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https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#1
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780889/how-to-conceptualize-and-implement-a-phd-program-in-health-sciences-the-basel-approach
#2
Franziska Keller, Suzanne Dhaini, Matthias Briel, Sina Henrichs, Christoph Höchsmann, Daniel Kalbermatten, Nino Künzli, Annette Mollet, Christian Puelacher, Arno Schmidt-Trucksäss, Belinda von Niederhäusern, Sabina De Geest
Objectives: Over the past decade, several excellent guidelines have been published on how to enhance the quality of PhD education in Europe. Aimed primarily at preparing students for innovative roles in their fields, they include variously structured approaches to curricular offerings, as well as other program components applicable across specialties (eg: supervisor support, scientific conduct, transferable skills). Since 2012, the interdisciplinary PhD Program in Health Sciences (PPHS) at the Faculty of Medicine of the University of Basel in Switzerland has focused on translating these guidelines into a 21st-century health sciences PhD program...
January 2018: Journal of Medical Education and Curricular Development
https://www.readbyqxmd.com/read/29780878/microfluidics-in-malignant-glioma-research-and-precision-medicine
#3
Meghan Logun, Wujun Zhao, Leidong Mao, Lohitash Karumbaiah
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that has no effective treatments and a prognosis of only 12-15 months. Microfluidic technologies deliver microscale control of fluids and cells, and have aided cancer therapy as point-of-care devices for the diagnosis of breast and prostate cancers. However, a few microfluidic devices are developed to study malignant glioma. The ability of these platforms to accurately replicate the complex microenvironmental and extracellular conditions prevailing in the brain and facilitate the measurement of biological phenomena with high resolution and in a high-throughput manner could prove useful for studying glioma progression...
May 2018: Advanced Biosystems
https://www.readbyqxmd.com/read/29767290/stem-cells-in-alzheimer-s-disease-current-standing-and-future-challenges
#4
Haitham Salem, Gabriela D Colpo, Antonio L Teixeira
To date, there is no definitive treatment for Alzheimer's disease (AD). The realm of stem cells is very promising in regenerative medicine, particularly for neurodegenerative diseases. Various types of stem cells have been used in preclinical/clinical trials for AD aiming the development of an elusive disease modifying therapy. Over the last decade, much knowledge has been gained in this field regarding types of cells, routes and timing of administration, and outcomes of stem cells-based strategies for AD. In this chapter, we will trace the state of art and the challenges facing the use of stem cells in AD...
May 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29764369/vareporter-variant-reporter-for-cancer-research-of-massive-parallel-sequencing
#5
Po-Jung Huang, Chi-Ching Lee, Ling-Ya Chiu, Kuo-Yang Huang, Yuan-Ming Yeh, Chia-Yu Yang, Cheng-Hsun Chiu, Petrus Tang
BACKGROUND: High throughput sequencing technologies have been an increasingly critical aspect of precision medicine owing to a better identification of disease targets, which contributes to improved health care cost and clinical outcomes. In particular, disease-oriented targeted enrichment sequencing is becoming a widely-accepted application for diagnostic purposes, which can interrogate known diagnostic variants as well as identify novel biomarkers from panels of entire human coding exome or disease-associated genes...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29762482/nanocomposites-based-on-biodegradable-polymers
#6
REVIEW
Ilaria Armentano, Debora Puglia, Francesca Luzi, Carla Renata Arciola, Francesco Morena, Sabata Martino, Luigi Torre
In the present review paper, our main results on nanocomposites based on biodegradable polymers (on a time scale from 2010 to 2018) are reported. We mainly focused our attention on commercial biodegradable polymers, which we mixed with different nanofillers and/or additives with the final aim of developing new materials with tunable specific properties. A wide list of nanofillers have been considered according to their shape, properties, and functionalization routes, and the results have been discussed looking at their roles on the basis of different adopted processing routes (solvent-based or melt-mixing processes)...
