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https://www.readbyqxmd.com/read/28531319/improved-sperm-kinematics-in-semen-samples-collected-after-2-h-versus-4-7-days-of-ejaculation-abstinence
#1
H Alipour, G Van Der Horst, O B Christiansen, F Dardmeh, N Jørgensen, H I Nielsen, C Hnida
STUDY QUESTION: Does a short abstinence period of only 2 h yield spermatozoa with better motility characteristics than samples collected after 4-7 days? SUMMARY ANSWER: Despite lower semen volume, sperm concentration, total sperm counts and total motile counts, higher percentages of motile spermatozoa with higher velocity and progressiveness were detected in samples obtained after 2 h. WHAT IS KNOWN ALREADY: Most studies that have assessed the effect of abstinence periods on sperm motility parameters in men with a sperm concentration below 15 million/ml have detected a higher percentage of motile spermatozoa in samples obtained after short abstinence periods...
May 22, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28529922/governmental-efforts-for-cardiovascular-disease-prevention-efforts-in-the-russian-federation
#2
REVIEW
Nana Pogosova, Olga Sokolova
Cardiovascular disease (CVD) is the leading cause of death and disability in Russia as is case with the most other countries of the world, although Russia has unique features and demographic trends. In the late 90's and early 2000's Russia has sustained a profound demographical crisis with a period of overmortality but since 2003 the mortality rates are declining. By 2013, the birth rates exceeded mortality. The reversal of the demographic crisis took place on the background of a number of comprehensive governmental efforts with focus on non-communicable diseases prevention...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28529298/an-aspect-of-the-history-of-medicine-in-ancient-korea-as-examined-through-silla-buddhist-monks-annotations-on-the-chapter-on-eliminating-disease-in-the-sutra-of-golden-light-suvarnabh%C3%A4-sa-s%C3%A5-tra
#3
Chaekun Oh, Jongwook Jeon, Dongwon Shin
Nearly nothing is known of medicine in ancient Korea due to insufficient materials. With several extant prescriptions and esoteric methods of treating diseases alone, it is impossible to gauge in depth the management of medicine during this period. If one exception were to be cited, that would be the fact that the annotations for understanding the contents on Indian medicine in the "Chapter on Eliminating Disease" in the Sutra of Golden Light, a Buddhist sutra originating from India, reflected the medical knowledge of Buddhist monks from Silla (57 BC-935 AD) who were active immediately after the nation's unification of the two other kingdoms on the Korean Peninsula (668 AD) such as Wonhyo (617-686 AD), Gyeongheung (620?-700? AD), and Seungjang (684-? AD)...
December 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/28529235/alternative-medicine-contagion-and-cure-in-karel-%C3%A4-apek-s-i-the-white-plague-i
#4
Alexis Soloski
Though written amid an atmosphere of unprecedented medical advance in both diagnosis and therapeutics, Karel Čapek's The White Plague takes a starkly critical stance against overconfidence in medical science and its dubious ethical orbit. This article explores Čapek's censure of those who would privilege scientific interest in disease over the holistic plight of the sufferer. Provocatively, Čapek achieves this not only via the play's content, but also-prefiguring aspects of contemporary live art practice by several decades-by placing audience members in worrying proximity to abject ill bodies...
2017: Literature and Medicine
https://www.readbyqxmd.com/read/28524668/emerging-trends-in-micro-and-nanoscale-technologies-in-medicine-from-basic-discoveries-to-translation
#5
Mario M Alvarez, Joanna Aizenberg, Mostafa Analoui, Anne M Andrews, Gili Bisker, Edward S Boyden, Roger D Kamm, Jeffrey M Karp, David J Mooney, Rahmi Oklu, Dan Peer, Michelle Stolzoff, Michael S Strano, Grissel Trujillo-de Santiago, Thomas J Webster, Paul S Weiss, Ali Khademhosseini
We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events...
May 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28523494/-a-future-amalgamation-between-the-scientist-and-the-clinician
#6
Sarah Haywood-Small
Personalized medicine is gaining momentum and analytical methods such as MS are ideally situated to provide coherent imaging of human disease. The cancer research field is already starting to benefit from the MS imaging applications; non-cancerous diseases will hopefully enjoy the same success. Often, the way forward is to embrace several techniques, which can complement and verify each other. This approach can be seen as less confrontational as everyone can play a part in the development of a new working practice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28522145/wnt-signaling-a-novel-pathway-regulating-blood-pressure-state-of-the-art-review
#7
REVIEW
Maen D Abou Ziki, Arya Mani
Recent antihypertensive trials show conflicting results on blood pressure (BP) targets in patient populations with different metabolic profiles, with lowest benefit from tight BP control observed in patients with type 2 diabetes mellitus. This paradox could arise from the heterogeneity of study populations and underscores the importance of precision medicine initiatives towards understanding and treating hypertension. Wnt signaling pathways and genetic variations in its signaling peptides have been recently associated with metabolic syndrome, hypertension and diabetes, generating a breakthrough for advancement of precision medicine in the field of hypertension...
