of 51 prospectively enrolled patients (93 stenoses) who underwent 18F-NaF positron-emission tomography before invasive coronary angiography...
November 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29119262/role-of-cardiac-pet-in-clinical-practice
#9
REVIEW
Brian M Salata, Parmanand Singh
Early identification of atherosclerosis and at-risk lesions plays a critical role in reducing the burden of cardiovascular disease. While invasive coronary angiography serves as the gold standard for diagnosing coronary artery disease, non-invasive imaging techniques provide visualization of both anatomical and functional atherosclerotic processes prior to clinical presentation. The development of cardiac positron emission tomography (PET) has greatly enhanced our capability to diagnose and treat patients with early stages of atherosclerosis...
November 9, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29100114/wall-based-measurement-features-provides-an-improved-ivus-coronary-artery-risk-assessment-when-fused-with-plaque-texture-based-features-during-machine-learning-paradigm
#10
Sumit K Banchhor, Narendra D Londhe, Tadashi Araki, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
BACKGROUND: Planning of percutaneous interventional procedures involves a pre-screening and risk stratification of the coronary artery disease. Current screening tools use stand-alone plaque texture-based features and therefore lack the ability to stratify the risk. METHOD: This IRB approved study presents a novel strategy for coronary artery disease risk stratification using an amalgamation of IVUS plaque texture-based and wall-based measurement features. Due to common genetic plaque makeup, carotid plaque burden was chosen as a gold standard for risk labels during training-phase of machine learning (ML) paradigm...
October 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29059296/carotid-plaque-thickness-and-carotid-plaque-burden-predict-future-cardiovascular-events-in-asymptomatic-adult-americans
#11
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt, Usman Baber, Roxana Mehran, Valentin Fuster
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size: carotid plaque thickness and carotid and intima-media thickness (IMT). Methods and results: A total of 6102 asymptomatic persons underwent assessment of conventional risk factors and imaging by carotid ultrasound. Carotid plaque burden (cPB) and maximum carotid plaque thickness (cPTmax) were measured from 'cross-sectional sweep' video acquisition of the carotid artery...
October 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29036197/morphometric-measurements-of-systemic-atherosclerosis-and-visceral-fat-evidence-from-an-autopsy-study
#12
Aline Nishizawa, Claudia K Suemoto, Daniela S Farias-Itao, Fernanda M Campos, Karen C S Silva, Marcio S Bittencourt, Lea T Grinberg, Renata E P Leite, Renata E L Ferretti-Rebustini, Jose M Farfel, Wilson Jacob-Filho, Carlos A Pasqualucci
BACKGROUND: Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies. However, the few autopsy studies that have investigated the association of visceral fat with atherosclerosis had small sample sizes and focused on coronary arteries of young or middle-aged White subjects. We aimed to investigate the association of pericardial fat (PF) and abdominal visceral fat (AVF) with atherosclerosis in the aorta, coronary, carotid, and cerebral arteries in a large autopsy study...
2017: PloS One
https://www.readbyqxmd.com/read/29032716/prediction-of-coronary-plaque-progression-using-biomechanical-factors-and-vascular-characteristics-based-on-computed-tomography-angiography
#13
Xiujian Liu, Guanghui Wu, Chuangye Xu, Yuna He, Lixia Shu, Yuyang Liu, Nan Zhang, Changyan Lin
OBJECTIVES: Coronary atherosclerotic plaques progress in a highly individual manner. Accurately predicting plaque progression will promote clinical management of atherosclerosis. The purpose of this study was to investigate the role of local biomechanics factors and vascular characteristics in coronary plaque progression and arterial remodeling. METHODS: Computed tomography angiography-based three-dimensional reconstruction of the native right coronary artery was performed in vivo in twelve patients with acute coronary syndrome at baseline and 12-month follow-up...
October 16, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29032450/association-between-coronary-artery-disease-severity-and-overactive-bladder-in-geriatric-patients
#14
Muhammet Fatih Kilinc, Erdogan Yasar, Halil Ibrahim Aydin, Yildiray Yildiz, Omer Gokhan Doluoglu
PURPOSE: To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS: The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of OAB was documented using the self-administered OAB-V8 questionnaire. Formal stratification of the coronary vessels plaque burden was assessed by calculation of a Gensini score for each patient...
