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coronary plaque burden

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https://www.readbyqxmd.com/read/28109934/coronary-plaque-burden-and-adverse-plaque-characteristics-are-increased-in-healthy-relatives-of-patients-with-early-onset-coronary-artery-disease
#1
Morten K Christiansen, Jesper M Jensen, Bjarne L Nørgaard, Damini Dey, Hans Erik Bøtker, Henrik K Jensen
OBJECTIVES: This study characterized and quantified subclinical atherosclerosis by coronary computed tomography angiography (CTA) in first-degree relatives of patients with early onset coronary artery disease (CAD). BACKGROUND: A strong family history of CAD is an important risk factor for adverse cardiovascular events. Whether predisposed individuals suffer an increased burden of coronary atherosclerosis and adverse plaque features is not known. METHODS: We included 88 healthy middle-aged first-degree relatives from 59 families with early onset CAD...
January 12, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109718/lipid-core-burden-response-to-stent-implantation-assessed-with-near-infrared-spectroscopy-and-intravascular-ultrasound-evaluation-in-patients-with-myocardial-infarction
#2
Manijeh Noori, Per Thayssen, Karsten Tange Veien, Anders Junker, Knud Nørregaard Hansen, Henrik Steen Hansen, Lisette Okkels Jensen
INTRODUCTION: Near-infrared spectroscopy (NIRS) is a new method to identify lipid core plaque (LCP). The LCP and vascular response were assessed with NIRS to examine whether LCP was compressed or redistributed during percutaneous coronary intervention with stent implantation. METHODS: In 25 patients with non-ST segment elevation myocardial infarction (NSTEMI) NIRS acquisition was performed after predilation, stent implantation with nominal pressure and high-pressure post-dilation with a non-compliant balloon...
December 27, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28107355/assessment-of-inter-expert-variability-and-of-an-automated-segmentation-method-of-40-and-60-mhz-ivus-images-of-coronary-arteries
#3
François Destrempes, Marie-Hélène Roy Cardinal, Yoshifumi Saijo, Gérard Finet, Jean-Claude Tardif, Guy Cloutier
The objectives were to compare the performance of a segmentation algorithm, based on the minimization of an uncertainty function, to delineate contours of external elastic membrane and lumen of human coronary arteries imaged with 40 and 60 MHz IVUS, and to use values of this function to delineate portions of contours with highest uncertainty. For 8 patients, 40 and 60 MHz IVUS coronary data acquired pre- and post-interventions were used, for a total of 68,516 images. Manual segmentations of contours (on 2312 images) performed by experts at three core laboratories were the gold-standards...
2017: PloS One
https://www.readbyqxmd.com/read/28062170/an-artificial-neural-network-method-for-lumen-and-media-adventitia-border-detection-in-ivus
#4
Shengran Su, Zhenghui Hu, Qiang Lin, William Kongto Hau, Zhifan Gao, Heye Zhang
Intravascular ultrasound (IVUS) has been well recognized as one powerful imaging technique to evaluate the stenosis inside the coronary arteries. The detection of lumen border and media-adventitia (MA) border in IVUS images is the key procedure to determine the plaque burden inside the coronary arteries, but this detection could be burdensome to the doctor because of large volume of the IVUS images. In this paper, we use the artificial neural network (ANN) method as the feature learning algorithm for the detection of the lumen and MA borders in IVUS images...
November 17, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28060223/coronary-plaque-progression-and-regression-in-asymptomatic-african-american-chronic-cocaine-users-with-obstructive-coronary-stenoses-a-preliminary-study
#5
Veit Sandfort, David A Bluemke, Jose Vargas, Jeffrey A Brinker, Gary Gerstenblith, Thomas Kickler, Gang Zheng, Ji Li, Shaoguang Chen, Hong Lai, Elliot K Fishman, Shenghan Lai
OBJECTIVE: Although rapid progression of coronary atherosclerosis was observed in chronic cocaine users, it is unknown whether reduced cocaine use retards the progression of atherosclerosis. We investigated whether reduced cocaine use over a 12-month period was associated with coronary plaque regression in cocaine users. METHODS: Fifteen African American chronic cocaine users with previously coronary computed tomography angiography (CCTA)-confirmed >50% coronary stenosis in Baltimore, Maryland, were enrolled in a study to investigate whether reduced cocaine use is associated with changes in coronary plaque burden over a 12-month period of cash-based incentive intervention, which was implemented to systematically reinforce cocaine abstinence...
