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Jason Moore

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https://www.readbyqxmd.com/read/28319100/metagenomic-discovery-of-polybrominated-diphenyl-ether-biosynthesis-by-marine-sponges
#1
Vinayak Agarwal, Jessica M Blanton, Sheila Podell, Arnaud Taton, Michelle A Schorn, Julia Busch, Zhenjian Lin, Eric W Schmidt, Paul R Jensen, Valerie J Paul, Jason S Biggs, James W Golden, Eric E Allen, Bradley S Moore
Naturally produced polybrominated diphenyl ethers (PBDEs) pervade the marine environment and structurally resemble toxic man-made brominated flame retardants. PBDEs bioaccumulate in marine animals and are likely transferred to the human food chain. However, the biogenic basis for PBDE production in one of their most prolific sources, marine sponges of the order Dysideidae, remains unidentified. Here, we report the discovery of PBDE biosynthetic gene clusters within sponge-microbiome-associated cyanobacterial endosymbionts through the use of an unbiased metagenome-mining approach...
March 20, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28275193/structure-based-design-of-a-soluble-prefusion-closed-hiv-1-env-trimer-with-reduced-cd4-affinity-and-improved-immunogenicity
#2
Gwo-Yu Chuang, Hui Geng, Marie Pancera, Kai Xu, Cheng Cheng, Priyamvada Acharya, Michael Chambers, Aliaksandr Druz, Yaroslav Tsybovsky, Timothy G Wanninger, Yongping Yang, Nicole A Doria-Rose, Ivelin S Georgiev, Jason Gorman, M Gordon Joyce, Sijy O'Dell, Tongqing Zhou, Adrian B McDermott, John R Mascola, Peter D Kwong
The HIV-1-envelope (Env) trimer is a target for vaccine design as well as a conformational machine that facilitates virus entry by transitioning between prefusion-closed, CD4-bound, and co-receptor-bound conformations before rearranging into a postfusion state. Vaccine designers have sought to restrict the conformation of the HIV-1-Env trimer to its prefusion-closed state, as this state is recognized by most broadly neutralizing -but not by non-neutralizing- antibodies. We previously identified a disulfide bond, I201C-A433C (DS), which stabilizes Env in the vaccine-desired prefusion-closed state...
March 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28271566/minimum-lymph-node-yield-in-elective-level-i-iii-neck-dissection
#3
Jason D Pou, Blair M Barton, Claire M Lawlor, Christopher H Frederick, Brian A Moore, Christian P Hasney
OBJECTIVES/HYPOTHESIS: Unlike lymphadenectomy at other sites, there is no discrete lymph node count defining an adequate neck dissection. The purpose of this study was to determine the minimum lymph node yield (LNY) of an elective level I-III neck dissection required to reliably capture any positive nodes present in these nodal basins. STUDY DESIGN: Retrospective single-institution analysis. METHODS: All patients with the diagnosis of head and neck squamous cell carcinoma who underwent elective level I-III neck dissection between 2004 and 2015 at our institution were analyzed...
March 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28261008/a-low-cost-open-source-compliant-hand-for-enabling-sensorimotor-control-for-people-with-transradial-amputations
#4
Aadeel Akhtar, Kyung Yun Choi, Michael Fatina, Jesse Cornman, Edward Wu, Joseph Sombeck, Chris Yim, Patrick Slade, Jason Lee, Jack Moore, Daniel Gonzales, Alvin Wu, Garrett Anderson, David Rotter, Cliff Shin, Timothy Bretl
In this paper, we describe the design and implementation of a low-cost, open-source prosthetic hand that enables both motor control and sensory feedback for people with transradial amputations. We integrate electromyographic pattern recognition for motor control along with contact reflexes and sensory substitution to provide feedback to the user. Compliant joints allow for robustness to impacts. The entire hand can be built for around $550. This low cost makes research and development of sensorimotor prosthetic hands more accessible to researchers worldwide, while also being affordable for people with amputations in developing nations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28250200/cxcl14-is-a-candidate-biomarker-for-hedgehog-signalling-in-idiopathic-pulmonary-fibrosis
#5
Guiquan Jia, Sanjay Chandriani, Alexander R Abbas, Daryle J DePianto, Elsa N N'Diaye, Murat B Yaylaoglu, Heather M Moore, Ivan Peng, Jason DeVoss, Harold R Collard, Paul J Wolters, Jackson G Egen, Joseph R Arron
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with aberrant expression of developmental pathways, including Hedgehog (Hh). As Hh signalling contributes to multiple pro-fibrotic processes, Hh inhibition may represent a therapeutic option for IPF. However, no non-invasive biomarkers are available to monitor lung Hh activity. METHODS: We assessed gene and protein expression in IPF and control lung biopsies, mouse lung, fibroblasts stimulated in vitro with sonic hedgehog (SHh), and plasma in IPF patients versus controls, and cancer patients before and after treatment with vismodegib, a Hh inhibitor...
