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https://www.readbyqxmd.com/read/28528463/facebook-advertising-to-recruit-young-urban-women-into-an-hiv-prevention-clinical-trial
#1
Rachel Jones, Lorraine J Lacroix, Eloni Porcher
Advertising via Facebook to elicit involvement in clinical trials has demonstrated promise in expanding geographic reach while maintaining confidentiality. The purpose of this study is to evaluate Facebook advertising to reach at-risk, predominately African American or Black women in higher HIV prevalence communities for an HIV prevention clinical trial, and to compare baseline characteristics to those recruited on-the-ground. Maintaining confidentiality and the practical aspects of creating and posting ads on Facebook are described...
May 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28528389/a-life-less-lonely-the-state-of-the-art-in-interventions-to-reduce-loneliness-in-people-with-mental-health-problems
#2
REVIEW
Farhana Mann, Jessica K Bone, Brynmor Lloyd-Evans, Johanna Frerichs, Vanessa Pinfold, Ruimin Ma, Jingyi Wang, Sonia Johnson
PURPOSE: There is growing evidence of significant harmful effects of loneliness. Relatively little work has focused on how best to reduce loneliness in people with mental health problems. We aim to present an overview of the current state of the art in loneliness interventions in people with mental health problems, identify relevant challenges, and highlight priorities for future research and implementation. METHODS: A scoping review of the published and grey literature was conducted, as well as discussions with relevant experts, to propose a broad classification system for types of interventions targeting loneliness...
May 20, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28527855/initiation-of-extended-release-naltrexone-xr-ntx-for-opioid-use-disorder-prior-to-release-from-prison
#3
Peter D Friedmann, Donna Wilson, Randall Hoskinson, Michael Poshkus, Jennifer G Clarke
BACKGROUND: Opioid use disorder is common in prison populations, and prison release is a high-risk time for relapse and overdose. Initiation of extended release injectable naltrexone (XR-NTX)) prior to prison release might decrease relapse among opioid-dependent persons. OBJECTIVE: This pilot study examined the feasibility and acceptability of XR-NTX injection prior to prison release among adult inmates with opioid use disorder, followed by six months of community XR-NTX treatment...
April 19, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28526661/the-parasol-protocol-an-implementation-science-study-of-hiv-continuum-of-care-interventions-for-gay-men-and-transgender-women-in-burma-myanmar
#4
Andrea L Wirtz, Soe Naing, Emily Clouse, Kaung Htet Thu, Sandra Hsu Hnin Mon, Zin Min Tun, Stefan Baral, Aung Zayar Paing, Chris Beyrer
BACKGROUND: Efforts to improve HIV diagnosis and antiretroviral therapy (ART) initiation among people living with HIV and reduce onward transmission of HIV rely on innovative interventions along multiple steps of the HIV care continuum. These innovative methods are particularly important for key populations, including men who have sex with men (MSM) and transgender women (TW). The HIV epidemic in Myanmar is concentrated among key populations, and national efforts now focus on reducing stigma and improving engagement of MSM and TW in HIV prevention and care...
May 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28526482/reducing-trunk-compensation-in-stroke-survivors-a-randomized-crossover-trial-comparing-visual-vs-force-feedback-modalities
#5
Bulmaro Adolfo Valdés, Andrea Nicole Schneider, Hendrik Fridolijn Machiel Van der Loos
OBJECTIVE: To investigate whether the compensatory trunk movements of stroke survivors observed during reaching tasks can be decreased by force and visual feedback, and examine whether one of these feedback modalities is more efficacious than the other in reducing this compensatory tendency. DESIGN: Randomized Crossover Trial SETTING: University research laboratory PARTICIPANTS: 15 community dwelling older adults: 5 female, 64 ± 11 years old, with hemiplegia from non-traumatic hemorrhagic or ischemic stroke (> 3 months post-stroke), recruited from stroke recovery groups, the research group's website and the community...