January 6, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28052860/increased-prevalence-of-coronary-plaque-in-patients-with-psoriatic-arthritis-without-prior-diagnosis-of-coronary-artery-disease
#6
Jiayun Shen, Ka-Tak Wong, Isaac T Cheng, Qing Shang, Edmund K Li, Priscilla Wong, Emily W Kun, Mei Yan Law, Ronald Yip, Isaac Yim, Shirley Ying, Martin Li, Tena K Li, Chun-Kwok Wong, Tracy Y Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVES: To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using coronary CT angiography (CCTA). METHODS: Ninety consecutive patients with PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls (male: 137(57.1%); 49.6±10.7 years) without known cardiovascular (CV) diseases who underwent CCTA due to chest pain and/or multiple CV risk factors were recruited for comparison. RESULTS: Patients with PsA and controls were matched in age, gender and traditional CV risk factors (all p>0...
January 4, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28040277/microparticles-and-their-role-in-coronary-artery-disease
#7
REVIEW
Sudheer Koganti, Despina Eleftheriou, Paul A Brogan, Tushar Kotecha, Ying Hong, Roby D Rakhit
Despite significant advances in prevention, medical and interventional management, coronary artery disease (CAD) remains the leading cause of death worldwide. Although the number of people being diagnosed with CAD has plateaued in the western world, it is projected to increase significantly in the developing world reaching epidemic proportions, particularly in South Asia. To better stratify the risk of developing and suffering a cardiovascular event due to CAD, not only plasma biomarkers relating to disease burden but also disease activity in CAD are needed; this will allow targeting of appropriate management to high-risk patients for acute events...
December 22, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28025263/quantitative-plaque-features-from-coronary-computed-tomography-angiography-to-identify-regional-ischemia-by-myocardial-perfusion-imaging
#8
Mariana Diaz-Zamudio, Tobias A Fuchs, Piotr Slomka, Yuka Otaki, Reza Arsanjani, Heidi Gransar, Guido Germano, Daniel S Berman, Philipp A Kaufmann, Damini Dey
AIMS: We aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND RESULTS: Hundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state (99m)Tc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion)...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28024655/prevalence-by-computed-tomographic-angiography-of-coronary-plaques-in-south-asian-and-white-patients-with-type-2-diabetes-mellitus-at-low-and-high-risk-using-four-cardiovascular-risk-scores-ukpds-frs-ascvd-and-jbs3
#9
Sanjay N Gobardhan, Aukelien C Dimitriu-Leen, Alexander R van Rosendael, Erik W van Zwet, Cornelis J Roos, Pranobe V Oemrawsingh, Aan V Kharagjitsingh, J Wouter Jukema, Victoria Delgado, Martin J Schalij, Jeroen J Bax, Arthur J H A Scholte
The aim of this study was to explore the association between various cardiovascular (CV) risk scores and coronary atherosclerotic burden on coronary computed tomography angiography (CTA) in South Asians with type 2 diabetes mellitus and matched whites. Asymptomatic type 2 diabetic South Asians and whites were matched for age, gender, body mass index, hypertension, and hypercholesterolemia. Ten-year CV risk was estimated using different risk scores (United Kingdom Prospective Diabetes Study [UKPDS], Framingham Risk Score [FRS], AtheroSclerotic CardioVascular Disease [ASCVD], and Joint British Societies for the prevention of CVD [JBS3]) and categorized into low- and high-risk groups...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28024654/coronary-computed-tomography-angiography-derived-plaque-quantification-in-patients-with-acute-coronary%C3%A2-syndrome
#10
Christian Tesche, Damiano Caruso, Carlo N De Cecco, Darby C Shuler, Jess D Rames, Moritz H Albrecht, Taylor M Duguay, Akos Varga-Szemes, David Jochheim, Moritz Baquet, Richard R Bayer, Ullrich Ebersberger, Sheldon E Litwin, Salvatore A Chiaramida, Ellen Hoffmann, U Joseph Schoepf
