keyword
MENU ▼
Read by QxMD icon Read
search

metabolic memory

keyword
https://www.readbyqxmd.com/read/28424329/a-paternal-diet-for-offspring-success
#1
Christopher Hine
Supplementation of the diet of male mice with methyl donors, such as methionine and folic acid, prior to mating impaired learning, memory, and metabolic functions in the offspring.
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28422060/clarifying-the-ghrelin-system-s-ability-to-regulate-feeding-behaviours-despite-enigmatic-spatial-separation-of-the-ghsr-and-its-endogenous-ligand
#2
REVIEW
Alexander Edwards, Alfonso Abizaid
Ghrelin is a hormone predominantly produced in and secreted from the stomach. Ghrelin is involved in many physiological processes including feeding, the stress response, and in modulating learning, memory and motivational processes. Ghrelin does this by binding to its receptor, the growth hormone secretagogue receptor (GHSR), a receptor found in relatively high concentrations in hypothalamic and mesolimbic brain regions. While the feeding and metabolic effects of ghrelin can be explained by the effects of this hormone on regions of the brain that have a more permeable blood brain barrier (BBB), ghrelin produced within the periphery demonstrates a limited ability to reach extrahypothalamic regions where GHSRs are expressed...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28421673/endothelial-erbb4-deficit-induces-alterations-in-exploratory-behavior-and-brain-energy-metabolism-in-mice
#3
Gang Wu, Xiu-Xiu Liu, Nan-Nan Lu, Qi-Bing Liu, Yun Tian, Wei-Feng Ye, Guo-Jun Jiang, Rong-Rong Tao, Feng Han, Ying-Mei Lu
AIMS: The receptor tyrosine kinase ErbB4 is present throughout the primate brain and has a distinct functional profile. In this study, we investigate the potential role of endothelial ErbB4 receptor signaling in the brain. RESULTS: Here, we show that the endothelial cell-specific deletion of ErbB4 induces decreased exploratory behavior in adult mice. However, the water maze task for spatial memory and the memory reconsolidation test reveal no changes; additionally, we observe no impairment in CaMKII phosphorylation in Cdh5Cre;ErbB4(f/f) mice, which indicates that the endothelial ErbB4 deficit leads to decreased exploratory activity rather than direct memory deficits...
April 18, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28410777/evidence-for-neurocognitive-improvement-after-bariatric-surgery-a-systematic-review
#4
REVIEW
Gurneet Thiara, Michela Cigliobianco, Alexei Muravsky, Riccardo A Paoli, Rodrigo Mansur, Raed Hawa, Roger S McIntyre, Sanjeev Sockalingam
BACKGROUND: Bariatric surgery is an effective means of weight reduction in severely obese patients and correlates with improvements in quality of life, mental health outcomes, and neurocognition, especially in those with high psychosocial burden. OBJECTIVE: The primary purpose of this systematic review was to evaluate the impact of bariatric surgery on long-term neurocognitive functioning and neuropsychological outcomes. METHODS: OVID Medline and PsychInfo databases from January 1990 to August 2015 were searched with key terms and phrases: "bariatric surgery" and "cognition...
February 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28398234/down-regulated-drebrin-aggravates-cognitive-impairments-in-a-mouse-model-of-alzheimer-s-disease
#5
Yan Liu, Yanfeng Xu, Ling Zhang, Lan Huang, Pin Yu, Hua Zhu, Wei Deng, Chuan Qin
The developmentally regulated brain protein drebrin (Dbn) is a functional protein involved with long-term memory formation and is widely distributed in brain neurons, especially in the dendritic spines. A noticeable decline of this protein has been found in the hippocampus and cortex of patients with Alzheimer's disease (AD), yet the relationship between Dbn and AD has not been fully understood. In the present study, we examined how down-regulation of Dbn impacts the progression of AD in experimental animals...
