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https://www.readbyqxmd.com/read/29341974/feasibility-and-effectiveness-of-continuing-methadone-maintenance-treatment-during-incarceration-compared-with-forced-withdrawal
#1
Kelly E Moore, Lindsay Oberleitner, Kathryn M Z Smith, Kathleen Maurer, Sherry A McKee
BACKGROUND: Methadone maintenance treatment (MMT) is underutilized in correctional settings, and those receiving MMT in the community often undergo withdrawal upon incarceration. Federal and state regulations present barriers to providing methadone in correctional facilities. For this investigation, a community provider administered methadone to inmates who had been receiving methadone prior to incarceration. We hypothesized that inmates continued on MMT would have improved behavior during incarceration and post-release...
January 16, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29341214/cue-reactivity-habituation-and-eating-in-the-absence-of-hunger-in-children-with-loss-of-control-eating-and-attention-deficit-hyperactivity-disorder
#2
Anja Hilbert, Susanne Kurz, Daniela Dremmel, Susann Weihrauch Blüher, Simone Munsch, Ricarda Schmidt
OBJECTIVE: Childhood loss of control (LOC) eating and attention-deficit/hyperactivity disorder (ADHD) are highly comorbid conditions and present with disordered eating behaviors, such as overeating. This study sought to delineate shared and specific abnormalities in physiological, cognitive-motivational, and behavioral components of food-specific impulsivity in children with LOC eating and ADHD. Specifically, children's reactivity and habituation to food and eating in the absence of hunger were examined...
January 17, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29340887/toward-evidence-based-chinese-medicine-status-quo-opportunities-and-challenges
#3
Yao-Long Chen, Chen Zhao, Li Zhang, Bo Li, Chuan-Hong Wu, Wei Mu, Jia-Ying Wang, Ke-Hu Yang, You-Ping Li, Chiehfeng Chen, Yong-Yan Wang, Chen Wang, Zhao-Xiang Bian, Hong-Cai Shang
How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare. Over the recent years, evidence-based medicine (EBM) has been increasingly applied to CM, strengthening its theoretical basis...
January 16, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29340790/an-automated-framework-for-qsar-model-building
#4
Samina Kausar, Andre O Falcao
BACKGROUND: In-silico quantitative structure-activity relationship (QSAR) models based tools are widely used to screen huge databases of compounds in order to determine the biological properties of chemical molecules based on their chemical structure. With the passage of time, the exponentially growing amount of synthesized and known chemicals data demands computationally efficient automated QSAR modeling tools, available to researchers that may lack extensive knowledge of machine learning modeling...
January 16, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29339565/a-home-visiting-parenting-program-and-child-obesity-a-randomized-trial
#5
Monica Roosa Ordway, Lois S Sadler, Margaret L Holland, Arietta Slade, Nancy Close, Linda C Mayes
BACKGROUND: Young children living in historically marginalized families are at risk for becoming adolescents with obesity and subsequently adults with increased obesity-related morbidities. These risks are particularly acute for Hispanic children. We hypothesized that the prevention-focused, socioecological approach of the "Minding the Baby" (MTB) home visiting program might decrease the rate of childhood overweight and obesity early in life. METHODS: This study is a prospective longitudinal cohort study in which we include data collected during 2 phases of the MTB randomized controlled trial...
January 16, 2018: Pediatrics
https://www.readbyqxmd.com/read/29338723/preventing-suicidal-behaviours-with-a-multilevel-intervention-a-cluster-randomised-controlled-trial
#6
Sunny Collings, Gabrielle Jenkin, James Stanley, Sarah McKenzie, Simon Hatcher
BACKGROUND: In the context of the recent surge in community based multilevel interventions for suicide prevention, all of which show promising results, we discuss the implications of the findings of such an intervention designed for and implemented in New Zealand. The multi-level intervention for suicide prevention in New Zealand (MISP-NZ) was a cluster randomised controlled community intervention trial involving eight hospital regions matched into four pairs and randomised to either the intervention or practice as usual (the control)...
January 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29338462/rethinking-revascularization-in-patients-with-stable-angina
#7
Ralf E Harskamp, Duk-Woo Park
Traditional and current perception for benefit of percutaneous coronary intervention (PCI) is that patients with stable angina will obtain symptom relief as well as improved exercise capacity after percutaneous revascularization. This common clinical perception is put to test in the ORBITA trial, the first blinded, randomized placebo-controlled clinical study ever conducted. The findings of this study will send shockwaves throughout the cardiology community.
January 17, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29338322/associations-of-mindfulness-with-depressive-symptoms-and-well-being-in-older-adults-the-moderating-role-of-neuroticism
#8
Ari J Elliot, Autumn M Gallegos, Jan A Moynihan, Benjamin P Chapman
OBJECTIVE: To investigate whether observed interactions of mindfulness with the personality trait neuroticism extend to older adults and to aspects of psychological functioning other than depressive symptoms, and whether effects of mindfulness training in this population depend on levels of neuroticism. METHOD: We performed a secondary analysis of data from a randomized controlled trial of Mindfulness-Based Stress Reduction (MBSR) for community-dwelling older adults...