May 15, 2018: Materials
https://www.readbyqxmd.com/read/29760254/learning-narrative-based-medicine-skills-narrative-based-medicine-3
#7
REVIEW
George Zaharias
OBJECTIVE: To raise awareness of narrative-based medicine (NBM) as a valuable approach to the consultation, which, if practised more widely by GPs, would convey considerable benefits to both patient and doctor. SOURCES OF INFORMATION: While this article draws on the perspectives of 2 of NBM's key proponents, Rita Charon and John Launer, it also presents the author's perspective on the usefulness of the arts. MAIN MESSAGE: This article presents some practical ways in which GPs can start using the skills of NBM and methods for developing those skills further...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29758534/investigations-of-the-corneal-epithelium-in-veterinary-medicine-state-of-the-art-on-corneal-stem-cells-found-in-different-mammalian-species-and-their-putative-application
#8
REVIEW
M Patruno, A Perazzi, T Martinello, C Gomiero, L Maccatrozzo, I Iacopetti
The existence of progenitor cells that can readily differentiate into a specific cell type is a common cellular strategy for physiological tissue growth and repair mechanisms. In the mammalian cornea, many aspects regarding the nature and location of these cells are still unclear. In the human limbus (peripheral area of the cornea) progenitor cells have been found and characterized but in non-human mammals, the picture is not so clear. In this review, we examine current knowledge about the morphology of limbus and the localization of corneal epithelial stem cells in all species studied so far, comparing data with humans...
May 8, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29749854/personalized-precision-medicine-personalised-healthcare-the-art-of-giving-different-names-to-the-same-thing
#9
Ruth March, Cecilia Schott
No abstract text is available yet for this article.
November 2017: Personalized Medicine
https://www.readbyqxmd.com/read/29745321/selected-applications-for-current-polymers-in-prosthetic-dentistry-state-of-the-art
#10
Maciej Kawala, Joanna Smardz, Lukasz Adamczyk, Natalia Grychowska, Mieszko Wieckiewicz
BACKGROUND: Polymers are widely applied in medicine, including dentistry, i.e. in prosthodontics. AIM: The following paper is aimed at demonstrating the applications of selected modern polymers in prosthetic dentistry based on the reported literature. MATERIAL AND METHODS: The study was conducted using the PubMed, SCOPUS and CINAHL databases in relation to documents published during 1999-2017. The following keywords were used: polymers with: prosthetic dentistry, impression materials, denture base materials, bite registration materials, denture soft liners, occlusal splint materials and 3D printing...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29740579/the-role-of-genetics-in-advancing-precision-medicine-for-alzheimer-s-disease-a-narrative-review
#11
REVIEW
Yun Freudenberg-Hua, Wentian Li, Peter Davies
Alzheimer's disease (AD) is the most common type of dementia, which has a substantial genetic component. AD affects predominantly older people. Accordingly, the prevalence of dementia has been rising as the population ages. To date, there are no effective interventions that can cure or halt the progression of AD. The only available treatments are the management of certain symptoms and consequences of dementia. The current state-of-the-art medical care for AD comprises three simple principles: prevent the preventable, achieve early diagnosis, and manage the manageable symptoms...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29739700/catalysing-the-development-and-introduction-of-paediatric-drug-formulations-for-children-living-with-hiv-a-new-global-collaborative-framework-for-action
#12
Martina Penazzato, Melynda Watkins, Sébastien Morin, Linda Lewis, Fernando Pascual, Marissa Vicari, Janice Lee, Sally Hargreaves, Meg Doherty, George K Siberry
Progress in the development and introduction of paediatric formulations for key infectious diseases is poor in low-income and middle-income countries (LMICs). Although major steps have been made in the scale-up of antiretroviral medicines in LMICs, the development and deployment of formulations for infants and children is suboptimal. Of the children living with HIV globally (most in Africa), only 43% are receiving antiretroviral therapy (ART), many with suboptimal formulations. These shortfalls pose a series of challenges to meeting global treatment targets of 1·6 million children (aged 0-14 years) on ART by the end of 2018 (95% coverage) and to ensuring that 95% of those on ART are virologically suppressed...