April 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28395123/focused-ultrasound-as-a-novel-strategy-for-alzheimer-s-disease-therapeutics
#6
Ying Meng, Matthew Volpini, Sandra Black, Andres M Lozano, Kullervo Hynynen, Nir Lipsman
Despite decades of advances in the pathology, genetics and imaging of Alzheimer's disease (AD), there remain no effective treatments that significantly alter its natural history. Several late phase clinical trials, focused largely on amyloid beta metabolism and clearance, have unfortunately demonstrated no significant benefit in early AD patients. Recent work investigating blood-brain barrier opening using focused ultrasound in transgenic animal models has shown that repeated ultrasound administration coupled with microbubble-containing contrast can reduce plaque burden and reverse memory deficits...
April 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28394286/sodium-p-aminosalicylic-acid-reverses-sub-chronic-manganese-induced-impairments-of-spatial-learning-and-memory-abilities-in-rats-but-fails-to-restore-%C3%AE-aminobutyric-acid-levels
#7
Shao-Jun Li, Chao-Yan Ou, Sheng-Nan He, Xiao-Wei Huang, Hai-Lan Luo, Hao-Yang Meng, Guo-Dong Lu, Yue-Ming Jiang, Tanara Vieira Peres, Yi-Ni Luo, Xiang-Fa Deng
Excessive manganese (Mn) exposure is not only a health risk for occupational workers, but also for the general population. Sodium para-aminosalicylic acid (PAS-Na) has been successfully used in the treatment of manganism, but the involved molecular mechanisms have yet to be determined. The present study aimed to investigate the effects of PAS-Na on sub-chronic Mn exposure-induced impairments of spatial learning and memory, and determine the possible involvements of γ-aminobutyric acid (GABA) metabolism in vivo...
April 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28392756/brain-metabolic-changes-in-rats-following-acoustic-trauma
#8
Jun He, Yejin Zhu, Jiye Aa, Paul F Smith, Dirk De Ridder, Guangji Wang, Yiwen Zheng
Acoustic trauma is the most common cause of hearing loss and tinnitus in humans. However, the impact of acoustic trauma on system biology is not fully understood. It has been increasingly recognized that tinnitus caused by acoustic trauma is unlikely to be generated by a single pathological source, but rather a complex network of changes involving not only the auditory system but also systems related to memory, emotion and stress. One obvious and significant gap in tinnitus research is a lack of biomarkers that reflect the consequences of this interactive "tinnitus-causing" network...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28383716/essential-role-for-non-canonical-poly-a-polymerase-gld4-in-cytoplasmic-polyadenylation-and-carbohydrate-metabolism
#9
Jihae Shin, Ki Young Paek, Maria Ivshina, Emily E Stackpole, Joel D Richter
Regulation of gene expression at the level of cytoplasmic polyadenylation is important for many biological phenomena including cell cycle progression, mitochondrial respiration, and learning and memory. GLD4 is one of the non-canonical poly(A) polymerases that regulates cytoplasmic polyadenylation-induced translation, but its target mRNAs and role in cellular physiology is not well known. To assess the full panoply of mRNAs whose polyadenylation is controlled by GLD4, we performed an unbiased whole genome-wide screen using poy(U) chromatography and thermal elution...
April 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28383509/self-referential-encoding-on-modules-of-anticodon-pairs-roots-of-the-biological-flow-system
#10
REVIEW
Romeu Cardoso Guimarães
The proposal that the genetic code was formed on the basis of (proto)tRNA Dimer-Directed Protein Synthesis is reviewed and updated. The tRNAs paired through the anticodon loops are an indication on the process. Dimers are considered mimics of the ribosomes-structures that hold tRNAs together and facilitate the transferase reaction, and of the translation process-anticodons are at the same time codons for each other. The primitive protein synthesis system gets stabilized when the product peptides are stable and apt to bind the producers therewith establishing a self-stimulating production cycle...
