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Paediatric endocrine

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https://www.readbyqxmd.com/read/29151082/survey-on-paediatric-differentiated-thyroid-cancer-care-in-europe
#1
Bernadette L Dekker, Kate L Newbold, Dagmar Führer, Steven G Waguespack, Daria Handkiewicz-Junak, Thera P Links
BACKGROUND/AIMS: Thyroid cancer among children is a very rare disease. Although survival is favourable, morbidity caused by the treatment remains considerable, so there is a great need to optimize management by international cooperation. For this reason, the 2016 European Thyroid Association-Cancer Research Network (ETA-CRN) meeting in Copenhagen, Denmark, paid considerable attention to this topic and aimed to give an overview of the care for this paediatric patient group in different European countries...
November 17, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29037775/neuroendocrine-late-effects-after-tailored-photon-radiotherapy-for-children-with-low-grade-gliomas-long-term-correlation-with-tumour-and-treatment-parameters
#2
Deborah Aloi, Liliana Belgioia, Salvina Barra, Flavio Giannelli, Francesca Cavagnetto, Fabio Gallo, Claudia Milanaccio, MariaLuisa Garrè, Sonia Di Profio, Natascia Di Iorgi, Renzo Corvò
PURPOSE: To evaluate neuroendocrine late effects in paediatric patients with low grade glioma (LGG) who underwent radiotherapy. METHODS AND MATERIAL: We performed a retrospective evaluation of 40 children with LGG treated from July 2002 to January 2015 with external radiotherapy. Tumour locations were cerebral hemisphere (n=2); posterior fossa (n=15); hypothalamic-pituitary axis (HPA, n=15); spine (n=5). Three patients presented a diffuse disease. We looked for a correlation between endocrine toxicity and tumour and treatment parameters...
October 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28989569/clinical-profile-of-diabetes-at-diagnosis-among-children-and-adolescents-at-an-endocrine-clinic-in-ghana
#3
Emmanuel Ameyaw, Serwah B Asafo-Agyei, Sumithira Thavapalan, Angela C Middlehurst, Graham D Ogle
AIM: To determine the clinical features of diabetes in children and adolescents in Ghana. METHODS: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS: One hundred and six subjects presented with diabetes. Ninety (84.9%) were diagnosed by clinical features and family history as type 1, and 16 (15...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28982953/neuroimaging-and-endocrine-disorders-in-paediatric-optic-nerve-hypoplasia
#4
Xiaoxiao Qian, Samksha Fouzdar Jain, Linda A Morgan, Travis Kruse, Monina Cabrera, Donny W Suh
PURPOSE: Optic nerve hypoplasia (ONH) is one of the leading causes of blindness among children. The purpose of this retrospective study is to determine the risk factors and association between brain MRI findings, pituitary abnormalities and endocrine disorders with the presence of ONH. METHODS: A retrospective review of patients seen at paediatric ophthalmology clinics from January 2006 to December 2016 at Children's Hospital and Medical Center and the University of Nebraska Medical Center was performed...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28866630/primary-osteoporosis-in-children
#5
Lay Ong Tan, Soo Yen Lim, Rashida Farhad Vasanwala
Osteoporosis in childhood is uncommon, and it may be secondary to a spectrum of diverse conditions. Idiopathic juvenile osteoporosis is a primary osteoporosis of unknown aetiology present in previously well children and is a diagnosis of exclusion. We describe a 10-year-old prepubertal boy who presented with back pain of 1-week duration. His spinal X-ray showed generalised loss of vertebral body heights in keeping with osteoporosis. Endocrine and haematological work-up were normal. He was treated with vitamin D supplement and intravenous pamidronate...
September 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28803524/endocrinopathies-in-paediatric-onset-neuromyelitis-optica-spectrum-disorder-with-aquaporin-4-aqp4-antibody
#6
Yael Hacohen, Silvia Messina, Hoong-Wei Gan, Sukhvir Wright, Saleel Chandratre, Maria Isabel Leite, Penny Fallon, Angela Vincent, Olga Ciccarelli, Evangeline Wassmer, Ming Lim, Jacqueline Palace, Cheryl Hemingway
The involvement of the diencephalic regions in neuromyelitis optica spectrum disorder (NMOSD) may lead to endocrinopathies. In this study, we identified the following endocrinopathies in 60% (15/25) of young people with paediatric-onset aquaporin 4-Antibody (AQP4-Ab) NMOSD: morbid obesity ( n = 8), hyperinsulinaemia ( n = 5), hyperandrogenism ( n = 5), amenorrhoea ( n = 5), hyponatraemia ( n = 4), short stature ( n = 3) and central hypothyroidism ( n = 2) irrespective of hypothalamic lesions...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28767734/prediction-of-glycaemic-control-in-young-children-and-adolescents-with-type-1-diabetes-mellitus-using-mixed-effects-logistic-regression-modelling
#7
Michiel Joost van Esdonk, Bonnie Tai, Andrew Cotterill, Bruce Charles, Stefanie Hennig
OBJECTIVES: Glycaemic control in children and adolescents with type 1 diabetes mellitus can be challenging, complex and influenced by many factors. This study aimed to identify patient characteristics that were predictive of satisfactory glycaemic control in the paediatric population using a logistic regression mixed-effects (population) modelling approach. METHODS: The data were obtained from 288 patients aged between 1 and 22 years old recorded retrospectively over 3 years (1852 HbA1c observations)...