March 1, 2017: Thorax
https://www.readbyqxmd.com/read/28244969/patients-attitudes-toward-nonphysician-screening-of-low-back-and-low-back-related-leg-pain-complaints-referred-for-surgical-assessment
#6
Joshua Rempel, Jason W Busse, Brian Drew, Kesava Reddy, Aleksa Cenic, Edward Kachur, Naresh Murty, Henry Candelaria, Ainsley E Moore, John J Riva
STUDY DESIGN: A questionnaire survey. OBJECTIVE: The aim of this study was to explore patient attitudes toward screening to assess suitability for low back surgery by nonphysician health care providers. SUMMARY OF BACKGROUND DATA: Canadian spine surgeons have shown support for nonphysician screening to assess and triage patients with low back pain and low back related leg pain. However, patients' attitudes toward this proposed model are largely unknown...
March 2017: Spine
https://www.readbyqxmd.com/read/28239419/variant-set-enrichment-an-r-package-to-identify-disease-associated-functional-genomic-regions
#7
Musaddeque Ahmed, Richard C Sallari, Haiyang Guo, Jason H Moore, Housheng Hansen He, Mathieu Lupien
BACKGROUND: Genetic predispositions to diseases populate the noncoding regions of the human genome. Delineating their functional basis can inform on the mechanisms contributing to disease development. However, this remains a challenge due to the poor characterization of the noncoding genome. Here, we propose an R package that can pinpoint which genomic features are etiologically important based on the genetic predispositions. RESULTS: Variant Set Enrichment (VSE) is an R package to calculate the enrichment of a set of disease-associated variants across functionally annotated genomic regions, consequently highlighting the mechanisms important in the etiology of the disease studied...
2017: BioData Mining
https://www.readbyqxmd.com/read/28227547/a-low-cost-open-source-compliant-hand-for-enabling-sensorimotor-control-for-people-with-transradial-amputations
#8
Aadeel Akhtar, Kyung Yun Choi, Michael Fatina, Jesse Cornman, Edward Wu, Joseph Sombeck, Chris Yim, Patrick Slade, Jason Lee, Jack Moore, Daniel Gonzales, Alvin Wu, Garrett Anderson, David Rotter, Cliff Shin, Timothy Bretl, Aadeel Akhtar, Kyung Yun Choi, Michael Fatina, Jesse Cornman, Edward Wu, Joseph Sombeck, Chris Yim, Patrick Slade, Jason Lee, Jack Moore, Daniel Gonzales, Alvin Wu, Garrett Anderson, David Rotter, Cliff Shin, Timothy Bretl, Kyung Yun Choi, Michael Fatina, Chris Yim, Jesse Cornman, Alvin Wu, Garrett Anderson, Jason Lee, Edward Wu, Daniel Gonzales, Aadeel Akhtar, David Rotter, Cliff Shin, Timothy Bretl, Patrick Slade, Jack Moore, Joseph Sombeck
In this paper, we describe the design and implementation of a low-cost, open-source prosthetic hand that enables both motor control and sensory feedback for people with transradial amputations. We integrate electromyographic pattern recognition for motor control along with contact reflexes and sensory substitution to provide feedback to the user. Compliant joints allow for robustness to impacts. The entire hand can be built for around $550. This low cost makes research and development of sensorimotor prosthetic hands more accessible to researchers worldwide, while also being affordable for people with amputations in developing nations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225738/pneumatosis-intestinalis-predictive-evaluation-study-a-multicenter-epidemiologic-study-of-the-american-association-for-the-surgery-of-trauma
#9
Paula Ferrada, Rachael Callcut, Graciela Bauza, Karen R O'Bosky, Xian Luo-Owen, Nicky J Mansfield, Kenji Inaba, Jason Pasley, Nikolay Bugaev, Bruno Pereira, Forrest O Moore, Jinfeng Han, Amelia Pasley, Joseph DuBose
BACKGROUND: Our group has previously published a retrospective review defining variables predictive of transmural bowel ischemia in the setting of pneumatosis intestinalis (PI). We hypothesize this prospective study will confirm the findings of the retrospective review, enhancing legitimacy to the predictive factors for pathologic PI previously highlighted. METHODS: Data were collected using the Research Electronic Data Capture. Forward logistic regression was utilized to identify independent predictors for pathologic PI...
