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Low frequency fatigue

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https://www.readbyqxmd.com/read/29334129/a-mitochondrial-targeted-antioxidant-improves-myofilament-ca2-sensitivity-during-prolonged-low-frequency-force-depression-at-low-po2
#1
Paulo G Gandra, Amy A Shiah, Leonardo Nogueira, Michael C Hogan
Skeletal muscle can develop a prolonged low frequency-stimulation force depression (PLFFD) following fatigue-inducing contractions. Increased levels of reactive oxygen species (ROS) have been implicated in the development of PLFFD. During exercise the skeletal muscle intracellular PO2 decreases to relatively low levels, and can be further decreased when there is an impairment in O2 diffusion or availability, such as in certain chronic diseases and during exercise at high altitude. Since ROS generation by mitochondria is elevated at very low PO2 in cells, we tested the hypothesis that treatment of muscle fibres with a mitochondrial-targeted antioxidant at a very low, near hypoxic PO2 , can attenuate PLFFD...
January 15, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29318742/extracellular-water-excess-and-increased-self-reported-fatigue-in-chronic-hemodialysis-patients
#2
Kamonwan Tangvoraphonkchai, Andrew Davenport
Hemodialysis patients (HD) commonly report fatigue. Muscle wasting (sarcopenia) and extracellular water (ECW) excess have been reported to be associated with fatigue in other conditions. We wished to determine whether muscle loss and ECW excess were associated with fatigue in HD patients. Patients completed the Multidimensional Fatigue Inventory (MFI), Beck Depression Inventory-II (BDI-II), Patient Health Questionnaires (PHQ-9) and recorded their post-dialysis recovery time. Sessional dialysis data were recorded along with pre- and post-dialysis multi-frequency bioimpedance assessments (MFBIA)...
January 10, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29309405/cardinal-features-of-involuntary-force-variability-can-arise-from-the-closed-loop-control-of-viscoelastic-afferented-muscles
#3
Akira Nagamori, Christopher M Laine, Francisco J Valero-Cuevas
Involuntary force variability below 15 Hz arises from, and is influenced by, many factors including descending neural drive, proprioceptive feedback, and mechanical properties of muscles and tendons. However, their potential interactions that give rise to the well-structured spectrum of involuntary force variability are not well understood due to a lack of experimental techniques. Here, we investigated the generation, modulation, and interactions among different sources of force variability using a physiologically-grounded closed-loop simulation of an afferented muscle model...
January 8, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29247626/low-frequency-pulsed-current-versus-kilohertz-frequency-alternating-current-a-scoping-literature-review
#4
Marco Aurélio Vaz, Viviane Bortoluzzi Frasson
OBJECTIVE: To compare the effectiveness of low-frequency pulsed current versus kilohertz-frequency alternating current in terms of evoked-force, discomfort level, current intensity, and muscle fatigability, to discuss the physiological mechanisms of each Neuromuscular Electrical Stimulation type, and to determine if kilohertz-frequency alternating current is better than low-frequency pulsed current for clinical treatment. DATA SOURCES: Manuscripts were obtained from PUBMED, SCOPUS, CENTRAL, CINAHL and SPORTSDISCUS databases using the terms "Russian current" OR "Kilohertz current" OR "Alternating current" OR "Pulsed current" OR "Aussie current" AND torque OR discomfort OR fatigue OR "current intensity", and through citation tracking up to July 2017...
December 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29246267/autonomic-nervous-system-functioning-related-to-nocturnal-sleep-in-patients-with-chronic-fatigue-syndrome-compared-to-tired-controls
#5
Maija Orjatsalo, Anniina Alakuijala, Markku Partinen
STUDY OBJECTIVES: Autonomic nervous system (ANS) dysfunction is common in chronic fatigue syndrome (CFS). One of the main complaints in CFS is unrefreshing sleep. We aimed to study the nocturnal cardiac ANS in different sleep stages in patients filling the 2015 Institute of Medicine CFS diagnostic criteria. METHODS: In this case series study, the nocturnal heart rate variability and blood pressure (BP) variables in polysomnography were studied in groups of patients with CFS (n = 8) and tired controls (n = 8) aged 16-49 years...
December 13, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29231243/neuromuscular-electrical-stimulation-nmes-for-patellofemoral-pain-syndrome
#6
REVIEW
Ana Luiza C Martimbianco, Maria Regina Torloni, Brenda Ng Andriolo, Gustavo Jm Porfírio, Rachel Riera
BACKGROUND: Patellofemoral pain syndrome, now generally referred to as patellofemoral pain (PFP), is one of the most common orthopaedic disorders, characterised by pain in the anterior or retropatellar knee region. Neuromuscular electrical stimulation (NMES) has been proposed generally as a complementary treatment, associated with other interventions such as exercise, or as a single treatment to increase muscle force, reduce knee pain, and improve function. OBJECTIVES: To assess the effects (benefits and harms) of neuromuscular electrical stimulation for people with patellofemoral pain...
