keyword
https://read.qxmd.com/read/38524636/semaglutide-as-a-potential-therapeutic-alternative-for-hnf1b-mody-a-case-study
#21
Angham Almutair, Beshaier Almulhem
Maturity-onset diabetes of the young (MODY) is a grouping of monogenic disorders. It is characterized by dominantly inherited, non-insulin-dependent diabetes. MODY is relatively rare, encompassing up to 3.5% in those diagnosed under 30 years of age. Specific types are most commonly treated with sulfonylurea, particularly those identified as HNF4A-MODY and HNF1A-MODY. HNF1B-MODY is another type that is most frequently managed with insulin therapy but lacks a defined precision treatment. We present an 18-year-old, non-obese female patient diagnosed with HNF1B-MODY...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38523875/a-re-audit-of-the-management-of-diabetic-ketoacidosis-dka-the-importance-of-the-seven-day-working-inpatient-diabetes-specialist-nurse-service
#22
JOURNAL ARTICLE
Roobala K Periyasami, Andrew Pei Wern Lim, Dineth C Jayatilake, Samson O Oyibo
Background Diabetic ketoacidosis (DKA) is a life-threatening metabolic emergency due to insulin deficiency in patients with diabetes mellitus. The United Kingdom national survey and local audits of the management of DKA have revealed several areas of suboptimal care, and room for improvement, necessitating the need for intensified education, updating local guidelines, and increased recruitment of seven-day working inpatient diabetes specialist nurses. Therefore, this project aimed to re-audit our adherence to the DKA treatment guidelines...
March 2024: Curēus
https://read.qxmd.com/read/38521531/association-of-the-triglyceride-glucose-index-with-severity-of-coronary-stenosis-and-in-hospital-mortality-in-patients-with-acute-st-elevation-myocardial-infarction-after-percutaneous-coronary-intervention-a-multicentre-retrospective-analysis-cohort-study
#23
JOURNAL ARTICLE
Xin Lu, Xin Lin, Yingying Cai, Xiaoxiao Zhang, Haoyu Meng, Weiwei Chen, Peng Yu, Xiaohu Chen
OBJECTIVES: To explore the impact of the triglyceride-glucose (TyG) index on the severity of coronary stenosis and the risk of in-hospital mortality in patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). DESIGN: A multicentre retrospective cohort study. SETTING: Patients with STEMI undergoing PCI from three centres in China from 2015 to 2019. PARTICIPANTS: A total of 1491 individuals presenting with STEMI were enrolled...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521517/non-linear-relationship-between-pulse-pressure-and-the-risk-of-pre-diabetes-a-secondary-retrospective-chinese-cohort-study
#24
JOURNAL ARTICLE
Changchun Cao, Yong Han, Haofei Hu, Yongcheng He, Jiao Luo
OBJECTIVE: Previous research has shown that pulse pressure (PP) has a significant role in the start and development of type 2 diabetes mellitus. However, there is little proof that PP and pre-diabetes mellitus (Pre-DM) are related. Our study aimed to investigate the relationship between PP and incident pre-DM in a substantial cohort of Chinese participants. DESIGN: The 'DATADRYAD' database (www.Datadryad.org) was used to retrieve the data for this secondary retrospective cohort analysis...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38518862/modelling-remission-from-overweight-type-2-diabetes-reveals-how-altering-advice-may-counter-relapse
#25
JOURNAL ARTICLE
Catherine Z W Hassell Sweatman
The development or remission of diet-induced overweight type 2 diabetes involves many biological changes which occur over very different timescales. Remission, defined by HbA1c <6.5%, or fasting plasma glucose concentration G<126 mg/dl, may be achieved rapidly by following weight loss guidelines. However, remission is often short-term, followed by relapse. Mathematical modelling provides a way of investigating a typical situation, in which patients are advised to lose weight and then maintain fat mass, a slow variable...