May 4, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28520105/large-scale-computational-models-of-liver-metabolism-how-far-from-the-clinics
#8
REVIEW
Tanja Cvitanović, Matthias C Reichert, Miha Moškon, Miha Mraz, Frank Lammert, Damjana Rozman
Understanding the dynamics of human liver metabolism is fundamental for effective diagnosis and treatment of liver diseases in general and the metabolism of drugs in particular. This knowledge can be obtained with systems biology/medicine approaches that account for the complexity of hepatic responses and their systemic consequences in other organs. Computational modelling can reveal hidden principles of the system by classification of individual components, analysing their interactions and simulating the effects that are difficult to investigate experimentally...
May 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28512395/keypress-based-musical-preference-is-both-individual-and-lawful
#9
Sherri L Livengood, John P Sheppard, Byoung W Kim, Edward C Malthouse, Janet E Bourne, Anne E Barlow, Myung J Lee, Veronica Marin, Kailyn P O'Connor, John G Csernansky, Martin P Block, Anne J Blood, Hans C Breiter
Musical preference is highly individualized and is an area of active study to develop methods for its quantification. Recently, preference-based behavior, associated with activity in brain reward circuitry, has been shown to follow lawful, quantifiable patterns, despite broad variation across individuals. These patterns, observed using a keypress paradigm with visual stimuli, form the basis for relative preference theory (RPT). Here, we sought to determine if such patterns extend to non-visual domains (i.e...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28508939/-the-worlds-of-gods-in-medicine
#10
REVIEW
A Karenberg
BACKGROUND: A number of designations for diseases, medicines and human body structures derive from classical mythology. To date, these eponyms have not been systematically investigated. OBJECTIVES: This paper provides an overview of this fringe component of medical vocabulary, looks at the history of several terms and formulates hypotheses as to why such creative etymologies have come into being. MATERIALS AND METHODS: In addition to relevant texts on ancient mythology, a variety of medical textbooks from the early modern period were analyzed...
May 16, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28508782/the-use-of-restful-web-services-in-medical-informatics-and-clinical-research-and-its-implementation-in-europe
#11
Jozef Aerts
BACKGROUND: RESTful web services nowadays are state-of-the-art in business transactions over the internet. They are however not very much used in medical informatics and in clinical research, especially not in Europe. OBJECTIVES: To make an inventory of RESTful web services that can be used in medical informatics and clinical research, including those that can help in patient empowerment in the DACH region and in Europe, and to develop some new RESTful web services for use in clinical research and regulatory review...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28503375/network-science-meets-respiratory-medicine-for-osas-phenotyping-and-severity-prediction
#12
Stefan Mihaicuta, Mihai Udrescu, Alexandru Topirceanu, Lucretia Udrescu
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that OSAS risk factors associate and converge is not a random process. As such, defining OSAS phenotypes fosters personalized patient management and population screening. In this paper, we present a network-based observational, retrospective study on a cohort of 1,371 consecutive OSAS patients and 611 non-OSAS control patients in order to explore the risk factor associations and their correlation with OSAS comorbidities. To this end, we construct the Apnea Patients Network (APN) using patient compatibility relationships according to six objective parameters: age, gender, body mass index (BMI), blood pressure (BP), neck circumference (NC) and the Epworth sleepiness score (ESS)...
2017: PeerJ
https://www.readbyqxmd.com/read/28501885/euforea-rhinology-research-forum-2016-report-of-the-brainstorming-sessions-on-needs-and-priorities-in-rhinitis-and-rhinosinusitis
#13
P W Hellings, C A Akdis, C Bachert, J Bousquet, B Pugin, G Adriaensen, R Advani, I Agache, C Anjo, R Anmolsingh, E Annoni, T Bieber, A Bizaki, I Braverman, I Callebaut, J A Castillo Vizuete, T Chalermwatanachai, R Chmielewski, C Cingi, L Cools, C Coppije, M E Cornet, I De Boeck, E De Corso, G De Greve, M Doulaptsi, R Edmiston, S Erskine, E Gevaert, P Gevaert, K Golebski, C Hopkins, V Hox, C Jaeggi, G Joos, S Khwaja, A Kjeldsen, L Klimek, M Koennecke, I Kortekaas Krohn, O Krysko, B N Kumar, C Langdon, B Lange, G Lekakis, P Levie, E Lourijsen, V J Lund, K Martens, R Mösges, J Mullol, T D Nyembue, S Palkonen, C Philpott, J Pimentel, A Poirrier, A C Pratas, E Prokopakis, L Pujols, P Rombaux, C Schmidt-Weber, C Segboer, I Spacova, J Staikuniene, B Steelant, E A Steinsvik, A Teufelberger, L Van Gerven, K Van Gool, R Verbrugge, B Verhaeghe, P Virkkula, S Vlaminck, E Vries-Uss, M Wagenmann, T Zuberbier, S F Seys, W J Fokkens
The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care pathways and research needs in rhinitis and rhinosinusitis...