October 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29020908/cardiac-society-of-australia-and-new-zealand-position-statement-executive-summary-coronary-artery-calcium-scoring
#15
Christian R Hamilton-Craig, Clara K Chow, John F Younger, V M Jelinek, Jonathan Chan, Gary Yh Liew
Introduction This article summarises the Cardiac Society of Australia and New Zealand position statement on coronary artery calcium (CAC) scoring. CAC scoring is a non-invasive method for quantifying coronary artery calcification using computed tomography. It is a marker of atherosclerotic plaque burden and the strongest independent predictor of future myocardial infarction and mortality. CAC scoring provides incremental risk information beyond traditional risk calculators such as the Framingham Risk Score...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28993120/coronary-lumen-volume-to-myocardial-mass-ratio-in-primary-microvascular-angina
#16
Rominder Grover, Jonathon A Leipsic, John Mooney, Shaw-Hua Kueh, Mickael Ohana, Bjarne L Nᴓrgaard, Ashkan Eftekhari, Jeroen J Bax, Darra T Murphy, Cameron J Hague, Michael A Seidman, Philipp Blanke, Tara Sedlak, Stephanie L Sellers
BACKGROUND: Microvascular angina (MVA) is an incompletely understood clinical entity. Computational analysis of coronary Computed Tomography Angiography (CTA) has shown an association between low coronary lumen volume to myocardial mass (V/M) ratio and lower Fractional Flow Reserve values, independent of plaque measures. We hypothesized that low V/M ratio may be present in patients with MVA. METHODS: A retrospective case-control analysis was performed using patients fulfilling guideline criteria for MVA with controls matched for age, gender, coronary risk factors and atherosclerotic plaque burden...
September 22, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28984758/expression-of-matrix-metalloproteinases-12-in-st-segment-elevation-myocardial-infarction-a-case-control-study
#17
Jing Wang, Guoqing Wei, Wei Hu, Linhua Li, Yujia Ye, Huawei Wang, Wen Wan, Rui Li, Longjun Li, Linling Ma, Zhaohui Meng
Matrix metalloproteinases-12 (MMP12) can lead to degradation of elastin resulting in plaque destabilization and rupture. MMP12 also facilitates platelet aggregation, adhesion, and granule secretion. However, evidence in the literature related to the function of MMP12 in ST-segment elevation myocardial infarction (STEMI) is little. This study investigated the expression of MMP12 in human coronary thrombus and examined the relationship between plasma MMP12 and STEMI.Arterial plasma was obtained from 46 STEMI patients and 52 stable angina pectoris (SAP) patients and 30 controls with angiographically normal coronary arteries...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982648/high-risk-coronary-atherosclerosis-is-it-the-plaque-burden-the-calcium-the-lipid-or-something-else
#18
EDITORIAL
Akiko Maehara, Gregg W Stone
No abstract text is available yet for this article.
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28982647/multimodality-intracoronary-imaging-with-near-infrared-spectroscopy-and-intravascular-ultrasound-in-asymptomatic-individuals-with-high-calcium-scores
#19
Ryan D Madder, Stacie VanOosterhout, David Klungle, Abbey Mulder, Matthew Elmore, Jeffrey M Decker, David Langholz, Thomas F Boyden, Jessica Parker, James E Muller
BACKGROUND: This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS: Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS ≥300 Agatston units...
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28979905/the-role-of-intracoronary-imaging-in-acute-coronary-syndromes-oct-in-focus
#20
REVIEW
Ahmad Samir, Ahmed ElGuindy
Optical coherence tomography (OCT) has emerged as a powerful intravascular imaging modality in recent years. The introduction of frequency-domain OCT has simplified the procedure and enabled its safe utilisation in different clinical settings including acute coronary syndromes, where it can determine the mechanism of plaque disruption, thrombus burden, and guide percutaneous coronary intervention. In patients presenting with stent failure (stent thrombosis and instent restenosis), OCT can also be very useful in determining the underlying mechanism and guiding therapy thereafter...
December 30, 2016: Global Cardiology Science & Practice
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