May 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28526388/serum-vitamin-d-and-change-in-lipid-levels-over-5%C3%A2-y-the-atherosclerosis-risk-in-communities-study
#6
Kamil F Faridi, Di Zhao, Seth S Martin, Joshua R Lupton, Steven R Jones, Eliseo Guallar, Christie M Ballantyne, Pamela L Lutsey, Erin D Michos
OBJECTIVES: Deficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia. Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. The aim of this study was to determine the relationship of 25(OH)D deficiency to longitudinal lipid changes and risk for incident dyslipidemia. METHODS: This was a longitudinal community-based study of 13 039 participants from the ARIC (Atherosclerosis Risk in Communities) study who had 25(OH)D and lipids measured at baseline (1990-1992) and lipids remeasured in 1993 to 1994 and 1996 to 1998...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526380/comparison-between-two-assessment-tools-for-fruit-and-vegetable-intake-relative-to-the-24-h-recall
#7
Mariana Souza Lopes, Luana Caroline Dos Santos, Aline Cristine Souza Lopes, Mery Natali Silva Abreu
OBJECTIVE: The aim of this study was to evaluate the validity of methods assessing fruit and vegetable (FV) intake among Brazilian users of the Primary Attention Health Care Program. METHODS: The present study included 299 participants (age ≥20 y) from a representative sample from a randomized controlled community trial performed as part of a health promotion program in a Brazilian metropolis. All participants completed three methods for the assessment of FV consumption: brief questionnaire of FV (QBrief-FV), food frequency questionnaire of FV, and a 24-h dietary recall...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526255/associations-of-objective-and-subjective-sleep-disturbance-with-cognitive-function-in-older-men-with-comorbid-depression-and-insomnia
#8
Daniel J Biddle, Sharon L Naismith, Kathleen M Griffiths, Helen Christensen, Ian B Hickie, Nicholas S Glozier
OBJECTIVES: To examine whether poor objective and subjective sleep quality are differentially associated with cognitive function. DESIGN: Cross-sectional. SETTING: Participants were recruited from primary and secondary care, and directly from the community, in Sydney, Australia. PARTICIPANTS: The sample consisted of 74 men 50years and older (mean [SD], 58.4 [6.2] years), with comorbid depression and above-threshold insomnia symptoms, participating in a trial of online cognitive behavioral therapy for insomnia...
June 2017: Sleep Health
https://www.readbyqxmd.com/read/28526019/mass-anti-malarial-administration-in-western-cambodia-a-qualitative-study-of-factors-affecting-coverage
#9
Christopher Pell, Rupam Tripura, Chea Nguon, Phaikyeong Cheah, Chan Davoeung, Chhouen Heng, Lim Dara, Ma Sareth, Arjen Dondorp, Lorenz von Seidlein, Thomas J Peto
BACKGROUND: Mass anti-malarial administration has been proposed as a key component of the Plasmodium falciparum malaria elimination strategy in the Greater Mekong sub-Region. Its effectiveness depends on high levels of coverage in the target population. This article explores the factors that influenced mass anti-malarial administration coverage within a clinical trial in Battambang Province, western Cambodia. METHODS: Qualitative data were collected through semi-structured interviews and focus group discussions with villagers, in-depth interviews with study staff, trial drop-outs and refusers, and observations in the communities...
May 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28526003/the-basic-research-factors-questionnaire-for-studying-early-childhood-caries
#10
Judith Albino, Tamanna Tiwari, Stuart A Gansky, Michelle M Henshaw, Judith C Barker, Angela G Brega, Steven E Gregorich, Brenda Heaton, Terrence S Batliner, Belinda Borrelli, Paul Geltman, Nancy R Kressin, Jane A Weintraub, Tracy L Finlayson, Raul I Garcia
BACKGROUND: We describe development of the Early Childhood Caries (ECC) Basic Research Factors Questionnaire (BRFQ), a battery of measures assessing common potential predictors, mediators, and moderators of ECC. Individual-, family-, and community-level factors that are linked to oral health outcomes across at-risk populations are included. Developing standard measures of factors implicated in ECC has the potential to enhance our ability to understand mechanisms underlying successful prevention and to develop more effective interventions...
May 19, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28525984/study-protocol-evaluation-of-the-probiotic-lactobacillus-fermentum-cect5716-for-the-prevention-of-mastitis-in-breastfeeding-women-a-randomised-controlled-trial
#11
Diana M Bond, Jonathan M Morris, Natasha Nassar
BACKGROUND: Mastitis and accompanying pain have been associated with the cessation of breastfeeding. Mastitis is an inflammatory condition of the breast and may be a result of decreased immunity and a lowered resistance to infection. Mastitis affects up to one in five breastfeeding women with most episodes occurring in the first 6-8 weeks postpartum. Antibiotics are often used in the treatment of mastitis, but have not been popular or proven effective as a preventative agent. The WHO has highlighted significant concerns relating to adverse harms of antibiotic use with the production of antibiotic-resistant strains of disease organisms...
