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JOURNAL ARTICLE
Joseph D Romano, Van Truong, Rachit Kumar, Mythreye Venkatesan, Britney E Graham, Yun Hao, Nick Matsumoto, Xi Li, Zhiping Wang, Marylyn D Ritchie, Li Shen, Jason H Moore
BACKGROUND: As global populations age and become susceptible to neurodegenerative illnesses, new therapies for Alzheimer disease (AD) are urgently needed. Existing data resources for drug discovery and repurposing fail to capture relationships central to the disease's etiology and response to drugs. OBJECTIVE: We designed the Alzheimer's Knowledge Base (AlzKB) to alleviate this need by providing a comprehensive knowledge representation of AD etiology and candidate therapeutics...
April 18, 2024: Journal of Medical Internet Research
#2
JOURNAL ARTICLE
Walid K Salah, Matthew C Findlay, Cordell M Baker, Jonathan P Scoville, Michael Bounajem, Christopher Ogilvy, Justin Moore, Howard Riina, Elad I Levy, Adnan H Siddiqui, Alejandro Spiotta, C Michael Cawley, Alexander Khalessi, Omar Tanweer, Ricardo Hanel, Bradley Gross, Okkes Kuybu, Brian M Howard, Alex N Hoang, Ammad A Baig, MirHojjat Khorasanizadeh, Aldo A Mendez Ruiz, Gustavo Cortez, Jason M Davies, Mike Lang, Ajith J Thomas, Daniel Tonetti, Jane Khalife, Georgios S Sioutas, Kate Carroll, Zachary A Abecassis, Brian Jankowitz, Juan Francisco Ruiz Rodriguez, MIchael Levitt, Peter Kan, Jan Karl Burkhardt, Visish Srinivasan, Mohamed M Salem, Ramesh Grandhi
Middle meningeal artery embolization (MMAE) is emerging as a safe and effective standalone intervention for nonacute subdural hematomas (NASHs); however, the risk of hematoma recurrence after MMAE in coagulopathic patients is unclear. To characterize the impact of coagulopathy on treatment outcomes, we analyzed a multi-institutional database of patients who underwent standalone MMAE as treatment of NASH. We classified 537 patients who underwent MMAE as a standalone intervention between 2019 and 2023 by coagulopathy status...
March 13, 2024: Journal of Neurotrauma
#3
JOURNAL ARTICLE
Phillip Gu, Oreen Mendonca, Dan Carter, Shishir Dube, Paul Wang, Xiuzhen Huang, Debiao Li, Jason H Moore, Dermot P B McGovern
Endoscopy, histology, and cross-sectional imaging serve as fundamental pillars in the detection, monitoring, and prognostication of inflammatory bowel disease (IBD). However, interpretation of these studies often relies on subjective human judgment, which can lead to delays, intra- and interobserver variability, and potential diagnostic discrepancies. With the rising incidence of IBD globally coupled with the exponential digitization of these data, there is a growing demand for innovative approaches to streamline diagnosis and elevate clinical decision-making...
March 7, 2024: Inflammatory Bowel Diseases
#4
JOURNAL ARTICLE
William E Allen, Joshua D Greendyk, H Richard Alexander, Toni Beninato, Mariam F Eskander, Miral S Grandhi, Haejin In, Timothy J Kennedy, Russell C Langan, Jason C Maggi, Dirk F Moore, Henry A Pitt, Subhajoyti De, Syed F Haider, Brett L Ecker
BACKGROUND: Racial and ethnic disparities have been observed in the multidisciplinary management of pancreatic ductal adenocarcinoma. Intraductal papillary mucinous neoplasm is the most common identifiable precursor to pancreatic ductal adenocarcinoma, where early surgical intervention before the development of an invasive intraductal papillary mucinous neoplasm improves survival. The association of race/ethnicity with the risk of identifying invasive intraductal papillary mucinous neoplasms during resection has not been previously defined...
February 28, 2024: Surgery
#5
JOURNAL ARTICLE
Sandra Batista, Vered Senderovich Madar, Philip J Freda, Priyanka Bhandary, Attri Ghosh, Nicholas Matsumoto, Apurva S Chitre, Abraham A Palmer, Jason H Moore
PURPOSE: Epistasis, the interaction between two or more genes, is integral to the study of genetics and is present throughout nature. Yet, it is seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all pairwise and higher-order interactions requires significant computational resources. Furthermore, existing methods for epistasis detection only consider a Cartesian (multiplicative) model for interaction terms. This is likely limiting as epistatic interactions can evolve to produce varied relationships between genetic loci, some complex and not linearly separable...
