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S Ferdousi, S Akhtar, S Begum
This study assessed maternal serum copper and zinc levels in preeclampsia to find out the role of trace element disorder in the aetiology of preeclampsia. This cross sectional study was conducted in the dept of Physiology of BSMMU during 2009. Sixty patients of Preeclampsia (BP--140/90 aged 18-39 years, with >20th weeks of pregnancy with proteinuria and edema) participated. Thirty normotensive gravida was control. All subjects were collected from in and out patient department of Obstetric and Gynecology of BSMMU and Dhaka medical college hospital...
October 2015: Mymensingh Medical Journal: MMJ
Masatoshi Nakagawa, Kazuyuki Kojima, Mikito Inokuchi, Keiji Kato, Hirofumi Sugita, Sho Otsuki, Kyoko Higuchi, Kenta Kobayashi, Kenichi Sugihara
BACKGROUND: Some recent reports have noted that copper deficiency can occur in obese patients who have undergone bariatric surgery, such as Roux-en-Y (RY) gastric bypass or biliopancreatic diversion, or in patients who receive enteral nutrition through a jejunostomy. No reports appear to have assessed the serum copper state of patients following gastrectomy with RY reconstruction for gastric cancer. METHODS: A cross-sectional study was conducted from June 2013 to December 2014...
2015: Digestive Surgery
Camila Bitu Moreno Braga, Iahel Manon de Lima Ferreira, Júlio Sérgio Marchini, Selma Freire de Carvalho da Cunha
BACKGROUND: Patients with short bowel syndrome have significant fluid and electrolytes loss. OBJECTIVE: Evaluate the mineral and electrolyte status in short bowel syndrome patients receiving intermittent parenteral nutrition or oral feeding. METHODS: Twenty two adults with short bowel syndrome, of whom 11 were parenteral nutrition dependent (PN group), and the 11 remaining had been weaned off parenteral nutrition for at least 1 year and received all nutrients by oral feeding (OF group)...
April 2015: Arquivos de Gastroenterologia
Aarathi R Rau, M Usha, Pooja Mallya, A T K Rau
We describe a sixteen year old with Wilson's disease on copper chelation and subsequent high dose oral zinc who developed severe anemia and neutropenia. Bone marrow aspirate done to evaluate the cause of bicytopenia revealed trilineage dysplasia. Correlating the clinical context with bone marrow and biochemical parameters, copper deficiency was suspected and he was given a trial of therapy, following which the hematological parameters improved. This case highlights hypocupremia as a reversible cause of bone marrow dysplasia in patients with Wilson's disease on chelation, where serum copper levels are not useful in the diagnosis...
September 2014: Indian Journal of Hematology & Blood Transfusion
Rekha Bhat, Swati Pai, Ashish Dixit
Copper plays an essential role in numerous enzymatic reactions in the human body and hypocupremia manifests itself as cytopenias and/or neuropathy. Copper deficiency is also a mimic of dysplasia, and this may cause diagnostic difficulties with true myelodysplasia. In this case report, we present a patient with anaemia, thrombocytopenia and marginally decreased leucocyte count, who was found to have low copper levels. In addition, he had isolated 20q deletion and a small paroxysmal nocturnal haemoglobinuria clone, which have not been reported previously...
September 2014: Indian Journal of Hematology & Blood Transfusion
Shivam Om Mittal, Duarte G Machado
BACKGROUND: We report a patient, diagnosed with late cortical cerebellar atrophy, who had persistent low serum copper levels. CASE REPORT: A 48-year-old male developed progressive difficulty with balance, frequent falls, and dysarthric speech, which worsened over a short time span. He had an extensive ataxia work-up, which was unremarkable except for persistent low serum copper levels despite adequate supplementation. Magnetic resonance imaging of the brain showed marked cerebellar atrophy...
2014: Tremor and Other Hyperkinetic Movements
H Kodera, N Ando, I Yuasa, Y Wada, Y Tsurusaki, M Nakashima, N Miyake, S Saitoh, N Matsumoto, H Saitsu
The conserved oligomeric Golgi (COG) complex is involved in intra-Golgi retrograde trafficking, and mutations in six of its eight subunits have been reported in congenital disorders of glycosylation (CDG). Here we report a patient showing severe acquired microcephaly, psychomotor retardation, seizures, liver dysfunction, hypocupremia, and hypoceruloplasminemia. Analysis of his serum glycoproteins revealed defects in both sialylation and galactosylation of glycan termini. Trio-based whole-exome sequencing identified two heterozygous mutations in COG2: a de novo frameshift mutation [c...
