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https://www.readbyqxmd.com/read/27905124/assessment-of-early-atherosclerosis-and-left-ventricular-dysfunction-in-children-with-21-hydroxylase-deficiency
#1
Rahmi Özdemir, Hüseyin Anil Korkmaz, Mehmet Küçük, Cem Karadeniz, Timur Meşe, Behzat Özkan
AIM: We analysed 25 children with 21-hydroxylase deficiency who received glucocorticoid and/or mineralocorticoid treatment for at least 12 months to determine the effects of the disease and its treatment on vascular structures and ventricular function. METHODS: Twenty-five patients with 21-hydroxylase-deficient congenital adrenal hyperplasia (CAH) and 25 control subjects were enrolled into this observational, cross-sectional study. The patients were investigated in terms of fasting blood glucose and insulin; fasting serum lipid profile; serum 17-hydroxyprogesterone; dehydroepiandrosterone sulphate; androstenedione; and adrenocorticotropic hormone...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27884238/the-pressure-of-aging
#2
REVIEW
Majd AlGhatrif, Mingyi Wang, Olga V Fedorova, Alexei Y Bagrov, Edward G Lakatta
Significant hemodynamic changes ensue with aging, leading to an ever-growing epidemic of hypertension. Alterations in central arterial properties play a major role in these hemodynamic changes. These alterations are characterized by an initial decline in aortic distensibility and an increase of diastolic blood pressure, followed by a sharp increase in pulse wave velocity (PWV), and an increase in pulse pressure (PP) beyond the sixth decade. However, the trajectories of PWV and PP diverge with advancing age...
January 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/27856475/assessment-of-cardiovascular-remodelling-following-endovascular-aortic-repair-through-imaging-and-computation-the-core-prospective-observational-cohort-study-protocol
#3
Foeke J H Nauta, Arnoud V Kamman, El-Sayed H Ibrahim, Prachi P Agarwal, Bo Yang, Karen Kim, David M Williams, Joost A van Herwaarden, Frans L Moll, Kim A Eagle, Santi Trimarchi, Himanshu J Patel, C Alberto Figueroa
INTRODUCTION: Thoracic aortic stent grafts are orders of magnitude stiffer than the native aorta. These devices have been associated with acute hypertension, elevated pulse pressure, cardiac remodelling and reduced coronary perfusion. However, a systematic assessment of such cardiovascular effects of thoracic endovascular aortic repair (TEVAR) is missing. The CardiOvascular Remodelling following Endovascular aortic repair (CORE) study aims to (1) quantify cardiovascular remodelling following TEVAR and compare echocardiography against MRI, the reference method; (2) validate computational modelling of cardiovascular haemodynamics following TEVAR using clinical measurements, and virtually assess the impact of more compliant stent grafts on cardiovascular haemodynamics; and (3) investigate diagnostic accuracy of ECG and serum biomarkers for cardiac remodelling compared to MRI...
November 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27846043/aortic-stiffness-and-blood-pressure-variability-in-young-people-a-multimodality-investigation-of-central-and-peripheral-vasculature
#4
Henry Boardman, Adam J Lewandowski, Merzaka Lazdam, Yvonne Kenworthy, Polly Whitworth, Charlotte L Zwager, Jane M Francis, Christina Y L Aye, Wilby Williamson, Stefan Neubauer, Paul Leeson
INTRODUCTION: Increased blood pressure (BP) variability is a cardiovascular risk marker for young individuals and may relate to the ability of their aorta to buffer cardiac output. We used a multimodality approach to determine relations between central and peripheral arterial stiffness and BP variability. METHODS: We studied 152 adults (mean age of 31 years) who had BP variability measures based on SD of awake ambulatory BPs, 24-h weighted SD and average real variability (ARV)...
