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https://www.readbyqxmd.com/read/29770505/poor-self-reported-sleep-quality-and-health-related-quality-of-life-in-patients-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis
#1
Jesús Castro-Marrero, Maria C Zaragozá, Sergio González-Garcia, Luisa Aliste, Naia Sáez-Francàs, Odile Romero, Alex Ferré, Tomás Fernández de Sevilla, José Alegre
Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort. A prospective cross-sectional cohort study was conducted in 1,455 Spanish chronic fatigue syndrome/myalgic encephalomyelitis patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression and health-related quality of life were assessed using validated subjective measures...
May 16, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29767836/how-do-we-manage-iron-deficiency-after-blood-donation
#2
REVIEW
Joseph E Kiss, Ralph R Vassallo
Blood donors and the RBCs and other components they willingly provide are essential in the delivery of healthcare in all parts of the world. Nearly 70% of donated blood comes from repeat or committed donors. The amount of iron removed in the 10 min or so it takes to withdraw a unit of blood (500 ml, plus 25 ml for testing) requires over 24 weeks to replace on a "standard" diet, i.e., without added iron in the form of supplements The cumulative effect of repeat blood donations without adequate iron replacement or a longer wait between donations results in iron deficiency (ID) in many donors, low haemoglobin deferral (~8% of donation attempts), and frank anaemia in some...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29765878/effects-of-very-high-stimulation-frequency-and-wide-pulse-duration-on-stimulated-force-and-fatigue-of-quadriceps-in-healthy-participants
#3
Kitima Rongsawad, Jonjin Ratanapinunchai
Objective: To determine the effect of very high stimulation frequency (150 and 200 Hz) with wide pulse duration versus 50 Hz with wide pulse duration on stimulated force and fatigue of quadriceps femoris in healthy participants. Methods: Thirty-four healthy participants underwent fatigue test using three stimulation frequency conditions (50, 150, and 200 Hz) with pulse duration of 0.9 ms. Normalized force values at the end of each fatigue protocol and curve fitting patterns were compared among stimulated frequencies...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29756638/sex-differences-in-diaphragmatic-fatigue-the-cardiovascular-response-to-inspiratory-resistance
#4
Joseph F Welch, Bruno Archiza, Jordan A Guenette, Christopher R West, A William Sheel
KEY POINTS: Diaphragmatic fatigue (DF) elicits a sympathetically mediated metaboreflex resulting in increased heart rate, blood pressure and limb vascular resistance. Women may be more resistant to DF compared to men and therefore, it was hypothesised that women would experience an attenuated inspiratory muscle metaboreflex during inspiratory pressure-threshold loading (PTL) performed to task failure. At the time of PTL task failure, the severity of DF was not different between sexes; however, inspiratory muscle endurance time was significantly longer in women than men...
May 14, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29755590/wide-pulse-high-frequency-low-intensity-neuromuscular-electrical-stimulation-has-potential-for-targeted-strengthening-of-an-intrinsic-foot-muscle-a-feasibility-study
#5
Darren C James, Matthew C Solan, Katya N Mileva
Background: Strengthening the intrinsic foot muscles is a poorly understood and largely overlooked area. In this study, we explore the feasibility of strengthening m . abductor hallucis (AH) with a specific paradigm of neuromuscular electrical stimulation; one which is low-intensity in nature and designed to interleave physiologically-relevant low frequency stimulation with high-frequencies to enhance effective current delivery to spinal motoneurones, and enable a proportion of force produced by the target muscle to be generated from a central origin...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29751850/comparison-between-transcutaneous-electrical-nerve-stimulation-and-stabilization-exercises-in-fatigue-and-transversus-abdominis-activation-in-patients-with-lumbar-disk-herniation-a-randomized-study
#6
Luiz Armando Vidal Ramos, Bianca Callegari, Fábio Jorge Renovato França, Maurício Oliveira Magalhães, Thomaz Nogueira Burke, Ana Paula de Moura Campos Carvalho E Silva, Gabriel Peixoto Leão Almeida, Josielli Comachio, Amélia Pasqual Marques
OBJECTIVE: The purpose of this study was to compare transcutaneous electrical nerve stimulation (TENS) and stabilization exercises in an attempt to prevent fatigue and improve muscle activation in patients with lumbar disk herniation associated with low back pain. METHODS: This study involved 29 patients (age range 25-58 years) randomized into 2 groups: the segmental stabilization group (n = 15), who received stabilization exercises on the transversus abdominis (TrA) and lumbar multifidus muscles; and the TENS group (n = 14), who received electrotherapy...
May 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29748158/scoping-review-of-dance-for-adults-with-fibromyalgia-what-do-we-know-about-it
#7
REVIEW
Julia Bidonde, Catherine Boden, Soo Kim, Angela J Busch, Suelen M Goes, Emily Knight
BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread muscular tenderness, pain, fatigue, and cognitive difficulties. Nonpharmacological treatment options, such as physical activity, are important for people with fibromyalgia. There are strong recommendations to support engagement in physical activity for symptom management among adults with fibromyalgia. Dance is a mode of physical activity that may allow individuals with fibromyalgia to improve their physical function, health, and well-being...