This study investigated the discriminatory value of quantitative atherosclerotic plaque markers derived from coronary computed tomography angiography (cCTA) in patients with first acute coronary syndrome (ACS) compared with patients with stable coronary artery disease (CAD). Forty patients (56.9 ± 9.3 years, 55% men) admitted with their first ACS and Framingham risk score-matched controls with stable CAD were retrospectively analyzed. All patients had undergone cCTA followed by invasive coronary angiography...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28017925/intravascular-ultrasound-and-near-infrared-spectroscopic-features-of-coronary-lesions-with-intraplaque-haemorrhage
#11
Mitsuaki Matsumura, Gary S Mintz, Soo-Jin Kang, Stephen T Sum, Sean P Madden, Allen P Burke, James Goldstein, Rupa Parvataneni, Gregg W Stone, James E Muller, Renu Virmani, Akiko Maehara
AIMS: Intraplaque haemorrhage is considered a major contributor to lesion progression. We assessed coronary lesions with intraplaque haemorrhage using intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS). METHODS AND RESULTS: We evaluated coronary arteries from autopsy hearts using 40MHz IVUS and NIRS and compared the imaging findings to histopathology. A total of 2324 2-mm long histological segments from 101 coronary arteries from 56 autopsy hearts were included...
December 25, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28017258/long-term-follow-up-after-near-infrared-spectroscopy-coronary-imaging-insights-from-the-lipid-core-plaque-association-with-clinical-events-oracle-nirs-registry
#12
Barbara Anna Danek, Aris Karatasakis, Judit Karacsonyi, Aya Alame, Erica Resendes, Pratik Kalsaria, Phuong-Khanh J Nguyen-Trong, Bavana V Rangan, Michele Roesle, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Coronary lipid core plaque may be associated with the incidence of subsequent cardiovascular events. METHODS: We analyzed outcomes of 239 patients who underwent near-infrared spectroscopy (NIRS) coronary imaging between 2009-2011. Multivariable Cox regression was used to identify variables independently associated with the incidence of major adverse cardiovascular events (MACE; cardiac mortality, acute coronary syndromes (ACS), stroke, and unplanned revascularization) during follow-up...
December 15, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28007746/optical-coherence-tomography-to-evaluate-plaque-burden-and-morphology-in-patients-with-takotsubo-syndrome
#13
Ingo Eitel, Thomas Stiermaier, Tobias Graf, Christian Möller, Karl-Philipp Rommel, Charlotte Eitel, Gerhard Schuler, Holger Thiele, Steffen Desch
BACKGROUND: Disrupted atherosclerotic plaques in the left anterior descending coronary artery are discussed controversially as a potential pathophysiological mechanism in Takotsubo syndrome (TTS). Therefore, the aim of the present study was to assess plaque burden and morphology by using optical coherence tomography in patients with TTS. METHODS AND RESULTS: A total of 23 consecutive TTS patients were included in this single-center study and underwent optical coherence tomography imaging of the left main coronary artery and the left anterior descending coronary artery at acute presentation...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27999110/subclinical-disease-burden-as-assessed-by-whole-body-mri-in-subjects-with-prediabetes-subjects-with-diabetes-and-normal-control-subjects-from-the-general-population-the-kora-mri-study
#14
Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D Auweter, Christopher L Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian F Reiser, Annette Peters
Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of metabolic and cardio-cerebrovascular complications affecting multiple organs in individuals with prediabetes. Subjects without a history of stroke, coronary artery disease, or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MRI assessment to characterize cerebral parameters (white matter lesions, microbleeds), cardiovascular parameters (carotid plaque, left ventricular function, and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density fat fraction [PDFF] and subcutaneous and visceral abdominal fat)...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27998840/quantification-and-characterisation-of-released-plaque-material-during-bioresorbable-vascular-scaffold-implantation-into-right-coronary-artery-lesions-by-multimodality-intracoronary-imaging