November 23, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754124/os-24-05-impaired-vascular-function-of-aorta-in-adolescent-with-turner-syndrome
#5
Hyosoon An, Gi Beom Kim, Jae Suk Baek, Young Ah Lee, Bo Sang Kwon, Eun Jung Bae, Chung Il Noh
OBJECTIVE: Aortic dilatation and dissection are complications in some Turner syndrome (TS) patients. To better understand vascular nature of aorta before adult, we evaluated several elastic properties of the aorta in adolescent with TS in comparison to healthy controls. DESIGN AND METHOD: Various indices of the vascular function of ascending aorta were assessed prospectively in TS (n = 28), with a mean age of 14.9 ± 3.3 years and age-matched control (n = 18) groups with the transthoracic echocardiography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752907/evaluation-of-myocardial-strain-and-aortic-elasticity-in-patients-with-bicuspid-aortic-valve
#6
Yang Li, You-Bin Deng, Xiao-Jun Bi, Ya-Ni Liu, Jun Zhang, Li Li, Bin Chen
This study evaluated the myocardial strain and aortic elasticity in patients with bicuspid aortic valve (BAV) and then investigated the relation between them. Thirty-nine patients (30 males; mean age 44±19 years; range 6 to 75 years) with BAV were recruited as BAV group, and 29 age- and sex-matched healthy controls (21 males; mean age 42±11 years; range 20 to 71 years) served as control group. Aortic strain, distensibility and stiffness index were derived using M-mode echocardiography. Left ventricular global myocardial strain was acquired with speckle-tracking echocardiography...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27737744/arterial-effects-of-canakinumab-in-patients%C3%A2-with-atherosclerosis-and-type%C3%A2-2%C3%A2-diabetes-or-glucose-intolerance
#7
Robin P Choudhury, Jacqueline S Birks, Venkatesh Mani, Luca Biasiolli, Matthew D Robson, Philippe L L'Allier, Marc-Alexandre Gingras, Nadia Alie, Mary Ann McLaughlin, Craig T Basson, Alison D Schecter, Eric C Svensson, Yiming Zhang, Denise Yates, Jean-Claude Tardif, Zahi A Fayad
BACKGROUND: Evidence suggests that interleukin (IL)-1β is important in the pathogenesis of atherosclerosis and its complications and that inhibiting IL-1β may favorably affect vascular disease progression. OBJECTIVES: The goal of this study was to evaluate the effects of IL-1β inhibition with canakinumab versus placebo on arterial structure and function, determined by magnetic resonance imaging. METHODS: Patients (N = 189) with atherosclerotic disease and either type 2 diabetes mellitus or impaired glucose tolerance were randomized to receive placebo (n = 94) or canakinumab 150 mg monthly (n = 95) for 12 months...
October 18, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27733734/decreased-aortic-elasticity-in-children-with-marfan-syndrome-or-loeys-dietz-syndrome
#8
Yohei Akazawa, Noriko Motoki, Akira Tada, Shoko Yamazaki, Akira Hachiya, Satoshi Matsuzaki, Motoko Kamiya, Tomohiko Nakamura, Tomoki Kosho, Yuji Inaba
BACKGROUND: The characteristics of aortic elasticity are unclear in children with connective tissue disorders (CTDs) such as Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), especially in those with a non-dilated aortic root (AoR). This study evaluated the aortic elasticity properties of pediatric MFS and LDS patients with either dilated or non-dilated AoR.Methods and Results:The 31 children with MFS or LDS were classified into dilated (Z score of AoR diameter ≥2.5; n=17) or non-dilated (Z score of AoR diameter <2...
October 13, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27693512/cutaneous-microvascular-reactivity-and-aortic-elasticity-in-coronary-artery-disease-comparison-of-the-laser-doppler-flowmetry-and-echocardiography
#9
Edip Güvenç Çekiç, Özcan Başaran, Nesrin Filiz Başaran, Onur Elmas, Volkan Doğan, Gurbet Özge Mert, Kadir Uğur Mert, Ibrahim Altun, Fatih Akın, Murat Biteker
BACKGROUND AND AIM: Decreased vascular reactivity in atherosclerosis was previously shown. In our study, it was aimed to demonstrate the decreased vascular functions in both microvascular and macrovascular tissues and to estimate any correlation between them. METHODS: Twenty-five control outpatients with no coronary artery disease (CAD) history and 26 outpatients with CAD history were enrolled in the study. Local cutaneous post-occlusive reactive hyperemia (PORH) responses after three minutes of brachial occlusion with a pneumatic cuff were recorded noninvasively by a Perimed Periflux 5010 laser Doppler flow system...
September 28, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27686337/ascending-aortic-elasticity-and-related-risk-factors-study-on-prehypertension-patients
#10
Chong-Fu Jia, Yi-Nong Jiang, Zhi-Qiang Yang, Xi-Xia Sun, Yang Yu, Hao Wang, Yan Lu, Ai-Jun Chen, Zhao-Qian Wang
BACKGROUND: A new feature of coronary computed tomography angiography (CTA) is to estimate ascending aortic elasticity without additional cost, but its applicable benefit for prehypertension patients is still unclear. The aim of this study is to discuss the characteristic of ascending aortic elasticity for specific prehypertension patients and its risk factors. METHODS: Coronary CTA examinations of 398 participants were performed using a 128 slicer CT scanner. The differences of 3 ascending aortic elasticity related indices, including aortic distensibility (AD), aortic compliance (AC), and aortic stiffness (ASI), and anatomical measurements were analyzed among the normal, prehypertension, and primary hypertension groups...