January 17, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29337679/the-effects-of-physical-activity-on-chronic-subclinical-systemic-inflammation
#9
Alba Maria Dalbello Tir, Marina Labor, Davor Plavec
Chronic subclinical systemic inflammation (CSSI) is a pathogenic event and a common risk factor for many noncommunicable diseases like atherosclerosis, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes, cancer, and obstructive lung disease. On the other hand, regular physical activity has been found to reduce this risk. Many studies of different design were conducted to assess the association between inflammatory mediators as markers of CSSI and regular physical activity. The aim of this review was to present the current level of evidence and understanding of potential mechanisms by which physical activity reduces inflammatory mediators involved in CSSI and the types of physical activity required for the expected effect...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337024/moderators-of-treatment-outcomes-following-telehealth-self-management-and-education-in-adults-with-multiple-sclerosis-a-secondary-analysis-of-a-randomized-controlled-trial
#10
Dawn M Ehde, Anne Arewasikporn, Kevin N Alschuler, Abbey J Hughes, Aaron P Turner
OBJECTIVE: To examine moderators of treatment effects in a randomized controlled trial comparing a telehealth self-management intervention to a telehealth MS education intervention for fatigue, pain, and mood in adults with multiple sclerosis (MS). DESIGN: Secondary analysis of a single-blind randomized controlled trial. SETTING: community. PARTICIPANTS: Adults with MS and chronic fatigue, chronic pain, and/or moderate depressive symptoms (N=163) recruited from across the United States...
January 11, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29335013/fit-for-function-study-protocol-for-a-randomized-controlled-trial
#11
Julie Richardson, Ada Tang, Gordon Guyatt, Lehana Thabane, Feng Xie, Demetrios Sahlas, Robert Hart, Rebecca Fleck, Genevieve Hladysh, Louise Macrae
BACKGROUND: The current state of evidence suggests that community-based exercise programs are beneficial in improving impairment, function, and health status, and are greatly needed for persons with stroke. However, limitations of these studies include risk of bias, feasibility, and cost issues. METHODS/DESIGN: This single-blinded, randomized controlled trial (RCT) of 216 participants with stroke will compare the effectiveness of a 12-week YMCA community-based wellness program (FIT for FUNCTION) specifically designed for community-dwelling persons with stroke to persons who receive a standard YMCA membership...
January 15, 2018: Trials
https://www.readbyqxmd.com/read/29334900/process-evaluation-of-the-radiant-community-study-a-dialysis-facility-level-intervention-to-increase-referral-for-kidney-transplantation
#12
Reem E Hamoda, Jennifer C Gander, Laura J McPherson, Kimberly J Arriola, Loren Cobb, Stephen O Pastan, Laura Plantinga, Teri Browne, Erica Hartmann, Laura Mulloy, Carlos Zayas, Jenna Krisher, Rachel E Patzer
BACKGROUND: The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral for kidney transplant evaluation among selected Georgia dialysis facilities. METHODS: To assess implementation of the RaDIANT intervention, we conducted a process evaluation at the conclusion of the intervention period (January-December 2014)...
January 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29334874/a-comparison-of-collaborative-care-outcomes-in-two-health-care-systems-va-clinics-and-federally-qualified-health-centers
#13
Kathleen M Grubbs, John C Fortney, Jeffrey Pyne, Dinesh Mittal, John Ray, Teresa J Hudson
OBJECTIVE: Collaborative care for depression results in symptom reduction when compared with usual care. No studies have systematically compared collaborative care outcomes between veterans treated at Veterans Affairs (VA) clinics and civilians treated at publicly funded federally qualified health centers (FQHCs) after controlling for demographic and clinical characteristics. METHODS: Data from two randomized controlled trials that used a similar collaborative care intervention for depression were combined to conduct post hoc analyses (N=759)...
January 16, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29333954/prevalence-diagnosis-and-treatment-rates-of-mood-disorders-among-opioid-users-under-criminal-justice-supervision
#14
Mary Mbaba, Shan-Estelle Brown, Alese Wooditch, Marissa Kiss, Amy Murphy, Suneeta Kumari, Faye Taxman, Frederick Altice, William B Lawson, Sandra A Springer
BACKGROUND: Individuals involved in the criminal justice system have disproportionately high rates of psychiatric disorders when compared to the general U.S. POPULATION: If left untreated, the likelihood of subsequent arrest increases and risk for adverse health consequences is great, particularly among opioid users. OBJECTIVES: To explore the prevalence, characteristics, and treatment of mood disorders among justice involved opioid-dependent populations...