May 2015: Clinical Genetics
Sara D Robinson, Barry Cooper, Temekka V Leday
Hypocupremia, or copper deficiency, is a rare and underrecognized cause of bone marrow dysplasia. Most cases of copper deficiency in adults occurred historically in patients receiving total parenteral hyperalimentation or total parental nutrition. More recently, with the obesity epidemic and the prevalence of gastric bypass, cases of malabsorption-related copper deficiency have occurred. Copper deficiency can lead to significant cytopenias and possible neurologic sequelae, which can be misdiagnosed and mismanaged...
October 2013: Proceedings of the Baylor University Medical Center
Farhard Khimani, Ryan Livengood, Olukemi Esan, Jeffrey A Vos, Vivek Abhyankar, Ludwig Gutmann, William Tse
Copper deficiency resulting in hypocupremia is a rare cause of pancytopenia associated with a neurological syndrome. Hypocupremia may also occur as a consequence of excessive oral zinc consumption as described by Brewer et al and several other groups. Dental fixatives have been described as a potential source of hyperzincemia in patients. Despite the recently modified dental fixatives with safer zinc content, zinc poisoning results in hypocupremia secondary to inappropriate use of them can still happen and more likely be misdiagnosed...
2013: American Journal of Stem Cells
Rajesh Verma, H N Praharaj, Vinay Kumar Khanna, Ravindra Kumar Garg, Maneesh Kumar Singh, Hardeep Singh Malhotra
BACKGROUND: Vitamin B12 deficiency is a well recognized cause of posterolateral myelopathy. In Indian subcontinent, it may coexist with nutritional copper deficiency producing partial response of patients to B12 supplementation. Hence the study was planned to look for association of hypocupremia and B12 deficiency. METHODS: Twenty-three patients with posterolateral myelopathy (Romberg sign positive) were enrolled and investigated for levels of vitamin B12, copper and zinc and followed up for six months...
June 15, 2013: Journal of the Neurological Sciences
Diego Martinelli, Lorena Travaglini, Christian A Drouin, Irene Ceballos-Picot, Teresa Rizza, Enrico Bertini, Rosalba Carrozzo, Stefania Petrini, Pascale de Lonlay, Maya El Hachem, Laurence Hubert, Alexandre Montpetit, Giuliano Torre, Carlo Dionisi-Vici
MEDNIK syndrome-acronym for mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratodermia-is caused by AP1S1 gene mutations, encoding σ1A, the small subunit of the adaptor protein 1 complex, which plays a crucial role in clathrin coat assembly and mediates trafficking between trans-Golgi network, endosomes and the plasma membrane. MEDNIK syndrome was first reported in a few French-Canadian families sharing common ancestors, presenting a complex neurocutaneous phenotype, but its pathogenesis is not completely understood...
March 2013: Brain: a Journal of Neurology
Allison Beck Blackmer, Elizabeth Bailey
Copper is an essential trace element, playing a critical role in multiple functions in the body. Despite the necessity of adequate copper provision and data supporting the safety of copper administration during cholestasis, it remains common practice to reduce or remove copper in parenteral nutrition (PN) solutions after the development of cholestasis due to historical recommendations supporting this practice. In neonates, specifically premature infants, less is known about required copper intakes to accumulate copper stores and meet increased demands during rapid growth...
February 2013: Nutrition in Clinical Practice
Alemayehu A Gabreyes, Hina Naz Abbasi, Kirsten P Forbes, Grant McQuaker, Andrew Duncan, Ian Morrison
Copper is an essential trace element that is involved in a number of important enzymatic processes throughout the body. Recent single case reports and small studies have shown that deficiency of copper can cause reversible haematological changes and irreversible neurological injury. We chose to undertake a national study, looking at all cases of copper deficiency in Scotland over a 5-yr period using information from a national reference laboratory. From 16 identified patients, we determined that 86% had both haematological and neurological features of copper deficiency, while 18% had haematological features only at presentation...