December 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29218906/addressing-vital-sign-alarm-fatigue-using-personalized-alarm-thresholds
#7
Sarah Poole, Nigam Shah
Alarm fatigue, a condition in which clinical staff become desensitized to alarms due to the high frequency of unnecessary alarms, is a major patient safety concern. Alarm fatigue is particularly prevalent in the pediatric setting, due to the high level of variation in vital signs with patient age. Existing studies have shown that the current default pediatric vital sign alarm thresholds are inappropriate, and lead to a larger than necessary alarm load. This study leverages a large database containing over 190 patient-years of heart rate data to accurately identify the 1st and 99th percentiles of an individual's heart rate on their first day of vital sign monitoring...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29179158/modelling-nonlinearity-of-guided-ultrasonic-waves-in-fatigued-materials-using-a-nonlinear-local-interaction-simulation-approach-and-a-spring-model
#8
Rafal Radecki, Zhongqing Su, Li Cheng, Pawel Packo, Wieslaw J Staszewski
Modelling and numerical simulation - based on the framework of the Local Interaction Simulation Approach - was developed to have more insight into nonlinear attributes of guided ultrasonic waves propagating in fatigued metallic materials. Various sources of nonlinearity were considered in this modelling work, with particular emphases on higher-order harmonic generation and accumulation of nonlinearity along wave propagation. The material hyper-elasticity was considered in the model using an energy density approach based on the Landau-Lifshitz formulation; and the "breathing" motion pattern of a fatigue crack in the material was interrogated using a spring model...
November 16, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29148413/variable-impacts-of-different-remission-states-on-health-related-quality-of-life-in-rheumatoid-arthritis
#9
Margaret H Y Ma, Fowzia Ibrahim, Gabrielle H Kingsley, Andrew Cope, David L Scott
OBJECTIVES: Targeting remission in rheumatoid arthritis (RA) improves health-related quality of life (HRQoL) and disability. However, the impacts of different remission criteria and durations and their frequencies are uncertain. Our observational study assessed these factors. METHODS: We recruited RA patients with disease durations <10 years, stable suppressive therapies and stable disease activity scores for 28 joints using ESR (DAS28-ESR) ≤3.2. Intermittent and sustained remisisons were classified using DAS28ESR, simple disease activity index (SDAI) and ACR/EULAR Boolean criteria...
October 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29129663/compensation-strategies-in-voice-production-with-glottal-insufficiency
#10
Zhaoyan Zhang
OBJECTIVES: This study evaluates potential compensation strategies under conditions of glottal insufficiency. METHODS: Using a numerical respiratory-laryngeal model of voice production, voice production under conditions of glottal insufficiency is investigated across a large range of voice conditions, and compared with normal voice production. RESULTS: This study shows that glottal insufficiency leads to increased noise production, reduced fundamental frequency range, and inability to produce very low-intensity voice...
November 9, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29122618/effects-of-tai-chi-exercise-on-cancer-related-fatigue-in-patients-with-nasopharyngeal-carcinoma-undergoing-chemoradiotherapy-a-randomized-controlled-trial
#11
Wei Zhou, Yong-Hui Wan, Qian Chen, Yan-Ru Qiu, Xiao-Min Luo
CONTEXT: Tai Chi exercise has been shown to improve cancer-related fatigue (CRF) and autonomic nervous system (ANS) balance in some cancer patients or survivors, however, such effects are yet to be verified in nasopharyngeal carcinoma (NPC) patients undergoing chemoradiotherapy. OBJECTIVES: To explore the effects of Tai Chi exercise on CRF in NPC patients undergoing chemoradiotherapy and then to evaluate ANS information indicated by heart rate variability (HRV) parameters and their association with CRF...
November 6, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29116645/the-impact-of-physical-activity-on-fatigue-and-quality-of-life-during-and-after-adjuvant-treatment-for-breast-cancer
#12
Florian Manneville, Christine Rotonda, Thierry Conroy, Franck Bonnetain, Francis Guillemin, Abdou Y Omorou
BACKGROUND: Although physical activity (PA) can alleviate fatigue and improve quality of life (QoL) in patients with breast cancer (BC), not all domains of PA may have equal impact. The objective of the current study was to examine the longitudinal impact of PA components on the evolution of fatigue and QoL during and after adjuvant treatment for BC. METHODS: The women included in the study were participants in the 2-year longitudinal FATSEIN ("Fatigue dans le cancer du Sein") study...
November 8, 2017: Cancer
https://www.readbyqxmd.com/read/29112627/impact-of-blood-flow-restriction-exercise-on-muscle-fatigue-development-and-recovery
#13
Florian Husmann, Thomas Mittlmeier, Sven Bruhn, Volker Zschorlich, Martin Behrens
PURPOSE: The present study was designed to provide mechanistic insight into the time-course and etiology of muscle fatigue development and recovery during and after low-intensity exercise when it is combined with blood flow restriction (BFR). METHODS: Seventeen resistance-trained males completed four sets of low-intensity isotonic resistance exercise under two experimental conditions: knee extension exercise combined with (i) BFR and (ii) without BFR (CON). Neuromuscular tests were performed before, during (immediately after each set of knee extension exercise) and 1, 2, 4, and 8 min after each experimental condition...
