keyword
https://read.qxmd.com/read/35710974/are-h1-and-h3-haplotypes-of-endothelial-protein-c-receptor-procr-an-important-factor-in-contracting-covid-19
#21
JOURNAL ARTICLE
Mehmet Reşat Ceylan, Nazım Kankılıç, Özlem Öz
OBJECTIVE: The development of cardiovascular disease shows increase after contracting COVID-19 disease and myocardial damage is observed in patients who have had the disease severely. The relationship between genetic cardiovascular risk factors with COVID-19 infection was investigated in our study. METHOD: 135 patients, 27 of whom were COVID-19 (-) and 108 were COVID-19 (+) patients, were included in the study. Patients were divided into three groups [(COVID-19 (-), COVID-19 (+) Asymptomatic and COVID-19 (+) Symptomatic + Patients with pulmonary involvement)]...
June 16, 2022: Journal of Medical Virology
https://read.qxmd.com/read/35587592/embryonic-vascular-establishment-requires-protein-c-receptor-expressing-endothelial-progenitors
#22
JOURNAL ARTICLE
Qing Cissy Yu, Lanyue Bai, Yingying Chen, Yujie Chen, Guangdun Peng, Daisong Wang, Guowei Yang, Guizhong Cui, Naihe Jing, Yi Arial Zeng
Vascular establishment is one of the early events in embryogenesis. It is believed that vessel-initiating endothelial progenitors cluster to form the first primitive vessel. Understanding the molecular identity of these progenitors is crucial in order to elucidate lineage hierarchy. In this study, we identify protein C receptor (Procr) as an endothelial progenitor marker and investigate the role of Procr+ progenitors during embryonic vascular development. Using a ProcrmGFP-2A-lacZ reporter, we reveal a much earlier Procr expression (embryonic day 7...
June 15, 2022: Development
https://read.qxmd.com/read/35463956/development-and-validation-of-novel-prognostic-models-for-immune-related-genes-in-osteosarcoma
#23
JOURNAL ARTICLE
Junqing Li, Li Su, Xing Xiao, Feiran Wu, Guijuan Du, Xinjun Guo, Fanguo Kong, Jie Yao, Huimin Zhu
Immunotherapy has shown excellent therapeutic effects on various malignant tumors; however, to date, immunotherapy for osteosarcoma is still suboptimal. In this study, we performed comprehensive bioinformatic analysis of immune-related genes (IRGs) and tumor-infiltrating immune cells (TIICs). Datasets of differentially expressed IRGs were extracted from the GEO database (GSE16088). The functions and prognostic values of these differentially expressed IRGs were systematically investigated using a series of bioinformatics methods...
2022: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/35396545/isolation-of-mouse-pancreatic-islet-procr-progenitors-and-long-term-expansion-of-islet-organoids-in-vitro
#24
REVIEW
Jingqiang Wang, Daisong Wang, Xinyi Chen, Shubo Yuan, Lanyue Bai, Chunye Liu, Yi Arial Zeng
Insulin production is required for glucose homeostasis. Pancreatic islet β cells are the only cells that produce insulin in humans; however, generation of functional β cells in vitro from embryonic or adult tissues has been challenging. Here, we describe isolation of pancreatic islet progenitors from adult mice, which enables the efficient generation and long-term expansion of functional islet organoids in vitro. This protocol starts with purification of protein C receptor (Procr)-expressing islet progenitors...
May 2022: Nature Protocols
https://read.qxmd.com/read/35388009/publisher-correction-elucidating-mechanisms-of-genetic-cross-disease-associations-at-the-procr-vascular-disease-locus
#25
David Stacey, Lingyan Chen, Paulina J Stanczyk, Joanna M M Howson, Amy M Mason, Stephen Burgess, Stephen MacDonald, Jonathan Langdown, Harriett McKinney, Kate Downes, Neda Farahi, James E Peters, Saonli Basu, James S Pankow, Weihong Tang, Nathan Pankratz, Maria Sabater-Lleal, Paul S de Vries, Nicholas L Smith, Amy D Gelinas, Daniel J Schneider, Nebojsa Janjic, Nilesh J Samani, Shu Ye, Charlotte Summers, Edwin R Chilvers, John Danesh, Dirk S Paul
No abstract text is available yet for this article.