March 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28155079/fluorescence-imaging-for-cancer-screening-and-surveillance
#10
K E Tipirneni, E L Rosenthal, L S Moore, A D Haskins, N Udayakumar, A H Jani, W R Carroll, A B Morlandt, M Bogyo, J Rao, Jason M Warram
The advent of fluorescence imaging (FI) for cancer cell detection in the field of oncology is promising for both cancer screening and surgical resection. Particularly, FI in cancer screening and surveillance is actively being evaluated in many new clinical trials with over 30 listed on Clinical Trials.gov . While surgical resection forms the foundation of many oncologic treatments, early detection is the cornerstone for improving outcomes and reducing cancer-related morbidity and mortality. The applications of FI are twofold as it can be applied to high-risk patients in addition to those undergoing active surveillance...
February 2, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28148964/cellular-prion-protein-is-present-in-mitochondria-of-healthy-mice
#11
Robert Faris, Roger A Moore, Anne Ward, Brent Race, David W Dorward, Jason R Hollister, Elizabeth R Fischer, Suzette A Priola
Cellular prion protein (PrP(C)) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycophosphatidylinositol (GPI) anchor. PrP(C) misfolds to a pathogenic isoform PrP(Sc), the causative agent of neurodegenerative prion diseases. The precise function of PrP(C) remains elusive but may depend upon its cellular localization. Here we show that PrP(C) is present in brain mitochondria from 6-12 week old wild-type and transgenic mice in the absence of disease. Mitochondrial PrP(C) was fully processed with mature N-linked glycans and did not require the GPI anchor for localization...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28133797/ontogeny-based-immunogens-for-the-induction-of-v2-directed-hiv-broadly-neutralizing-antibodies
#12
REVIEW
Penny L Moore, Jason Gorman, Nicole A Doria-Rose, Lynn Morris
The development of a preventative HIV vaccine able to elicit broadly neutralizing antibodies (bNAbs) remains a major challenge. Antibodies that recognize the V2 region at the apex of the HIV envelope trimer are among the most common bNAb specificities during chronic infection and many exhibit remarkable breadth and potency. Understanding the developmental pathway of these antibodies has provided insights into their precursors, and the viral strains that engage them, as well as defined how such antibodies mature to acquire breadth...
January 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28112924/discovery-of-pyrrolidine-containing-gpr40-agonists-stereochemistry-effects-a-change-in-binding-mode
#13
Elizabeth A Jurica, Ximao Wu, Kristin N Williams, Andres S Hernandez, David S Nirschl, Richard A Rampulla, Arvind Mathur, Min Zhou, Gary Cao, Chunshan Xie, Biji Jacob, Hong Cai, Tao Wang, Brian J Murphy, Heng Liu, Carrie Xu, Lori K Kunselman, Michael B Hicks, Qin Sun, Dora M Schnur, Doree F Sitkoff, Elizabeth A Dierks, Atsu Apedo, Douglas B Moore, Kimberly A Foster, Mary Ellen Cvijic, Reshma Panemangalore, Neil A Flynn, Brad D Maxwell, Yang Hong, Yuan Tian, Jason J Wilkes, Bradley A Zinker, Jean M Whaley, Joel C Barrish, Jeffrey A Robl, William R Ewing, Bruce A Ellsworth
A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-cis-CF3 to the pyrrolidine improves the human GPR40 binding Ki and agonist efficacy. After further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the radioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displacing the radioligand...
February 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28092686/epigenomic-reprogramming-during-pancreatic-cancer-progression-links-anabolic-glucose-metabolism-to-distant-metastasis
#14
Oliver G McDonald, Xin Li, Tyler Saunders, Rakel Tryggvadottir, Samantha J Mentch, Marc O Warmoes, Anna E Word, Alessandro Carrer, Tal H Salz, Sonoko Natsume, Kimberly M Stauffer, Alvin Makohon-Moore, Yi Zhong, Hao Wu, Kathryn E Wellen, Jason W Locasale, Christine A Iacobuzio-Donahue, Andrew P Feinberg
During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death. However, the genetics of metastases largely reflects that of the primary tumor in untreated patients, and PDAC driver mutations are shared by all subclones. This raises the possibility that an epigenetic process might operate during metastasis. Here we report large-scale reprogramming of chromatin modifications during the natural evolution of distant metastasis...