November 6, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29084357/adverse-events-associated-with-medium-and-long-term-use-of-opioids-for-chronic-non-cancer-pain-an-overview-of-cochrane-reviews
#14
REVIEW
Charl Els, Tanya D Jackson, Diane Kunyk, Vernon G Lappi, Barend Sonnenberg, Reidar Hagtvedt, Sangita Sharma, Fariba Kolahdooz, Sebastian Straube
BACKGROUND: Chronic pain is common and can be challenging to manage. Despite increased utilisation of opioids, the safety and efficacy of long-term use of these compounds for chronic non-cancer pain (CNCP) remains controversial. This overview of Cochrane Reviews complements the overview entitled 'High-dose opioids for chronic non-cancer pain: an overview of Cochrane Reviews'. OBJECTIVES: To provide an overview of the occurrence and nature of adverse events associated with any opioid agent (any dose, frequency, or route of administration) used on a medium- or long-term basis for the treatment of CNCP in adults...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29079651/frequency-duration-and-cause-of-ventilator-alarms-on-a-neonatal-intensive-care-unit
#15
Gusztav Belteki, Colin J Morley
OBJECTIVE: To investigate the frequency and cause of neonatal ventilator alarms. Neonatal ventilators frequently alarm and also disturb babies, parents and nurses. If frequent they may cause alarm fatigue and be ignored. The number, frequency and details of neonatal ventilator alarms are unreported. METHODS: We developed programs for retrieving and analysing ventilator data each second on alarms and ventilation parameters from 46 babies ventilated with Dräger Babylog VN500 ventilators using various modes...
October 27, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29072728/lead-free-bnt-based-composite-materials-enhanced-depolarization-temperature-and-electromechanical-behavior
#16
Wangfeng Bai, Peng Zheng, Fei Wen, Jingji Zhang, Daqin Chen, Jiwei Zhai, Zhenguo Ji
The development of (Bi0.5Na0.5)TiO3-based solid solutions with both high depolarization temperature Td and excellent piezoelectric and electromechanical properties for practical application is intractable because improved thermal stability is usually accompanied by a deterioration in piezoelectric and electromechanical performance. Herein, we report a 0-3 type 0.93(Bi0.5Na0.5)TiO3-0.07BaTiO3 : 30 mol%ZnO composite (BNT-7BT : 0.3ZnO), in which the ZnO nanoparticles exist in two forms, to resolve the abovementioned long-standing obstacle...
November 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29058083/exercise-program-design-considerations-for-head-and-neck-cancer-survivors
#17
Adrian W Midgley, Derek Lowe, Andrew R Levy, Vishal Mepani, Simon N Rogers
The present study aimed to establish exercise preferences, barriers, and perceived benefits among head and neck cancer survivors, as well as their level of interest in participating in an exercise program. Patients treated for primary squamous cell carcinoma of the head and neck between 2010 and 2014 were identified from the hospital database and sent a postal questionnaire pack to establish exercise preferences, barriers, perceived benefits, current physical activity levels, and quality of life. A postal reminder was sent to non-responders 4 weeks later...
October 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#18
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045021/reduced-dietary-intake-of-micronutrients-with-antioxidant-properties-negatively-impacts-muscle-health-in-aged-mice
#19
Miriam van Dijk, Francina J Dijk, Anita Hartog, Klaske van Norren, Sjors Verlaan, Ardy van Helvoort, Richard T Jaspers, Yvette Luiking
BACKGROUND: Inadequate intake of micronutrients with antioxidant properties is common among older adults and has been associated with higher risk of frailty, adverse functional outcome, and impaired muscle health. However, a causal relationship is less well known. The aim was to determine in old mice the impact of reduced dietary intake of vitamins A/E/B6/B12/folate, selenium, and zinc on muscle mass, oxidative capacity, strength, and physical activity (PA) over time. METHODS: Twenty-one-month-old male mice were fed either AIN-93-M (control) or a diet low in micronutrients with antioxidant properties (=LOWOX-B: 50% of mouse recommended daily intake of vitamins A, E, B6, and B12, folate, selenium, and zinc) for 4 months...
October 16, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29044670/the-effect-of-blue-light-blocking-spectacle-lenses-on-visual-performance-macular-health-and-the-sleep-wake-cycle-a%C3%A2-systematic-review-of-the-literature
#20
REVIEW
John G Lawrenson, Christopher C Hull, Laura E Downie
PURPOSE: Blue-blocking (BB) spectacle lenses, which attenuate short-wavelength light, are being marketed to alleviate eyestrain and discomfort when using digital devices, improve sleep quality and potentially confer protection from retinal phototoxicity. The aim of this review was to investigate the relative benefits and potential harms of these lenses. METHODS: We included randomised controlled trials (RCTs), recruiting adults from the general population, which investigated the effect of BB spectacle lenses on visual performance, symptoms of eyestrain or eye fatigue, changes to macular integrity and subjective sleep quality...
November 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
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