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Jason Moore

Xiaohui Yao, Jingwen Yan, Sungeun Kim, Kwangsik Nho, Shannon L Risacher, Mark Inlow, Jason H Moore, Andrew J Saykin, Li Shen
Enrichment analysis has been widely applied in the genome-wide association studies, where gene sets corresponding to biological pathways are examined for significant associations with a phenotype to help increase statistical power and improve biological interpretation. In this work, we expand the scope of enrichment analysis into brain imaging genetics, an emerging field that studies how genetic variation influences brain structure and function measured by neuroimaging quantitative traits (QT). Given the high dimensionality of both imaging and genetic data, we propose to study Imaging Genetic Enrichment Analysis (IGEA), a new enrichment analysis paradigm that jointly considers meaningful gene sets (GS) and brain circuits (BC) and examines whether any given GS-BC pair is enriched in a list of gene-QT findings...
May 13, 2016: Brain Informatics
Nuri Kodaman, Melinda C Aldrich, Rafal Sobota, Folkert W Asselbergs, Kwabena A Poku, Nancy J Brown, Jason H Moore, Scott M Williams
Populations in sub-Saharan Africa are shifting from rural to increasingly urban. Although the burden of cardiovascular disease is expected to increase with this changing landscape, few large studies have assessed a wide range of risk factors in urban and rural populations, particularly in West Africa. We conducted a cross-sectional, population-based survey of 3317 participants from Ghana (≥18 years old), of whom 2265 (57% female) were from a mid-sized city (Sunyani, population ~250,000) and 1052 (55% female) were from surrounding villages (populations <5000)...
2016: PloS One
Sarah A Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y Ma
BACKGROUND: Intestinal barrier dysfunction has been implicated in necrotizing enterocolitis (NEC), but has not been directly measured in human NEC. METHODS: Small intestines removed during surgery were immediately mounted in an Ussing chamber. mRNA expression of tight junction (TJ) proteins was measured with RT-PCR. RESULTS: Fifteen infants were included, 5 with NEC and 10 with other diagnoses. Average transepithelial resistance (TER) was 11...
September 15, 2016: Journal of Pediatric Surgery
Maya Matheis, Johnny L Matson, Claire O Burns, Xinrui Jiang, W Jason Peters, Michael Moore, Kaitlin A de Back, Jasper Estabillo
PURPOSE: The age of first concern (AOC) of parents of children with autism spectrum disorders (ASD) has substantial implications for early diagnosis and intervention. The current study sought to determine the average AOC, what types of first concerns are most common, and what factors predict earlier AOC in toddlers with ASD. METHODS: This study analyzed the predictive influence of the type of concern, symptom severity, medical diagnoses, and other independent variables on AOC among toddlers with ASD using multiple regressions...
August 11, 2016: Developmental Neurorehabilitation
Jason D Jones, J Cobb Scott, Monica E Calkins, Kosha Ruparel, Tyler M Moore, Ruben C Gur, Raquel E Gur
Inclusion of collateral informant reports is common in adolescent psychopathology research and clinical assessment, yet few studies have examined agreement on ratings of adolescent substance use or factors that may be associated with reporter agreement. The present study aimed to extend prior work on the correspondence between adolescent and informant reports of adolescent substance use with data from a large (n=5214), diverse, community-based sample of youth aged 11-17 (mean age=14.53, SD=1.98; 52% female)...
September 22, 2016: Addictive Behaviors
Michael G Stanford, Kyle Mahady, Brett B Lewis, Jason D Fowlkes, Shida Tan, Richard H Livengood, Gregory A Magel, Thomas M Moore, Philip D Rack
Focused helium ion (He+) milling has been demonstrated as a high-resolution nanopatterning technique, however it can be limited by its low sputter yield as well as the introduction of undesired sub-surface damage. Here, we introduce pulsed laser and gas assisted processes to enhance the material removal rate and patterning fidelity. A pulsed laser-assisted He+ milling process is shown to enable high resolution milling of titanium while reducing sub-surface damage in situ. Gas-assisted focused ion beam induced etching (FIBIE) of Ti is also demonstrated in which the XeF2 precursor provides a chemical assist for enhanced material removal rate...
October 4, 2016: ACS Applied Materials & Interfaces
Nuri Kodaman, Melinda C Aldrich, Rafal Sobota, Folkert W Asselbergs, Nancy J Brown, Jason H Moore, Scott M Williams
BACKGROUND: Metabolic syndrome (MetS) is diagnosed by the presence of at least 3 of the following: obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low high-density lipoprotein. Individuals with MetS also typically have elevated plasma levels of the antifibrinolytic factor, plasminogen activator inhibitor-1 (PAI-1), but the relationships between PAI-1 and MetS diagnostic criteria are not clear. Understanding these relationships can elucidate the relevance of MetS to cardiovascular disease risk, because PAI-1 is associated with ischemic events and directly involved in thrombosis...