February 28, 2024: BioData Mining
#6
JOURNAL ARTICLE
Mohamed M Salem, Georgios S Sioutas, Jane Khalife, Okkes Kuybu, Kate Caroll, Alex Nguyen Hoang, Ammad A Baig, Mira Salih, Mirhojjat Khorasanizadeh, Cordell Baker, Aldo A Mendez, Gustavo Cortez, Zachary A Abecassis, Juan F Ruiz Rodriguez, Jason M Davies, Sandra Narayanan, C Michael Cawley, Howard A Riina, Justin M Moore, Alejandro M Spiotta, Alexander A Khalessi, Brian M Howard, Ricardo Hanel, Omar Tanweer, Daniel A Tonetti, Adnan H Siddiqui, Michael J Lang, Elad I Levy, Peter Kan, Tudor Jovin, Ramesh Grandhi, Visish M Srinivasan, Christopher S Ogilvy, Bradley A Gross, Brian T Jankowitz, Ajith J Thomas, Michael R Levitt, Jan-Karl Burkhardt
BACKGROUND AND OBJECTIVES: The choice of anesthesia type (general anesthesia [GA] vs nongeneral anesthesia [non-GA]) in middle meningeal artery embolization (MMAE) procedures for chronic subdural hematomas (cSDH) differs between institutions and left to care team discretion given lack of standard guidelines. We compare the outcomes of GA vs non-GA in MMAE. METHODS: Consecutive patients receiving MMAE for cSDH at 14 North American centers (2018-2023) were included...
February 27, 2024: Neurosurgery
#7
JOURNAL ARTICLE
Hayley S Clements, Emmanuel Do Linh San, Gareth Hempson, Birthe Linden, Bryan Maritz, Ara Monadjem, Chevonne Reynolds, Frances Siebert, Nicola Stevens, Reinette Biggs, Alta De Vos, Ryan Blanchard, Matthew Child, Karen J Esler, Maike Hamann, Ty Loft, Belinda Reyers, Odirilwe Selomane, Andrew L Skowno, Tshegofatso Tshoke, Diarrassouba Abdoulaye, Thierry Aebischer, Jesús Aguirre-Gutiérrez, Graham J Alexander, Abdullahi H Ali, David G Allan, Esther E Amoako, Samuel Angedakin, Edward Aruna, Nico L Avenant, Gabriel Badjedjea, Adama Bakayoko, Abraham Bamba-Kaya, Michael F Bates, Paul J J Bates, Steven R Belmain, Emily Bennitt, James Bradley, Chris A Brewster, Michael B Brown, Michelle Brown, Josef Bryja, Thomas M Butynski, Filipe Carvalho, Alan Channing, Colin A Chapman, Callan Cohen, Marina Cords, Jennifer D Cramer, Nadine Cronk, Pamela M K Cunneyworth, Fredrik Dalerum, Emmanuel Danquah, Harriet T Davies-Mostert, Andrew D de Blocq, Yvonne A De Jong, Terrence C Demos, Christiane Denys, Chabi A M S Djagoun, Thomas M Doherty-Bone, Marine Drouilly, Johan T du Toit, David A Ehlers Smith, Yvette C Ehlers Smith, Seth J Eiseb, Peter J Fashing, Adam W Ferguson, José M Fernández-García, Manfred Finckh, Claude Fischer, Edson Gandiwa, Philippe Gaubert, Jerome Y Gaugris, Dalton J Gibbs, Jason S Gilchrist, Jose M Gil-Sánchez, Anthony N Githitho, Peter S Goodman, Laurent Granjon, J Paul Grobler, Bonginkosi C Gumbi, Vaclav Gvozdik, James Harvey, Morgan Hauptfleisch, Firas Hayder, Emmanuel M Hema, Marna Herbst, Mariano Houngbédji, Brian J Huntley, Rainer Hutterer, Samuel T Ivande, Kate Jackson, Gregory F M Jongsma, Javier Juste, Blaise Kadjo, Prince K Kaleme, Edwin Kamugisha, Beth A Kaplin, Humphrey N Kato, Christian Kiffner, Duncan M Kimuyu, Robert M Kityo, N'goran G Kouamé, Marcel Kouete T, Aliza le Roux, Alan T K Lee, Mervyn C Lötter, Anne Mette Lykke, Duncan N MacFadyen, Gacheru P Macharia, Zimkitha J K Madikiza, Themb'alilahlwa A M Mahlaba, David Mallon, Mnqobi L Mamba, Claude Mande, Rob A Marchant, Robin A