April 6, 2022: Nature Communications
https://read.qxmd.com/read/35320720/procr-functions-as-a-signaling-receptor-and-is-essential-for-the-maintenance-and-self-renewal-of-mammary-stem-cells
#26
JOURNAL ARTICLE
Chunye Liu, Changdong Lin, Daisong Wang, Jingqiang Wang, Yu Tao, Yue Li, Xinyi Chen, Lanyue Bai, Yingying Jia, Jianfeng Chen, Yi Arial Zeng
The protein C receptor (Procr) has been implicated as a stem cell surface marker in several tissues. It is unknown whether Procr acts as a functional signaling receptor in stem cells. Here, by conditional knockout in mammary stem cells (MaSCs), we demonstrate that Procr is essential for mammary gland development and homeostasis. Through proteomics profiling, we identify that, upon stimulation by the ligand protein C, Procr interacts with heat shock protein 90 (HSP90AA1) via its short cytoplasmic tail, recruiting Src and IGF1R to the complex at the plasma membrane...
March 22, 2022: Cell Reports
https://read.qxmd.com/read/35141024/analyzing-large-scale-gene-expression-data-in-colorectal-cancer-reveals-important-clues-clca1-and-selenbp1-downregulated-in-crc-not-in-normal-and-not-in-adenoma
#27
JOURNAL ARTICLE
Fariborz Asghari Alashti, Bahram Goliaei, Zarrin Minuchehr
Early detection of colorectal cancer (CRC) increases the chances of survival and reduces the therapeutic problems and costs of treatment. Since molecular biomarkers can help us diagnose colorectal cancer early, we need to identify novel gene for predicting the early stages of tumorigenesis. Here, we integrated five independent CRC gene expression datasets derived from expression profiling by array comparing CRC with normal samples in: GSE21510, GSE4107, GSE25071, GSE15781 dataset, and GSE8671 dataset, including 64 samples from 32 patients comparing 32 colonic normal mucosa with 32 colorectal adenoma...
2022: American Journal of Cancer Research
https://read.qxmd.com/read/35021256/thrombotic-risk-determined-by-protein-c-receptor-procr-variants-among-middle-aged-and-older-adults-a-population-based-cohort-study
#28
JOURNAL ARTICLE
Eric Manderstedt, Christer Halldén, Christina Lind-Halldén, Johan Elf, Peter J Svensson, Gunnar Engström, Olle Melander, Aris Baras, Luca A Lotta, Bengt Zöller
BACKGROUND:  The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor ( PROCR ) was associated with venous thromboembolism (VTE) in genome-wide association studies. OBJECTIVES:  This study aimed to determine the thrombotic risk of rare and common PROCR variants in a large population-based cohort of middle-aged and older adults. METHODS:  The exonic sequence of PROCR was analyzed for the Ser219Gly variant and other qualifying variants in 28,794 subjects (born 1923-1950, 60% women) without previous VTE, who participated in the Malmö Diet and Cancer study (1991-1996)...
August 2022: Thrombosis and Haemostasis
https://read.qxmd.com/read/35018451/inflammatory-bowel-disease-risk-variants-are-associated-with-an-increased-risk-of-skin-cancer
#29
JOURNAL ARTICLE
Kelly C Cushing, Xiaomeng Du, Yanhua Chen, L C Stetson, Annapurna Kuppa, Vincent L Chen, J Michelle Kahlenberg, Johann E Gudjonsson, Brett Vanderwerff, Peter D R Higgins, Elizabeth K Speliotes
BACKGROUND: Inflammatory bowel disease is associated with an increased risk of skin cancer. The aims of this study were to determine whether IBD susceptibility variants are also associated with skin cancer susceptibility and if such risk is augmented by use of immune-suppressive therapy. METHODS: The discovery cohort included participants in the UK Biobank. The validation cohort included participants in the Michigan Genomics Initiative. The primary outcome of interest was skin cancer, subgrouped into nonmelanoma skin cancers (NMSC) and melanoma skin cancers (MSC)...
January 8, 2022: Inflammatory Bowel Diseases
https://read.qxmd.com/read/34805179/programmed-cell-death-ligand-1-is-enriched-in-mammary-stem-cells-and-promotes-mammary-development-and-regeneration
#30
JOURNAL ARTICLE
Ruirui Wang, Fujing Huang, Wei Wei, Yu Zhou, Zi Ye, Liya Yu, Junyuan Hu, Cheguo Cai
Programmed cell death ligand 1 (PD-L1) is widely expressed in a variety of human tumors, and inhibition of the PD-L1/PD-1 pathway represents one of the most promising therapy for many types of cancer. However, the physiological function of PD-L1 in tissue development is still unclear, although PD-L1 mRNA is abundant in many tissues. To address this puzzle, we investigated the function of PD-L1 in mammary gland development. Interestingly, we found that PD-L1 is enriched in protein C receptor (Procr)-expressing mammary stem cells (MaSCs), and PD-L1-expressing mammary basal cells (PD-L1+ basal cells) exhibit robust mammary regeneration capacity in transplantation assay...