March 20, 2024: Mathematical Biosciences
https://read.qxmd.com/read/38517484/the-innodia-type-1-diabetes-natural-history-study-a-european-cohort-of-newly-diagnosed-children-adolescents-and-adults
#26
JOURNAL ARTICLE
M Loredana Marcovecchio, A Emile J Hendriks, Carl Delfin, Tadej Battelino, Thomas Danne, Mark L Evans, Jesper Johannesen, Simranjeet Kaur, Mikael Knip, Lut Overbergh, Flemming Pociot, John A Todd, Bart Van der Schueren, Linda S Wicker, Mark Peakman, Chantal Mathieu
AIMS/HYPOTHESIS: Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual's clinical course and treatment response will have important clinical and research implications. Our aim was to explore type 1 diabetes heterogeneity, as assessed by clinical characteristics, autoantibodies, beta cell function and glycaemic outcomes, during the first 12 months from diagnosis, and how it relates to age at diagnosis. METHODS: Data were collected from the large INNODIA cohort of individuals (aged 1...
March 22, 2024: Diabetologia
https://read.qxmd.com/read/38517029/sorghum-phytonutrients-and-their-health-benefits-a-systematic-review-from-cell-to-clinical-trials
#27
REVIEW
Lívia de Lacerda de Oliveira, Lúcio Flávio de Alencar Figueiredo
Sorghum is key for global food security due to its genetic variability, resilience, and rich phytonutrient content, which are linked to numerous health benefits. A systematic review assessed the health effects of sorghum by analyzing cell (n = 22), animal (n = 20), and human (n = 7) studies across antioxidant, anti-inflammatory, obesity, cancer, cardiovascular, and diabetes outcomes. This review, involving 42 papers and 177 researchers from 12 countries, collected data from sorghum accessions (acc) and significant effects...
March 22, 2024: Journal of Food Science
https://read.qxmd.com/read/38515515/assessing-interstitial-fluid-dynamics-in-type-2-diabetes-mellitus-and-prediabetes-cases-through-diffusion-tensor-imaging-analysis-along-the-perivascular-space
#28
JOURNAL ARTICLE
Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki
BACKGROUND AND PURPOSE: Glymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial fluid dynamics using the DTI-ALPS in both Pre-DM and T2DM and association with insulin resistance...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38515202/serine-synthesis-and-catabolism-in-starved-lung-cancer-and-primary-bronchial-epithelial-cells
#29
JOURNAL ARTICLE
Theresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak, Thomas Eichmann, Harald C Köfeler, Katharina Leithner
Serine and glycine give rise to important building blocks in proliferating cells. Both amino acids are either synthesized de novo or taken up from the extracellular space. In lung cancer, serine synthesis gene expression is variable, yet, expression of the initial enzyme, phosphoglycerate dehydrogenase (PHGDH), was found to be associated with poor prognosis. While the contribution of de novo synthesis to serine pools has been shown to be enhanced by serine starvation, the impact of glucose deprivation, a commonly found condition in solid cancers is poorly understood...
March 21, 2024: Cancer & Metabolism
https://read.qxmd.com/read/38514590/dietary-composition-and-time-in-range-in-population-with-type-2-diabetes-mellitus-exploring-the-association-using-continuous-glucose-monitoring-device
#30
JOURNAL ARTICLE
Aditi R Deshmane, Arti S Muley
AIM: To understand the association between macronutrient composition of a diet with Time in Range (TIR), Time above Range (TAR) and Time below Range (TBR) derived using a Continuous Glucose Monitoring (CGM) device for 14 days. METHODOLOGY: An exploratory analysis on the baseline data of 50 Type 2 Diabetes Mellitus participants with age 25-55 years, HbA1c upto 8% and on Metformin only) enrolled for an interventional clinical trial was performed. RESULTS: Participants consuming adequate carbohydrates (CHO) of 55 to 60% of total calories had better Average Blood Glucose of 142...
March 21, 2024: Endocrine
https://read.qxmd.com/read/38514345/-establishment-and-verification-of-invasion-syndrome-prediction-model-in-patients-with-diabetes-complicated-with-klebsiella-pneumoniae-liver-abscess
#31
JOURNAL ARTICLE
C Y Feng, L W Zhang, T Liu, S F Jiang, X M Li, J Di
Objective: To analyze the correlative factors of invasion syndrome in patients with diabetes complicated with Klebsiella pneumoniae liver abscess, and to construct and verify the online nomographic prediction model. Methods: A case control study. The clinical data of 213 diabetic patients with Klebsiella pneumoniae liver abscess admitted to the Third Affiliated Hospital of Soochow University from January 1, 2015 to December 31, 2021 were retrospectively analyzed. The patients were divided into the training set (149 cases) and the test set (64 cases) by stratified random sampling method at a ratio of 7∶3...
