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Glucose variability

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https://www.readbyqxmd.com/read/28922573/diastolic-blood-pressure-rises-with-the-exacerbation-of-obstructive-sleep-apnea-in-males
#1
Wei Hu, Xian Jin, Chengjun Chen, Peng Zhang, Dandan Li, Qian Su, Guizhi Yin, Yanwen Hang
OBJECTIVE: To characterize the association pattern between blood pressure (BP), metabolism changes, and obstructive sleep apnea (OSA) severity within male OSA patients. METHODS: The association between systolic BP (SBP), diastolic BP (DBP), glucose, lipids, apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and arousal index (ArI) was evaluated after adjustment for BMI and waist circumference/hip circumference ratio (WHR) in 1,370 male OSA patients. RESULTS: In the multiple linear regression models using SBP as an independent variable, SBP did not associate with the increase of any OSA indexes...
September 18, 2017: Obesity
https://www.readbyqxmd.com/read/28922276/risk-factors-for-surgical-site-infection-after-posterior-lumbar-spinal-surgery
#2
Jia-Ming Liu, Hui-Lin Deng, Xuan-Yin Chen, Yang Zhou, Dong Yang, Man-Sheng Duan, Shan-Hu Huang, Zhi-Li Liu
STUDY DESIGN: A retrospective study. OBJECTIVE: The purpose of this study was to identify the independent risk factors for postoperative SSI after posterior lumbar spinal surgery based on the perioperative factors analysis. SUMMARY OF BACKGROUND DATA: Surgical site infection (SSI) is one of the most common complications after spinal surgery. Previous studies have identified different risk factors for postoperative SSI following lumbar spinal surgery...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28921914/comparison-of-relation-between-multiple-parameters-of-glycemic-variability-and-coronary-plaque-vulnerability-assessed-by-virtual-histology-intravascular-ultrasound
#3
Natsu Otowa-Suematsu, Kazuhiko Sakaguchi, Hisako Komada, Tomoaki Nakamura, Anna Sou, Yushi Hirota, Masaru Kuroda, Toshiro Shinke, Ken-Ich Hirata, Wataru Ogawa
AIMS/INTRODUCTION: Increased glycemic variability is an important contributing factor to coronary artery disease. Although various parameters of glycemic variability can be derived by continuous glucose monitoring, the clinical relevance of individual parameters has remained unclear. We have now analyzed the relation of such parameters to coronary plaque vulnerability MATERIALS AND METHODS: The standard deviation of glucose levels (SD glucose), mean amplitude of glycemic excursions (MAGE), continuous overlapping net glycemic action calculated every 1 h (CONGA-1), and mean of daily differences (MODD) were calculated from continuous glucose monitoring data for 53 subjects hospitalized for percutaneous coronary intervention...
September 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28921908/biphasic-insulin-aspart-30-reduces-glycemic-variability-to-a-greater-degree-than-insulin-detemir-a-randomized-controlled-trial-of-once-daily-insulin-regimens-using-continuous-glucose-monitoring
#4
Daisuke Tsujino, Rimei Nishimura, Yoshiko Onda, Chiaki Seo, Kiyotaka Ando, Kazunori Utsunomiya
INTRODUCTION: We compared the efficacy of insulin detemir and biphasic insulin aspart-30 given in the morning as an add-on to oral hypoglycemic agents (OHAs) in type 2 diabetic patients. MATERIALS AND METHODS: This study enrolled 30 patients with poorly controlled type 2 diabetes (8%≤HbA1c<11%) being treated with OHA mono- or combination therapy with biguanides, sulfonylureas, or thiazolidinediones. The patients were randomly assigned to insulin detemir (group D) or insulin aspart-30 (group A) given in the morning as add-on to OHAs...
September 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28921743/exercise-training-dose-differentially-alters-muscle-and-heart-capillary-density-and-metabolic-functions-in-an-obese-rat-with-metabolic-syndrome
#5
Marcus Vinicius Machado, Aline Bomfim Vieira, Fabiana Gomes da Conceição, Alessandro Rodrigues Nascimento, Antonio Claudio Lucas da Nóbrega, Eduardo Tibirica
We evaluated the effect of frequency, duration and intensity of exercise training on metabolic parameters and structural capillary density in obese rats with metabolic syndrome (MS). Wistar-Kyoto rats were fed a either standard commercial diet (CON) or high-fat diet (HFD). Animals that received the HFD were randomly separated into either a sedentary (SED) group or 8 different exercise groups that varied by the frequency, duration and intensity of training. After 12 weeks of aerobic exercise training, body composition, aerobic capacity, hemodynamic variables, metabolic parameters and capillary density in the heart and skeletal muscle were evaluated...
September 17, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28919119/global-regional-and-national-comparative-risk-assessment-of-84-behavioural-environmental-and-occupational-and-metabolic-risks-or-clusters-of-risks-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#6
(no author information available yet)
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2016...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28918470/assessment-of-glucose-regulation-in-pregnancy-after-gastric-bypass-surgery
#7
Christian S Göbl, Latife Bozkurt, Andrea Tura, Michael Leutner, Laura Andrei, Lukas Fahr, Peter Husslein, Wolfgang Eppel, Alexandra Kautzky-Willer
AIMS/HYPOTHESIS: Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS: Sixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese control women and 19 normal weight control women) were included. Frequently sampled 3 h OGTTs and 1 h IVGTTs were performed between 24 and 28 weeks of gestation and, in a subgroup, were repeated at 3-6 months after delivery...