Maritz, Wanda Markotter, Trevor McIntyre, John Measey, Addisu Mekonnen, Paulina Meller, Haemish I Melville, Kevin Z Mganga, Michael G L Mills, Liaan Minnie, Alain Didier Missoup, Abubakr Mohammad, Nancy N Moinde, Bakwo Fils E Moise, Pedro Monterroso, Jennifer F Moore, Simon Musila, Sedjro Gilles A Nago, Maganizo W Namoto, Fatimata Niang, Violaine Nicolas, Jerry B Nkenku, Evans E Nkrumah, Gonwouo L Nono, Mulavwa M Norbert, Katarzyna Nowak, Benneth C Obitte, Arnold D Okoni-Williams, Jonathan Onongo, M Justin O'Riain, Samuel T Osinubi, Daniel M Parker, Francesca Parrini, Mike J S Peel, Johannes Penner, Darren W Pietersen, Andrew J Plumptre, Damian W Ponsonby, Stefan Porembski, R John Power, Frans G T Radloff, Ramugondo V Rambau, Tharmalingam Ramesh, Leigh R Richards, Mark-Oliver Rödel, Dominic P Rollinson, Francesco Rovero, Mostafa A Saleh, Ute Schmiedel, M Corrie Schoeman, Paul Scholte, Thomas L Serfass, Julie Teresa Shapiro, Sidney Shema, Stefan J Siebert, Jasper A Slingsby, Alexander Sliwa, Hanneline A Smit-Robinson, Etotepe A Sogbohossou, Michael J Somers, Stephen Spawls, Jarryd P Streicher, Lourens Swanepoel, Iroro Tanshi, Peter J Taylor, William A Taylor, Mariska Te Beest, Paul T Telfer, Dave I Thompson, Elie Tobi, Krystal A Tolley, Andrew A Turner, Wayne Twine, Victor Van Cakenberghe, Frederik Van de Perre, Helga van der Merwe, Chris J G van Niekerk, Pieter C V van Wyk, Jan A Venter, Luke Verburgt, Geraldine Veron, Susanne Vetter, Maria S Vorontsova, Thomas C Wagner, Paul W Webala, Natalie Weber, Sina M Weier, Paula A White, Melissa A Whitecross, Benjamin J Wigley, Frank J Willems, Christiaan W Winterbach, Galena M Woodhouse
Sub-Saharan Africa is under-represented in global biodiversity datasets, particularly regarding the impact of land use on species' population abundances. Drawing on recent advances in expert elicitation to ensure data consistency, 200 experts were convened using a modified-Delphi process to estimate 'intactness scores': the remaining proportion of an 'intact' reference population of a species group in a particular land use, on a scale from 0 (no remaining individuals) to 1 (same abundance as the reference) and, in rare cases, to 2 (populations that thrive in human-modified landscapes)...
February 12, 2024: Scientific Data
#8
JOURNAL ARTICLE
Peter Abadir, Esther Oh, Rama Chellappa, Niteesh Choudhry, George Demiris, Deepak Ganesan, Jason Karlawish, Benjamin Marlin, Rose M Li, Najim Dehak, Alicia Arbaje, Mathias Unberath, Thomas Cudjoe, Christopher Chute, Jason H Moore, Phillip Phan, Quincy Samus, Nancy L Schoenborn, Alexis Battle, Jeremy D Walston
This perspective outlines the Artificial Intelligence and Technology Collaboratories (AITC) at Johns Hopkins University, University of Pennsylvania, and University of Massachusetts, highlighting their roles in developing AI-based technologies for older adult care, particularly targeting Alzheimer's disease (AD). These National Institute on Aging (NIA) centers foster collaboration among clinicians, gerontologists, ethicists, business professionals, and engineers to create AI solutions. Key activities include identifying technology needs, stakeholder engagement, training, mentoring, data integration, and navigating ethical challenges...
