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https://www.readbyqxmd.com/read/28273701/-analysis-of-clinical-characteristics-and-factors-associated-with-short-term-outcomes-in-early-term-neonates
#1
S S Long, Q X Tang, B X Huang, B Y Lin, L S Wang
Objective: To investigate the clinical characteristics of early term and full term neonates, and analyze the risk factors associated with short term outcomes in early term neonates. Method: Neonates with birth weight (BW) ≥2 500 g from year 2013 were analyzed retrospectively based on American Congress of Obstericians & Gynecologists (ACOG) latest definition of term infants. According to inclusion and exclusion criteria, early term (gestational age 37-38 weeks) and full term(gestational age 39-40 weeks) neonates were included, whose morbidity constituent proportion was analyzed by χ(2) test or Fisher accuracy test or t test or Wilcoxon test...
March 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28212478/-risk-factors-related-with-ventilator-associated-pneumonia-in-a-neonatal-intensive-care-therapy
#2
Juan Pablo Romo-Gamboa, Bertha Alicia Sandoval-Pérez, Ana Bertha Rodríguez-López, Marco Antonio Torres-González, Juan Carlos Barrera-de León
BACKGROUND: Ventilator-associated pneumonia (VAP) represents the second cause of nosocomial infections and it is associated with greater morbility, duration of mechanical ventilation (MV), and hospital stay. The objective was to determine factors related with VAP in neonates. METHODS: Analytical transversal study including newborns admitted already intubated with at least 48 hours of MV or who were intubated in Neonatal Therapy. VAP was defined according to the criteria of the Centers for Disease Control and Prevention: "those patients submitted to MV during at least 48 hours"...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28124966/-a-case-of-bronchiolitis-obliterans-secondary-to-human-metapneumovirus-bronchiolitis
#3
Osman Yeşilbaş, Esra Şevketoğlu, Hasan Serdar Kıhtır, Mey Talip Petmezci, Elif Bato, Seda Balkaya, Nevin Hatipoğlu, Mert Ahmet Kuşkucu, Figen Palabıyık, Erkan Çakır
Human metapneumovirus (hMPV), formerly classified in Paramyxoviridae family is now moved into Pneumoviridae, which was described as a novel family. It causes upper and lower respiratory tract infections (LRTIs) usually in children younger than five years old. The recent epidemiological studies indicated that hMPV is the second most frequently detected virus in LRTIs of young children, following the respiratory syncytial virus (RSV). Bronchiolitis obliterans (BO) is a chronic obstructive lung disease characterized by fibrosis of the distal respiratory airways...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28040456/exhaled-breath-condensate-analysis-from-intubated-newborns-by-nano-hplc-coupled-to-high-resolution-ms
#4
A S Kononikhin, N L Starodubtseva, V V Chagovets, A Y Ryndin, A A Burov, I A Popov, A E Bugrova, R A Dautov, A O Tokareva, Y L Podurovskaya, O V Ionov, V E Frankevich, E N Nikolaev, G T Sukhikh
Invasiveness of examination and therapy methods is a serious problem for intensive care and nursing of premature infants. Exhaled breath condensate (EBC) is the most attractive biofluid for non-invasive methods development in neonatology for monitoring the status of intubated infants. The aim of the study was to propose an approach for EBC sampling and analysis from mechanically ventilated neonates. EBC collection system with good reproducibility of sampling was demonstrated. Discovery-based proteomic and metabolomic studies were performed using nano-HPLC coupled to high resolution MS...
March 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27779696/microfloral-diversity-in-the-lower-respiratory-tracts-of-neonates-with-bacterial-infectious-pneumonia-combined-with-ventilator%C3%A2-associated-pneumonia
#5
Wei Lu, Jia-Lin Yu, Lu-Quan Li, Qi Lu, Zheng-Li Wang, Yun Pan
Bacterial infectious pneumonia is one of the major causes of mortality in neonates, particularly when the neonates suffer from ventilator‑associated pneumonia (VAP). However, the causes of pneumonia are difficult to define. Thus, the present study focused on understanding the diversity of microflora in the lower respiratory tract to elucidate the causes. The experimental groups comprised newborns who suffered from infectious pneumonia with or without VAP (IVAP and IP groups, respectively), whereas the control group comprised newborns who suffered from respiratory distress syndrome (RDS) without VAP (RDS group)...