September 16, 2017: Diabetologia
https://www.readbyqxmd.com/read/28918462/development-of-a-new-scoring-system-to-predict-5-year-incident-diabetes-risk-in-middle-aged-and-older-chinese
#8
Xu Han, Jing Wang, Yaru Li, Hua Hu, Xiulou Li, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Tangchun Wu, Meian He
AIMS: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population. METHODS: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Incident diabetes was defined as self-reported clinician diagnosed diabetes, fasting glucose ≥7.0 mmol/l, or the use of insulin or oral hypoglycemic agent...
September 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28918342/the-potential-effect-of-ultra-long-insulin-degludec-on-glycemic-variability
#9
REVIEW
M Rodacki, R M Carvalho, L Zajdenverg
Despite the therapeutic advances in the treatment of diabetes, metabolic control instability due to glycemic variability (GV) is frequently observed in patients with diabetes on intensive insulin therapy and is associated with hyperglycemic peaks and hypoglycemic episodes. Hyperglycemia associated with GV has been implicated in the development of chronic complications due to its pro-oxidative consequences. On the other hand, hypoglycemia can be associated with increased cardiovascular risk secondarily to adrenergic activation...
June 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28918212/an-%C3%AE-glucosidase-inhibitor-could-reduce-t-wave-alternans-in-type-2-diabetes-patients
#10
Kazuo Eguchi, Takahiro Komori, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario
BACKGROUND: We tested the hypothesis that an alpha-glucosidase inhibitor (α-GI), miglitol, is effective in protecting the cardiovascular system in type 2 diabetes mellitus (T2DM). METHODS: We studied 19 hospitalized heart disease patients with T2DM in whom we performed continuous glucose monitoring, Holter electrocardiogram, and ambulatory blood pressure (BP) monitoring simultaneously for 48h. The α-GI miglitol was administered for half of the study period by a cross-over fashion...
August 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28918195/impact-of-body-mass-index-and-metabolic-phenotypes-on-coronary-artery-disease-according-to-glucose-tolerance-status
#11
K Fujihara, Y Matsubayashi, M Yamamoto, T Osawa, M Ishizawa, M Kaneko, S Matsunaga, K Kato, H Seida, N Yamanaka, S Kodama, H Sone
OBJECTIVE: This study aimed to examine the impact of obesity, as defined by body mass index (BMI), and a metabolically unhealthy phenotype on the development of coronary artery disease (CAD) according to glucose tolerance status. METHODS: This population-based retrospective cohort study included 123,746 Japanese men aged 18-72years (normal glucose tolerance: 72,047; prediabetes: 39,633; diabetes: 12,066). Obesity was defined as a BMI≥25kg/m(2). Metabolically unhealthy individuals were defined as those with one or more of the following conditions: hypertension, hypertriglyceridaemia and/or low HDL cholesterol...
September 14, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28917374/short-term-effect-of-add-on-bell-pepper-capsicum-annuum-var-grossum-juice-with-integrated-approach-of-yoga-therapy-on-blood-glucose-levels-and-cardiovascular-functions-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-study
#12
Padakandla Nagasukeerthi, A Mooventhan, N K Manjunath
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major global health problem. Though various studies have reported the beneficial effect of Yoga in patient with T2DM, there is a lack of study in combination with bell pepper and yoga. Hence, the present study aims at evaluating short-term effect of add on bell pepper juice with integrated approach of yoga therapy (IAYT) on blood glucose levels and cardiovascular variables in patients with T2DM. MATERIALS AND METHODS: Fifty T2DM subjects with the age varied from 34 to 69-years were recruited and randomly divided into either study group or control group...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28916591/continuous-glucose-monitoring-in-very-preterm-infants-a-randomized-controlled-trial
#13
Alfonso Galderisi, Andrea Facchinetti, Garry M Steil, Paulina Ortiz-Rubio, Francesco Cavallin, William V Tamborlane, Eugenio Baraldi, Claudio Cobelli, Daniele Trevisanuto
BACKGROUND AND OBJECTIVES: Impaired glucose control in very preterm infants is associated with increased morbidity, mortality, and poor neurologic outcome. Strategies based on insulin titration have been unsuccessful in achieving euglycemia in absence of an increase in hypoglycemia and mortality. We sought to assess whether glucose administration guided by continuous glucose monitoring (CGM) is more effective than standard of care blood glucose monitoring in maintaining euglycemia in very preterm infants...