May 14, 2017: Rhinology
https://www.readbyqxmd.com/read/28494732/pharmacokinetics-of-botanical-drugs-and-plant-extracts
#14
Gina Paola Domínguez Moré, Paola Andrea Cárdenas, Geison M Costa, Cláudia M O Simões, Diana Marcela Aragón
Botanical drugs contain plant extracts, which are complex mixtures of compounds. As with conventional drugs, it is necessary to validate their efficacy and safety through preclinical and clinical studies. However, pharmacokinetic studies for active constituents or characteristic markers in botanical drugs are rare. The objective of this review was to investigate the global state of the art in pharmacokinetic studies of active ingredients present in plant extracts and botanical drugs. A review of pharmacokinetics studies of chemical constituents of plant extracts and botanical drugs was performed, with a total of 135 studies published between January 2004 and February 2015 available in recognized scientific databases...
May 9, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28494717/gelatin-as-biomaterial-for-tissue-engineering
#15
Mari Carmen Echave, Laura Saenz Del Burgo, Jose Luis Pedraz, Gorka Orive
Tissue engineering is considered one of the most important therapeutic strategies of regenerative medicine. The main objective of these new technologies is the development of substitutes made with biomaterials that are able to heal, repair or regenerate injured or diseased tissues and organs. These constructs seek to unlock the limited ability of human tissues and organs to regenerate. In this review, we highlight the convenient intrinsic properties of gelatin for the design and development of advanced systems for tissue engineering...
May 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28490362/different-perceptions-of-narrative-medicine-between-western-and-chinese-medicine-students
#16
Chien-Da Huang, Kuo-Chen Liao, Fu-Tsai Chung, Hsu-Min Tseng, Ji-Tseng Fang, Shu-Chung Lii, Han-Pin Kuo, San-Jou Yeh, Shih-Tseng Lee
BACKGROUND: Western medicine is an evidence-based science, whereas Chinese medicine is more of a healing art. To date, there has been no research that has examined whether students of Western and Chinese medicine differentially engage in, or benefit from, educational activities for narrative medicine. This study fills a gap in current literature with the aim of evaluating and comparing Western and Chinese Medicine students' perceptions of narrative medicine as an approach to learning empathy and professionalism...
May 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28490169/ethical-considerations-in-the-field-of-assisted-reproductive-technology
#17
Lindsey N Cobb, Raymond W Ke
Human reproduction has always generated more than its share of emotion that exceeds the life and death issues of medicine. For patients that are unable to conceive naturally, medical advances have greatly expanded treatment options. Assisted reproductive technology (ART) is a highly evolving, complex, and controversial field of medicine in which ethical principles play a large role in decision-making. The following highlights ethical considerations regarding ART, specifically in vitro fertilization (IVF), that practicing obstetricians and indeed all physicians may encounter...
May 8, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28488234/microphysiological-human-brain-and-neural-systems-on-a-chip-potential-alternatives-to-small-animal-models-and-emerging-platforms-for-drug-discovery-and-personalized-medicine
#18
Alexander P Haring, Harald Sontheimer, Blake N Johnson
Translational challenges associated with reductionist modeling approaches, as well as ethical concerns and economic implications of small animal testing, drive the need for developing microphysiological neural systems for modeling human neurological diseases, disorders, and injuries. Here, we provide a comprehensive review of microphysiological brain and neural systems-on-a-chip (NSCs) for modeling higher order trajectories in the human nervous system. Societal, economic, and national security impacts of neurological diseases, disorders, and injuries are highlighted to identify critical NSC application spaces...
May 10, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28483827/public-reporting-ii-state-of-the-art-current-public-reporting-in-cardiovascular-medicine
#19
William S Weintraub, Kirk N Garratt
No abstract text is available yet for this article.
May 9, 2017: Circulation
https://www.readbyqxmd.com/read/28475365/the-differences-between-medical-trust-and-mistrust-and-their-respective-influences-on-medication-beliefs-and-art-adherence-among-african-americans-living-with-hiv
#20
Jennifer A Pellowski, Devon M Price, Aerielle M Allen, Lisa A Eaton, Seth C Kalichman
OBJECTIVE: The purpose of this study was to examine the relationships between medical mistrust and trust and to determine if these measures differentially predict antiretroviral therapy (ART) medication adherence for African-American adults living with HIV. DESIGN: A total of 458 HIV positive African-Americans completed a cross-sectional survey. MAIN OUTCOME MEASURES: Self-reported ART adherence was collected using the visual-analog scale...
May 5, 2017: Psychology & Health
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