December 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27264244/most-international-guidelines-on-prevention-of-healthcare-associated-infection-lack-comprehensive-recommendations-for-neonates-and-children
#6
A R Araujo da Silva, W Zingg, A Dramowski, J A Bielicki, M Sharland
International infection prevention and control (IPC) guidelines provide standardized recommendations for healthcare-associated infection (HCAI) prevention in adults, but often lack specific information about neonates and children. We reviewed ten international IPC/HCAI guidelines to identify paediatric-specific recommendations for HCAI prevention. Hand hygiene, bloodstream infection, ventilator-associated pneumonia, environmental control and outbreak management were frequently reported with recommendations applicable to children and newborns, but documents on catheter-associated urinary tract infection and surgical site infection were lacking...
October 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27220313/lung-ultrasound-as-a-predictor-of-mechanical-ventilation-in-neonates-older-than-32-weeks
#7
Javier Rodríguez-Fanjul, Carla Balcells, Victoria Aldecoa-Bilbao, Julio Moreno, Martín Iriondo
BACKGROUND: The prognosis of neonatal respiratory distress may be difficult to estimate at admission. Lung ultrasound is a useful diagnostic tool that is quick, requires little training, and is radiation free. OBJECTIVE: This study aims to analyze whether early lung ultrasound can predict respiratory failure. METHODS: From January to December 2014, lung ultrasound was performed on neonates admitted with breathing difficulties if they were older than 32 weeks and not intubated...
2016: Neonatology
https://www.readbyqxmd.com/read/27167667/use-of-normothermic-default-humidifier-settings-causes-excessive-humidification-of-respiratory-gases-during-therapeutic-hypothermia
#8
Shoichiro Tanaka, Sachiko Iwata, Masahiro Kinoshita, Kennosuke Tsuda, Sayaka Sakai, Mamoru Saikusa, Ryota Shindo, Eimei Harada, Junichiro Okada, Tadashi Hisano, Hiroshi Kanda, Yasuki Maeno, Yuko Araki, Kazuo Ushijima, Teruo Sakamoto, Yushiro Yamashita, Osuke Iwata
Adult patients frequently suffer from serious respiratory complications during therapeutic hypothermia. During therapeutic hypothermia, respiratory gases are humidified close to saturated vapor at 37°C (44 mg/L) despite that saturated vapor reduces considerably depending on temperature reduction. Condensation may cause serious adverse events, such as bronchial edema, mucosal dysfunction, and ventilator-associated pneumonia during cooling. To determine clinical variables associated with inadequate humidification of respiratory gases during cooling, humidity of inspiratory gases was measured in 42 cumulative newborn infants who underwent therapeutic hypothermia...
December 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27077625/kidney-injury-owing-to-streptococcus-pneumoniae-infection-in-critically-ill-infants-and-children-report-of-four-cases
#9
M Piastra, A Tempera, E Luca, E Buffone, C Cafforio, V Briganti, O Genovese, M Marano, D Rigante
Streptococcus pneumoniae sepsis has high morbidity, particularly if complicated by renal injury. Four patients with S. pneumonia invasive infections complicated by renal disorders are presented. The first case was an 18-month-old girl with pneumococcal empyema complicated by haemolytic uraemic (HUS) syndrome. She made a full recovery after mechanical ventilation, inotropic support and haemodiafiltration. The second was a 4-year-old boy who presented with acute post-infectious glomerulonephritis associated with bilateral pneumococcal pneumonia...
January 29, 2016: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/26954659/do-gestational-age-dating-criteria-matter-in-medically-indicated-late-preterm-early-term-and-full-term-inductions-of-labor
#10
Kristen Kelley, Kristen O'Dillon Goerg, Jessica Rhinehart-Ventura, Catherine Eppes, Haleh Sangi-Haghpeykar, Christina Davidson
OBJECTIVES: To assess short-term neonatal respiratory morbidity from inductions of labor (IOL) in well-dated (WD) pregnancies (dating ultrasound [US] <20 0/7 weeks) versus non-well-dated (NWD) pregnancies when applying National Institutes of Health/Society for Maternal-Fetal Medicine/American College of Obstetricians and Gynecologists delivery recommendations at ≥34 0/7 weeks. METHODS: Ours was a 1-year retrospective cohort of women with medically indicated IOL between 34 0/7 and 40 6/7 weeks with a live, cephalic, singleton gestation and no lethal anomaly...
