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D N Dutt, P K Mahapatra, B N Gangadhar, P K Sadasivan, N Janakiramaiah, D K Subbakrishna, K M Rao
EEG was recorded from right and left frontal leads during bilateral (n=11) and unilateral (n=l4) ECTs. The seizure EEG was analyzed using East Fourier 'Transform and the spectral power oj the Delta (1-4 Hz) band was computed. The spectral power on both sides was similar in the bilateral ECT. Unilateral ECT produced asymmetry in the early - (first 8 seconds after stimulus offset) and mid - (17-32 seconds after the stimulus offset) siezure phases; the spectral power was lower on the unstimulated hemisphere. Studies to elucidate the relevance of EEG delta band of the seizure to therapeutic potency of ECT are suggested...
January 1997: Indian Journal of Psychiatry
L A Malikova, I B Fedotova, I I Poletaeva, K S Raevskiĭ
The new antiepileptic drug levetiracetam (LVT) at doses of 40 and 80 mg/kg exhibits a pronounced anticonvulsant effect, influencing all the parameters of audiogenic epileptiform seizures (AES) in Krushinsky-Molodkina (KM) rats. The latent period of the motor reaction was increased 3-15 times compared to control, and the intensity of single convulsive episodes was significantly decreased. Changes were also detected in the profile of the first stage of motor activity, and the "two-wave" reaction was observed in 50-80% of animals...
November 2007: Eksperimental'naia i Klinicheskaia Farmakologiia
No abstract text is available yet for this article.
May 1961: Journal of Neurology, Neurosurgery, and Psychiatry
Y Takahashi, T Ozawa, H Nakamura, S Yamada, H Okamoto, S Yajima, K Goto, N Kondo
PURPOSE: We investigated a role of long-wavelength red light emission from TV in the induction of photosensitive seizures by an animated TV program called "Pocket Monsters". METHODS: The luminance energy of recorded color bar was measured by a spectroradiometer in cathode-ray tubes (CRTs) of photosensitive patients with and without seizures on the program (induced patients and photosensitive controls). RESULTS: The mean ratio of long-wavelength red light to total visible range was significantly higher in the CRTs of induced patients than in the CRTs of photosensitive controls...
February 2001: Acta Neurologica Scandinavica
E Isaacs, D Christie, F Vargha-Khadem, M Mishkin
Dichotic listening, manual functions, and IQ were measured in a large group of hemiplegic children with unilateral hemispheric damage. In the children without a history of seizure disorder, only manual functions were impaired, but in those with such a history (and hence a regime of anticonvulsant medication), all measures were affected. Some children with congenital left hemisphere lesions (with and without siezure disorder) showed a left ear advantage for dichotic digits as well as greater impairment in right hand function than those who showed the usual right ear advantage...
February 1996: Neuropsychologia
L Cervoni, M Artico, M Salvati, R Bristot, C Franco, R Delfini
Fifty-five cases of epileptic siezures associated with spontaneous intracerebral hemorrhage are reported. Seizures appeared as the first symptom in 23 patients, early (within two weeks after HI) in 18 and late (later than 2 weeks after HI) in 14. From the analysis of the observed cases we noticed that: 1) partial seizures were most frequent type (63%). These appeared mainly in cases with lobar hemorrhage above all; 2) development chronic epilepsy occurred frequently in the case of patients affected by late seizures...
1994: Neurosurgical Review
H Ferngren
No abstract text is available yet for this article.
1968: Acta Pharmacologica et Toxicologica
G G Celesia, R C Chen, B J Bamforth
Ketamine, a rapid-acting general anesthetic, was administered intravenously to 26 epileptics. The effects of ketamine on the patients' clinical seizures and electroencephalograms were compared with similar periods during alert and sleep states. Epileptic discharges were present in the alert electroencephalogram of 17 (65 percent) of the patients. Epileptic discharges were precipitated or aggravated by sleep in 15 patients (58 percent) and by ketamine in eight patients (31 percent). No siezures were recorded during ketamine anesthesia...