2021: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/34551372/snp-prioritization-in-targeted-sequencing-data-associated-with-humoral-immune-responses-in-chicken
#31
JOURNAL ARTICLE
Tomasz Suchocki, Bartosz Czech, Aleksandra Dunislawska, Anna Slawinska, Natalia Derebecka, Joanna Wesoly, Maria Siwek, Joanna Szyda
Our study aimed to identify single nucleotide polymorphisms (SNPs) with a significant impact on the innate immunity represented by antibody response against lipopolysaccharide (LPS) and lipoteichoid acid (LTA) and the adaptive immune response represented toward keyhole limpet hemocyanin (KLH) using the SNP prioritization method. Data set consisted of 288 F2 experimental individuals, created by crossing Green-legged Partridgelike and White Leghorn. The analyzed SNPs were located within 24 short genomic regions of GGA1, GGA2, GGA3, GGA4, GGA9, GGA10, GGA14, GGA18, and GGZ, pre-targeted based on literature references and database information...
August 19, 2021: Poultry Science
https://read.qxmd.com/read/34544533/trojan-like-peptide-drug-conjugate-design-and-construction-for-application-in-treatment-of-triple-negative-breast-cancer
#32
JOURNAL ARTICLE
Chuanguang Xiao, Jieru Han, Jixiang Bai, Yanjie Xia, Shuhui Wang
Clinical treatment of triple negative breast cancer (TNBC) is very poor for lack of effective treatment combination selection. Protein C receptor (PROCR) is a novel cancer stem marker in TNBC patients tumor tissues. Developed based on peptide BP10 with affinity to PROCR as a targeting element, constructing a peptide drug conjugate of BP10 covalently coupling doxorubicin with disulfide bonds. This study demonstrated that the constructed BP10-DOX can selectively target Triplenegative breast cancer cells expressing PROCR and controlled release of DOX in response to the GSH environment...
August 1, 2021: Journal of Biomedical Nanotechnology
https://read.qxmd.com/read/34537302/snai1-mediated-transcriptional-regulation-of-epithelial-to-mesenchymal-transition-genes-in-breast-cancer-stem-cells
#33
JOURNAL ARTICLE
Digvijay Singh, Rohit K Deshmukh, Amitava Das
BACKGROUND: Triple-negative breast cancer (TNBC) tumors are composed of a heterogeneous population containing both cancer cells and cancer stem cells (CSCs). These CSCs are generated through an epithelial-to-mesenchymal transition (EMT), thus making it pertinent to identify the unique EMT-molecular targets that regulate this phenomenon. METHODS AND RESULTS: In the present study, we performed in silico analysis of microarray data from luminal, Her2+ , and TNBC cell lines and identified 15 relatively unexplored EMT-related differentially expressed genes (DEGs) along with the markedly high expression of EMT-transcription factor (EMT-TF), SNAI1...
November 2021: Cellular Signalling
https://read.qxmd.com/read/34523383/the-potential-of-pancreatic-organoids-for-diabetes-research-and-therapy
#34
REVIEW
Katerina Bittenglova, David Habart, Frantisek Saudek, Tomas Koblas
The success of clinical transplantation of pancreas or isolated pancreatic islets supports the concept of cell-based cure for diabetes. One limitation is the shortage of cadaver human pancreata. The demand-supply gap could potentially be bridged by harnessing the self-renewal capacity of stem cells. Pluripotent stem cells and adult pancreatic stem cells have been explored as possible cell sources. Recently, a system for long-term culture of proposed adult pancreatic stem cells in a form of organoids was developed...
September 3, 2021: Islets
https://read.qxmd.com/read/34432915/intratumoural-heterogeneity-and-clone-evolution-of-oral-squamous-cell-carcinoma
#35
JOURNAL ARTICLE
Lin Wang, Xinmiao Wang, Yulin Jia, Fengyuan Guo, Shang Zhengjun, Zhe Shao
Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy. Our study uses multipoint materials to explore the heterogeneity and metastasis mechanism of OSCC to find more accurate molecular markers and new therapeutic targets. By using whole-exome capture and sequencing and tumor evolution analysis, we found that most clone-driven mutations were located in the branches of tumor phylogenetic tree, such as COTL1, CASP8, and PROCR. Most clone-driven OSCC mutations occur mainly in tumor suppressor genes, including TP53, SFRP4, and NOTCH1...