April 6, 2017: Life
https://www.readbyqxmd.com/read/28381654/disorder-of-executive-function-of-the-brain-after-head-injury-and-mild-traumatic-brain-injury-neuroimaging-and-diagnostic-criteria-for-implementation-of-administrative-support-in-japan
#11
Jun Shinoda, Yoshitaka Asano
The diagnotic criteria for disorder of the executive function of the brain (DEFB) as a syndrome of sequela were administratively established (ad-DEFB) in Japan in 2006 to support disabled patients whose impairment, limited to cognition (memory, attention, execution, and behavior), emerges after organic brain injuries regardless of physical deficits. However, some patients suffering from traumatic brain injury (TBI) have been excluded from receiving medico-social services. In particular, this tendency is more prominent in patients with mild TBI because no lesions are apparent on conventional computed tomography (CT) or magnetic resonance imaging (MRI) in the chronic phase...
April 6, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28381517/hippocampal-hypometabolism-in-older-adults-with-memory-complaints-and-increased-amyloid-burden
#12
Patrizia Vannini, Bernard Hanseeuw, Catherine E Munro, Rebecca E Amariglio, Gad A Marshall, Dorene M Rentz, Alvaro Pascual-Leone, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To identify the functional and pathologic correlates underlying subjective memory complaints (SMCs) in cognitively normal older adults. METHODS: Two hundred fifty-one older adults underwent resting-state fluorodeoxyglucose (FDG)-PET and Pittsburg compound B-PET β-amyloid (Aβ) imaging and filled out a questionnaire regarding SMCs. Participants were classified into 2 groups based on their Aβ burden. Age-adjusted voxel-wise correlations were used to examine SMCs, amyloid status (Aβ(+) vs Aβ(-)), and the interaction between SMCs and Aβ status as predictors of metabolism...
April 5, 2017: Neurology
https://www.readbyqxmd.com/read/28380673/acyl-ghrelin-improves-cognition-synaptic-plasticity-deficits-and-neuroinflammation-following-amyloid-beta-a%C3%AE-1-40-administration-in-mice
#13
Vanessa V Santos, Romana Stark, Daniel Rial, Henrique B Silva, Jacqueline A Bayliss, Moyra B Lemus, Jeffrey S Davies, Rodrigo A Cunha, Rui Daniel Prediger, Zane B Andrews
Ghrelin is a metabolic hormone that has neuroprotective actions in a number of neurological conditions including Parkinson's disease (PD), stroke and traumatic brain injury. Acyl ghrelin treatment in vivo and in vitro also shows protective capacity in Alzheimer's disease (AD). In this study, we used ghrelin knockout (KO) and their wildtype (WT) littermates to test whether or not endogenous ghrelin is protective in a mouse model of AD, in which human amyloid beta peptide (Aβ1-40 ) was injected into the lateral ventricles (icv)...
April 5, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28379235/characterizing-serum-metabolic-alterations-of-alzheimer-s-disease-and-intervention-of-shengmai-san-by-ultra-performance-liquid-chromatography-electrospray-ionization-quadruple-time-of-flight-mass-spectrometry
#14
Shengwen Lu, Ying Han, Hang Chu, Ling Kong, Aihua Zhang, Guangli Yan, Hui Sun, Ping Wang, Xijun Wang
Alzheimer's disease (AD) is a chronic and multi-factor-induced neurodegenerative disorder. The development of a single-target treatment strategy for AD has not been successful. Shengmai-San (SMS), a traditional Chinese medicine containing multi-active components, has been reported to be effective for treating AD. However, the mechanism of SMS is still unclear, and as a multicomponent combination therapy, there is a lack of appropriate evaluation. Thereby, metabolomics was applied to investigate the multi-target intervention of SMS by monitoring the fold changes of metabolites in serum...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28378260/effect-of-metformin-on-adult-hippocampal-neurogenesis-comparison-with-donepezil-and-links-to-cognition
#15
Sara Ahmed, Zahra Mahmood, Aneela Javed, Shoaib Naiyer Hashmi, Inga Zerr, Saima Zafar, Saadia Zahid
Recent studies have uncovered evidence suggesting that interference with hippocampal adult neurogenesis contributes to neurodegeneration in Alzheimer's disease (AD). Evidence supporting that AD is a metabolic disease with derangements in brain glucose utilization implies the use of anti-diabetics as an alternate therapeutic strategy. The present study drew comparison between the pro-neurogenic potential of metformin and donepezil in AlCl3-induced mouse model of neurodegeneration. Morris water maze task and subsequent immunohistochemical evaluation for NeuN was conducted...
