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https://www.readbyqxmd.com/read/29216421/multidimensional-quantum-mechanical-modeling-of-electron-transfer-and-electronic-coherence-in-plant-cryptochromes-the-role-of-initial-bath-conditions
#1
David Mendive-Tapia, Etienne Mangaud, Thiago Firmino, Aurélien de la Lande, Michele Desouter-Lecomte, Hans-Dieter Meyer, Fabien Gatti
A multi-dimensional quantum mechanical protocol is used to describe the photo-induced electron transfer and electronic coherence in plant cryptochromes without any semi-empirical, e.g. experimentally obtained, parameters. Starting from a two-level spin-boson Hamiltonian we look at the effect that the initial photo-induced nuclear bath distribution has on an intermediate step of this biological electron transfer cascade for two idealized cases. The first assumes a slow equilibration of the nuclear bath with respect to the previous electron transfer step that leads to an ultrafast decay with little temperature dependence; whilst the second assumes a prior fast bath equilibration on the donor potential energy surface leading to a much slower decay, which contrarily displays a high temperature dependence and a better agreement with previous theoretical and experimental results...
December 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29210583/time-resolved-infrared-spectroscopy-on-plant-cryptochrome-relevance-of-proton-transfer-and-atp-binding-for-signaling
#2
Lea Schroeder, Sabine Oldemeyer, Tilman Kottke
Plant cryptochromes are light receptors in land plants and algae with very diverse functions such as circadian timing and life cycle progression. The receptor consists of a photolyase homology region (PHR) binding the flavin chromophore and a C-terminal extension (CCT) responsible for signaling. The reputed signaling state, the flavin neutral radical, is formed by a femtosecond electron and microsecond proton transfer to the excited, oxidized flavin. Subsequently, a 500 μs loss of β-sheet structure ~25 Å away from flavin was resolved and suggested to be part of the signal conduction to the CCT...
December 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29192250/coupling-optogenetics-and-light-sheet-microscopy-a-method-to-study-wnt-signaling-during-embryogenesis
#3
Prameet Kaur, Timothy E Saunders, Nicholas S Tolwinski
Optogenetics allows precise, fast and reversible intervention in biological processes. Light-sheet microscopy allows observation of the full course of Drosophila embryonic development from egg to larva. Bringing the two approaches together allows unparalleled precision into the temporal regulation of signaling pathways and cellular processes in vivo. To develop this method, we investigated the regulation of canonical Wnt signaling during anterior-posterior patterning of the Drosophila embryonic epidermis. Cryptochrome 2 (CRY2) from Arabidopsis Thaliana was fused to mCherry fluorescent protein and Drosophila β-catenin to form an easy to visualize optogenetic switch...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29179610/a-tug-of-war-between-cryptochrome-and-the-visual-system-allows-the-adaptation-of-evening-activity-to-long-photoperiods-in-drosophila-melanogaster
#4
Christa Kistenpfennig, Mayumi Nakayama, Ruri Nihara, Kenji Tomioka, Charlotte Helfrich-Förster, Taishi Yoshii
In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and one in the evening. These peaks appear to be regulated by 2 separate circadian oscillators (the morning and evening oscillators) that reside in different subsets of pacemaker clock neurons in the brain...
November 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29139123/new-insights-into-the-mechanisms-of-phytochrome-cryptochrome-coaction
#5
REVIEW
Qin Wang, Qing Liu, Xu Wang, Zecheng Zuo, Yoshito Oka, Chentao Lin
Contents I. II. III. IV. SUMMARY: Plants perceive and respond to light signals by multiple sensory photoreceptors, including phytochromes and cryptochromes, which absorb different wavelengths of light to regulate genome expression and plant development. Photophysiological analyses have long revealed the coordinated actions of different photoreceptors, a phenomenon referred to as the photoreceptor coaction. The mechanistic explanations of photoreceptor coactions are not fully understood...