October 3, 2016: Journal of the American Heart Association
Romolo Gaspari, Anthony Weekes, Srikar Adhikari, Vicki E Noble, Jason T Nomura, Daniel Theodoro, Michael Woo, Paul Atkinson, David Blehar, Samuel M Brown, Terrell Caffery, Emily Douglass, Jacqueline Fraser, Christine Haines, Samuel Lam, Michael Lanspa, Margaret Lewis, Otto Liebmann, Alexander Limkakeng, Fernando Lopez, Elke Platz, Michelle Mendoza, Hal Minnigan, Christopher Moore, Joseph Novik, Louise Rang, Will Scruggs, Christopher Raio
BACKGROUND: Point-of-care ultrasound has been suggested to improve outcomes from advanced cardiac life support (ACLS), but no large studies have explored how it should be incorporated into ACLS. Our aim was to determine whether cardiac activity on ultrasound during ACLS is associated with improved survival. METHODS: We conducted a non-randomized, prospective, protocol-driven observational study at 20 hospitals across United States and Canada. Patients presenting with out-of-hospital arrest or in-ED arrest with pulseless electrical activity or asystole were included...
September 28, 2016: Resuscitation
Spiros C Denaxas, Folkert W Asselbergs, Jason H Moore
Modern cohort studies include self-reported measures on disease, behavior and lifestyle, sensor-based observations from mobile phones and wearables, and rich -omics data. Follow-up is often achieved through electronic health record (EHR) linkages across primary and secondary healthcare providers. Historically however, researchers typically only get to see the tip of the iceberg: coded administrative data relating to healthcare claims which mainly record billable diagnoses and procedures. The rich data generated during the clinical pathway remain submerged and inaccessible...
2016: BioData Mining
Joseph Zenga, Ryan S Jackson, Evan M Graboyes, Parul Sinha, Miranda Lindberg, Eliot J Martin, Daniel Ma, Wade L Thorstad, Jason T Rich, Eric J Moore, Bruce H Haughey
OBJECTIVES: To examine outcomes of selective neck dissection (SND) in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) who present with clinical neck disease. STUDY DESIGN: Multi-institutional retrospective review. METHODS: Two institutional databases of patients with HPV-related OPSCC were reviewed to identify patients with clinical (c) N1-N3 neck disease who underwent SND ± adjuvant therapy...
September 16, 2016: Laryngoscope
Jason R Vogel, Trisha L Moore
The following review presents a synthesis of 181 journal articles published during 2015 that represent progress toward better characterizing, controlling, and treating urban stormwater runoff. The review is structured by general topical areas related to (1) stormwater quality and quantity characterization; (2) engineered stormwater control and treatment practices, including erosion and sediment control, stormwater ponds, constructed stormwater wetlands, bioretention, permeable pavement, greenroofs, and rainwater harvesting systems; and (3) watershed-scale modeling and optimization of stormwater control and treatment practices...
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
Pallav A Bulsara, Peter Varlashkin, Jason Dickens, David J Moore, Anthony Vincent Rawlings, Martyn J Clarke
OBJECTIVE: The focus of this communication is the study of phospholipid structured-emulsions whose phase behavior is modified with monoalkyl fatty amphiphiles. Ideally these systems would mimic key physical and structural attributes observed in human stratum corneum (SC)(7) so that they better alleviate xerotic skin conditions. METHODS: Phosphatidylcholine structured emulsions were prepared and their phase behavior modified with monoalkyl fatty amphiphiles. The effect of molecular volume, acyl chain length and head-group interactions was studied using a combination of physical methods...
September 10, 2016: International Journal of Cosmetic Science
John C Moore, Timothy S Mulligan, Nora Torres Yordán, Daniel Castranova, Van N Pham, Qin Tang, Riadh Lobbardi, Anthony Anselmo, Robert S Liwski, Jason N Berman, Ruslan I Sadreyev, Brant M Weinstein, David M Langenau
The zeta-chain (TCR) associated protein kinase 70kDa (ZAP70) is required for T-cell activation. ZAP70 deficiencies in humans and null mutations in mice lead to severe combined immunodeficiency. Here, we describe a zap70 loss-of-function mutation in zebrafish (zap70(y442)) that was created using TALENs. In contrast to what has been reported in morphant zebrafish, zap70(y442) homozygous mutant zebrafish displayed normal development of blood and lymphatic vasculature. Hematopoietic cell development was also largely unaffected in mutant larvae...
September 6, 2016: Molecular and Cellular Biology
Lyndon D Bastatas, Kuo-Yao Lin, Matthew D Moore, Kristin J Suhr, Melanie H Bowler, Yulong Shen, Bradley J Holliday, Jason D Slinker
Light-emitting electrochemical cells (LEECs) from small molecules, such as iridium complexes, have great potential as low-cost emissive devices. In these devices, ions rearrange during operation to facilitate carrier injection, bringing about efficient operation from simple, single-layer devices. Prior work has shown that the luminance, efficiency, and responsiveness of iridium LEECs is greatly enhanced by the inclusion of small fractions of lithium salts, but much remains to be understood about the origin of this enhancement...