March 26, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38513989/continuous-moderate-and-intermittent-high-intensity-exercise-in-youth-with-type-1-diabetes-which-protection-for-dysglycemia
#32
JOURNAL ARTICLE
Cassandra Parent, Elodie Lespagnol, Serge Berthoin, Sémah Tagougui, Chantal Stuckens, Cajsa Tonoli, Michelle Dupire, Aline Dewaele, Julie Dereumetz, Chloé Dewast, Iva Gueorgieva, Rémi Rabasa-Lhoret, Elsa Heyman
AIM: From an early age, exercise is key to managing type 1 diabetes (T1D). However, hypoglycemia around aerobic exercise is a major barrier to physical activity in children. We explore whether intermittent high-intensity aerobic exercise (IHE), designed to mimic spontaneous childhood physical activity patterns, offers better protection against glycemic drop than continuous moderate-intensity exercise (CME). METHODS: Five boys and 7 girls with T1D (9.8 ± 1...
March 19, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38513648/cytosolic-ph-is-a-direct-nexus-in-linking-environmental-cues-with-insulin-processing-and-secretion-in-pancreatic-%C3%AE-cells
#33
JOURNAL ARTICLE
Yujiang Fang, Hexi Feng, Bowen Zhang, Shuwei Zhang, Yanjie Zhou, Pengcheng Hao, Zhongshu Zhou, Shanshan Zhou, Nan Li, Yi Hui, Lin Ma, Jie Xiong, Jinjin Wu, Ling Liu, Xiaoqing Zhang
Pancreatic β cells actively respond to glucose fluctuations through regulating insulin processing and secretion. However, how this process is elaborately tuned in circumstance of variable microenvironments as well as β cell-intrinsic states and whether its dysfunction links to metabolic diseases remain largely elusive. Here, we show that the cytosolic pH (pHc) in β cells is increased upon glucose challenge, which can be sensed by Smad5 via its nucleocytoplasmic shuttling. Lesion of Smad5 in β cells results in hyperglycemia and glucose intolerance due to insulin processing and secretion deficiency...
March 15, 2024: Cell Metabolism
https://read.qxmd.com/read/38513367/high-intensity-interval-training-combining-rowing-and-cycling-improves-but-does-not-restore-beta-cell-function-in-type-2-diabetes
#34
JOURNAL ARTICLE
Maria Houborg Petersen, Jacob Volmer Stidsen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund
AIMS: We investigated whether a high-intensity interval training (HIIT)-protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals. MATERIALS AND METHODS: In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8-weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index) and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38512387/cgm-derived-glucometrics-in-adults-with-type-1-diabetes-when-switching-basal-insulins
#35
JOURNAL ARTICLE
Robbe De Groote, Eveline Lefever, Sara Charleer, Phebe Donné, Christophe De Block, Chantal Mathieu, Pieter Gillard
Context : Limited evidence is available on the real-world effect of insulin degludec (IDeg) in type 1 diabetes (T1D), using continuous glucose monitoring (CGM)-derived metrics. Objective : To assess the real-world effect of switching to IDeg from other long-acting insulins on time in ranges measured by CGM, metabolic control, and insulin dose for people with T1D. Design : This retrospective multicenter study encompassed five time points during a 12-month pre-switch of IDeg and a 12-month follow-up period. For each visit, clinical and CGM data were collected to evaluate temporal trends in glycemic outcomes...
March 21, 2024: Diabetes Technology & Therapeutics
https://read.qxmd.com/read/38511631/prepartum-behaviors-as-early-indicators-for-postpartum-energy-associated-biomarkers-status-in-holstein-dairy-cows
#36
JOURNAL ARTICLE
M H Emam, E Shepley, M M Mahmoud, M Ruch, S Elmaghawry, W Abdelrazik, A M Abdelaal, B A Crooker, L S Caixeta
Our main aim was to investigate the predictive value of prepartum behaviors such as total daily rumination (TDR), total daily activity (TDA) and dry matter intake (DMI) as early indicators to detect cows at risk for hyperketonemia (HYK), hypoglycemia (HYG) or high non-esterified fatty acid (NEFA) status in the first (wk1) and second week (wk2) postpartum. In a case control study, 64 Holstein cows were enrolled 3 weeks before the expected time of calving and monitored until 15 days in milk (DIM). Postpartum blood samples were taken at D3 and D6 for wk1 and at D12 and D15 for wk2 to measure beta-hydroxybutyrate, NEFA and glucose concentration...