February 7, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#9
JOURNAL ARTICLE
Monica Tang, Anna Ibrahim, Christopher Laughon, Kaila Moore, Angibel Tejada, Dean Tran, Ryan Kilpatrick, Rachel G Greenberg, Christoph P Hornik, Kanecia Zimmerman, Matthew M Laughon, Reese H Clark, Jason E Lang
OBJECTIVE: Despite limited safety and efficacy data, inhaled corticosteroids (ICS) are prescribed to premature infants in the neonatal intensive care unit (NICU). We examined contemporary use and risk factors for ICS use in the NICU. STUDY DESIGN: Infants <33 weeks gestational age and <1500 gm birth weight discharged from Pediatrix Medical Group NICUs between 2010 and 2020 were included. We evaluated the association between ICS prescription and clinical characteristics using univariable and multivariable logistic regression...
January 31, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
#10
Ruowang Li, Luke Benz, Rui Duan, Joshua C Denny, Hakon Hakonarson, Jonathan D Mosley, Jordan W Smoller, Wei-Qi Wei, Marylyn D Ritchie, Jason H Moore, Yong Chen
Genome-wide association studies (GWAS) have been instrumental in identifying genetic associations for various diseases and traits. However, uncovering genetic underpinnings among traits beyond univariate phenotype associations remains a challenge. Multi-phenotype associations (MPA), or genetic pleiotropy, offer important insights into shared genes and pathways among traits, enhancing our understanding of genetic architectures of complex diseases. GWAS of biobank-linked electronic health record (EHR) data are increasingly being utilized to identify MPA among various traits and diseases...
January 10, 2024: medRxiv
#11
JOURNAL ARTICLE
Arsen Osipov, Ognjen Nikolic, Arkadiusz Gertych, Sarah Parker, Andrew Hendifar, Pranav Singh, Darya Filippova, Grant Dagliyan, Cristina R Ferrone, Lei Zheng, Jason H Moore, Warren Tourtellotte, Jennifer E Van Eyk, Dan Theodorescu
Contemporary analyses focused on a limited number of clinical and molecular biomarkers have been unable to accurately predict clinical outcomes in pancreatic ductal adenocarcinoma. Here we describe a precision medicine platform known as the Molecular Twin consisting of advanced machine-learning models and use it to analyze a dataset of 6,363 clinical and multi-omic molecular features from patients with resected pancreatic ductal adenocarcinoma to accurately predict disease survival (DS). We show that a full multi-omic model predicts DS with the highest accuracy and that plasma protein is the top single-omic predictor of DS...
January 22, 2024: Nature Cancer
#12
JOURNAL ARTICLE
Hanaan Bing-Canar, Jane K Stocks, Humza Khan, Andrew A Rauch, Maximillian A Obolsky, Franchezka Lapitan-Moore, Matthew S Phillips, Jason R Soble, Neil H Pliskin, Woojin Song, Zachary J Resch
BACKGROUND: Evidence suggests that adverse childhood experiences (ACEs) predict cognitive dysfunction, possibly through direct (e.g., brain structure/function changes) and indirect (e.g., increased psychopathology risk) pathways. However, extant studies have focused on young and older adults, with limited understanding of how ACEs affect cognitive health in midadulthood. OBJECTIVE: This study compared psychiatric and cognitive differences between adults at high- and low-risk of adverse health outcomes based on the ACE risk classification scheme...