March 2017: Nature Genetics
https://www.readbyqxmd.com/read/28089180/enteric-coating-and-aspirin%C3%A2-nonresponsiveness-in-patients%C3%A2-with-type%C3%A2-2%C3%A2-diabetes-mellitus
#15
Deepak L Bhatt, Tilo Grosser, Jing-Fei Dong, Douglas Logan, Walter Jeske, Dominick J Angiolillo, Andrew L Frelinger, Lanyu Lei, Juan Liang, Jason E Moore, Byron Cryer, Upendra Marathi
BACKGROUND: A limitation of aspirin is that some patients, particularly those with diabetes, may not have an optimal antiplatelet effect. OBJECTIVES: The goal of this study was to determine if oral bioavailability mediates nonresponsiveness. METHODS: The rate and extent of serum thromboxane generation and aspirin pharmacokinetics were measured in 40 patients with diabetes in a randomized, single-blind, triple-crossover study. Patients were exposed to three 325-mg aspirin formulations: plain aspirin, PL2200 (a modified-release lipid-based aspirin), and a delayed-release enteric-coated (EC) aspirin...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28076415/structure-and-recognition-of-a-novel-hiv-1-gp120-gp41-interface-antibody-that-caused-mper-exposure-through-viral-escape
#16
Constantinos Kurt Wibmer, Jason Gorman, Gabriel Ozorowski, Jinal N Bhiman, Daniel J Sheward, Debra H Elliott, Julie Rouelle, Ashley Smira, M Gordon Joyce, Nonkululeko Ndabambi, Aliaksandr Druz, Mangai Asokan, Dennis R Burton, Mark Connors, Salim S Abdool Karim, John R Mascola, James E Robinson, Andrew B Ward, Carolyn Williamson, Peter D Kwong, Lynn Morris, Penny L Moore
A comprehensive understanding of the regions on HIV-1 envelope trimers targeted by broadly neutralizing antibodies may contribute to rational design of an HIV-1 vaccine. We previously identified a participant in the CAPRISA cohort, CAP248, who developed trimer-specific antibodies capable of neutralizing 60% of heterologous viruses at three years post-infection. Here, we report the isolation by B cell culture of monoclonal antibody CAP248-2B, which targets a novel membrane proximal epitope including elements of gp120 and gp41...
2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28067909/smchd1-mutations-associated-with-a-rare-muscular-dystrophy-can-also-cause-isolated-arhinia-and-bosma-arhinia-microphthalmia-syndrome
#17
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-Ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders...
February 2017: Nature Genetics
https://www.readbyqxmd.com/read/28045715/oncologic-procedures-amenable-to-fluorescence-guided-surgery
#18
Kiranya E Tipirneni, Jason M Warram, Lindsay S Moore, Andrew C Prince, Esther de Boer, Aditi H Jani, Irene L Wapnir, Joseph C Liao, Michael Bouvet, Nicole K Behnke, Mary T Hawn, George A Poultsides, Alexander L Vahrmeijer, William R Carroll, Kurt R Zinn, Eben Rosenthal
OBJECTIVE: Although fluorescence imaging is being applied to a wide range of cancers, it remains unclear which disease populations will benefit greatest. Therefore, we review the potential of this technology to improve outcomes in surgical oncology with attention to the various surgical procedures while exploring trial endpoints that may be optimal for each tumor type. BACKGROUND: For many tumors, primary treatment is surgical resection with negative margins, which corresponds to improved survival and a reduction in subsequent adjuvant therapies...
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28030499/the-coalition-for-national-trauma-research-cntr-supports-the-call-for-a-national-trauma-research-action-plan
#19
Raul Coimbra, Rosemary A Kozar, Jason W Smith, Ben L Zarzaur, Carl J Hauser, Frederick A Moore, Jeffrey A Bailey, Alex Valadka, Gregory J Jurkovich, Donald H Jenkins, Kimberly A Davis, Michelle A Price, Ronald V Maier
No abstract text is available yet for this article.
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28029313/safety-and-activity-of-mirvetuximab-soravtansine-imgn853-a-folate-receptor-alpha-targeting-antibody-drug-conjugate-in-platinum-resistant-ovarian-fallopian-tube-or-primary-peritoneal-cancer-a-phase-i-expansion-study
#20
Kathleen N Moore, Lainie P Martin, David M O'Malley, Ursula A Matulonis, Jason A Konner, Raymond P Perez, Todd M Bauer, Rodrigo Ruiz-Soto, Michael J Birrer
Purpose This phase I expansion cohort study evaluated the safety and clinical activity of mirvetuximab soravtansine (IMGN853), an antibody-drug conjugate consisting of a humanized anti-folate receptor alpha (FRα) monoclonal antibody linked to the tubulin-disrupting maytansinoid DM4, in a population of patients with FRα-positive and platinum-resistant ovarian cancer. Patients and Methods Patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer received IMGN853 at 6...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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