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Paediatric endocrine

Yasmeen Ganie, Colleen Aldous, Yusentha Balakrishna, Rinus Wiersma
BACKGROUND: The objective of the study was to describe the prevalence, clinical characteristics and aetiological diagnosis in children with disorders of sex development (DSDs) presenting to a tertiary referral centre. METHODS: This is a retrospective review of all cases of DSD referred to the Paediatric Endocrine Unit in Inkosi Albert Luthuli Central Hospital (IALCH) from January 1995 to December 2014. RESULTS: A total of 416 children (15...
October 18, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Bedowra Zabeen, Jebun Nahar, Samin Tayyeb, Fauzia Mohsin, Nazmun Nahar, Kishwar Azad
INTRODUCTION: Recent data show that the prevalence of diabetes among children and adolescents is increasing in some ethnic groups. The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of type 2 diabetes (T2D) in youth. METHODS: The aim of this study was to describe the baseline characteristics of children and adolescents diagnosed ≤18 years who had features of T2D and presented at Changing Diabetes in Children, Paediatric Diabetes Clinic at Bangladesh Institute of Research and Rehabilitation of Diabetes, Endocrine, and Metabolic Disorders...
September 2016: Indian Journal of Endocrinology and Metabolism
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
S Sreekantam, M A Preece, S Vijay, J Raiman, S Santra
Controlled fasts can play a valuable role in the diagnosis and management of hypoglycaemia in paediatric clinical practice, but are no substitute for the collecting of appropriate critical samples at the time of hypoglycaemia for metabolic and endocrine studies. Fatty acid oxidation defects, hyperinsulinism and adrenal insufficiency should always be excluded prior to organising controlled fasts. Controlled fasts are safe if conducted in an experienced setting with strict protocols in place. Failure to adhere to protocol can defeat the purpose of the study and can potentially be dangerous...
August 24, 2016: Archives of Disease in Childhood. Education and Practice Edition
Kazeem Olalekan, Andy Fox, Rodney Gilbert
BACKGROUND: Unlicensed medications are used all the time in the management of diseases in childhood. Tolvaptan (Jinarc®) is a vasopressin V2-receptor antagonist licensed for use to slow the progression of cyst development and renal insufficiency of ADPKD in adults with CKD stage 1 to 3 with evidence of rapidly progressing disease. Studies of animal models implicate the antidiuretic hormone arginine vasopressin and its messenger cyclic adenosine monophosphate (cAMP) as promoters of kidney-cyst cell proliferation and luminal fluid secretion...
September 2016: Archives of Disease in Childhood
V Chauhan, R Dada, V Jain
46, XY differences of sex development (DSD) constitute a heterogenous group of rare genetic defects. Definitive aetiological diagnosis cannot be made in more than half of these cases. The aim of our study was to prospectively evaluate and assign a probable diagnosis based on clinical and biochemical parameters in children with 46, XY DSD. Prospective clinical and biochemical screening was performed in a series of 46, XY children referred to paediatric endocrine services of our centre. Forty children with 46, XY DSD were investigated, and presumptive aetiological diagnoses of 5-alpha reductase deficiency (5αRD), partial gonadal dysgenesis (PGD), partial androgen insensitivity syndrome (PAIS), congenital bilateral anorchia (CBA), congenital lipoid adrenal hyperplasia (CLAH), ovotesticular DSD (OT-DSD) and Frasier syndrome (FS) were made...
August 8, 2016: Andrologia
Nasir A M Al Jurayyan, Sarar Mohamed, Sharifah D A Al Issa, Abdulaziz N A Al Jurayyan
This is a retrospective study in which we report our clinical experience during the period from January 1990 to December 2009, from a paediatric endocrine clinic at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. The diagnosis of rickets and oestomalacia was based on clinical, biochemical and radiological data. Eighty-one (34 males and 47 females) children and adolescents with rickets or osteomalacia aged 2 to 18 years (mean; 9.5 years) were evaluated. The commonest causes were nutritional; either low Vitamin D or calcium, or both...
2012: Sudan J Paediatr
Julia Rohayem, Berthold P Hauffa, Margaret Zacharin, Sabine Kliesch, Michael Zitzmann
CONTEXT/OBJECTIVE: Testosterone treatment for pubertal induction in boys with hypogonadotrophic hypogonadism (HH) provides virilisation, but does not induce testicular growth or fertility. Larger studies evaluating the outcomes of gonadotrophin replacement during adolescence have not been reported to date; whether previous testosterone substitution affects testicular responses is unresolved. We aimed to assess the effects of human chorionic gonadotrophin (hCG) and recombinant FSH (rFSH) in boys and adolescents with HH with respect to a) testicular growth, b) spermatogenesis, c) quality of life (QoL) and to identify factors influencing therapeutic success...