January 15, 2024: Psychological Trauma: Theory, Research, Practice and Policy
#13
JOURNAL ARTICLE
Declan L M Cooper, Simon L Lewis, Martin J P Sullivan, Paulo I Prado, Hans Ter Steege, Nicolas Barbier, Ferry Slik, Bonaventure Sonké, Corneille E N Ewango, Stephen Adu-Bredu, Kofi Affum-Baffoe, Daniel P P de Aguiar, Manuel Augusto Ahuite Reategui, Shin-Ichiro Aiba, Bianca Weiss Albuquerque, Francisca Dionízia de Almeida Matos, Alfonso Alonso, Christian A Amani, Dário Dantas do Amaral, Iêda Leão do Amaral, Ana Andrade, Ires Paula de Andrade Miranda, Ilondea B Angoboy, Alejandro Araujo-Murakami, Nicolás Castaño Arboleda, Luzmila Arroyo, Peter Ashton, Gerardo A Aymard C, Cláudia Baider, Timothy R Baker, Michael Philippe Bessike Balinga, Henrik Balslev, Lindsay F Banin, Olaf S Bánki, Chris Baraloto, Edelcilio Marques Barbosa, Flávia Rodrigues Barbosa, Jos Barlow, Jean-Francois Bastin, Hans Beeckman, Serge Begne, Natacha Nssi Bengone, Erika Berenguer, Nicholas Berry, Robert Bitariho, Pascal Boeckx, Jan Bogaert, Bernard Bonyoma, Patrick Boundja, Nils Bourland, Faustin Boyemba Bosela, Fabian Brambach, Roel Brienen, David F R P Burslem, José Luís Camargo, Wegliane Campelo, Angela Cano, Sasha Cárdenas, Dairon Cárdenas López, Rainiellen de Sá Carpanedo, Yrma Andreina Carrero Márquez, Fernanda Antunes Carvalho, Luisa Fernanda Casas, Hernán Castellanos, Carolina V Castilho, Carlos Cerón, Colin A Chapman, Jerome Chave, Phourin Chhang, Wanlop Chutipong, George B Chuyong, Bruno Barçante Ladvocat Cintra, Connie J Clark, Fernanda Coelho de Souza, James A Comiskey, David A Coomes, Fernando Cornejo Valverde, Diego F Correa, Flávia R C Costa, Janaina Barbosa Pedrosa Costa, Pierre Couteron, Heike Culmsee, Aida Cuni-Sanchez, Francisco Dallmeier, Gabriel Damasco, Gilles Dauby, Nállarett Dávila, Hilda Paulette Dávila Doza, Jose Don T De Alban, Rafael L de Assis, Charles De Canniere, Thales De Haulleville, Marcelo de Jesus Veiga Carim, Layon O Demarchi, Kyle G Dexter, Anthony Di Fiore, Hazimah Haji Mohammad Din, Mathias I Disney, Brice Yannick Djiofack, Marie-Noël K Djuikouo, Tran Van Do, Jean-Louis Doucet, Freddie C Draper, Vincent Droissart, Joost F Duivenvoorden, Julien Engel, Vittoria Estienne, William Farfan-Rios, Sophie Fauset, Kenneth J Feeley, Yuri Oliveira Feitosa, Ted R Feldpausch, Cid Ferreira, Joice Ferreira, Leandro Valle Ferreira, Christine D Fletcher, Bernardo Monteiro Flores, Alusine Fofanah, Ernest G Foli, Émile Fonty, Gabriella M Fredriksson, Alfredo Fuentes, David Galbraith, George Pepe Gallardo Gonzales, Karina Garcia-Cabrera, Roosevelt García-Villacorta, Vitor H F Gomes, Ricardo Zárate Gómez, Therany Gonzales, Rogerio Gribel, Marcelino Carneiro Guedes, Juan Ernesto Guevara, Khalid Rehman Hakeem, Jefferson S Hall, Keith C Hamer, Alan C Hamilton, David J Harris, Rhett D Harrison, Terese B Hart, Andy Hector, Terry W Henkel, John Herbohn, Mireille B N Hockemba, Bruce Hoffman, Milena Holmgren, Euridice N Honorio Coronado, Isau Huamantupa-Chuquimaco, Wannes Hubau, Nobuo Imai, Mariana Victória Irume, Patrick A Jansen, Kathryn J Jeffery, Eliana M Jimenez, Tommaso Jucker, André Braga Junqueira, Michelle Kalamandeen, Narcisse G Kamdem, Kuswata Kartawinata, Emmanuel Kasongo Yakusu, John M Katembo, Elizabeth Kearsley, David Kenfack, Michael Kessler, Thiri Toe Khaing, Timothy J Killeen, Kanehiro Kitayama, Bente Klitgaard, Nicolas Labrière, Yves Laumonier, Susan G W Laurance, William F Laurance, Félix Laurent, Tinh Cong Le, Trai Trong Le, Miguel E Leal, Evlyn Márcia Leão de Moraes Novo, Aurora Levesley, Moses B Libalah, Juan Carlos Licona, Diógenes