March 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/26903968/autoinducer-2-of-streptococcus-mitis-as-a-target-molecule-to-inhibit-pathogenic-multi-species-biofilm-formation-in-vitro-and-in-an-endotracheal-intubation-rat-model
#11
Zhengli Wang, Qingqing Xiang, Ting Yang, Luquan Li, Jingli Yang, Hongong Li, Yu He, Yunhui Zhang, Qi Lu, Jialin Yu
Streptococcus mitis (S. mitis) and Pseudomonas aeruginosa (P. aeruginosa) are typically found in the upper respiratory tract of infants. We previously found that P. aeruginosa and S. mitis were two of the most common bacteria in biofilms on newborns' endotracheal tubes (ETTs) and in their sputa and that S. mitis was able to produce autoinducer-2 (AI-2), whereas P. aeruginosa was not. Recently, we also found that exogenous AI-2 and S. mitis could influence the behaviors of P. aeruginosa. We hypothesized that S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26875468/-clinical-features-and-antibiotic-resistance-of-escherichia-coli-bloodstream-infections-in-children
#12
Shaoying Li, Lingyun Guo, Linlin Liu, Fang Dong, Gang Liu
OBJECTIVE: To analyze risk factors, clinical features, outcomes and antibiotic resistance of Escherichia coli(E.coli) causing bloodstream infections in children. METHOD: All inpatients with E. coli positive blood culture in Beijing Children's Hospital from January 2012 to May 2014 were enrolled; 112 cases were included, 66 cases (58.9%) were male, and 46 cases(41.1%) were female. Age range was 2 days to 16 years. Among them, 43 cases (38.4%) were neonates, 19 cases (17...
February 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/26781404/-efficacy-of-volume-targeted-ventilation-for-the-treatment-of-neonatal-respiratory-distress-syndrome
#13
RANDOMIZED CONTROLLED TRIAL
Chen-Zhou Liu, Bi-Yin Huang, Bao-Ying Tan, Hao-Feng Guan, Xiao-Hui Xu, Qing-Yun Guo
OBJECTIVE: To investigate the efficacy of volume-targeted ventilation (VTV) for the treatment of neonatal respiratory distress syndrome (NRDS). METHODS: Fifty-two neonates with NRDS between August 2013 and August 2015 were randomly divided into two groups: VTV and pressure-controlled ventilation (PCV) (n=26 each ). A/C+Vc+ ventilation model was applied in the VTV group, and A/C+PCV ventilation model was applied in the PCV group. Arterial blood gas analysis was performed at 6, 24, and 48 hours after ventilation...
January 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/26760414/newborn-respiratory-distress
#14
Christian L Hermansen, Anand Mahajan
Newborn respiratory distress presents a diagnostic and management challenge. Newborns with respiratory distress commonly exhibit tachypnea with a respiratory rate of more than 60 respirations per minute. They may present with grunting, retractions, nasal flaring, and cyanosis. Common causes include transient tachypnea of the newborn, respiratory distress syndrome, meconium aspiration syndrome, pneumonia, sepsis, pneumothorax, persistent pulmonary hypertension of the newborn, and delayed transition. Congenital heart defects, airway malformations, and inborn errors of metabolism are less common etiologies...
December 1, 2015: American Family Physician
https://www.readbyqxmd.com/read/26625231/-nasal-highflow-treatment-option-in-severe-hypoxaemia
#15
REVIEW
Jens Bräunlich, Hubert Wirtz
Nasal High Flow (NHF) provides a warmed and humidified air stream. In pediatrics, this method is already in widespread use and is increasingly replacing the CPAP. New studies show success in treating adults. Currently the acute hypoxemic insufficiency cause of pneumoniae is a secured area of use. NHF is not inferior in comparison to other oxygen delivery systems. At this juncture effectiveness of this easy to use method is not clear. Preliminary reports describe an improvement in ventilation by the NHF. Here, a wash-out of the airways and improved alveolar ventilation seem to be the main operating principles...