#15
Heike A Hildebrandt, Polykarpos C Patsalis, Fadi Al-Rashid, Markus Neuhäuser, Tienush Rassaf, Gerd Heusch, Philipp Kahlert, Petra Kleinbongard
AIMS: We aimed to compare intravascular ultrasound with virtual histology (VH-IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) for their ability to quantify the true amount and characterise the nature of released plaque material during bioresorbable vascular scaffold (BVS) implantation into right coronary artery (RCA) lesions using a distal occlusion and aspiration device. METHODS AND RESULTS: Seventeen patients underwent BVS implantation into the right coronary artery under distal protection with intracoronary imaging using VH-IVUS, OCT and NIRS...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27993755/clinical-angiographic-ivus-and-oct-predictors-for-irregular-protrusion-after-coronary-stenting
#16
Krzysztof L Bryniarski, Seung-Jea Tahk, So-Yeon Choi, Tsunenari Soeda, Takumi Higuma, Erika Yamamoto, Lei Xing, Jiannan Dai, Thomas Zanchin, Hang Lee, Ik-Kyung Jang
AIMS: Irregular protrusion identified by optical coherence tomography (OCT) immediately following stent implantation has been reported as an independent predictor for adverse cardiac events at 1 year. However, baseline characteristics for development of irregular protrusion are unknown. The aim of the study was to identify predictors for irregular protrusion following stent implantation. METHODS AND RESULTS: A total of 900 lesions in 786 patients who had post-stent OCT imaging were analyzed...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27992371/relation-between-baseline-plaque-features-and-subsequent-coronary-artery-remodeling-determined-by-optical-coherence-tomography-and-intravascular-ultrasound
#17
Zulong Xie, Nana Dong, Rong Sun, Xinxin Liu, Xia Gu, Yong Sun, Hongwei Du, Jiannan Dai, Youbin Liu, Jingbo Hou, Jinwei Tian, Bo Yu
Atherosclerosis often leads to myocardial infarction and stroke. We examined the influence of baseline plaque characteristics on subsequent vascular remodeling in response to changes in plaque size. Using optical coherence tomography (OCT) and intravascular ultrasound (IVUS), we examined 213 plaques from 138 patients with acute coronary syndrome at baseline and repeated IVUS at the 12-month follow-up. The change in external elastic membrane (EEM) area for each 1 mm2 change in plaque area (i.e., the slope of the regression line) was calculated as a measure of vascular remodeling capacity...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27969979/tct-605-introduction-of-a-novel-and-robust-parameter-to-quantifiy-coronary-plaque-burden-by-oct-evaluation-of-feasibility-interobserver-analysis-and-graphical-illustration-of-luminal-surface-plaque-area
#18
Sylvia Otto, Kristina Nitsche, Bjoern Goebel, P Christian Schulze, Hans R Figulla, Tudor Poerner
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969945/tct-575-combined-near-infrared-spectroscopy-and-intravascular-ultrasound-nirs-ivus-coronary-imaging-as-a-means-to-improve-prediction-of-events-by-ivus-plaque-burden-alone
#19
Jimmy Su, Cherry Greiner, Stephanie Grainger, Matthew Saybolt, William Pickering, Robert Wilensky, Joel Raichlen, Veronica He, Stephen Sum, James Muller, Sean Madden
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27958614/the-relationship-between-location-specific-epicardial-adipose-tissue-volume-and-coronary-atherosclerotic-plaque-burden-in-type-2-diabetic-patients
#20
Begum Uygur, Omer Celik, Derya Ozturk, Mehmet Erturk, Hafize Otcu, Fethi Emre Ustabasıoglu, Aydın Yıldırım
BACKGROUND AND AIM: Epicardial adipose tissue is a metabolically active visceral fat depot which plays an important role in the pathogenesis of coronary atherosclerosis. Due to its asymmetrical distribution, the relation between location-specific epicardial adipose tissue measurements and coronary atherosclerosis remains unclear. Our study investigated the relationship between location-specific epicardial adipose tissue volume and coronary atherosclerotic plaque burden which was detected by coronary computed tomography angiography in Type 2 diabetic patients without coronary artery disease history...
December 13, 2016: Kardiologia Polska
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