May 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28522798/cut-off-optimization-for-13-c-urea-breath-test-in-a-community-based-trial-by-mathematic-histology-and-serology-approach
#12
Zhe-Xuan Li, Lei-Lei Huang, Cong Liu, Luca Formichella, Yang Zhang, Yu-Mei Wang, Lian Zhang, Jun-Ling Ma, Wei-Dong Liu, Kurt Ulm, Jian-Xi Wang, Lei Zhang, Monther Bajbouj, Ming Li, Michael Vieth, Michael Quante, Tong Zhou, Le-Hua Wang, Stepan Suchanek, Erwin Soutschek, Roland Schmid, Meinhard Classen, Wei-Cheng You, Markus Gerhard, Kai-Feng Pan
The performance of diagnostic tests in intervention trials of Helicobacter pylori (H.pylori) eradication is crucial, since even minor inaccuracies can have major impact. To determine the cut-off point for (13)C-urea breath test ((13)C-UBT) and to assess if it can be further optimized by serologic testing, mathematic modeling, histopathology and serologic validation were applied. A finite mixture model (FMM) was developed in 21,857 subjects, and an independent validation by modified Giemsa staining was conducted in 300 selected subjects...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522654/diabetic-kidney-disease-challenges-progress-and-possibilities
#13
Radica Z Alicic, Michele T Rooney, Katherine R Tuttle
Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. Although ESRD may be the most recognizable consequence of diabetic kidney disease, the majority of patients actually die from cardiovascular diseases and infections before needing kidney replacement therapy. The natural history of diabetic kidney disease includes glomerular hyperfiltration, progressive albuminuria, declining GFR, and ultimately, ESRD. Metabolic changes associated with diabetes lead to glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis...
May 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28522244/low-molecular-weight-heparin-and-the-relative-risk-of-surgical-site-bleeding-complications-results-of-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-of-venous-thromboprophylaxis-in-patients-after-total-joint-arthroplasty
#14
REVIEW
Kary Suen, Roger N Westh, Leonid Churilov, Andrew J Hardidge
BACKGROUND: Venous thromboembolism causes significant morbidity and mortality in patients after total joint arthroplasty. Although network meta-analyses have demonstrated a benefit of various thromboprophylactic agents, there remains a concern in the surgical community regarding the resulting wound complications. There is currently no systematic review of the surgical site bleeding complications of thromboprophylactic agents. The aim of this study was to systematically review the surgical site bleeding outcomes of venous thromboembolism prophylaxis in this population...
April 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28522227/promoting-motor-skills-in-low-income-ethnic-children-the-physical-activity-in-linguistically-diverse-communities-paldc-nonrandomized-trial
#15
Anthony D Okely, Louise L Hardy, Marijka Batterham, Phillip Pearson, Kim McKeen, Lauren Puglisi
OBJECTIVES: This study reports the long-term effects of a professional learning program for classroom teachers on fundamental motor skill (FMS) proficiency of primary school students from ethnically diverse backgrounds. DESIGN: A cluster non-randomized trial using a nested cross-sectional design. METHODS: The study was conducted in 8 primary schools located in disadvantaged and culturally diverse areas in Sydney, Australia. The intervention used an action learning framework, with each school developing and implementing an action plan for enhancing the teaching of FMS in their school...
May 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28521955/prevalence-of-relevant-ns5a-resistance-associated-substitutions-to-elbasvir-in-genotype-1a-hepatitis-c-virus-patients-in-spain
#16
Claudia Palladino, Beatriz Esteban-Cartelle, Irene Mate-Cano, Marta Sánchez-Carrillo, Salvador Resino, Verónica Briz
Resistance-associated substitutions (RASs) to the new HCV NS5A inhibitor elbasvir may limit its efficacy and lead to virological failure in HCV-GT1a-infected patients. There are no data outside clinical trials evaluating their prevalence and impact in grazoprevir/elbasvir in GT1a-infected patients in Spain. A multicentre cross-sectional study of 632 initial patients was conducted. In 13 of these patients, the sample could not be amplified or a consensus sequence by Sanger sequencing could not be performed. Ultimately, 617 HCV-G1a-infected individuals treated at 84 Spanish hospitals from the 17 autonomous communities plus the 2 autonomous cities of Spain were analysed...
