keyword
MENU ▼
Read by QxMD icon Read
search

Jason H Moore

keyword
https://www.readbyqxmd.com/read/28076415/structure-and-recognition-of-a-novel-hiv-1-gp120-gp41-interface-antibody-that-caused-mper-exposure-through-viral-escape
#1
Constantinos Kurt Wibmer, Jason Gorman, Gabriel Ozorowski, Jinal N Bhiman, Daniel J Sheward, Debra H Elliott, Julie Rouelle, Ashley Smira, M Gordon Joyce, Nonkululeko Ndabambi, Aliaksandr Druz, Mangai Asokan, Dennis R Burton, Mark Connors, Salim S Abdool Karim, John R Mascola, James E Robinson, Andrew B Ward, Carolyn Williamson, Peter D Kwong, Lynn Morris, Penny L Moore
A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28045715/oncologic-procedures-amenable-to-fluorescence-guided-surgery
#2
Kiranya E Tipirneni, Jason M Warram, Lindsay S Moore, Andrew C Prince, Esther de Boer, Aditi H Jani, Irene L Wapnir, Joseph C Liao, Michael Bouvet, Nicole K Behnke, Mary T Hawn, George A Poultsides, Alexander L Vahrmeijer, William R Carroll, Kurt R Zinn, Eben Rosenthal
OBJECTIVE: Although fluorescence imaging is being applied to a wide range of cancers, it remains unclear which disease populations will benefit greatest. Therefore, we review the potential of this technology to improve outcomes in surgical oncology with attention to the various surgical procedures while exploring trial endpoints that may be optimal for each tumor type. BACKGROUND: For many tumors, primary treatment is surgical resection with negative margins, which corresponds to improved survival and a reduction in subsequent adjuvant therapies...
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28030499/the-coalition-for-national-trauma-research-cntr-supports-the-call-for-a-national-trauma-research-action-plan
#3
Raul Coimbra, Rosemary A Kozar, Jason W Smith, Ben L Zarzaur, Carl J Hauser, Frederick A Moore, Jeffrey A Bailey, Alex Valadka, Gregory J Jurkovich, Donald H Jenkins, Kimberly A Davis, Michelle A Price, Ronald V Maier
No abstract text is available yet for this article.
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28008626/outcomes-of-surgically-treated-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma-with-n3-disease
#4
Joseph Zenga, Bruce H Haughey, Ryan S Jackson, Douglas R Adkins, John Aranake-Chrisinger, Neel Bhatt, Hiram A Gay, Dorina Kallogjeri, Eliot J Martin, Eric J Moore, Randal C Paniello, Jason T Rich, Wade L Thorstad, Brian Nussenbaum
OBJECTIVES/HYPOTHESIS: To evaluate outcomes for patients with pathological N3 (pN3) neck disease from human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and determine variables predictive of survival. STUDY DESIGN: Retrospective case series with chart review. METHODS: This study was conducted between 1998 and 2013 and included patients with HPV-related OPSCC treated with surgery with or without adjuvant therapy and who had pN3 nodal disease...
December 23, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27999618/complex-systems-analysis-of-bladder-cancer-susceptibility-reveals-a-role-for-decarboxylase-activity-in-two-genome-wide-association-studies
#5
Samantha Cheng, Angeline S Andrew, Peter C Andrews, Jason H Moore
BACKGROUND: Bladder cancer is common disease with a complex etiology that is likely due to many different genetic and environmental factors. The goal of this study was to embrace this complexity using a bioinformatics analysis pipeline designed to use machine learning to measure synergistic interactions between single nucleotide polymorphisms (SNPs) in two genome-wide association studies (GWAS) and then to assess their enrichment within functional groups defined by Gene Ontology. The significance of the results was evaluated using permutation testing and those results that replicated between the two GWAS data sets were reported...