November 15, 2017: New Phytologist
https://www.readbyqxmd.com/read/29113166/expression-of-circadian-clock-genes-in-human-colorectal-adenoma-and-carcinoma
#6
Tomoyuki Momma, Hirokazu Okayama, Masaru Saitou, Hidekazu Sugeno, Nobuhiro Yoshimoto, Yuji Takebayashi, Shinji Ohki, Seiichi Takenoshita
Circadian rhythms are fundamental biological systems in most organisms. Epidemiological and animal studies have demonstrated that disruption of circadian rhythms is linked to tumor progression and mammalian tumorigenesis. However, the clinical significance of in situ clock gene expression in precancerous and cancerous colorectal lesions remains unknown. The present study aimed to investigate mRNA transcript levels of circadian clock genes within human colorectal cancer and adenoma tissue sections. Using in situ hybridization, the expression of key clock genes, including period circadian protein homolog (Per) 1 and 2, cryptochrome 1 (Cry1), circadian locomoter output cycles protein kaput (Clock), brain and muscle ARNT-like protein 1 (Bmal1) and casein kinase 1ε (CK1ε) were retrospectively examined in 51 cases of colorectal carcinoma and 10 cases of adenoma...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29109286/circadian-clock-cryptochrome-proteins-regulate-autoimmunity
#7
Qi Cao, Xuan Zhao, Jingwen Bai, Sigal Gery, Haibo Sun, De-Chen Lin, Qi Chen, Zhengshan Chen, Lauren Mack, Henry Yang, Ruishu Deng, Xianping Shi, Ling-Wa Chong, Han Cho, Jianjun Xie, Quan-Zhen Li, Markus Müschen, Annette R Atkins, Christopher Liddle, Ruth T Yu, Serhan Alkan, Jonathan W Said, Ye Zheng, Michael Downes, Ronald M Evans, H Phillip Koeffler
The circadian system regulates numerous physiological processes including immune responses. Here, we show that mice deficient of the circadian clock genes Cry1 and Cry2 [Cry double knockout (DKO)] develop an autoimmune phenotype including high serum IgG concentrations, serum antinuclear antibodies, and precipitation of IgG, IgM, and complement 3 in glomeruli and massive infiltration of leukocytes into the lungs and kidneys. Flow cytometry of lymphoid organs revealed decreased pre-B cell numbers and a higher percentage of mature recirculating B cells in the bone marrow, as well as increased numbers of B2 B cells in the peritoneal cavity of Cry DKO mice...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29100427/aberrant-rhythmic-expression-of-cryptochrome2-regulates-the-radiosensitivity-of-rat-gliomas
#8
Wang Fan, Li Caiyan, Zhu Ling, Zhao Jiayun
In this study, we investigated the role of the clock regulatory protein cryptochrome 2 (Cry2) in determining the radiosensitivity of C6 glioma cells in a rat model. We observed that Cry2 mRNA and protein levels showed aberrant rhythmic periodicity of 8 h in glioma tissues, compared to 24 h in normal brain tissue. Cry2 mRNA and protein levels did not respond to irradiation in normal tissues, but both were increased at the ZT4 (low Cry2) and ZT8 (high Cry2) time points in gliomas. Immunohistochemical staining of PCNA and TUNEL assays demonstrated that high Cry2 expression in glioma tissues was associated with increased cell proliferation and decreased apoptosis...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098377/overexpression-of-sweet-sorghum-cryptochrome-1a-confers-hypersensitivity-to-blue-light-abscisic-acid-and-salinity-in-arabidopsis
#9
Tingting Zhou, Lingyang Meng, Yue Ma, Qing Liu, Yunyun Zhang, Zhenming Yang, Deguang Yang, Mingdi Bian
This work provides the bioinformatics, expression pattern and functional analyses of cryptochrome 1a from sweet sorghum (SbCRY1a), together with an exploration of the signaling mechanism mediated by SbCRY1a. Sweet sorghum [Sorghum bicolor (L.) Moench] is considered to be an ideal candidate for biofuel production due to its high efficiency of photosynthesis and the ability to maintain yield under harsh environmental conditions. Blue light receptor cryptochromes regulate multiple aspects of plant growth and development...