April 4, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28366537/hif-has-biff-crosstalk-between-hif1a-and-the-family-of-bhlh-pas-proteins
#16
Emily L Button, David C Bersten, Murray L Whitelaw
Two decades of research into functions of the ubiquitous transcription factor HIF have revealed pervasive roles in development, oxygen homeostasis, metabolism, cancer and responses to ischemia. Unsurprisingly, HIF activities impinge on many pathologies, for which underlying molecular mechanisms are actively sought. HIF is a member of the heterodimeric bHLH/PAS family of transcription factors, a set of proteins that commonly function in developmental pathways and adaptive responses to environmental or physiological stress...
March 31, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28363691/myc-and-hif-in-shaping-immune-response-and-immune-metabolism
#17
REVIEW
J N Rashida Gnanaprakasam, John William Sherman, Ruoning Wang
Upon antigen stimulation, quiescent naive T cells undergo a phase of cell mass accumulation followed by cell cycle entry, clonal expansion, differentiation into functional subsets and back again to a quiescent state as they develop into memory cells. The transitions between these distinct cellular states place unique metabolic demands on energy, redox and biosynthesis. To fulfill these demands, T cells switch back and forth between their primary catabolic pathways. While quiescent naive and memory T cells largely rely on the oxidation of fatty acids and glucose, active T cells rely on glycolysis and glutaminolysis to sustain cell growth, proliferation and differentiation...
March 23, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28363347/increased-serum-levels-of-cysteine-in-patients-with-schizophrenia-a-potential-marker-of-cognitive-function-preservation
#18
Liang-Jen Wang, Pao-Yen Lin, Yu Lee, Yu-Chi Huang, Chih-Ching Wu, Su-Ting Hsu, Chien-Chih Chen, Mian-Yoon Chong, Chieh-Hsin Lin, Chi-Fa Hung
BACKGROUND: Oxidative stress has been implicated in the psychopathology of schizophrenia. Cysteine, a semi-essential amino acid, is the precursor of the antioxidant glutathione. The aim of this study was to investigate the differences in serum levels of cysteine between patients with schizophrenia and healthy controls. The relationships between levels of cysteine, psychopathology and cognitive function were also explored. METHODS: We recruited 65 patients with schizophrenia and 65 age- and gender-matched healthy controls...
March 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28362493/effect-of-major-royal-jelly-proteins-on-spatial-memory-in-aged-rats-metabolomics-analysis-in-urine
#19
Di Chen, Fang Liu, Jian-Bo Wan, Chao-Qiang Lai, Li-Rong Shen
Royal jelly (RJ) produced by worker honeybees is the sole food for the queen bee throughout her life as well as the larvae of worker bees for the first 3 days after hatching. Supplementation of RJ in the diet has been shown to increase spatial memory in rodents. However, the key constituents in RJ responsible for improvement of cognitive function are unknown. Our objective was to determine if the major royal jelly proteins (MRJPs) extracted from RJ can improve the spatial memory of aged rats. The spatial memory assay using the Morris water maze test was administered once to rats after a 14-week feeding...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28360839/emerging-roles-for-glycogen-in-the-cns
#20
REVIEW
Alice E Waitt, Liam Reed, Bruce R Ransom, Angus M Brown
The ability of glycogen, the depot into which excess glucose is stored in mammals, to act as a source of rapidly available energy substrate, has been exploited by several organs for both general and local advantage. The liver, expressing the highest concentration of glycogen maintains systemic normoglycemia ensuring the brain receives a supply of glucose in excess of demand. However the brain also contains glycogen, although its role is more specialized. Brain glycogen is located exclusively in astrocytes in the adult, with the exception of pathological conditions, thus in order to benefit neurons, and energy conduit (lactate) is trafficked inter-cellularly...
2017: Frontiers in Molecular Neuroscience
keyword
keyword
114263
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"