de Andrade Lima Filho, Jeremy A Lindsell, Aline Lopes, Maria Aparecida Lopes, Jon C Lovett, Richard Lowe, José Rafael Lozada, Xinghui Lu, Nestor K Luambua, Bruno Garcia Luize, Paul Maas, José Leonardo Lima Magalhães, William E Magnusson, Ni Putu Diana Mahayani, Jean-Remy Makana, Yadvinder Malhi, Lorena Maniguaje Rincón, Asyraf Mansor, Angelo Gilberto Manzatto, Beatriz S Marimon, Ben Hur Marimon-Junior, Andrew R Marshall, Maria Pires Martins, Faustin M Mbayu, Marcelo Brilhante de Medeiros, Italo Mesones, Faizah Metali, Vianet Mihindou, Jerome Millet, William Milliken, Hugo F Mogollón, Jean-François Molino, Mohd Nizam Mohd Said, Abel Monteagudo Mendoza, Juan Carlos Montero, Sam Moore, Bonifacio Mostacedo, Linder Felipe Mozombite Pinto, Sharif Ahmed Mukul, Pantaleo K T Munishi, Hidetoshi Nagamasu, Henrique Eduardo Mendonça Nascimento, Marcelo Trindade Nascimento, David Neill, Reuben Nilus, Janaína Costa Noronha, Laurent Nsenga, Percy Núñez Vargas, Lucas Ojo, Alexandre A Oliveira, Edmar Almeida de Oliveira, Fidèle Evouna Ondo, Walter Palacios Cuenca, Susamar Pansini, Marcelo Petratti Pansonato, Marcos Ríos Paredes, Ekananda Paudel, Daniela Pauletto, Richard G Pearson, José Luis Marcelo Pena, R Toby Pennington, Carlos A Peres, Andrea Permana, Pascal Petronelli, Maria Cristina Peñuela Mora, Juan Fernando Phillips, Oliver L Phillips, Georgia Pickavance, Maria Teresa Fernandez Piedade, Nigel C A Pitman, Pierre Ploton, Andreas Popelier, John R Poulsen, Adriana Prieto, Richard B Primack, Hari Priyadi, Lan Qie, Adriano Costa Quaresma, Helder Lima de Queiroz, Hirma Ramirez-Angulo, José Ferreira Ramos, Neidiane Farias Costa Reis, Jan Reitsma, Juan David Cardenas Revilla, Terhi Riutta, Gonzalo Rivas-Torres, Iyan Robiansyah, Maira Rocha, Domingos de Jesus Rodrigues, M Elizabeth Rodriguez-Ronderos, Francesco Rovero, Andes H Rozak, Agustín Rudas, Ervan Rutishauser, Daniel Sabatier, Le Bienfaiteur Sagang, Adeilza Felipe Sampaio, Ismayadi Samsoedin, Manichanh Satdichanh, Juliana Schietti, Jochen Schöngart, Veridiana Vizoni Scudeller, Naret Seuaturien, Douglas Sheil, Rodrigo Sierra, Miles R Silman, Thiago Sanna Freire Silva, José Renan da Silva Guimarães, Murielle Simo-Droissart, Marcelo Fragomeni Simon, Plinio Sist, Thaiane R Sousa, Emanuelle de Sousa Farias, Luiz de Souza Coelho, Dominick V Spracklen, Suzanne M Stas, Robert Steinmetz, Pablo R Stevenson, Juliana Stropp, Rahayu S Sukri, Terry C H Sunderland, Eizi Suzuki, Michael D Swaine, Jianwei Tang, James Taplin, David M Taylor, J Sebastián Tello, John Terborgh, Nicolas Texier, Ida Theilade, Duncan W Thomas, Raquel Thomas, Sean C Thomas, Milton Tirado, Benjamin Toirambe, José Julio de Toledo, Kyle W Tomlinson, Armando Torres-Lezama, Hieu Dang Tran, John Tshibamba Mukendi, Roven D Tumaneng, Maria Natalia Umaña, Peter M Umunay, Ligia Estela Urrego Giraldo, Elvis H Valderrama Sandoval, Luis Valenzuela Gamarra, Tinde R Van Andel, Martin van de Bult, Jaqueline van de Pol, Geertje van der Heijden, Rodolfo Vasquez, César I A Vela, Eduardo Martins Venticinque, Hans Verbeeck, Rizza Karen A Veridiano, Alberto Vicentini, Ima Célia Guimarães Vieira, Emilio Vilanova Torre, Daniel Villarroel, Boris Eduardo Villa Zegarra, Jason Vleminckx, Patricio von Hildebrand, Vincent Antoine Vos, Corine Vriesendorp, Edward L Webb, Lee J T White, Serge Wich, Florian Wittmann, Roderick Zagt, Runguo Zang, Charles Eugene Zartman, Lise Zemagho, Egleé L Zent, Stanford Zent
Trees structure the Earth's most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations1-6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia...