September 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28914421/acid-base-safety-during-the-course-of-a-very-low-calorie-ketogenic-diet
#14
Diego Gomez-Arbelaez, Ana B Crujeiras, Ana I Castro, Albert Goday, Antonio Mas-Lorenzo, Ana Bellon, Cristina Tejera, Diego Bellido, Cristobal Galban, Ignacio Sajoux, Patricio Lopez-Jaramillo, Felipe F Casanueva
BACKGROUND AND AIMS: Very low-calorie ketogenic (VLCK) diets have been consistently shown to be an effective obesity treatment, but the current evidence for its acid-base safety is limited. The aim of the current work was to evaluate the acid-base status of obese patients during the course of a VLCK diet. METHOD: Twenty obese participants undertook a VLCK diet for 4 months. Anthropometric and biochemical parameters, and venous blood gases were obtained on four subsequent visits: visit C-1 (baseline); visit C-2, (1-2 months); maximum ketosis; visit C-3 (2-3 months), ketosis declining; and visit C-4 at 4 months, no ketosis...
September 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28913889/prevalence-and-contributors-to-low-grade-inflammation-in-three-u-s-populations-of-reproductive-age-women
#15
Lindsey A Sjaarda, Rose G Radin, Chandra Swanson, Daniel L Kuhr, Sunni L Mumford, Noya Galai, Robert M Silver, Jean Wactawski-Wende, Neil J Perkins, Enrique F Schisterman
BACKGROUND: Inflammation, measured by high-sensitivity C-reactive protein (hsCRP), is linked to adverse reproductive outcomes. However, prevalence and predictors of low-grade inflammation are poorly understood among reproductive age women. Therefore, the current aim was to characterize: (i) the prevalence of elevated hsCRP and (ii) whether the association of various demographic, anthropometric, life style, and metabolic characteristics with higher hsCRP varies across populations of reproductive age women with varying risk profiles for adverse reproductive outcomes...
September 15, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28913745/management-of-type-1-diabetes-in-the-hospital-setting
#16
REVIEW
Carlos E Mendez, Guillermo E Umpierrez
PURPOSE OF REVIEW: The purpose of this article was to review recent guideline recommendations on glycemic target, glucose monitoring, and therapeutic strategies, while providing practical recommendations for the management of medical and surgical patients with type 1 diabetes (T1D) admitted to critical and non-critical care settings. RECENT FINDINGS: Studies evaluating safety and efficacy of insulin pump therapy, continuous glucose monitoring, electronic glucose management systems, and closed loop systems for the inpatient management of hyperglycemia are described...
September 14, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28913602/devoting-attention-to-glucose-variability-and-hypoglycaemia-in-type-2-diabetes
#17
EDITORIAL
Martin K Rutter
In the Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE), insulin degludec was non-inferior to insulin glargine in terms of cardiovascular events and mortality. However, there were lower rates of severe hypoglycaemia with insulin degludec. DEVOTE investigators now extend these findings by presenting the results of two observational epidemiological analyses based on trial data. In the first of these analyses (DEVOTE 2), Zinman et al (Diabetologia DOI: 10...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28913575/day-to-day-fasting-glycaemic-variability-in-devote-associations-with-severe-hypoglycaemia-and-cardiovascular-outcomes-devote-2
#18
Bernard Zinman, Steven P Marso, Neil R Poulter, Scott S Emerson, Thomas R Pieber, Richard E Pratley, Martin Lange, Kirstine Brown-Frandsen, Alan Moses, Ann Marie Ocampo Francisco, Jesper Barner Lekdorf, Kajsa Kvist, John B Buse
AIMS/HYPOTHESIS: The Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) was a double-blind, randomised, event-driven, treat-to-target prospective trial comparing the cardiovascular safety of insulin degludec with that of insulin glargine U100 (100 units/ml) in patients with type 2 diabetes at high risk of cardiovascular events. This paper reports a secondary analysis investigating associations of day-to-day fasting glycaemic variability (pre-breakfast self-measured blood glucose [SMBG]) with severe hypoglycaemia and cardiovascular outcomes...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28913365/frequency-and-predictors-of-self-reported-hypoglycemia-in-insulin-treated-diabetes
#19
Samir Malkani, Anupam Kotwal
AIMS: Hypoglycemia is a limiting factor for achieving stringent glycemic control in diabetes. This study analyzes the frequency and predictors of hypoglycemia in insulin-treated diabetes in an ambulatory setting. METHODS: A retrospective chart review was performed to study self-monitored blood glucose (SMBG) data for 3 months prior to a patient's HbA1c test. RESULTS: Hypoglycemia occurred more frequently in type 1 than in type 2 diabetes; however, 19% of type 2 diabetes patients did experience at least one episode of severe hypoglycemia...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28912902/effects-of-dapagliflozin-on-body-composition-and-liver-tests-in-patients-with-nonalcoholic-steatohepatitis-associated-with-type-2-diabetes-mellitus-a-prospective-open-label-uncontrolled-study
#20
Hiroshi Tobita, Shuichi Sato, Tatsuya Miyake, Shunji Ishihara, Yoshikazu Kinoshita
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Dapagliflozin is a potent, selective SGLT2 inhibitor that reduces hyperglycemia in patients with T2DM and has been demonstrated to reduce some complications associated with NASH in rodent models...
2017: Current Therapeutic Research, Clinical and Experimental
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