May 15, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28521831/the-sitless-project-exercise-referral-schemes-enhanced-by-self-management-strategies-to-battle-sedentary-behaviour-in-older-adults-study-protocol-for-a-randomised-controlled-trial
#17
Maria Giné-Garriga, Laura Coll-Planas, Míriam Guerra, Àlex Domingo, Marta Roqué, Paolo Caserotti, Michael Denkinger, Dietrich Rothenbacher, Mark A Tully, Frank Kee, Emma McIntosh, Carme Martín-Borràs, Guillermo R Oviedo, Javier Jerez-Roig, Marta Santiago, Oriol Sansano, Guillermo Varela, Mathias Skjødt, Katharina Wirth, Dhayana Dallmeier, Jochen Klenk, Jason J Wilson, Nicole E Blackburn, Manuela Deidda, Guillaume Lefebvre, Denise González, Antoni Salvà
BACKGROUND: Older adults are the fastest growing segment of the world's population. Recent evidence indicates that excessive sitting time is harmful to health, independent of meeting the recommended moderate to vigorous physical activity (PA) guidelines. The SITLESS project aims to determine whether exercise referral schemes (ERS) can be enhanced by self-management strategies (SMSs) to reduce sedentary behaviour (SB), increase PA and improve health, quality of life and function in the long term, as well as psychosocial outcomes in community-dwelling older European citizens from four countries, within a three-armed pragmatic randomised controlled trial, compared with ERS alone and also with general recommendations about PA...
May 18, 2017: Trials
https://www.readbyqxmd.com/read/28521781/telling-our-stories-heroin-assisted-treatment-and-snap-activism-in-the-downtown-eastside-of-vancouver
#18
Susan Boyd, Dave Murray, Donald MacPherson
BACKGROUND: This article highlights the experiences of a peer-run group, SALOME/NAOMI Association of Patients (SNAP), that meets weekly in the Downtown Eastside of Vancouver, British Columbia, Canada. SNAP is a unique independent peer- run drug user group that formed in 2011 following Canada's first heroin-assisted treatment trial (HAT), North America Opiate Medication Initiative (NAOMI). SNAP's members are now made up of former research participants who participated in two heroin-assisted trials in Vancouver...
May 18, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28521748/contextualizing-willingness-to-participate-recommendations-for-engagement-recruitment-enrolment-of-kenyan-msm-in-future-hiv-prevention-trials
#19
Monika Doshi, Lisa Avery, Ronnie P Kaddu, Mary Gichuhi, Gloria Gakii, Elsabé du Plessis, Sumit Dutta, Shamshad Khan, Joshua Kimani, Robert R Lorway
BACKGROUND: The HIV epidemic among men who have sex with men (MSM) continues to expand globally. The addition of an efficacious, prophylactic vaccine to combination prevention offers immense hope, particularly in low- and middle- income countries which bear the greatest global impact. However, in these settings, there is a paucity of vaccine preparedness studies that specifically pertain to MSM. Our study is the first vaccine preparedness study among MSM and female sex workers (FSWs) in Kenya...
May 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28520473/a-new-method-and-mass-spectrometric-instrument-for-extraterrestrial-microbial-life-detection-using-the-elemental-composition-analyses-of-martian-regolith-and-permafrost-ice
#20
G G Managadze, A A Safronova, K A Luchnikov, E A Vorobyova, N S Duxbury, P Wurz, N G Managadze, A E Chumikov, R Kh Khamizov
We propose a new technique for the detection of microorganisms by elemental composition analyses of a sample extracted from regolith, permafrost, and ice of extraterrestrial bodies. We also describe the design of the ABIMAS instrument, which consists of the onboard time-of-flight laser mass-reflectron (TOF LMR) and the sample preparation unit (SPU) for biomass extraction. This instrument was initially approved to fly on board the ExoMars 2020 lander mission. The instrument can be used to analyze the elemental composition of possible extraterrestrial microbial communities and compare it to that of terrestrial microorganisms...
May 2017: Astrobiology
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