2016: BioData Mining
https://www.readbyqxmd.com/read/27960086/integrated-epi-genomic-analyses-identify-subgroup-specific-therapeutic-targets-in-cns-rhabdoid-tumors
#6
Jonathon Torchia, Brian Golbourn, Shengrui Feng, King Ching Ho, Patrick Sin-Chan, Alexandre Vasiljevic, Joseph D Norman, Paul Guilhamon, Livia Garzia, Natalia R Agamez, Mei Lu, Tiffany S Chan, Daniel Picard, Pasqualino de Antonellis, Dong-Anh Khuong-Quang, Aline C Planello, Constanze Zeller, Dalia Barsyte-Lovejoy, Lucie Lafay-Cousin, Louis Letourneau, Mathieu Bourgey, Man Yu, Deena M A Gendoo, Misko Dzamba, Mark Barszczyk, Tiago Medina, Alexandra N Riemenschneider, A Sorana Morrissy, Young-Shin Ra, Vijay Ramaswamy, Marc Remke, Christopher P Dunham, Stephen Yip, Ho-Keung Ng, Jian-Qiang Lu, Vivek Mehta, Steffen Albrecht, Jose Pimentel, Jennifer A Chan, Gino R Somers, Claudia C Faria, Lucia Roque, Maryam Fouladi, Lindsey M Hoffman, Andrew S Moore, Yin Wang, Seung Ah Choi, Jordan R Hansford, Daniel Catchpoole, Diane K Birks, Nicholas K Foreman, Doug Strother, Almos Klekner, Laszló Bognár, Miklós Garami, Péter Hauser, Tibor Hortobágyi, Beverly Wilson, Juliette Hukin, Anne-Sophie Carret, Timothy E Van Meter, Eugene I Hwang, Amar Gajjar, Shih-Hwa Chiou, Hideo Nakamura, Helen Toledano, Iris Fried, Daniel Fults, Takafumi Wataya, Chris Fryer, David D Eisenstat, Katrin Scheinemann, Adam J Fleming, Donna L Johnston, Jean Michaud, Shayna Zelcer, Robert Hammond, Samina Afzal, David A Ramsay, Nongnuch Sirachainan, Suradej Hongeng, Noppadol Larbcharoensub, Richard G Grundy, Rishi R Lulla, Jason R Fangusaro, Harriet Druker, Ute Bartels, Ronald Grant, David Malkin, C Jane McGlade, Theodore Nicolaides, Tarik Tihan, Joanna Phillips, Jacek Majewski, Alexandre Montpetit, Guillaume Bourque, Gary D Bader, Alyssa T Reddy, G Yancey Gillespie, Monika Warmuth-Metz, Stefan Rutkowski, Uri Tabori, Mathieu Lupien, Michael Brudno, Ulrich Schüller, Torsten Pietsch, Alexander R Judkins, Cynthia E Hawkins, Eric Bouffet, Seung-Ki Kim, Peter B Dirks, Michael D Taylor, Anat Erdreich-Epstein, Cheryl H Arrowsmith, Daniel D De Carvalho, James T Rutka, Nada Jabado, Annie Huang
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors...
December 12, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27908648/interdisciplinary-care-of-children-with-severe-bronchopulmonary-dysplasia
#7
Steven H Abman, Joseph M Collaco, Edward G Shepherd, Martin Keszler, Milenka Cuevas-Guaman, Stephen E Welty, William E Truog, Sharon A McGrath-Morrow, Paul E Moore, Lawrence M Rhein, Haresh Kirpalani, Huayan Zhang, Linda L Gratny, Susan K Lynch, Jennifer Curtiss, Barbara S Stonestreet, Robin L McKinney, Kevin C Dysart, Jason Gien, Christopher D Baker, Pamela K Donohue, Eric Austin, Candice Fike, Leif D Nelin
No abstract text is available yet for this article.
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27897015/no-boundary-thinking-in-bioinformatics
#8
Jason H Moore, Steven F Jennings, Casey S Greene, Lawrence E Hunter, Andy D Perkins, Clarlynda Williams-Devane, Donald C Wunsch, Zhongming Zhao, Xiuzhen Huang
The following sections are included:Bioinformatics is a Mature DisciplineThe Golden Era of Bioinformatics Has BegunNo-Boundary Thinking in BioinformaticsReferences.