July 28, 2016: Clinical Endocrinology
Helen Clapin, Helen Phelan, Loren Bruns, Richard Sinnott, Peter Colman, Maria Craig, Timothy Jones
Australasia is a region with a high incidence of type 1 diabetes (T1D). There are approximately 140 000 individuals with T1D, and of these 10 000 are children. Although the region covers a huge geographical area, most children with T1D are managed by tertiary academic centers in the major capital cities. Local longitudinal data collection has been in place for several decades in most of these centers, however ongoing national data collection had not been attempted. In 2012, with funding from the Juvenile Diabetes Research Foundation (JDRF) Australian Type 1 Clinical Research Network, a national collaboration was formed to provide ongoing longitudinal collection of T1D patient characteristics and outcomes...
September 2016: Journal of Diabetes Science and Technology
Sabine Malivoir, Carine Courtillot, Anne Bachelot, Zeina Chakhtoura, Isabelle Téjédor, Philippe Touraine
UNLABELLED: The purpose of this study is to contribute to better identifying the transition of patients with chronic endocrine conditions from paediatric to adult department. The aim was to specify the means and the competences that must be used by patients and health care teams and which could be help to the best quality care. METHOD: We propose group sessions and individual interviews. A thematic analysis of the sessions and the responses to questionnaires have enabled the development of individual educational diagnosis and assess the autonomy of young adolescents...
May 2016: La Presse Médicale
Feyza Darendeliler
No abstract text is available yet for this article.
2016: Hormone Research in Pædiatrics
Prashant Singh, Piyush Kumar Sharma, Abhishek Agnihotri, Viveka P Jyotsna, Prasenjit Das, Siddhartha Datta Gupta, Govind K Makharia, Rajesh Khadgawat
BACKGROUND: We aimed to determine the prevalence of coeliac disease among children with short stature at a tertiary care centre and to define the predictors for coeliac disease, if any, in them. METHODS: In this retrospective study, we reviewed the case records of children and adolescents with growth retardation attending the Paediatric Endocrinology Clinic from January 2008 to June 2011. All patients underwent the multi-tier stratified diagnostic protocol for complete evaluation of short stature...
July 2015: National Medical Journal of India
Claire E Higham, Gudmundur Johannsson, Stephen M Shalet
Hypopituitarism refers to deficiency of one or more hormones produced by the anterior pituitary or released from the posterior pituitary. Hypopituitarism is associated with excess mortality, a key risk factor being cortisol deficiency due to adrenocorticotropic hormone (ACTH) deficiency. Onset can be acute or insidious, and the most common cause in adulthood is a pituitary adenoma, or treatment with pituitary surgery or radiotherapy. Hypopituitarism is diagnosed based on baseline blood sampling for thyroid stimulating hormone, gonadotropin, and prolactin deficiencies, whereas for ACTH, growth hormone, and antidiuretic hormone deficiency dynamic stimulation tests are usually needed...
March 31, 2016: Lancet
Susan R Rose, Vincent E Horne, Jonathan Howell, Sarah A Lawson, Meilan M Rutter, Gylynthia E Trotman, Sarah D Corathers
The cure rate for paediatric malignancies is increasing, and most patients who have cancer during childhood survive and enter adulthood. Surveillance for late endocrine effects after childhood cancer is required to ensure early diagnosis and treatment and to optimize physical, cognitive and psychosocial health. The degree of risk of endocrine deficiency is related to the child's sex and their age at the time the tumour is diagnosed, as well as to tumour location and characteristics and the therapies used (surgery, chemotherapy or radiation therapy)...
June 2016: Nature Reviews. Endocrinology
Jacqueline Collin, Amanda Whitehead, Jenny Walker
Growth hormone deficiency (GHD) is a long-term condition, therefore creating ongoing partnerships with families is a fundamental part of the role of a paediatric endocrine nurse specialist (PENS). Teaching children, young people and their families about GHD and exploring what it means to them and how they can manage their ongoing treatment is central to building positive relationships. Educating children about the management of their growth hormone treatment (GHT) is an ongoing process and professionals must respond to the changing needs for that information children may have as they grow and develop...