September 29, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27685325/associations-of-novel-and-traditional-vascular-biomarkers-of-arterial-stiffness-results-of-the-sapaldia-3-cohort-study
#11
Simon Endes, Seraina Caviezel, Emmanuel Schaffner, Julia Dratva, Christian Schindler, Nino Künzli, Martin Bachler, Siegfried Wassertheurer, Nicole Probst-Hensch, Arno Schmidt-Trucksäss
BACKGROUND AND OBJECTIVES: There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional vascular biomarkers in a population-based Caucasian cohort. We examined these associations in the second follow-up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3). METHODS: Arterial stiffness was measured oscillometrically by pulse wave analysis to derive the cardio-ankle vascular index (CAVI), brachial-ankle (baPWV) and aortic pulse wave velocity (aPWV), and amplitude of the forward and backward wave...
2016: PloS One
https://www.readbyqxmd.com/read/27680580/aortic-root-stiffness-affects-the-kinematics-of-bioprosthetic-aortic-valves
#12
Silje Ekroll Jahren, Bernhard Michael Winkler, Paul Philipp Heinisch, Jessica Wirz, Thierry Carrel, Dominik Obrist
OBJECTIVES: In this study, the influence of aortic root distensibility on the haemodynamic parameters and valve kinematics of a bioprosthetic aortic valve was investigated in a controlled in vitro experiment. METHODS: An Edwards INTUITY Elite 21 mm sutureless aortic valve (Edwards Lifesciences, Irvine, CA, USA) was inserted in three transparent aortic root phantoms with different wall thicknesses (0.55, 0.85 and 1.50 mm) mimicking different physiological distensibilities...
September 28, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27659099/aortic-elastic-properties-in-preschool-children-born-preterm
#13
Irena Odri Komazec, Anna Posod, Martin Schwienbacher, Maria Resch, Ulrike Pupp Peglow, Stefan Kiechl, Daniela Baumgartner, Ursula Kiechl-Kohlendorfer
OBJECTIVE: Preterm birth predisposes to the development of cardiovascular diseases in adulthood. The aim of this study was to characterize elastic properties of the aorta at preschool age and test the hypothesis that prematurity is associated with decreased aortic distensibility and increased stiffness, both of which are predictors of increased cardiovascular risk. APPROACH AND RESULTS: In an observational study of 76 five- to seven-year-old children born at a gestational age <32 weeks and 79 term-born controls, elastic parameters of the ascending and descending abdominal aorta were determined noninvasively by means of M mode echocardiographic tracings and calculated using computerized wall contour analysis...
September 22, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27643051/os-24-05-impaired-vascular-function-of-aorta-in-adolescent-with-turner-syndrome
#14
Hyosoon An, Gi Beom Kim, Jae Suk Baek, Young Ah Lee, Bo Sang Kwon, Eun Jung Bae, Chung Il Noh
OBJECTIVE: Aortic dilatation and dissection are complications in some Turner syndrome (TS) patients. To better understand vascular nature of aorta before adult, we evaluated several elastic properties of the aorta in adolescent with TS in comparison to healthy controls. DESIGN AND METHOD: Various indices of the vascular function of ascending aorta were assessed prospectively in TS (n = 28), with a mean age of 14.9 ± 3.3 years and age-matched control (n = 18) groups with the transthoracic echocardiography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27637377/aortic-root-dilatation-in-the-children-and-young-adults-prevalence-determinants-and-association-with-target-organ-damage
#15
Silvia Totaro, Franco Rabbia, Alberto Milan, Elaine M Urbina, Franco Veglio
Aortic root dilatation is associated with increased cardiovascular risk in hypertensive adults. In the young, few data have been published evaluating the cardiovascular organ damage that may be present in patients with aortic dilatation. The objective was to evaluate the prevalence of proximal aorta dilatation, its possible determinants, and its relation with target organ damage in young subjects. The aorta was measured at the level of the sinus of valsalva and at its proximal ascending aorta (pAA) in a total of 177 young subjects (11-35 years)...