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27897014/the-training-of-next-generation-data-scientists-in-biomedicine
#9
Lana X Garmire, Stephen Gliske, Quynh C Nguyen, Jonathan H Chen, Shamim Nemati, John D VAN Horn, Jason H Moore, Carol Shreffler, Michelle Dunn
With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896976/missing-data-imputation-in-the-electronic-health-record-using-deeply-learned-autoencoders
#10
Brett K Beaulieu-Jones, Jason H Moore
Electronic health records (EHRs) have become a vital source of patient outcome data but the widespread prevalence of missing data presents a major challenge. Different causes of missing data in the EHR data may introduce unintentional bias. Here, we compare the effectiveness of popular multiple imputation strategies with a deeply learned autoencoder using the Pooled Resource Open-Access ALS Clinical Trials Database (PRO-ACT). To evaluate performance, we examined imputation accuracy for known values simulated to be either missing completely at random or missing not at random...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896910/novel-delivery-technique-for-atrial-septal-defect-closure-in-young-children-utilizing-the-gore-%C3%A2-cardioform-%C3%A2-septal-occluder
#11
Jason H Anderson, Hannah Fraint, Phillip Moore, Allison K Cabalka, Nathaniel W Taggart
OBJECTIVES: To develop a novel delivery technique to overcome vascular size limitations for device closure of a secundum ASD in the young patient. BACKGROUND: The efficacy, clinical utility, and safety of transcatheter closure in comparison to surgical closure are well established; however, access vessel size remains a potential limitation to device selection in the young patient. METHODS: A retrospective medical record review of all cases of secundum ASD closure between April 2015 and April 2016 utilizing a novel delivery method described herein at two separate academic institutions...
November 29, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27848076/identifying-gene-gene-interactions-that-are-highly-associated-with-four-quantitative-lipid-traits-across-multiple-cohorts
#12
Rishika De, Shefali S Verma, Emily Holzinger, Molly Hall, Amber Burt, David S Carrell, David R Crosslin, Gail P Jarvik, Helena Kuivaniemi, Iftikhar J Kullo, Leslie A Lange, Matthew B Lanktree, Eric B Larson, Kari E North, Alex P Reiner, Vinicius Tragante, Gerard Tromp, James G Wilson, Folkert W Asselbergs, Fotios Drenos, Jason H Moore, Marylyn D Ritchie, Brendan Keating, Diane Gilbert-Diamond
Genetic loci explain only 25-30 % of the heritability observed in plasma lipid traits. Epistasis, or gene-gene interactions may contribute to a portion of this missing heritability. Using the genetic data from five NHLBI cohorts of 24,837 individuals, we combined the use of the quantitative multifactor dimensionality reduction (QMDR) algorithm with two SNP-filtering methods to exhaustively search for SNP-SNP interactions that are associated with HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG)...
November 15, 2016: Human Genetics
https://www.readbyqxmd.com/read/27833658/considerations-for-higher-efficiency-and-productivity-in-research-activities
#13
EDITORIAL
Diego A Forero, Jason H Moore
There are several factors that are known to affect research productivity; some of them imply the need for large financial investments and others are related to work styles. There are some articles that provide suggestions for early career scientists (PhD students and postdocs) but few publications are oriented to professors about scientific leadership. As academic mentoring might be useful at all levels of experience, in this note we suggest several key considerations for higher efficiency and productivity in academic and research activities...
2016: BioData Mining
https://www.readbyqxmd.com/read/27747820/two-dimensional-enrichment-analysis-for-mining-high-level-imaging-genetic-associations
#14
Xiaohui Yao, Jingwen Yan, Sungeun Kim, Kwangsik Nho, Shannon L Risacher, Mark Inlow, Jason H Moore, Andrew J Saykin, Li Shen
Enrichment analysis has been widely applied in the genome-wide association studies, where gene sets corresponding to biological pathways are examined for significant associations with a phenotype to help increase statistical power and improve biological interpretation. In this work, we expand the scope of enrichment analysis into brain imaging genetics, an emerging field that studies how genetic variation influences brain structure and function measured by neuroimaging quantitative traits (QT). Given the high dimensionality of both imaging and genetic data, we propose to study Imaging Genetic Enrichment Analysis (IGEA), a new enrichment analysis paradigm that jointly considers meaningful gene sets (GS) and brain circuits (BC) and examines whether any given GS-BC pair is enriched in a list of gene-QT findings...
May 13, 2016: Brain Informatics
https://www.readbyqxmd.com/read/27732601/cardiovascular-disease-risk-factors-in-ghana-during-the-rural-to-urban-transition-a-cross-sectional-study
#15
Nuri Kodaman, Melinda C Aldrich, Rafal Sobota, Folkert W Asselbergs, Kwabena A Poku, Nancy J Brown, Jason H Moore, Scott M Williams
Populations in sub-Saharan Africa are shifting from rural to increasingly urban. Although the burden of cardiovascular disease is expected to increase with this changing landscape, few large studies have assessed a wide range of risk factors in urban and rural populations, particularly in West Africa. We conducted a cross-sectional, population-based survey of 3317 participants from Ghana (≥18 years old), of whom 2265 (57% female) were from a mid-sized city (Sunyani, population ~250,000) and 1052 (55% female) were from surrounding villages (populations <5000)...