January 10, 2024: Nature
#14
RANDOMIZED CONTROLLED TRIAL
Lauren C Daniel, Kimberly L Venella, Kelsey Woodard, Polina Poliakova, J Yael Gross, Iris N Bercovitz, Dirk Moore, Lamia P Barakat, Jason L Freedman
BACKGROUND: Patients undergoing hematopoietic stem cell transplant (HSCT) experience barriers to quality sleep. Frequent vital sign checks are necessary early posttransplant given risk of complications but can disrupt sleep. This study tested feasibility and acceptability of extending time between checking vitals (EVs) from every 4 to every 6 h to improve sleep. PROCEDURE: HSCT patients ages 8-21 years (N = 50, mean age = 14.06, SD = 3...
April 2024: Pediatric Blood & Cancer
#15
JOURNAL ARTICLE
Machteld J Boonstra, Davy Weissenbacher, Jason H Moore, Graciela Gonzalez-Hernandez, Folkert W Asselbergs
Natural language processing techniques are having an increasing impact on clinical care from patient, clinician, administrator, and research perspective. Among others are automated generation of clinical notes and discharge letters, medical term coding for billing, medical chatbots both for patients and clinicians, data enrichment in the identification of disease symptoms or diagnosis, cohort selection for clinical trial, and auditing purposes. In the review, an overview of the history in natural language processing techniques developed with brief technical background is presented...
February 1, 2024: European Heart Journal
#16
JOURNAL ARTICLE
Ruowang Li, Rui Duan, Lifang He, Jason H Moore
The following sections are included:Introduction to the workshopWorkshop Presenters.
2024: Pacific Symposium on Biocomputing
#17
JOURNAL ARTICLE
Alena Orlenko, Philip J Freda, Attri Ghosh, Hyunjun Choi, Nicholas Matsumoto, Tiffani J Bright, Corey T Walker, Tayo Obafemi-Ajayi, Jason H Moore
This work demonstrates the use of cluster analysis in detecting fair and unbiased novel discoveries. Given a sample population of elective spinal fusion patients, we identify two overarching subgroups driven by insurance type. The Medicare group, associated with lower socioeconomic status, exhibited an over-representation of negative risk factors. The findings provide a compelling depiction of the interwoven socioeconomic and racial disparities present within the healthcare system, highlighting their consequential effects on health inequalities...
2024: Pacific Symposium on Biocomputing
#18
JOURNAL ARTICLE
Jason H Moore, Xi Li, Jui-Hsuan Chang, Nicholas P Tatonetti, Dan Theodorescu, Yong Chen, Folkert W Asselbergs, Mythreye Venkatesan, Zhiping Paul Wang
The concept of a digital twin came from the engineering, industrial, and manufacturing domains to create virtual objects or machines that could inform the design and development of real objects. This idea is appealing for precision medicine where digital twins of patients could help inform healthcare decisions. We have developed a methodology for generating and using digital twins for clinical outcome prediction. We introduce a new approach that combines synthetic data and network science to create digital twins (i...
2024: Pacific Symposium on Biocomputing
#19
JOURNAL ARTICLE
Philip J Tubergen, Greg Medlock, Anni Moore, Xiaomu Zhang, Jason A Papin, Cristian H Danna
Bacterial pathogens adapt their metabolism to the plant environment to successfully colonize their hosts. In our efforts to uncover the metabolic pathways that contribute to the colonization of Arabidopsis thaliana leaves by Pseudomonas syringae pv tomato DC3000 (Pst DC3000), we created iPst19, an ensemble of 100 genome-scale network reconstructions of Pst DC3000 metabolism. We developed a novel approach for gene essentiality screens, leveraging the predictive power of iPst19 to identify core and ancillary condition-specific essential genes...
December 27, 2023: PLoS Computational Biology
#20
Jiayi Tong, Rui Duan, Ruowang Li, Chongliang Luo, Jason H Moore, Jingsan Zhu, Gary D Foster, Kevin G Volpp, William S Yancy, Pamela A Shaw, Yong Chen
No abstract text is available yet for this article.
December 18, 2023: Scientific Reports
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