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Brown adipose tissue polyphenols

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https://www.readbyqxmd.com/read/27874268/a-combination-of-resveratrol-and-quercetin-induces-browning-in-white-adipose-tissue-of-rats-fed-an-obesogenic-diet
#1
Noemí Arias, Catalina Picó, M Teresa Macarulla, Paula Oliver, Jonatan Miranda, Andreu Palou, María P Portillo
OBJECTIVE: To analyze whether a combination of quercetin (Q) and resveratrol (RSV) would induce a white adipose tissue (WAT) browning effect. METHODS: Thirty-six rats were fed an obesogenic diet and divided into four groups: control, treated with RSV (15 mg/kg body weight/day; RSV group), treated with Q (30 mg/kg body weight/day; Q group), or treated with both polyphenols (RSV + Q group). RESULTS: After 6 weeks, body and WAT weights were significantly reduced in the RSV + Q group...
November 22, 2016: Obesity
https://www.readbyqxmd.com/read/27077216/the-effects-of-high-fat-diet-and-resveratrol-on-mitochondrial-activity-of-brown-adipocytes
#2
Cheol Ryong Ku, Yoon Hee Cho, Zhen Yu Hong, Ha Lee, Sue Ji Lee, Seung Soo Hong, Eun Jig Lee
BACKGROUND: Resveratrol (RSV) is a polyphenolic phytoalexin that has many effects on metabolic diseases such as diabetes and obesity. Given the importance of brown adipose tissue (BAT) for energy expenditure, we investigated the effects of RSV on brown adipocytes. METHODS: For the in vitro study, interscapular BAT was isolated from 7-week-old male Sprague Dawley rats. For the in vivo study, 7-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were divided into four groups and treated for 27 weeks with: standard diet (SD); SD+RSV (10 mg/kg body weight, daily); high fat diet (HFD); HFD+RSV...
June 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26569269/polyphenol-rich-fraction-of-ecklonia-cava-improves-nonalcoholic-fatty-liver-disease-in-high-fat-diet-fed-mice
#3
Eun-Young Park, Hojung Choi, Ji-Young Yoon, In-Young Lee, Youngwan Seo, Hong-Seop Moon, Jong-Hee Hwang, Hee-Sook Jun
Ecklonia cava (E. cava; CA) is an edible brown alga with beneficial effects in diabetes via regulation of various metabolic processes such as lipogenesis, lipolysis, inflammation, and the antioxidant defense system in liver and adipose tissue. We investigated the effect of the polyphenol-rich fraction of E. cava produced from Gijang (G-CA) on nonalcoholic fatty liver disease (NAFLD) in high-fat diet (HFD)-fed mice. C57BL6 mice were fed a HFD for six weeks and then the HFD group was administered 300 mg/kg of G-CA extracts by oral intubation for 10 weeks...
November 12, 2015: Marine Drugs
https://www.readbyqxmd.com/read/26375960/a-single-oral-administration-of-theaflavins-increases-energy-expenditure-and-the-expression-of-metabolic-genes
#4
Naoto Kudo, Yasunori Arai, Yoshitomo Suhara, Takeshi Ishii, Tsutomu Nakayama, Naomi Osakabe
Theaflavins are polyphenols found in black tea, whose physiological activities are not well understood. This study on mice evaluated the influence of a single oral administration of theaflavins on energy metabolism by monitoring the initial metabolic changess in skeletal muscle and brown adipose tissue (BAT). Oxygen consumption (VO2) and energy expenditure (EE) were increased significantly in mice treated with theaflavin rich fraction (TF) compared with the group administered vehicle alone. There was no difference in locomotor activity...
2015: PloS One
https://www.readbyqxmd.com/read/25761413/resveratrol-induces-brown-like-adipocyte-formation-in-white-fat-through-activation-of-amp-activated-protein-kinase-ampk-%C3%AE-1
#5
S Wang, X Liang, Q Yang, X Fu, C J Rogers, M Zhu, B D Rodgers, Q Jiang, M V Dodson, M Du
OBJECTIVE: Development of brown-like/beige adipocytes in white adipose tissue (WAT) helps to reduce obesity. Thus we investigated the effects of resveratrol, a dietary polyphenol capable of preventing obesity and related complications in humans and animal models, on brown-like adipocyte formation in inguinal WAT (iWAT). METHODS: CD1 female mice (5-month old) were fed a high-fat diet with/without 0.1% resveratrol. In addition, primary stromal vascular cells separated from iWAT were subjected to resveratrol treatment...