2016: PloS One
https://www.readbyqxmd.com/read/27720222/intestinal-barrier-dysfunction-in-human-necrotizing-enterocolitis
#16
Sarah A Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y Ma
BACKGROUND: Intestinal barrier dysfunction has been implicated in necrotizing enterocolitis (NEC), but has not been directly measured in human NEC. METHODS: Small intestines removed during surgery were immediately mounted in an Ussing chamber. mRNA expression of tight junction (TJ) proteins was measured with RT-PCR. RESULTS: Fifteen infants were included, 5 with NEC and 10 with other diagnoses. Average transepithelial resistance (TER) was 11...
December 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27700046/laser-assisted-focused-he-ion-beam-induced-etching-with-and-without-xef2-gas-assist
#17
Michael G Stanford, Kyle Mahady, Brett B Lewis, Jason D Fowlkes, Shida Tan, Richard H Livengood, Gregory A Magel, Thomas M Moore, Philip D Rack
Focused helium ion (He+) milling has been demonstrated as a high-resolution nanopatterning technique, however it can be limited by its low sputter yield as well as the introduction of undesired sub-surface damage. Here, we introduce pulsed laser and gas assisted processes to enhance the material removal rate and patterning fidelity. A pulsed laser-assisted He+ milling process is shown to enable high resolution milling of titanium while reducing sub-surface damage in situ. Gas-assisted focused ion beam induced etching (FIBIE) of Ti is also demonstrated in which the XeF2 precursor provides a chemical assist for enhanced material removal rate...
October 4, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27697752/plasminogen-activator-inhibitor-1-and-diagnosis-of-the-metabolic-syndrome-in-a-west-african-population
#18
Nuri Kodaman, Melinda C Aldrich, Rafal Sobota, Folkert W Asselbergs, Nancy J Brown, Jason H Moore, Scott M Williams
BACKGROUND: Metabolic syndrome (MetS) is diagnosed by the presence of at least 3 of the following: obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low high-density lipoprotein. Individuals with MetS also typically have elevated plasma levels of the antifibrinolytic factor, plasminogen activator inhibitor-1 (PAI-1), but the relationships between PAI-1 and MetS diagnostic criteria are not clear. Understanding these relationships can elucidate the relevance of MetS to cardiovascular disease risk, because PAI-1 is associated with ischemic events and directly involved in thrombosis...
October 3, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27688810/the-tip-of-the-iceberg-challenges-of-accessing-hospital-electronic-health-record-data-for-biological-data-mining
#19
EDITORIAL
Spiros C Denaxas, Folkert W Asselbergs, Jason H Moore
Modern cohort studies include self-reported measures on disease, behavior and lifestyle, sensor-based observations from mobile phones and wearables, and rich -omics data. Follow-up is often achieved through electronic health record (EHR) linkages across primary and secondary healthcare providers. Historically however, researchers typically only get to see the tip of the iceberg: coded administrative data relating to healthcare claims which mainly record billable diagnoses and procedures. The rich data generated during the clinical pathway remain submerged and inaccessible...
2016: BioData Mining
https://www.readbyqxmd.com/read/27634021/oncologic-outcomes-of-selective-neck-dissection-in-hpv-related-oropharyngeal-squamous-cell-carcinoma
#20
Joseph Zenga, Ryan S Jackson, Evan M Graboyes, Parul Sinha, Miranda Lindberg, Eliot J Martin, Daniel Ma, Wade L Thorstad, Jason T Rich, Eric J Moore, Bruce H Haughey
OBJECTIVES: To examine outcomes of selective neck dissection (SND) in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) who present with clinical neck disease. STUDY DESIGN: Multi-institutional retrospective review. METHODS: Two institutional databases of patients with HPV-related OPSCC were reviewed to identify patients with clinical (c) N1-N3 neck disease who underwent SND ± adjuvant therapy...
September 16, 2016: Laryngoscope
keyword
keyword
114269
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"