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Glucose variability

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https://www.readbyqxmd.com/read/29147762/phenotypic-effects-and-inhibition-of-botrydial-biosynthesis-induced-by-different-plant-based-elicitors-in-botrytis-cinerea
#1
Eva Liñeiro, Antonio J Macias-Sánchez, Marisa Espinazo, Jesús M Cantoral, Javier Moraga, Isidro G Collado, Francisco J Fernández-Acero
Botrytis cinerea is considered a model organism for the study of plant-pathogen interaction showing great genetic diversity and a high degree of morphological variability depending on environmental conditions. The use of new compounds and plant-based elicitors may trigger the expression of different B. cinerea genes, providing new sources of virulence factors. This work is focused on elucidating the phenotypic effect in B. cinerea of different carbon sources such as glucose, cellulose and tomato cell walls (TCW)...
November 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29146654/diagnostic-and-laboratory-test-ordering-in-northern-portuguese-primary-health-care-a-cross-sectional-study
#2
Luísa Sá, Andreia Sofia Costa Teixeira, Fernando Tavares, Cristina Costa-Santos, Luciana Couto, Altamiro Costa-Pereira, Alberto Pinto Hespanhol, Paulo Santos, Carlos Martins
OBJECTIVES: To characterise the test ordering pattern in Northern Portugal and to investigate the influence of context-related factors, analysing the test ordered at the level of geographical groups of family physicians and at the level of different healthcare organisations. DESIGN: Cross-sectional study. SETTING: Northern Primary Health Care, Portugal. PARTICIPANTS: Records about diagnostic and laboratory tests ordered from 2035 family physicians working at the Northern Regional Health Administration, who served approximately 3...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145714/clinical-and-biochemical-correlates-of-male-hypogonadism-in-type-2-diabetes
#3
A Herrero, M Marcos, P Galindo, J M Miralles, J J Corrales
The origin of hypogonadism, a condition including both symptoms and biochemical criteria of androgen deficiency, in type 2 diabetes is poorly known. In a cross-sectional study of 267 unselected patients, we analyzed the potential correlation of several clinical and biochemical variables as well as chronic micro- and macrovascular diabetic complications with hypogonadism. Hypogonadism was present in 46 patients (17.2%) using a cutoff of total testosterone 10.4 nmol/L and in 31 (11.6%) with a cutoff of 8 nmol/L...
November 16, 2017: Andrology
https://www.readbyqxmd.com/read/29143522/mmp-2-sensitive-ha-end-conjugated-poly-amidoamine-dendrimers-via-click-reaction-to-enhance-drug-penetration-into-solid-tumor
#4
Min Han, Ming-Yi Huang-Fu, Wang-Wei Guo, Ningning Guo, Jiejian Chen, Huina Liu, Zhiqi Xie, Mengting Lin, Qichun Wei, Jianqing Gao
Currently, the limited tumor penetration of nanoparticles remains a major challenge of cancer nanomedicine. Herein, we propose a size-shrinkable, drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29141627/in-vitro-properties-of-concentrated-canine-platelets-stored-in-two-additive-solutions-a-comparative-study
#5
N Hlavac, C S Lasta, M L Dalmolin, L A Lacerda, D de Korte, N A Marcondes, S R Terra, F B Fernandes, F H D González
BACKGROUND: Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a realistic alternative. This study compares the in vitro platelet function in plasma, Composol, or SSP+ during storage for 13 days...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29141468/predictive-laboratory-findings-of-lower-extremity-amputation-in-diabetic-patients-meta-analysis
#6
Jong-Lim Kim, Jin Yong Shin, Si-Gyun Roh, Suk Choo Chang, Nae-Ho Lee
Lower extremity amputation is a source of morbidity and mortality among diabetic patients. This meta-analysis aimed to identify significant laboratory data in patients with diabetic foot ulcer with high rates of lower extremity amputation. We performed a systematic literature review and meta-analysis using MEDLINE, EMBASE, and Cochrane databases. We extracted and evaluated 11 variables from the included studies based on amputation rates. This study used the Newcastle-Ottawa Scale to assess the quality of the studies...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29141041/effects-of-a-mixed-berry-beverage-on-cognitive-functions-and-cardiometabolic-risk-markers-a-randomized-cross-over-study-in-healthy-older-adults
#7
Anne Nilsson, Ilkka Salo, Merichel Plaza, Inger Björck
BACKGROUND: Berries and associated bioactive compounds, e.g. polyphenols and dietary fibre (DF), may have beneficial implications with respect to the metabolic syndrome, including also cognitive functions. The aim of this study was to evaluate effects on cognitive functions and cardiometabolic risk markers of 5 wk intervention with a mixture of berries, in healthy humans. METHODS: Forty healthy subjects between 50-70 years old were provided a berry beverage based on a mixture of berries (150g blueberries, 50g blackcurrant, 50g elderberry, 50g lingonberries, 50g strawberry, and 100g tomatoes) or a control beverage, daily during 5 weeks in a randomized crossover design...