2017: PloS One
https://www.readbyqxmd.com/read/28683157/growth-impairment-and-gonadal-axis-abnormalities-are-common-in-survivors-of-paediatric-brain-tumours
#8
Sari Pietilä, Anne Mäkipernaa, Anna-Maija Koivisto, Hanna L Lenko
AIM: Childhood brain tumour survivors have a high risk of endocrine morbidity. This study evaluated the growth, pubertal development and gonadal function in survivors of childhood brain tumours and identified factors associated with the problems we observed. METHODS: The 52 subjects (52% male) were diagnosed in 1983-1997 and treated for brain tumours at Tampere University Hospital, Finland. They were followed up at a mean age of 14.2 (3.8-28.7) years, a mean of 7...
July 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28619024/communication-with-young-people-in-paediatric-and-adult-endocrine-consultations-an-intervention-development-and-feasibility-study
#9
J Downing, H Gleeson, P E Clayton, J R E Davis, P Dimitri, J Wales, B Young, P Callery
BACKGROUND: Communication is complex in endocrine care, particularly during transition from paediatric to adult services. The aims of this study were to examine the feasibility of interventions to support young people to interact with clinicians. METHODS: Development and evaluation of a complex intervention in 2 phases: Pre-intervention observational study; Intervention feasibility study. Purposive sample of recordings of 62 consultations with 58 young people aged 11-25 years with long-term endocrine conditions in two paediatric and two adult endocrine clinics...
June 15, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28486235/outcome-of-doctors-attending-the-european-society-for-paediatric-endocrinology-winter-schools-2008-2014
#10
Malcolm D C Donaldson
BACKGROUND/AIMS: Since 1995, the European Society for Paediatric Endocrinology (ESPE) has hosted Winter School (WS), a 5-day interactive meeting of 25 trainees and 7 teachers designed to cover all main endocrine topics. The aim of the present study was to determine subsequent outcome in ex-WS "students." METHODS: A questionnaire was sent in August 2016 to all ESPE WS participants between 2008 and 2014. Information was requested on job/training status at WS attendance and in 2016, and subsequent involvement with ESPE...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28448761/sleeping-cupid-by-caravaggio-what-diagnosis
#11
Paolo Pozzilli, Marco Cappa
OBJECTIVE: The Sleeping Cupid, by Italian painter Caravaggio is a masterpiece painted in 1608. Signs of an endocrine disease are hidden among the shadows of the painting. We decided to conduct a survey among endocrinologists practicing in Italy and asked them if they could identify a specific disease condition in Caravaggio's Sleeping Cupid. METHODS: A total of 86 members from 2 Italian endocrine societies completed the survey: 67 from the Society of Endocrinology and 19 from the Society of Paediatric Endocrinology and Diabetology...
July 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28397663/-a-rare-type-of-severe-obesity-in-children-and-adolescents
#12
Sara Østergaard Christensen, Kirsten Holm, Hanne Buciek Hove
A four-year-old girl was referred to a paediatric department with low height, obesity and hypothyroidism. Her paraclinical tests were characteristic with elevated P-parathyroid hormone concentration, hypothyroidism, growth hormone deficiency, abnormal phenotype with brachydactyly, tooth problems and mental retardation, which led to a suspicion of Albright's hereditary osteodystrophy (AHO). The diagnosis was verified by molecular genetic testing. Less than 1% of children with obesity have an endocrine disorder, and AHO is one of them...
February 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28341888/the-respiratory-control-of-carbon-dioxide-in-children-and-adolescents-referred-for-treatment-of-psychogenic-non-epileptic-seizures
#13
Kasia Kozlowska, Reena Rampersad, Catherine Cruz, Ubaid Shah, Catherine Chudleigh, Samantha Soe, Deepak Gill, Stephen Scher, Pascal Carrive
Psychogenic non-epileptic seizures (PNES) are a common problem in paediatric neurology and psychiatry that can best be understood as atypical responses to threat. Threats activate the body for action by mediating increases in arousal, respiration, and motor readiness. In previous studies, a range of cardiac, endocrine, brain-based, attention-bias, and behavioral measures have been used to demonstrate increases in arousal, vigilance, and motor readiness in patients with PNES. The current study uses respiratory measures to assess both the motor readiness of the respiratory system and the respiratory regulation of CO2...
October 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28169481/adverse-health-outcomes-and-health-concerns-among-survivors-of-various-childhood-cancers-perspectives-from-mothers
#14
C C Hsiao, S S Chiou, H-T Hsu, P C Lin, Y M Liao, L-M Wu
Advanced therapies have improved outcomes and also resulted in a growing risk of long-term adverse health events. This study intends to estimate incidences of adverse health events and examine differences in adverse health events among childhood cancer survivors, and to understand the concerns of mothers after their child has completed cancer treatment. An explanatory sequential mixed-method was used. A total of 201 paediatric cancer survivors' mothers with mean age 43.6 years were recruited. Of the survivors, 12...