March 2016: Nursing Children and Young People
Gordon Otieno Odundo, Thomas Ngwiri, Olivia Otuoma, Paul Laigong, Renson Mukhwana, Mary Slessor Limbe, Nadia Musimbi Chanzu
Background. The prevalence and distribution of endocrine disorders in children in Africa are not well known because most cases are often undiagnosed or diagnosed too late. The awareness of this led to the launch of the Paediatric Endocrinology Training Center for Africa (PETCA) designed to improve quality and access to health care by training paediatricians from Africa in paediatric endocrinology. Methods. The fellowship is undertaken over an 18-month period: six months of clinical and theoretical training in Kenya, nine months of project research at the fellow's home country, and three months of consolidation in Kenya...
2016: International Journal of Endocrinology
Barbara Jarząb, Marek Dedecjus, Daria Handkiewicz-Junak, Dariusz Lange, Andrzej Lewiński, Anna Nasierowska-Guttmejer, Marek Ruchała, Dorota Słowińska-Klencka, Janusz Nauman, Zbigniew Adamczewski, Maciej Bagłaj, Agata Bałdys-Waligórska, Marcin Barczyński, Tomasz Bednarczuk, Andrzej Cichocki, Agnieszka Czarniecka, Rafał Czepczyński, Aneta Gawlik, Alicja Hubalewska-Dydejczyk, Krystian Jażdżewski, Grzegorz Kamiński, Małgorzata Karbownik-Lewińska, Beata Kos-Kudła, Andrzej Kułakowski, Krzysztof Kuzdak, Katarzyna Łącka, Ewa Małecka-Tendera, Marek Niedziela, Lech Pomorski, Stanisław Sporny, Zoran Stojcev, Anhelli Syrenicz, Jan Włoch, Jolanta Krajewska, Sylwia Szpak-Ulczok, Michal Kalemba, Monika Buziak-Bereza
Revised Guidelines of Polish National Societies Prepared on the initiative of the Polish Group for Endocrine Tumours approved in their final version between November 16th and 28th, 2015 by the Scientific Committee of the V Conference "Thyroid Cancer and other malignancies of endocrine glands" organised between November 14th and 17th, 2015 in Wisla, Poland; called by the following Societies: Polish Endocrine Society, Polish Society of Oncology, Polish Thyroid Association, Polish Society of Pathologists, Society of Polish Surgeons, Polish Society of Surgical Oncology, Polish Society of Clinical Oncology, Polish Society of Radiation Oncology, Polish Society of Nuclear Medicine, Polish Society of Paediatric Endocrinology, Polish Society of Paediatric Surgeons, Polish Society of Ultrasonography Gliwice-Wisła, 2015 DECLARATION: These recommendations are created by the group of delegates of the National Societies, which declare their willingness to participate in the preparation of the revised version of the Polish Guidelines...
2016: Endokrynologia Polska
Jacqueline Collin, Amanda Whitehead, Jenny Walker
The management of growth hormone deficiency is long term. Children may be diagnosed at pre-school age meaning relationships with the paediatric endocrine team may last more than 15 years. The education role of the paediatric endocrine nurse specialist is essential in working in partnership with families over a long period of time. Children and young people have changing needs for information to help them understand their condition and growth hormone deficiency treatment as they grow up. Developing positive working relationships with parents, children and young people enables their developmental needs and the context in which they live their lives to be central to any educational planning for them...
February 2016: Nursing Children and Young People
R Adomaitis, B Vincel, A Eidukaite, E Ostaneviciute, R Kirka, V Bilius, D Malcius, G Verkauskas, F Hadziselimovic
Bilateral cryptorchidism treatment results are often shadowed by the majority of unilateral cases. We report the long-term follow-up results of boys treated for bilateral cryptorchidism during childhood. Patients treated in two main paediatric surgery centres were selected from medical registries and invited for a clinical examination including scrotal ultrasound, salivary testosterone measurement and a semen sample. Thirty-six men (38.3%) replied to the written invitation, and 21 agreed to be examined. The mean age at orchidopexy was 74 months (range 24-138)...
January 14, 2016: Andrologia
Matthias Schindler, Vera Mitter, Eva Bergstraesser, Fabienne Gumy-Pause, Gisela Michel, Claudia Elisabeth Kuehni
QUESTIONS UNDER STUDY: Completeness is important in cancer registration. Identifying areas to improve registry procedures might help to maximise completeness. We examined characteristics of childhood cancer cases that were registered via death certificate notification (DCN) rather than during life, and estimated completeness of the Swiss Childhood Cancer Registry (SCCR). METHODS: We analysed data from all children who died from cancer in Switzerland between 1985-2009 at age <16 years (n = 978), and checked whether they had been registered in the SCCR...
2015: Swiss Medical Weekly
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