May 10, 2018: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/29727405/nitrate-supplement-benefits-contractile-forces-in-fatigued-but-not-unfatigued-muscle
#8
Neale A Tillin, Sarah Moudy, Kirsty M Nourse, Christopher J Tyler
PURPOSE: Evidence suggests dietary nitrate supplementation enhances low-frequency (≤20 Hz) involuntary, but not voluntary, forces in unfatigued human muscle. We investigated the hypotheses that nitrate supplementation would also attenuate low-frequency fatigue and the loss of explosive-voluntary forces in fatigued conditions. METHODS: In a counterbalanced double-blinded order, 17 male participants completed two experimental trials following 7 days of dietary supplementation with either nitrate-rich (NIT) or nitrate-depleted (PLA) beetroot juice...
April 27, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29724872/diet-and-lifestyle-recommendations-for-the-treatment-of-chronic-cough-and-chronic-disease
#9
Nathaniel Bergman, David S Riley, Michelle Beidelschies
Chronic cough, possibly due to toxicant exposure, may be improved by using a low-risk nutrition-centred strategy. A 71-year-old man experiencing chronic cough for the past 25 years presented to the Cleveland Clinic. In recent years, the patient's cough had increased in frequency and intensity despite pulmonary interventions. The patient's social history revealed exposures as a foundry worker to dimethylethylamine and triethylamine two known respiratory irritants. The patient was placed on a nutrition programme (nutrient dense, low glycaemic index and anti-inflammatory), encouraged to use a sauna each day and placed on nutraceutical supplementation that supports liver detoxification, digestive health and inflammation reduction...
May 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29721605/estimation-of-critical-end-test-torque-using-neuromuscular-electrical-stimulation-of-the-quadriceps-in-humans
#10
Natalie R Janzen, Robert E Hight, Darshit S Patel, Jason A Campbell, Rebecca D Larson, Christopher D Black
Characterization of critical power/torque (CP/CT) during voluntary exercise requires maximal effort, making difficult for those with neuromuscular impairments. To address this issue we sought to determine if electrically stimulated intermittent isometric exercise resulted in a critical end-test torque (ETT) that behaved similar to voluntary CT. In the first experiment participants (n = 9) completed four bouts of stimulated exercise at a 3:2 duty cycle, at frequencies of 100, 50, 25 Hz, and a low frequency below ETT (Sub-ETT; ≤ 15 Hz)...
May 2, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29705497/presynaptic-inhibition-mechanisms-may-subserve-the-spinal-excitability-modulation-induced-by-neuromuscular-electrical-stimulation
#11
Sidney Grosprêtre, Nicolas Gueugneau, Alain Martin, Romuald Lepers
This study aimed at deciphering the origins of spinal excitability modulation that follows neuromuscular electrical stimulation (NMES). Ten participants (age: 24.6 ± 4.2 years) performed 2 randomized NMES sessions on plantar flexors with frequencies of stimulations of 20 or 100 Hz (pulse width: 1 ms) at 20% of maximal voluntary contraction (MVC). Before and after each session, the posterior tibial nerve was stimulated to record H-reflex of soleus (SOL), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)...
April 24, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#12
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29687898/neuromuscular-fatigue-after-low-and-medium-frequency-electrical-stimulation-in-healthy-adults
#13
Pedro Ferreira Alves de Oliveira, João Luiz Quagliotti Durigan, Karenina Arrais Guida Modesto, Martim Bottaro, Nicolas Babault
INTRODUCTION: We studied fatigue origins induced by low-frequency pulsed current (PC) and medium frequency current (MF) neuromuscular electrical stimulation (NMES) after a clinical-like session. METHODS: Eleven healthy men randomly underwent 2 NMES sessions, PC and MF, on quadriceps muscle (15-min duration, 6-s on and 18-s off). Maximal voluntary contraction (MVC), central activation ratio (CAR), vastus lateralis electromyographic activity (EMG) and evoked contractile properties were determined before and after sessions...
April 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29671103/role-of-ca-2-in-changing-active-force-during-intermittent-submaximal-stimulation-in-intact-single-mouse-muscle-fibers
#14
Lisa D Glass, Arthur J Cheng, Brian R MacIntosh
Fatigue of single mouse fibers during repeated high-frequency stimulation results initially from decreased Ca2+ sensitivity while free myoplasmic calcium concentration ([Ca2+ ]m ) increases, followed by decreasing [Ca2+ ]m . Recovery of active force with low-frequency stimulation is slow and persistent fatigue results from low [Ca2+ ]m . However, the consequences of intermittent submaximal contractions are not known. The aim of the present study was to investigate the changes in [Ca2+ ]m and active force during intermittent submaximal contractions and subsequent recovery...