February 1975: Neurology
R U Ostrovskaia, G M Molodavkin, R P Porfir'eva, A M Zubovskaia
Diazepam was shown to be highly efficient in preventing the convulsive siezures induced by thiosemicarbazide and connected with GABA insufficiency. In recording the recovery cycles of the intracortical response of the cat motor cortex it was found that diazepam induced a decrease of the testing respone. These data indicate the enhancement of the inhibitory processes. Using this test an antagonistic relationship was observed between diazepam on the one hand, and biculline and thiosemicarbazide--on the other Diazepam was capable of increasing GABA content in the brain by suppressing GABA-transaminase activity in the mitochondrial fraction of the brain tissue...
March 1975: Biulleten' Eksperimental'noĭ Biologii i Meditsiny
C S Chen, G R Gates, J A Reynoldson
1 Morphine (1-200 mg/kg s.c.) reduced the incidence and prolonged the latency of priming-induced audiogenic siezures in a dose-dependent manner. 2 This effect was reversed by naloxone (1 and 2 mg/kg) although naloxone was itself inactive. 3 This priming-induces seizure model may be useful in the study of tolerance and physical dependence.
December 1976: British Journal of Pharmacology
P V Taberner
The activity of the dissociative anaesthetics ketamine and gamma-hydroxybutyrate against seizures induced by mercaptopropionate and pentylenetetrazol have been determined. Ketamine (90 mg/kg) prevented the seizures induced by both convulsants, but gamma-hydroxybutyrate had negligible anticonvulsant activity. Mercaptopropionate (150 mg/kg) produced a rapid fall in whole brain glutamate decarboxylase activity which correlated with the onset of convulsions. Ketamine given prior to the mercaptopropionate prevented the convulsions, but had no effect on the reduction of enzyme activity...
October 1976: European Journal of Pharmacology
J S Lockard, R H Levy
Valproic acid [dipropylacetic acid (DPA)] was evaluated in an alumina-gel monkey model (N = 12) by constant-rate intravenous infusion. The data indicated: (a) a statistically significant decrease in seizure frequency the first 2 days of drug Step I (45-55 mug/ml) and drug Step II (90-110 mug/ml) which was temporary, lasting 2 days only; (b) a later, more permanent decrease in siezure frequency which was not apparent until drug Setp III (130-170 mug/ml); and a delayed return of the seizure frequency to predrug levels for 2 weeks after drug administration was discontinued, with no DPA detectable in plasma after the initial postdrug day...
December 1976: Epilepsia
D H Wilson, C Culver, M Waddington, M Gazzaniga
A boy with intractable siezures that had progressed to about 30 a day underwent complete disconnection of the cerebral hemispheres in January 1972. Using microsurgical technique, we followed the path described by Bogen and Vogel requiring division of the corpus callosum from rostrum to splenium, the anterior commisure, one fornix, and hippocampal commissure. Postoperative recovery was complicated by aseptic meningitis, which was treated with dexamethasone and, later by hydrocephalus, which was reduced by ventriculoperitoneal shunt...
December 1975: Neurology
K Miyasaki, J Matsumoto, S Murao, K Nakamura, S Yokoyama, M Hayano, H Nakamura
A 6-month-old boy, having suffered repeated convulsive siezures since birth, died of severe epilepsy, the disease remaining unknown. However, when a brother, born after the death of the present case, displayed the same clinical symptoms and was diagnosed clinically as having pyridoxine dependent convulsion, the deceased became suspected of having been a case of familial pyridoxine dependency. Pathologically, bilateral cerebellar hemorrhages were found accompanied by subdural and subarachnoidal hemorrhages. Histologically, neuronal loss and diffuse astrocyte hyperplasia were found in the brain: Beside marginal gliosis, proliferations of astroglia and glial fibers were found, especially in the pons, medulla oblongata, and cervical cord, although the fibrillary gliosis may be representative for a physiological intermediate state...
September 1978: Acta Pathologica Japonica
F Echlin
In alert monkeys the time course for development of supersensitivity to topical acetylcholine in partially isolated frontal cerebral cortex was determined. Thresholds for paroxysmal discharge fell progressively and markedly during 3 weeks, further in 5 and somewhat more after 6 months. ACh supersensitivity was demonstrated in chronic "isolated" occipital cortex. Epileptiform discharges were recorded selectively from chronic partially isolated frontal cortex on peripheral nerve stimulation and these spread, causing a clinical convulsive siezure when the open end of the isolation extended into the precentral gyrus...
March 1975: Electroencephalography and Clinical Neurophysiology
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