January 2013: European Journal of Haematology
Shanna K Patterson, Peter H R Green, Christina A Tennyson, Suzanne K Lewis, Thomas H Brannagan
OBJECTIVE: Neurological complications of celiac disease (CD) include neuropathy, myeloneuropathy, and cerebellar degeneration. The cause of neuropathy in patients with CD is not known. Prior publications describe copper deficiency in CD patients with myeloneuropathy and neuropathy and posit that hypocupremia is the cause of these neurological conditions. However, based on our clinical experience, we hypothesized that CD patients with polyneuropathy are not deficient in copper. METHODS: Patients who met diagnostic criteria for CD and peripheral neuropathy were included...
September 2012: Journal of Clinical Neuromuscular Disease
Malek-Mellouli Monia, Ben Amara Fethi, Loussaief-Ben Amara Wafa, Reziga Hédi
In order to evaluate the status of zinc and copper in pregnant women and in preeclampsia, we conducted a prospective case-control study. It involved 56 pregnant women compared with 30 non-pregnant women selected as controls. For pregnant women, serum levels of zinc, copper and ceruloplasmin were determined quarterly. These same measurements were performed once in controls. The comparison of various parameters in normal pregnancy and in control women revealed a statistically significant decrease in serum levels of zinc from 1st to 3rd quarter...
July 2012: Annales de Biologie Clinique
Loren A Crown, Jeffery A May
A 36-year-old female developed bone marrow failure diagnosed as myelodysplastic syndrome (MDS) (Sidebar), followed shortly by a peripheral neuropathy and a gait disturbance. While waiting for a bone marrow transplant, she reported to us that she had seen attorney-generated, televised advertisements concerning the role of denture adhesives relating to her malady. Labs were then obtained demonstrating she had dramatic and unsuspected hypocupremia and hyperzincemia. Administration of copper and cessation of denture adhesives resulted in recovery of her hematopoietic system and partial resolution of the neurological sequela...
February 2012: Tennessee Medicine: Journal of the Tennessee Medical Association
B Greenwood-Van Meerveld, C I Prodan
BACKGROUND: Copper deficiency affects the peripheral (PNS) and central (CNS) nervous systems and can lead to neurological deficits in humans. No studies have addressed whether copper deficiency affects the enteric nervous system (ENS). We hypothesized that ENS abnormalities impair intestinal function in copper deficiency. METHODS: We induced copper deficiency in rats by nutritional deprivation. Once hypocupremia was achieved, we euthanized the animals and harvested the small and large intestine...
March 2012: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Imad F Btaiche, Alice Y Yeh, Irene J Wu, Nabil Khalidi
The duodenal switch (DS) procedure is a type of restrictive-malabsorptive bariatric surgery that is typically reserved for severe morbidly obese people (body mass index >50 kg/m(2)) with obesity-related comorbidities, when diet, lifestyle changes, and pharmacologic therapy fail to achieve adequate weight loss. Patients who undergo the DS procedure are at risk for malabsorption, malnutrition, and nutrient deficiencies. Copper deficiency is a commonly reported long-term complication of Roux-en-Y gastric bypass (RYGB) surgery...
October 2011: Nutrition in Clinical Practice
José A Balsa, José I Botella-Carretero, Jesús M Gómez-Martín, Roberto Peromingo, Francisco Arrieta, Carmen Santiuste, Isabel Zamarrón, Clotilde Vázquez
BACKGROUND: There are limited data on the prevalence of copper and zinc deficiency in the long term after bariatric surgery. METHODS: We analysed copper and zinc serum levels in a cohort of 141 patients, 52 who underwent Roux-en-Y gastric bypass (RYGB) and 89 biliopancreatic diversion (BPD), with a follow-up of 5 years. RESULTS: Mean copper level was significantly lower in the BPD group (P < 0.0001 vs. RYGB). Forty-five (50.6%) BPD patients had, at least once, a low copper level, and half of them, 27 (30...
June 2011: Obesity Surgery
Zarko Mitić, Milorad Cakić, Goran M Nikolić, Ružica Nikolić, Goran S Nikolić, Radmila Pavlović, Enzo Santaniello
Bioactive copper(II) complexes with polysaccharides, like pullulan and dextran, are important in both veterinary and human medicine for the treatment of hypochromic microcitary anemia and hypocupremia. In aqueous alkaline solutions, Cu(II) ion forms complexes with the exopolysaccharide pullulan and its reduced low-molecular derivative. The metal content and the solution composition depend on pH, temperature, and time of the reaction. The complexing process begins in a weak alkali solution (pH >7) and involves OH groups of pullulan monomer (glucopyranose) units...
February 15, 2011: Carbohydrate Research
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