June 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/25479240/brown-alga-ecklonia-cava-polyphenol-extract-ameliorates-hepatic-lipogenesis-oxidative-stress-and-inflammation-by-activation-of-ampk-and-sirt1-in-high-fat-diet-induced-obese-mice
#6
Hyeyoon Eo, You-jin Jeon, Myoungsook Lee, Yunsook Lim
Obesity is considered to be a metaflammatory condition. Ecklonia cava, brown algae rich in polyphenols, has shown strong antioxidant activity in vitro. This study investigated the effect of E. cava polyphenol extract (ECPE) on the regulation of fat metabolism, inflammation, and the antioxidant defense system in high fat diet-induced obese mice. After obesity was induced by a high-fat diet (HFD), the mice were administered ECPE by gavage for 5 days/12 weeks. ECPE supplementation reduced body weight gain, adipose tissue mass, plasma lipid profiles, hepatic fat deposition, insulin resistance, and the plasma leptin/adiponectin ratio derived from HFD-induced obesity...
January 14, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25446988/resveratrol-and-obesity-can-resveratrol-relieve-metabolic-disturbances
#7
REVIEW
Marlies de Ligt, Silvie Timmers, Patrick Schrauwen
There is an increasing need for novel preventive and therapeutic strategies to combat obesity and related metabolic disorders. In this respect, the natural polyphenol resveratrol has attracted significant interest. Animal studies indicate that resveratrol mimics the effects of calorie restriction via activation of sirtuin 1 (SIRT1). SIRT1 is an important player in the regulation of cellular energy homeostasis and mitochondrial biogenesis. Rodent studies have shown beneficial effects of resveratrol supplementation on mitochondrial function, glucose metabolism, body composition and liver fat accumulation...
June 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25405284/resveratrol-anti-obesity-mechanisms-of-action
#8
REVIEW
Leixuri Aguirre, Alfredo Fernández-Quintela, Noemí Arias, Maria P Portillo
Resveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is produced naturally in several plants in response to injury or fungal attack. Resveratrol has been recently reported as preventing obesity. The present review aims to compile the evidence concerning the potential mechanisms of action which underlie the anti-obesity effects of resveratrol, obtained either in cultured cells lines and animal models. Published studies demonstrate that resveratrol has an anti-adipogenic effect. A good consensus concerning the involvement of a down-regulation of C/EBPα and PPARγ in this effect has been reached...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/25098399/oolong-black-and-pu-erh-tea-suppresses-adiposity-in-mice-via-activation-of-amp-activated-protein-kinase
#9
Yoko Yamashita, Liuqing Wang, Lihua Wang, Yuki Tanaka, Tianshun Zhang, Hitoshi Ashida
It is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. It is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. In this study, we investigated the suppression of adiposity by oolong, black and pu-erh tea and characterized the underlying molecular mechanism in vivo. We found that the consumption of oolong, black or pu-erh tea for a period of one week significantly decreased visceral fat without affecting body weight in male ICR mice...
October 2014: Food & Function
https://www.readbyqxmd.com/read/23790948/thermogenesis-is-involved-in-the-body-fat-lowering-effects-of-resveratrol-in-rats
#10
Goiuri Alberdi, Víctor M Rodríguez, Jonatan Miranda, M Teresa Macarulla, Itziar Churruca, María P Portillo
The effect of resveratrol on thermogenesis in skeletal muscle and interscapular brown adipose tissue (IBAT) was investigated. Rats were fed an obesogenic diet supplemented with resveratrol (30mg/kg/day) or not supplemented for 6weeks. Resveratrol intake led to increased gene expression of mitochondrial-transcription-factor-A (TFAM), mitochondrial-protein-cytochrome-C-oxidase subunit-2 (COX2), sirtuin-1 (SIRT1), peroxisome-proliferator-activated-receptor-β/δ (PPARβ/δ) and proliferator-activated-receptor-gamma-coactivator1-α (PGC-1α) in IBAT and increased UCP1protein expression; however, peroxisome-proliferator-activated-receptor-α (PPARα) expression remained unchanged...
November 15, 2013: Food Chemistry
https://www.readbyqxmd.com/read/22304913/resveratrol-ameliorates-aging-related-metabolic-phenotypes-by-inhibiting-camp-phosphodiesterases
#11
Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L Brown, Myung K Kim, Michael A Beaven, Alex B Burgin, Vincent Manganiello, Jay H Chung
Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading phosphodiesterases, leading to elevated cAMP levels. The resulting activation of Epac1, a cAMP effector protein, increases intracellular Ca(2+) levels and activates the CamKKβ-AMPK pathway via phospholipase C and the ryanodine receptor Ca(2+)-release channel...