September 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Lindsay Scott Moore, Eben L Rosenthal, Thomas K Chung, Esther de Boer, Neel Patel, Andrew C Prince, Melissa L Korb, Erika M Walsh, Erik Scott Young, Todd M Stevens, Kirk P Withrow, Anthony B Morlandt, Joshua Richman, William R Carroll, Kurt R Zinn, Jason M Warram
RATIONALE: To assess the potential of US Food and Drug Administration cleared devices designed for indocyanine green-based perfusion imaging to identify cancer-specific bioconjugates with overlapping excitation and emission wavelengths. BACKGROUND: Recent clinical trials have demonstrated potential for fluorescence-guided surgery, but the time and cost of the approval process may impede clinical translation. To expedite this translation, we explored the feasibility of repurposing existing optical imaging devices for fluorescence-guided surgery...
September 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
James J Finneran, Jason Mulsow, Brian Branstetter, Patrick Moore, Dorian S Houser
The potential for bottlenose dolphins to actively focus their biosonar transmissions was examined by measuring emitted clicks in four dolphins using horizontal, planar hydrophone arrays. Two hydrophone configurations were used: a rectangular array with hydrophones 0.2 to 2 m from the dolphins and a polar array with hydrophones 0.5 to 5 m from the dolphins. The biosonar task was a target change detection utilizing physical targets at ranges from 1.3 to 6.3 m with all subjects and "phantom" targets at simulated ranges from 2...
August 2016: Journal of the Acoustical Society of America
Lei Du, Heng Huang, Jingwen Yan, Sungeun Kim, Shannon Risacher, Mark Inlow, Jason Moore, Andrew Saykin, Li Shen
BACKGROUND: Recently, structured sparse canonical correlation analysis (SCCA) has received increased attention in brain imaging genetics studies. It can identify bi-multivariate imaging genetic associations as well as select relevant features with desired structure information. These SCCA methods either use the fused lasso regularizer to induce the smoothness between ordered features, or use the signed pairwise difference which is dependent on the estimated sign of sample correlation...
2016: BMC Systems Biology
Constantinos Kurt Wibmer, Jason Gorman, Colin S Anthony, Nonhlanhla N Mkhize, Aliaksandr Druz, Talita York, Stephen D Schmidt, Phillip Labuschagne, Mark K Louder, Robert T Bailer, Salim S Abdool Karim, John R Mascola, Carolyn Williamson, Penny L Moore, Peter D Kwong, Lynn Morris
: All HIV-1 infected individuals develop strain-specific neutralizing antibodies to their infecting virus, which in some cases mature into broadly neutralizing antibodies. Defining the epitopes of strain-specific antibodies that overlap with conserved sites of vulnerability might provide mechanistic insights into how broadly neutralizing antibodies arise. We have previously described an HIV-1 clade C infected donor, CAP257, who developed broadly neutralizing plasma antibodies targeting an N276 glycan-dependent epitope in the CD4 binding site...
August 31, 2016: Journal of Virology
H Robert Frost, Li Shen, Andrew J Saykin, Scott M Williams, Jason H Moore
Although gene-environment (G× E) interactions play an important role in many biological systems, detecting these interactions within genome-wide data can be challenging due to the loss in statistical power incurred by multiple hypothesis correction. To address the challenge of poor power and the limitations of existing multistage methods, we recently developed a screening-testing approach for G× E interaction detection that combines elastic net penalized regression with joint estimation to support a single omnibus test for the presence of G× E interactions...
November 2016: Genetic Epidemiology
Tracey Jones-Hughes, Tristan Snowsill, Marcela Haasova, Helen Coelho, Louise Crathorne, Chris Cooper, Ruben Mujica-Mota, Jaime Peters, Jo Varley-Campbell, Nicola Huxley, Jason Moore, Matt Allwood, Jenny Lowe, Chris Hyde, Martin Hoyle, Mary Bond, Rob Anderson
BACKGROUND: End-stage renal disease is a long-term irreversible decline in kidney function requiring renal replacement therapy: kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation, followed by immunosuppressive therapy (induction and maintenance therapy) to reduce the risk of kidney rejection and prolong graft survival. OBJECTIVES: To review and update the evidence for the clinical effectiveness and cost-effectiveness of basiliximab (BAS) (Simulect(®), Novartis Pharmaceuticals UK Ltd) and rabbit anti-human thymocyte immunoglobulin (rATG) (Thymoglobulin(®), Sanofi) as induction therapy, and immediate-release tacrolimus (TAC) (Adoport(®), Sandoz; Capexion(®), Mylan; Modigraf(®), Astellas Pharma; Perixis(®), Accord Healthcare; Prograf(®), Astellas Pharma; Tacni(®), Teva; Vivadex(®), Dexcel Pharma), prolonged-release tacrolimus (Advagraf(®) Astellas Pharma), belatacept (BEL) (Nulojix(®), Bristol-Myers Squibb), mycophenolate mofetil (MMF) (Arzip(®), Zentiva; CellCept(®), Roche Products; Myfenax(®), Teva), mycophenolate sodium (MPS) (Myfortic(®), Novartis Pharmaceuticals UK Ltd), sirolimus (SRL) (Rapamune(®), Pfizer) and everolimus (EVL) (Certican(®), Novartis) as maintenance therapy in adult renal transplantation...
August 2016: Health Technology Assessment: HTA
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