May 2018: Lancet HIV
https://www.readbyqxmd.com/read/29738820/classification-of-forensic-autopsy-reports-through-conceptual-graph-based-document-representation-model
#13
Ghulam Mujtaba, Liyana Shuib, Ram Gopal Raj, Retnagowri Rajandram, Khairunisa Shaikh, Mohammed Ali Al-Garadi
Text categorization has been used extensively in recent years to classify plain-text clinical reports. This study employs text categorization techniques for the classification of open narrative forensic autopsy reports. One of the key steps in text classification is document representation. In document representation, a clinical report is transformed into a format that is suitable for classification. The traditional document representation technique for text categorization is the bag-of-words (BoW) technique...
May 5, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29738419/hormone-therapy-for-the-treatment-of-postmenopausal-osteoporosis-will-it-soon-become-a-lost-art-in-medicine
#14
Xuezhi Daniel Jiang
No abstract text is available yet for this article.
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29736568/emerging-concepts-in-treating-cartilage-osteochondral-defects-and-osteoarthritis-of-the-knee-and-ankle
#15
Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, Pedro L Ripoll, João Espregueira-Mendes, J Miguel Oliveira, Rui L Reis, C Niek van Dijk
The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29732369/single-cell-multi-omics-technology-methodology-and-application
#16
REVIEW
Youjin Hu, Qin An, Katherine Sheu, Brandon Trejo, Shuxin Fan, Ying Guo
In the era of precision medicine, multi-omics approaches enable the integration of data from diverse omics platforms, providing multi-faceted insight into the interrelation of these omics layers on disease processes. Single cell sequencing technology can dissect the genotypic and phenotypic heterogeneity of bulk tissue and promises to deepen our understanding of the underlying mechanisms governing both health and disease. Through modification and combination of single cell assays available for transcriptome, genome, epigenome, and proteome profiling, single cell multi-omics approaches have been developed to simultaneously and comprehensively study not only the unique genotypic and phenotypic characteristics of single cells, but also the combined regulatory mechanisms evident only at single cell resolution...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#17
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29727736/paris-in-the-spring-a-review-of-the-trade-conservation-and-opportunities-in-the-shift-from-wild-harvest-to-cultivation-of-paris-polyphylla-trilliaceae
#18
REVIEW
A B Cunningham, J A Brinckmann, Y-F Bi, S-J Pei, U Schippmann, P Luo
ETHNOPHARMACOLOGICAL RELEVANCE: P. polyphylla Smith is used in traditional medicine in China, India and Nepal and is likely to be similarly used through most of its geographic range. China is at the centre of demand for P. polyphylla where it is used as an ingredient in several very successful Chinese medicinal herbal formulations. The Chinese e-commerce platform 'alibaba.com', for example, lists 97P. polyphylla items offered by 46 Asian suppliers, of which 21 are situated in the Chinese mainland, 12 in Nepal, 7 in India, 2 in Pakistan, and 1 each in Bhutan, Hong Kong, Thailand, and Vietnam...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29714582/the-near-term-viability-and-benefits-of-elabels-for-patients-clinical-sites-and-sponsors
#19
Jodi Smith-Gick, Nicola Barnes, Rocco Barone, Jeff Bedford, Jason R James, Stacy Frankovitz Reisner, Michael Stephenson
BACKGROUND: Current clinical trial labels are designed primarily to meet regulatory requirements. These labels have low patient and site utility, few are opened, and they have limited space and small fonts. As our world transitions from paper to electronic, an opportunity exists to provide patients with information about their investigational clinical trial product in a way that is more easily accessible, meets Health Authority requirements, and provides valuable additional information for the patient and caregiver...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29713277/greater-celandine-s-ups-and-downs-21-centuries-of-medicinal-uses-of-chelidonium-majus-from-the-viewpoint-of-today-s-pharmacology
#20
REVIEW
Sylwia Zielińska, Anna Jezierska-Domaradzka, Magdalena Wójciak-Kosior, Ireneusz Sowa, Adam Junka, Adam M Matkowski
As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the " signatura rerum " principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and cholagogue, pain-relieving, and quite often mentioned-ophthalmological problems. Central and Eastern European folk medicine has always been using this herb extensively. In this region, the plant is known under many unique vernacular names, especially in Slavonic languages, associated or not with old Greek relation to "chelidon"-the swallow...
2018: Frontiers in Pharmacology
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