December 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/26539945/association-of-systemic-inflammatory-response-syndrome-with-clinical-outcomes-of-pediatric-patients-with-pneumonia
#16
COMPARATIVE STUDY
Steven Barron Frazier, Robert Sepanski, Christopher Mangum, Christine Bovat, Arno Zaritsky, Sandip Godambe
OBJECTIVES: Systemic inflammatory response syndrome (SIRS) may complicate pneumonia. When present, it suggests that the patient's pneumonia is more severe. As such, recognition of SIRS among patients with pneumonia may be helpful in identifying those requiring more careful evaluation. Our objective was to examine the relation between the presence of SIRS and adverse clinical outcomes among children with pneumonia seen in the emergency department (ED). METHODS: A retrospective chart review was performed on children diagnosed as having community-acquired pneumonia who presented to a children's hospital ED during a 3-month period...
November 2015: Southern Medical Journal
https://www.readbyqxmd.com/read/26524811/incidence-and-factors-associated-with-nosocomial-infections-in-a-neonatal-intensive-care-unit-nicu-of-an-urban-children-s-hospital-in-china
#17
Y Yuan, W Zhou, X Rong, W N Lu, Z Zhang
OBJECTIVE: The study's aim was to assess incidence and epidemiologic profile of nosocomial infection (NI) in a NICU of China, and to identify main risk factors of NIs. MATERIALS AND METHODS: Chi square test for discrete variables and independent t-test for continuous variables to examine the association with NI. Univariate regression model was applied to the variables to predict the NI status. Finally the multivariate model was utilized with stepwise methods included all variables in the univariate model to extrapolate the independent variables to NI...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26509301/-ventilator-associated-pneumonia-in-a-neonatal-intensive-care-unit
#18
Dassaev Izelo-Flores, Fortino Solórzano-Santos, María Guadalupe Miranda-Novales
BACKGROUND: The studies that describe risk factors for the development of ventilator-associated pneumonia (VAP) in newborn infants report dissimilar information, possibly related to the type of intensive care unit and population included. The objective of this study was to identify risk factors for the development of VAP in a neonatal intensive-care unit. METHODS: Case-control study. Patients with the diagnosis of VAP were classified as cases and compared with two controls of the same gestational age, weight, and diagnosis at admission...
2015: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/26379907/molecular-analysis-of-biofilms-on-the-surface-of-neonatal-endotracheal-tubes-based-on-16s-rrna-pcr-dgge-and-species-specific-pcr
#19
Hongdong Li, Chao Song, Dong Liu, Qing Ai, Jialin Yu
Ventilator-associated pneumonia (VAP) results in considerable morbidity and mortality in neonatal intensive care units. VAP is associated with polymicrobial biofilms that form on endotracheal tubes (ETTs). We aimed to evaluate the diversity and the bacterial community in biofilms on ETTs extubated from mechanically ventilated newborns. ETTs (N = 29) and aerobic sputum cultures were obtained from 20 mechanically ventilated newborns. Denaturing gradient gel electrophoresis (DGGE) was used to characterize the bacterial species in the biofilms on the ETTs...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26365297/kidney-injury-owing-to-streptococcus-pneumoniae-infection-in-critically-ill-infants-and-children-report-of-four-cases
#20
M Piastra, A Tempera, E Luca, E Buffone, C Cafforio, V Briganti, O Genovese, M Marano, D Rigante
Streptococcus pneumoniae sepsis has high morbidity, particularly if complicated by renal injury. Four patients with S. pneumonia invasive infections complicated by renal disorders are presented. The first case was an 18-month-old girl with pneumococcal empyema complicated by haemolytic uraemic (HUS) syndrome. She made a full recovery after mechanical ventilation, inotropic support and haemodiafiltration. The second was a 4-year-old boy who presented with acute post-infectious glomerulonephritis associated with bilateral pneumococcal pneumonia...
November 2016: Paediatrics and International Child Health
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