November 2, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/29074139/optogenetic-control-of-focal-adhesion-kinase-signaling
#10
Maximilian Hörner, Claire Chatelle, Wignand W D Mühlhäuser, David R Stocker, Michael Coats, Wilfried Weber, Gerald Radziwill
Focal adhesion kinase (FAK) integrates signaling from integrins, growth factor receptors and mechanical stress to control cell adhesion, motility, survival and proliferation. Here, we developed a single-component, photo-activatable FAK, termed optoFAK, by using blue light-induced oligomerization of cryptochrome 2 (CRY2) to activate FAK-CRY2 fusion proteins. OptoFAK functions uncoupled from physiological stimuli and activates downstream signaling rapidly and reversibly upon blue light exposure. OptoFAK stimulates SRC creating a positive feedback loop on FAK activation, facilitating phosphorylation of paxillin and p130Cas in adherent cells...
October 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29066765/computational-reconstruction-reveals-a-candidate-magnetic-biocompass-to-be-likely-irrelevant-for-magnetoreception
#11
Ida Friis, Emil Sjulstok, Ilia A Solov'yov
Birds use the magnetic field of the Earth to navigate during their annual migratory travel. The possible mechanism to explain the biophysics of this compass sense involves electron transfers within the photoreceptive protein cryptochrome. The magnetoreceptive functioning of cryptochromes is supposedly facilitated through an iron rich polymer complex which couples to multiple cryptochromes. The present investigation aims to independently reconstruct this complex and describe its interaction with Drosophila melanogaster cryptochromes...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29066723/blue-light-induced-biosynthesis-of-ros-contributes-to-the-signaling-mechanism-of-arabidopsis-cryptochrome
#12
Mohamed El-Esawi, Louis-David Arthaut, Nathalie Jourdan, Alain d'Harlingue, Justin Link, Carlos F Martino, Margaret Ahmad
Cryptochromes are evolutionarily conserved blue light receptors with many roles throughout plant growth and development. They undergo conformational changes in response to light enabling interaction with multiple downstream signaling partners. Recently, it has been shown that cryptochromes also synthesize reactive oxygen species (ROS) in response to light, suggesting the possibility of an alternate signaling mechanism. Here we show by fluorescence imaging and microscopy that H202 and ROS accumulate in the plant nucleus after cryptochrome activation...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29063672/molecular-characterization-spatial-temporal-expression-and-magnetic-response-patterns-of-the-iron-sulfur-cluster-assembly1-isca1-in-the-rice-planthopper-nilaparvata-lugens
#13
Jing-Jing Xu, Ying-Chao Zhang, Jian-Qi Wu, Wei-Hong Wang, Yue Li, Gui-Jun Wan, Fa-Jun Chen, Gregory A Sword, Wei-Dong Pan
The mechanisms of magnetoreception have been proposed as the magnetite-based, the chemical radical-pair & biocompass model, in which magnetite particles, the cryptochrome (Cry) or iron-sulfur cluster assembly 1 (IscA1) may be involved. However, little is known about the association among the molecules. Here we investigated the molecular characterization and the mRNA expression of IscA1 in different developmental stages, tissues and magnetic fields in the migratory insect of brown planthoppers (BPH), Nilaparvata lugens...
October 23, 2017: Insect Science
https://www.readbyqxmd.com/read/29050555/natural-variation-in-human-clocks
#14
Malcolm von Schantz
Our own species has a diurnal activity pattern and an average circadian period of 24.2h. Exact determination of circadian period requires expensive and intrusive protocols, and investigators are therefore using chronotype questionnaires as a proxy quantitative measure. Both measures show a normal distribution suggestive of a polygenic trait. The genetic components of the 24-h feedback loop that generates circadian rhythms within our cells have been mapped in detail, identifying a number of candidate genes which have been investigated for genetic polymorphisms relating to the phenotypic variance...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29046014/tomato-cry1a-plays-a-critical-role-in-the-regulation-of-phytohormone-homeostasis-plant-development-and-carotenoid-metabolism-in-fruits
#15
Chao-Chao Liu, Golam Jalal Ahammed, Guo-Ting Wang, Chang-Jie Xu, Kun-Song Chen, Yan-Hong Zhou, Jing-Quan Yu
Blue light photoreceptors, cryptochromes (CRYs), regulate multiple aspects of plant growth and development. However, our knowledge of CRYs is predominantly based on model plant Arabidopsis at early growth stage. In this study, we elucidated functions of CRY1a gene in mature tomato (Solanum lycopersicum) plants by using cry1a mutants and CRY1a overexpressing lines (OE-CRY1a-1 and OE-CRY1a-2). In comparison with wild-type plants, cry1a mutants are relatively tall, accumulate low biomass and bear more fruits, whereas OE-CRY1a plants are short stature, and they not only flower lately but also bear less fruits...