2017: PloS One
https://www.readbyqxmd.com/read/29141038/depot-specific-inflammation-with-decreased-expression-of-atm2-in-white-adipose-tissues-induced-by-high-margarine-lard-intake
#8
Nannan Wang, Jie Guo, Fuding Liu, Mingxia Wang, Chuntao Li, Lihong Jia, Lingling Zhai, Wei Wei, Yinglong Bai
A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans fatty acids (TFAs)/ saturated fatty acids (SFAs), elaidic acid as a biomarker of margarine intake was used to screen affected adipokines on mature human adipocytes in vitro. Weaned male Wistar rats were fed a high-fat diet enriched with margarine/lard to generate obesity-prone (OP) and obesity-resistant (OR) models, which were then used to explore the inflammatory responses of depot-specific white adipose tissue...
2017: PloS One
https://www.readbyqxmd.com/read/29140513/amino-acid-and-fatty-acid-levels-affect-hepatic-phosphorus-metabolite-content-in-metabolically-healthy-humans
#9
Sabine Kahl, Bettina Nowotny, Klaus Straßburger, Alessandra Bierwagen, Birgit Klüppelholz, Barbara Hoffmann, Guido Giani, Peter J Nowotny, Franziska Wallscheid, Erifili Hatziagelaki, Giovanni Pacini, Jong-Hee Hwang, Michael Roden
Objective: Hepatic energy metabolism negatively relates to insulin resistance and liver fat content in type 2 diabetes patients, but its role in metabolically healthy humans is unclear. We hypothesized that intrahepatocellular γ-adenosine triphosphate (γATP) and inorganic phosphate (Pi) concentrations exhibit similar associations with insulin sensitivity in non-diabetic non-obese volunteers. Research Design and methods: A total of 76 participants underwent a 4-point sampling 75-g OGTT as well as in vivo31P/1H magnetic resonance spectroscopy...
November 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29140417/fasting-plasma-glucose-in-young-adults-free-of-diabetes-is-associated-with-cognitive-function-in-midlife
#10
Irit Cohen-Manheim, Ronit Sinnreich, Glen M Doniger, Ely S Simon, Ronit Pinchas-Mizrachi, Jeremy D Kark
Background: Evidence for an association of fasting plasma glucose (FPG) with cognitive function in adults free of diabetes is scarce and based on middle-aged and older adults. We examined the association of FPG, measured at age 30, and of change in FPG from age 30 to 43, with cognitive function at age 50. Methods: 505 nondiabetic participants of the population-based Jerusalem Lipid Research Clinic (LRC) cohort study had baseline FPG, 2-h post-oral challenge plasma glucose (OGTT) and insulin determined at ages 28-32, and FPG and OGTT again at ages 41-46...
November 13, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29137476/acute-glycemic-changes-in-brain-and-subcutaneous-tissue-measured-by-continuous-glucose-monitoring-system-in-hereditary-hypertriglyceridemic-rat
#11
M Žourek, P Kyselová, D Čechurová, Z Rušavý
Parallel glucose measurements in blood and other different tissues give us knowledge about dynamics of glycemia changes, which depend on vascularisation, distribution space and local utilization by tissues. Such information is important for the understanding of glucose homeostasis and regulation. The aim of our study was to determine the time-lag between blood, brain, and adipose tissue during rapid glucose changes in a male hHTG rat (n=15). The CGMS sensor Guardian RT (Minimed/Medtronic, USA) was inserted into the brain and into the abdominal subcutaneous tissue...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29136476/effectiveness-of-a-school-based-program-focusing-on-diet-and-health-habits-taught-through-physical-exercise
#12
Ana Pablos, Vicente Nebot, Vicente Vañó-Vicent, Diego Ceca, Laura Elvira
The global rate of obesity in childhood is becoming an epidemic and many authors have established a significant association between childhood obesity and overweight in adulthood. It is therefore necessary to seek effective strategies to reduce these levels of obesity. The aim of this study was to evaluate the impact of the Healthy Habits Program (HHP). The participants were 158 children from the 5th and 6th grades (Intervention Group [IG] n=82, Control Group [CG] n=76). The HHP is a school-based physical activity program focusing on promoting a healthy lifestyle...
November 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29136166/diabetes-induced-hyperglycemia-impairs-male-reproductive-function-a-systematic-review
#13
Constanze C Maresch, Dina C Stute, Marco G Alves, Pedro F Oliveira, David M de Kretser, Thomas Linn
BACKGROUND: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing...