October 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27628435/impaired-vascular-function-of-the-aorta-in-adolescents-with-turner-syndrome
#16
Hyo Soon An, Jae Suk Baek, Gi Beom Kim, Young Ah Lee, Mi Kyoung Song, Bo Sang Kwon, Eun Jung Bae, Chung Il Noh
To investigate intrinsic vascular abnormalities of the ascending aorta before adulthood in Turner syndrome patients (TS), we compared 25 adolescent TS patients (mean age 14.6 ± 3.4 years) and 16 healthy controls from a university hospital. Blood pressure and other vascular indices were evaluated using echocardiography such as aortic strain, stiffness index, distensibility, and pulse wave velocity. Aortic strain (0.1237 vs. 0.1865, respectively; P = 0.003) and aortic distensibility (0.0049 vs. 0.0081, P = 0...
September 15, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27618813/aortic-stiffening-and-its-impact-on-left-atrial-volumes-and-function-in-patients-after-successful-coarctation-repair-a-multiparametric-cardiovascular-magnetic-resonance-study
#17
Inga Voges, Julian Kees, Michael Jerosch-Herold, Hannes Gottschalk, Jens Trentmann, Christopher Hart, Dominik D Gabbert, Eileen Pardun, Minh Pham, Ana C Andrade, Philip Wegner, Ines Kristo, Olav Jansen, Hans-Heiner Kramer, Carsten Rickers
BACKGROUND: The increased cardiovascular morbidity of adults with late repair of aortic coarctation (CoA) has been well documented. In contrast, successful CoA repair in early childhood has a generally good prognosis, though adverse vascular and ventricular characteristics may be abnormal, which could increase long-term risk. This study sought to perform a comprehensive analysis of aortic elasticity and left ventricular (LV) function in patients with aortic coarctation (CoA) using cardiovascular magnetic resonance (CMR)...
September 12, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27508829/-op-7b-10-effect-of-bariatric-surgery-on-vascular-and-renal-biomarkers-in-morbidly-obese-normotensive-non-diabetic-patients
#18
R Bruno, E Vitolo, L Giannini, S Taddei, L Ghiadoni, A Solini
OBJECTIVE: Aim of the study is to evaluate the effect of effect of bariatric surgery on vascular and renal biomarkers in morbidly obese, normotensive, non-diabetic patients. DESIGN AND METHOD: 25 patients (19 women, age 44 ± 11 years, BMI 45 ± 7 kg/mq) were enrolled. A multidistrict vascular assessment was performed before and 12 months after bariatric surgery, including: aortic stiffness (carotid-femoral pulse wave velocity - PWV), endothelial function (flow-mediated dilation - FMD), carotid intima media thickness (cIMT) and distensibility coefficient (DC), and renal hemodynamics by means of renal resistive index (RI) in resting conditions and after sublingual administration of glyceryl trinitrite 25 mcg s...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508738/-op-5b-04-impact-of-simultaneous-central-blood-pressure-measurements-during-aortic-strain-magnetic-resonance-imaging
#19
G Soulat, S Millasseau, S Stroer, N Kachenoura, P Boutouyrie, S Laurent, E Mousseaux
OBJECTIVE: Proximal aortic function estimated by Magnetic Resonance Imaging (MRI) is booming to assess aortic diseases as stiffness indices have been shown to be independent predictors of cardiovascular events and mortality.Calculation of aortic distensibility (AD) requires MRI aortic strain data, but also local blood pressure (BP). Because of magnetic field limitations, most MRI studies used Brachial Pulse Pressure (bPP) as a surrogate of Central Pulse Pressure (cPP).New devices allow the estimation of cPP from brachial cuff and are compatible with MRI...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508578/-op-8d-04-comparison-study-of-carotid-distension-waves-measured-with-a-non-invasive-optical-fibre-sensor-and-aortic-invasive-pressure-waves
#20
C Leitao, P Antunes, V Afreixo, P Andre, L Pinto, R Fernandes, M Costa, J Bastos
OBJECTIVE: The present work aims to test a new optical fibre probe (POFpen) to measure the carotid distension waveform, comparing it with the simultaneously acquired invasive arterial pulses by an intracatheter in the ascending aorta. DESIGN AND METHOD: The optical fibre device detects the pulse wave by placing a reflector at the carotid surface, whose distension movements modulate an applied optical signal that is monitored in reflection. Simultaneous acquisitions of distension carotid pulses with the POFpen and invasive pressure catheter in the aortic root were performed in 19 subjects, with an average age of 71 ± 12 years...
September 2016: Journal of Hypertension
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