October 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29016997/the-influence-of-a-cryptochrome-on-the-gene-expression-profile-in-the-diatom-phaeodactylum-tricornutum-under-blue-light-and-in-darkness
#16
Sarah König, Marion Eisenhut, Andrea Bräutigam, Samantha Kurz, Andreas P M Weber, Claudia Büchel
Diatoms, albeit being only distantly related with higher plants, harbor a plant-like cryptochrome (CryP) that was proposed to act as a photoreceptor required for the regulation of some photosynthetic proteins. Plant cryptochromes are involved in the regulation of developmental processes relevant only to multicellular organisms. Their role in the unicellular diatoms to date is mostly enigmatic. To elucidate the function of this plant-like cryptochrome in a unicellular species, we examined the role of CryP in the regulation of transcription in the diatom Phaeodactylum tricornutum by comparative RNA-seq of wild type and CryP knock-down mutants, under prolonged darkness and one hour after onset of blue light...
November 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28992300/cop1-regulates-plant-growth-and-development-in-response-to-light-at-the-post-translational-level
#17
Joo Yong Kim, Jong Tae Song, Hak Soo Seo
Photoreceptors perceive different wavelengths of light and transduce light signals downstream via a range of proteins. COP1, an E3 ubiquitin ligase, regulates light signaling by mediating the ubiquitination and subsequent proteasomal degradation of photoreceptors such as phytochromes and cryptochromes, as well as various development-related proteins including other light-responsive proteins. COP1 is itself regulated by direct interactions with several signaling molecules that modulate its activity. The control of photomorphogenesis by COP1 is also regulated by its localization to the cytoplasm in response to light...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28991901/the-blue-light-induced-interaction-of-cryptochrome-1-with-cop1-requires-spa-proteins-during-arabidopsis-light-signaling
#18
Xu Holtkotte, Jathish Ponnu, Margaret Ahmad, Ute Hoecker
Plants constantly adjust their growth, development and metabolism to the ambient light environment. Blue light is sensed by the Arabidopsis photoreceptors CRY1 and CRY2 which subsequently initiate light signal transduction by repressing the COP1/SPA E3 ubiquitin ligase. While the interaction between cryptochromes and SPA is blue light-dependent, it was proposed that CRY1 interacts with COP1 constitutively, i.e. also in darkness. Here, our in vivo co-immunoprecipitation experiments suggest that CRY1 and CRY2 form a complex with COP1 only after seedlings were exposed to blue light...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28986813/effect-of-jiaotai-pill-on-intestinal-damage-in-partially-sleep-deprived-rats
#19
Wen-Ya Huang, Xin Zou, Fu-Er Lu, Chu Zhang, Yan-Lin Ren, Li-Jun Xu, Kai-Fu Wang, Hui Dong
OBJECTIVE: To explore the effect and mechanism of Jiaotai Pill (, JTW) on intestinal mucosal damage in rats with chronic partial sleep deprivation (PSD). METHODS: Obesity resistant (OR) rats were selected, and underwent 4 h PSD by being exposed to environmental noise for 4 weeks. During the whole PSD period, JTW and estazolam were orally given to the rats respectively in the treating groups. Plasma concentration of lipopolysaccharide (LPS) which is the marker of gut-origin endotoxemia was examined...
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28986016/effects-of-intentionally-treated-water-on-growth-of-arabidopsis-thaliana-seeds-with-cryptochrome-mutations
#20
Yung-Jong Shiah, Hsu-Liang Hsieh, Huai-Ju Chen, Dean I Radin
OBJECTIVE: A previous experiment suggested that consumption of intentionally treated tea influenced subjective mood under double-blind, controlled conditions. To investigate that effect objectively, again under double-blind, controlled conditions, we studied whether Arabidopsis thaliana seeds hydrated with intentionally treated vs. untreated water would show differences in hypocotyl length, anthocyanin, and chlorophyll. DESIGN: Three Buddhist monks focused their intention on commercially bottled water with the goal of improving the growth of seeds; bottled water from the same source served as an untreated control...
August 30, 2017: Explore: the Journal of Science and Healing
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