November 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29135080/a-comparison-of-adherence-and-persistence-by-medication-class-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#14
Andrew McGovern, Zayd Tippu, William Hinton, Neil Munro, Martin Whyte, Simon de Lusignan
Limited medication adherence and persistence are barriers to successful treatment in type 2 diabetes (T2D). We searched MEDLINE, EMBASE, The Cochrane Library, The Register of Controlled Trials, PsychINFO, and CINAHL for observational and interventional studies comparing medication adherence or persistence between two or more glucose lowering medications in people with T2D. Where several studies (n≥5) provided the same comparison a random effects meta-analysis was performed reporting mean difference (MD), odds ratio (OR), or hazard ratio (HR) depending on the pooled study outcomes...
November 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29134458/animal-cell-expression-systems
#15
M Butler, Ing U Reichl
The glycan profile of therapeutic recombinant proteins such as monoclonal antibodies is a critical quality attribute, which affects the efficacy of the final product. The cellular glycosylation process during protein expression is dependent upon a number of factors such as the availability of substrates in the media, the intracellular content of nucleotide sugars, and the enzyme repertoire of the host cells. In order to control the variability of glycosylation it is important to understand the critical process parameters and their acceptable range of values to enable reproducible production of proteins with a predetermined glycan profile providing the desired biological function or therapeutic effect...
October 3, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29133420/resident-macrophages-of-pancreatic-islets-have-a-seminal-role-in-the-initiation-of-autoimmune-diabetes-of-nod-mice
#16
Javier A Carrero, Derrick P McCarthy, Stephen T Ferris, Xiaoxiao Wan, Hao Hu, Bernd H Zinselmeyer, Anthony N Vomund, Emil R Unanue
Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response, insulin content, and transcriptional profile. In NOD mice depleted of islet-resident macrophages starting at 3 wk of age, several changes occurred: (i) the early entrance of CD4 T cells and dendritic cells into pancreatic islets was reduced, (ii) presentation of insulin epitopes by dispersed islet cells to T cells was impaired, and (iii) the development of autoimmune diabetes was significantly reduced...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29133317/association-between-visceral-obesity-and-hepatitis-c-infection-stratified-by-gender-a-cross-sectional-study-in-taiwan
#17
Yu-Chung Tsao, Jau-Yuan Chen, Wei-Chung Yeh, Yun-Shing Peng, Wen-Cheng Li
OBJECTIVES: The global prevalence of hepatitis C virus (HCV) is approximately 2%-3%, and the prevalence of the positive anti-HCV antibody has been increasing. Several studies have evaluated regional adipose tissue distribution and metabolism over the past decades. However, no study has focused on the gender difference in visceral obesity among patients with HCV infection. DESIGN: Retrospective cross-sectional study. SETTING: We reviewed the medical records of patients who visited a hospital in Southern Taiwan for health check-up from 2013 to 2015...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132475/relation-of-muscle-indices-with-metabolic-parameters-and-c-peptide-in-type-2-diabetes-mellitus
#18
Sabah Tuzun, Can Oner, M Resat Dabak, Halim Omer Kasikci, Mehmet Sargin
OBJECTIVE: To assess the relation between bioimpedance measurements and metabolic parameters and C-peptide in patient with type 2 diabetes mellitus (DM). STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Kartal Dr Lutfi Kirdar Training and Research Hospital, Pendik Kaynarca Diabetes Center, Exercise and Metabolism Unit, between January and March 2015. METHODOLOGY: Patients with DM, aged less than 65 years, were assessed for bioimpedance analysis, fasting plasma glucose (FPG), HbA1c, C-peptide levels, triglyceride levels, LDL-cholesterol, and HDL-cholesterol levels...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29130725/-eighth-jes%C3%A3%C2%BAs-culebras-lecture-critical-care-nutrition-and-hyperglycemia-a-close-relationship
#19
Alfonso Mesejo
Critically ill patients show a metabolic response to injury that affects carbohydrate metabolism, causing hyperglycemia and an increase in glycemic variability that makes the critically ill patient susceptible to infection, resulting in morbidity and mortality increase. Also, severe hypoglycemia was detected as a consequence of intensive insulin treatment that provokes deleterious effects in their clinical evolution, so a correct monitoring of plasma glucose would contribute to reduce morbidity and mortality...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29130716/-effect-of-quinua-chenopodium-quinoa-consumption-as-a-coadjuvant-in-nutritional-intervention-in-prediabetic-subjects
#20
María Salud Abellán Ruiz, María Dolores Barnuevo Espinosa, Carlos García Santamaría, Carlos Javier Contreras Fernández, Miriam Aldeguer García, Fulgencio Soto Méndez, Isabel Guillén Guillén, Antonio Jesús Luque Rubia, Francisco Javier Quinde Ràzuri, Antonio Martínez Garrido, Francisco Javier López Román
INTRODUCTION: Quinoa is a pseudocereal containing low glycemic index carbohydrates, dietary fiber, high biological value protein, phytosterols, and n-3 and n-6 fatty acids, which has generated interest in prediabetes nutritional interventions. This randomized (2:1), placebo-controlled, double-blind study evaluated the effects of processed quinoa on body mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and the satiation and fullness (complete) degree in prediabetic patients...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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