February 7, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27978600/social-educational-and-vocational-outcomes-in-patients-with-childhood-onset-and-young-adult-onset-growth-hormone-deficiency
#15
M Tanya Mitra, Peter Jönsson, Ann-Charlotte Åkerblad, Peter Clayton, Maria Kołtowska-Häggström, Márta Korbonits, Andy Toogood, Helena Gleeson
OBJECTIVE: Hypopituitarism diagnosed in childhood, adolescence and young adulthood has the potential to affect growth and somatic development. Less is known about the impact of such a diagnosis on other aspects of development. DESIGN: An analysis of the KIMS database (Pfizer International Metabolic Database) was performed to explore social, educational and vocational outcomes of adult patients diagnosed in childhood, adolescence and young adulthood compared with adult-onset controls...
April 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/27974186/classical-and-non-classical-causes-of-gh-deficiency-in-the-paediatric-age
#16
REVIEW
Natascia Di Iorgi, Giovanni Morana, Anna Elsa Maria Allegri, Flavia Napoli, Roberto Gastaldi, Annalisa Calcagno, Giuseppa Patti, Sandro Loche, Mohamad Maghnie
Growth hormone deficiency (GHD) may result from a failure of hypothalamic GHRH production or release, from congenital disorders of pituitary development, or from central nervous system insults including tumors, surgery, trauma, radiation or infiltration from inflammatory diseases. Idiopathic, isolated GHD is the most common sporadic form of hypopituitarism. GHD may also occur in combination with other pituitary hormone deficiencies, and is often referred to as hypopituitarism, combined pituitary hormone deficiency (CPHD), multiple pituitary hormone deficiency (MPHD) or panhypopituitarism...
December 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27959889/childhood-neuroendocrine-tumours-a-descriptive-study-revealing-clues-for-genetic-predisposition
#17
I J Diets, I D Nagtegaal, J Loeffen, I de Blaauw, E Waanders, N Hoogerbrugge, M C J Jongmans
BACKGROUND: Neuroendocrine tumours (NETs) are rare in children and limited data are available. We aimed to specify tumour and patient characteristics and to investigate the role of genetic predisposition in the aetiology of paediatric NETs. METHODS: Using the Dutch Pathology Registry PALGA, we collected patient- and tumour data of paediatric NETs in the Netherlands between 1991 and 2013 (N=483). RESULTS: The incidence of paediatric NETs in the Netherlands is 5...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27951529/predictor-variables-of-developing-anterior-pituitary-deficiencies-in-a-group-of-paediatric-patients-with-central-diabetes-insipidus-and-langerhans-cell-histiocytosis
#18
Elisa Vaiani, Carmen Malossetti, Lina Margarita Vega, Pedro Zubizarreta, Jorge Braier, Alicia Belgorosky
BACKGROUND: Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Central diabetes insipidus (CDI) is the most frequent endocrine manifestation and is a known risk factor for the development of further anterior pituitary hormone deficiencies (APD). However, not all CDI patients develop APD, as observed during prolonged periods of follow-up. AIM: To find predictors of developing APD in LCH children with CDI followed in our institution...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27872046/pituitary-dysfunction-after-traumatic-brain-injury-are-there-definitive-data-in-children
#19
REVIEW
Paula Casano-Sancho
In the past decade, several studies in adults and children have described the risk of pituitary dysfunction after traumatic brain injury (TBI). As a result, an international consensus statement recommended follow-up on the survivors. This paper reviews published studies regarding hypopituitarism after TBI in children and compares their results. The prevalence of hypopituitarism ranges from 5% to 57%. Growth hormone (GH) and ACTH deficiency are the most common, followed by gonadotropins and thyroid-stimulating hormone...
June 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27804856/papillary-thyroid-carcinoma-in-pediatric-age-an-example-of-a-rare-tumour-managed-within-a-cooperative-comprehensive-project
#20
Giovanna Sironi, Andrea Ferrari, Marta Podda, Stefano Chiaravalli, Gianni Bisogno, Giovanni Cecchetto, Maura Massimino
Though rare in childhood, thyroid cancers represent the most frequent tumours of endocrine glands in childhood and adolescence. Papillary thyroid carcinoma is a nonmedullary, follicular-derived differentiated tumour of the thyroid. There is still controversy concerning the therapeutic approach to be adopted of PTCs in the paediatric population, regarding the extent of the surgical approach, and the need for radioactive iodine (RAI) therapy. The cooperative TREP project (Tumori Rari in Età Pediatrica [Rare Tumours in Paediatric Age]) was launched in Italy in 2000 (under the patronage of AIEOP - Associazione Italiana Ematologia Oncologia Pediatrica) with a view to improving both researches on the clinical management of the less common paediatric cancers...
2016: Current Pediatric Reviews
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