February 3, 2012: Cell
https://www.readbyqxmd.com/read/21951333/the-search-for-compounds-that-stimulate-thermogenesis-in-obesity-management-from-pharmaceuticals-to-functional-food-ingredients
#12
REVIEW
A G Dulloo
The concept of managing obesity through the stimulation of thermogenesis is currently a focus of considerable attention by the pharmaceutical, nutraceutical and functional food industries. This paper first reviews the landmark discoveries that have fuelled the search for thermogenic anti-obesity products that range from single-target drugs to multi-target functional foods. It subsequently analyses the thermogenic and fat-oxidizing potentials of a wide array of bioactive food ingredients which are categorized under methylxanthines, polyphenols, capsaicinoids/capsinoids, minerals, proteins/amino acids, carbohydrates/sugars and fats/fatty acids...
October 2011: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/21751816/a-black-soybean-seed-coat-extract-prevents-obesity-and-glucose-intolerance-by-up-regulating-uncoupling-proteins-and-down-regulating-inflammatory-cytokines-in-high-fat-diet-fed-mice
#13
Yuki Kanamoto, Yoko Yamashita, Fumio Nanba, Tadashi Yoshida, Takanori Tsuda, Itsuko Fukuda, Sachiko Nakamura-Tsuruta, Hitoshi Ashida
Black soybean seed coat extract (BE) is a polyphenol-rich food material consisting of 9.2% cyanidin 3-glucoside, 6.2% catechins, 39.8% procyanidins, and others. This study demonstrated that BE ameliorated obesity and glucose intolerance by up-regulating uncoupling proteins (UCPs) and down-regulating inflammatory cytokines in C57BL/6 mice fed a control or high-fat diet containing BE for 14 weeks. BE suppressed fat accumulation in mesenteric adipose tissue, reduced the plasma glucose level, and enhanced insulin sensitivity in the high-fat diet-fed mice...
August 24, 2011: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/21439945/resveratrol-exerts-anti-obesity-effects-via-mechanisms-involving-down-regulation-of-adipogenic-and-inflammatory-processes-in-mice
#14
Soyoung Kim, Yoojeong Jin, Youngshim Choi, Taesun Park
Resveratrol is a natural polyphenolic stilbene derivative found in a variety of edible fruits, including nuts, berries, and grape skin. Although resveratrol has been suggested to improve thermogenesis in the brown adipose tissues of obese animals, there have been no reports on the anti-adipogenic and anti-inflammatory effects of resveratrol in the white adipose tissues of obese animals. The primary aim of this study was to investigate whether resveratrol attenuates high-fat diet (HFD)-induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in this attenuation...
June 1, 2011: Biochemical Pharmacology
https://www.readbyqxmd.com/read/17201629/green-tea-extract-thermogenesis-induced-weight-loss-by-epigallocatechin-gallate-inhibition-of-catechol-o-methyltransferase
#15
REVIEW
Q Shixian, B VanCrey, J Shi, Y Kakuda, Y Jiang
Epidemiological studies have shown that intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied. Reports have shown that green tea extract intake is associated with increased weight loss due to diet-induced thermogenesis, which is generally attributed to the catechin epigallocatechin gallate. That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis...
2006: Journal of Medicinal Food
https://www.readbyqxmd.com/read/10702779/green-tea-and-thermogenesis-interactions-between-catechin-polyphenols-caffeine-and-sympathetic-activity
#16
A G Dulloo, J Seydoux, L Girardier, P Chantre, J Vandermander
The thermogenic effect of tea is generally attributed to its caffeine content. We report here that a green tea extract stimulates brown adipose tissue thermogenesis to an extent which is much greater than can be attributed to its caffeine content per se, and that its thermogenic properties could reside primarily in an interaction between its high content in catechin-polyphenols and caffeine with sympathetically released noradrenaline (NA). Since catechin-polyphenols are known to be capable of inhibiting catechol-O-methyl-transferase (the enzyme that degrades NA), and caffeine to inhibit trancellular phosphodiesterases (enzymes that break down NA-induced cAMP), it is proposed that the green tea extract, via its catechin-polyphenols and caffeine, is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA-cAMP axis...
February 2000: International Journal of Obesity and related Metabolic Disorders
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