April 18, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29643430/highly-interactive-brain-computer-interface-based-on-flicker-free-steady-state-motion-visual-evoked-potential
#15
Chengcheng Han, Guanghua Xu, Jun Xie, Chaoyang Chen, Sicong Zhang
Visual evoked potential-based brain-computer interfaces (BCIs) have been widely investigated because of their easy system configuration and high information transfer rate (ITR). However, the uncomfortable flicker or brightness modulation of existing methods restricts the practical interactivity of BCI applications. In our study, a flicker-free steady-state motion visual evoked potential (FF-SSMVEP)-based BCI was proposed. Ring-shaped motion checkerboard patterns with oscillating expansion and contraction motions were presented by a high-refresh-rate display for visual stimuli, and the brightness of the stimuli was kept constant...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29617733/reflux-after-esophagectomy-with-gastric-conduit-reconstruction-in-the-posterior-mediastinum-for-esophageal-cancer-original-questionnaire-and-eortc-qlq-c30-survey
#16
Y Nakahara, M Yamasaki, Y Miyazaki, K Tanaka, T Makino, T Takahashi, Y Kurokawa, K Nakajima, S Takiguchi, M Mori, Y Doki
Reflux following an esophagectomy with gastric conduit reconstruction in the posterior mediastinum is a clinically significant problem. In this study, we investigated the frequency and impact of reflux on the quality of life (QOL) among 158 patients who underwent an esophagectomy for esophageal cancer using an original questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Version 3.0 (EORTC QLQ-C30). Reflux frequency was assessed using the original questionnaire...
March 28, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29611022/a-phase-i-open-label-two-stage-study-to-investigate-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-the-oral-akt-inhibitor-gsk2141795-in-patients-with-solid-tumors
#17
Carol Aghajanian, Katherine M Bell-McGuinn, Howard A Burris, Lillian L Siu, Lee-Ann Stayner, Jennifer J Wheler, David S Hong, Carla Kurkjian, Shubham Pant, Ademi Santiago-Walker, Jennifer L Gauvin, Joyce M Antal, Joanna B Opalinska, Shannon R Morris, Jeffrey R Infante
Background We sought to determine the recommended phase II dose (RP2D) and schedule of GSK2141795, an oral pan-AKT kinase inhibitor. Patients and Methods Patients with solid tumors were enrolled in the dose-escalation phase. Pharmacokinetic (PK) analysis after a single dose (Cycle 0) informed dose escalation using accelerated dose titration. Once one grade 2 toxicity or dose-limiting toxicity was observed in Cycle 1, the accelerated dose titration was terminated and a 3 + 3 dose escalation was started. Continuous daily dosing was evaluated along with two intermittent regimens (7 days on/7 days off and 3 times per week)...
April 3, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29607736/muscle-activation-and-local-muscular-fatigue-during-a-12-minute-rotational-bridge
#18
Sally D Lark, James A Dickie, James A Faulkner, Matthew J Barnes
Due to anecdotal reports of back pain during a 12-minute rotational bridge test by uniformed services, the level of fatigue leading to possible back pain and or injury was investigated. We hypothesised a high level of fatigue due to diminishing core muscle activation. Nineteen highly trained uniformed service members were measured by surface electromyography of the rectus abdominis, external oblique, internal oblique, lumbar erector spinae, thoracic erector spinae and latissimus dorsi. Average rectified electromyography amplitude (AEMG) and median power frequency were analysed to determine activation and fatigue...
April 2, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29570594/acute-neuromuscular-adaptations-in-response-to-low-intensity-blood-flow-restricted-exercise-and-high-intensity-resistance-exercise-are-there-any-differences
#19
Pedro Fatela, Joana F Reis, Goncalo V Mendonca, Tomás Freitas, Maria J Valamatos, Janne Avela, Pedro Mil-Homens
Fatela, P, Reis, JF, Mendonca, GV, Freitas, T, Valamatos, MJ, Avela, J, and Mil-Homens, P. Acute neuromuscular adaptations in response to low-intensity blood flow restricted exercise and high-intensity resistance exercise: are there any differences? J Strength Cond Res 32(4): 902-910, 2018-Numerous studies have reported similar neuromuscular adaptations between low-intensity (LI) blood-flow restricted exercise (BFRE) and high-intensity (HI) resistance training. Unfortunately, none of these experimental designs individualized blood flow restriction (BFR) levels to each participant...
April 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29559936/relationship-of-event-related-potentials-to-the-vigilance-decrement
#20
Ashley Haubert, Matt Walsh, Rachel Boyd, Megan Morris, Megan Wiedbusch, Mike Krusmark, Glenn Gunzelmann
Cognitive fatigue emerges in wide-ranging tasks and domains, but traditional vigilance tasks provide a well-studied context in which to explore the mechanisms underlying it. Though a variety of experimental methodologies have been used to investigate cognitive fatigue in vigilance, relatively little research has utilized electroencephalography (EEG), specifically event-related potentials (ERPs), to explore the nature of cognitive fatigue, also known as the vigilance decrement. Moreover, much of the research that has been done on vigilance and ERPs uses non-traditional vigilance paradigms, limiting generalizability to the established body of behavioral results and corresponding theories...
2018: Frontiers in Psychology
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