March 20, 2024: Polish Journal of Veterinary Sciences
https://read.qxmd.com/read/38511107/validation-of-the-efficacy-of-pooled-serum-for-serum-glucose-inhouse-quality-control-material-in-comparison-with-commercial-internal-quality-control-in-clinical-chemistry-laboratory
#37
JOURNAL ARTICLE
Haymanot Tewabe, Asaye Mitiku, Abebe Yenesew
BACKGROUND: This study aimed to create an in-house glucose quality control material for humans, addressing the challenge of obtaining high-cost commercially prepared quality control materials in developing countries. METHODS: An in-house quality control material for glucose was prepared using a pooled serum sample and analyzed using a fully automated chemistry analyzer following the ISO 80 guidelines. The mean, standard deviation (SD), and coefficient of variance were calculated from the first 30 days of measurement, and the variability was checked over eight months using SPSS software...
March 2024: Practical Laboratory Medicine
https://read.qxmd.com/read/38510574/impact-of-mhealth-application-on-adherence-to-cardiac-rehabilitation-guidelines-after-a-coronary-event-randomised-controlled-clinical-trial-protocol
#38
JOURNAL ARTICLE
Celia Cruz-Cobo, María Ángeles Bernal-Jiménez, Germán Calle-Pérez, Livia Gheorghe, Alejandro Gutiérrez-Barrios, Dolores Cañadas-Pruaño, Amelia Rodríguez-Martín, Josep A Tur, Rafael Vázquez-García, María José Santi-Cano
BACKGROUND: Coronary disease is the main cause of death around the world. mHealth technology is considered attractive and promising to promote behavioural changes aimed at healthy lifestyle habits among coronary patients. The purpose of this study is to evaluate the efficacy of an mHealth intervention regarding improved results in secondary prevention in patients after an acute myocardial infarction (AMI) or angina in terms of lifestyle, clinical variables and therapeutic compliance. METHODS: Randomised clinical trial with 300 patients who underwent a percutaneous coronary intervention (PCI) with stent implant...
2024: Digital Health
https://read.qxmd.com/read/38508988/establishment-of-a-machine-learning-predictive-model-for-non-alcoholic-fatty-liver-disease-a-longitudinal-cohort-study
#39
JOURNAL ARTICLE
Tengrui Cao, Qian Zhu, Chao Tong, Aheyeerke Halengbieke, Xuetong Ni, Jianmin Tang, Yumei Han, Qiang Li, Xinghua Yang
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, which lacks effective drug treatments. This study aimed to construct an eXtreme Gradient Boosting (XGBoost) prediction model to identify or evaluate potential NAFLD patients. METHODS AND RESULTS: We conducted a longitudinal study of 22,140 individuals from the Beijing Health Management Cohort. Variable filtering was performed using the least absolute shrinkage and selection operator...
February 15, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38508037/short-term-glucose-variability-as-a-determinant-of-the-healing-rate-of-diabetic-foot-ulcer-a-retrospective-study
#40
JOURNAL ARTICLE
Paola Caruso, Lorenzo Scappaticcio, Maurizio Gicchino, Filomena Castaldo, Mariluce Barrasso, Carla Carbone, Mariangela Caputo, Maria Tomasuolo, Vanda Amoresano Paglionico, Giuseppe Bellastella, Maria Ida Maiorino, Katherine Esposito
BACKGROUND: The aim of this study was to describe the clinical characteristics of people with diabetic foot ulcer (DFU) according to glucose variability (GV) and to investigate the relationship between GV and DFU outcome in a population with type 2 diabetes (T2D) and DFU. METHODS: This is a retrospective study of 300 individuals aged 64.3 years (181 males) treated for DFU in a tertiary-care center with a regular follow-up for 6 months. Laboratory measurements and clinical assessments were collected at baseline...
March 16, 2024: Diabetes & Metabolic Syndrome
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