January 15, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29333504/community-based-physical-activity-as-adjunctive-smoking-cessation-treatment-rationale-design-and-baseline-data-for-the-lifestyle-enhancement-program-leap-randomized-controlled-trial
#15
Mark W Vander Weg, Mace Coday, Michelle B Stockton, Barbara McClanahan, George Relyea, Mary C Read, Nancy Wilson, Stephanie Connelly, Phyllis Richey, Karen C Johnson, Kenneth D Ward
Despite advances in behavioral and pharmacological treatment for tobacco use and dependence, quit rates remain suboptimal. Increasing physical activity has shown some promise as a strategy for improving cessation outcomes. However, initial efficacy studies focused on intensive, highly structured exercise programs that may not be applicable to the general population of smokers. We describe the rationale and study design and report baseline participant characteristics from the Lifestyle Enhancement Program (LEAP), a two-group, randomized controlled trial...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29332909/type-2-myocardial-infarction%C3%A3-an-evolving-entity
#16
Cian P McCarthy, James L Januzzi, Hanna K Gaggin
Type 2 myocardial infarction (T2MI) refers to myocardial necrosis caused by an imbalance in myocardial oxygen supply and demand and in the absence of acute coronary thrombosis. Despite growing recognition of this entity, there remains little understanding of the pathophysiology and uncertainty over the diagnostic criteria for this subtype of MI. Alarmingly, recent studies suggest that a diagnosis of T2MI pertains a prognosis similar to, if not worse than, type 1 MI. With increasing clinical use of high-sensitivity cardiac troponin assays, the frequency of recognition of T2MI is expected to increase...
January 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29330880/concise-review-optimized-strategies-for-stem-cell-based-therapy-in-myocardial-repair-clinical-translatability-and-potential-limitation
#17
REVIEW
Rongrong Wu, Xinyang Hu, Jian'an Wang
Ischemic heart diseases (IHDs) remain major public health problems with high rates of morbidity and mortality worldwide. Despite significant advances, current therapeutic approaches are unable to rescue the extensive and irreversible loss of cardiomyocytes caused by severe ischemia. Over the past 16 years, stem cell-based therapy has been recognized as an innovative strategy for cardiac repair/regeneration and functional recovery after IHDs. Although substantial preclinical animal studies using a variety of stem/progenitor cells have shown promising results, there is a tremendous degree of skepticism in the clinical community as many stem cell trials do not confer any beneficial effects...
January 13, 2018: Stem Cells
https://www.readbyqxmd.com/read/29330083/rationale-and-design-of-the-clinic-and-community-approaches-to-healthy-weight-randomized-trial
#18
Lauren Fiechtner, Meghan Perkins, Vincent Biggs, Nancy Langhans, Mona Sharifi, Giselle O'Connor, Sarah Price, Joseph Locascio, Karen Kuhlthau, Jo-Ann Kwass, Candace Nelson, Thomas Land, Matt Longjohn, Valerie Lawson, Katherine Hohman, Elsie M Taveras
BACKGROUND: Recent studies have demonstrated the effectiveness of family-centered, pediatric weight management programs in reducing childhood obesity. Yet, programs to optimize the care of low-income children with obesity are needed. We sought to examine the comparative effectiveness of two, potentially scalable pediatric weight management programs delivered to low-income children in a clinical or community setting. MATERIALS AND METHODS: The Clinic and Community Approaches to Healthy Weight trial is a randomized trial in two communities in Massachusetts that serve a large population of low-income children and families...
January 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29329244/infant-development-at-the-age-of-6-months-in-relation-to-feeding-practices-iron-status-and-growth-in-a-peri-urban-community-of-south-africa
#19
Marinel Rothman, Mieke Faber, Namukolo Covic, Tonderayi M Matsungo, Marike Cockeran, Jane D Kvalsvig, Cornelius M Smuts
BACKGROUND: Evidence on the association between feeding practices, iron deficiency, anaemia, stunting, and impaired psychomotor development during infancy is limited. This study assessed the association between psychomotor development with early feeding practices, growth, iron status, and anaemia. METHODS: This was cross-sectional baseline data of a randomised controlled trial which included 6-month-old infants and their mothers or primary caregivers (n = 750) in a peri-urban community in the North West province of South Africa...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29327248/introducing-new-technology-safely-into-urological-practice
#20
Siska Van Bruwaene, Benjamin Namdarian, Ben Challacombe, Ben Eddy, Ignace Billiet
PURPOSE: Surgical innovation is necessary to ensure continued improvement in patient care. However, several challenges unique to the surgical craft are encountered during the development and validation of such new technology. This article highlights some of these challenges and gives an overview of existing solutions. METHODS: A Pubmed review was performed about the "introduction of new technology" to identify challenges. Cross-referencing was used to explore the possible solutions per challenge...
January 11, 2018: World Journal of Urology
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