August 25, 2021: Molecular Carcinogenesis
https://read.qxmd.com/read/34400611/spatially-defined-single-cell-transcriptional-profiling-characterizes-diverse-chondrocyte-subtypes-and-nucleus-pulposus-progenitors-in-human-intervertebral-discs
#36
JOURNAL ARTICLE
Yibo Gan, Jian He, Jun Zhu, Zhengyang Xu, Zhong Wang, Jing Yan, Ou Hu, Zhijie Bai, Lin Chen, Yangli Xie, Min Jin, Shuo Huang, Bing Liu, Peng Liu
A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) remains challenging. Here, the transcriptomic landscape of 108 108 IVD cells was mapped using single-cell RNA sequencing of three main compartments from young and adult healthy IVDs, including the nucleus pulposus (NP), annulus fibrosus, and cartilage endplate (CEP). The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis...
August 16, 2021: Bone Research
https://read.qxmd.com/read/34320033/integrated-microrna-and-mrna-signatures-associated-with-overall-survival-in-epithelial-ovarian-cancer
#37
JOURNAL ARTICLE
Joanna Lopacinska-Jørgensen, Douglas V N P Oliveira, Guy Wayne Novotny, Claus K Høgdall, Estrid V Høgdall
Ovarian cancer (OC), the eighth-leading cause of cancer-related death among females worldwide, is mainly represented by epithelial OC (EOC) that can be further subdivided into four subtypes: serous (75%), endometrioid (10%), clear cell (10%), and mucinous (3%). Major reasons for high mortality are the poor biological understanding of the OC mechanisms and a lack of reliable markers defining each EOC subtype. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression primarily by targeting messenger RNA (mRNA) transcripts...
2021: PloS One
https://read.qxmd.com/read/34281556/lentiviral-crispr-guided-rna-library-screening-identified-adam17-as-an-upstream-negative-regulator-of-procr-in-mammary-epithelium
#38
JOURNAL ARTICLE
Ting Wu, Yinghua Wang, Tianxiong Xiao, Yirui Ai, Jinsong Li, Yi Arial Zeng, Qing Cissy Yu
BACKGROUND: Protein C receptor (Procr) has recently been shown to mark resident adult stem cells in the mammary gland, vascular system, and pancreatic islets. More so, high Procr expression was also detected and used as indicator for subsets of triple-negative breast cancers (TNBCs). Previous study has revealed Procr as a target of Wnt/β-catenin signaling; however, direct upstream regulatory mechanism of Procr remains unknown. To comprehend the molecular role of Procr during physiology and pathology, elucidating the upstream effectors of Procr is necessary...
July 19, 2021: BMC Biotechnology
https://read.qxmd.com/read/34208790/proteomics-analysis-reveals-diverse-molecular-characteristics-between-endocardial-and-aortic-valvular-endothelium
#39
JOURNAL ARTICLE
A Aneesh Kumar, G S Ajith Kumar, Gopika Satheesh, Arun Surendran, Mahesh Chandran, Chandrasekharan C Kartha, Abdul Jaleel
The variations in the protein profile of aortic-valvular (AVE) and endocardial endothelial (EE) cells are currently unknown. The current study's objective is to identify differentially expressed proteins and associated pathways in both the endothelial cells. We used endothelial cells isolated from the porcine ( Sus scrofa ) aortic valve and endocardium for the profiling of proteins. Label-free proteomics was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Our proteomics analysis revealed that 29 proteins were highly expressed, and 25 proteins were less expressed in the valve than the endocardial endothelium...
June 30, 2021: Genes
https://read.qxmd.com/read/33965878/infliximab-modifies-regulatory-t-cells-and-co-inhibitory-receptor-expression-on-circulating-t-cells-in-psoriasis
#40
JOURNAL ARTICLE
Yingyuan Yu, Zeyu Chen, Yu Wang, Ying Li, Jiajing Lu, Lian Cui, Zengyang Yu, Yangfeng Ding, Chunyuan Guo, Xilin Zhang, Yuling Shi
BACKGROUND: Psoriasis is a T cell-mediated autoimmune skin disease. Accumulating evidence has demonstrated that co-inhibitory receptors (CIRs) play a vital role in regulating T cell-mediated immune response, especially in neoplasm and autoimmunity. However, the immuno-function of CIRs in the development of psoriasis remains unclear. OBJECTIVE: We investigated the expression of CIRs on the circulating T lymphocytes of psoriasis patients before and after anti-tumor necrosis factor-α (TNF-α) therapy...
July 2021: International Immunopharmacology
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