Sudhin Thayyil, Stuti Pant, Paolo Montaldo, Deepika Shukla, Vania Oliveira, Phoebe Ivain, Paul Bassett, Ravi Swamy, Josephine Mendoza, Maria Moreno-Morales, Peter J Lally, Naveen Benakappa, Prathik Bandiya, Indramma Shivarudhrappa, Jagadish Somanna, Usha B Kantharajanna, Ankur Rajvanshi, Sowmya Krishnappa, Poovathumkal K Joby, Kumutha Jayaraman, Rema Chandramohan, Chinnathambi N Kamalarathnam, Monica Sebastian, Indumathi A Tamilselvam, Usha D Rajendran, Radhakrishnan Soundrarajan, Vignesh Kumar, Harish Sudarsanan, Padmesh Vadakepat, Kavitha Gopalan, Mangalabharathi Sundaram, Arasar Seeralar, Prakash Vinayagam, Mohamed Sajjid, Mythili Baburaj, Kanchana D Murugan, Babu P Sathyanathan, Elumalai S Kumaran, Jayashree Mondkar, Swati Manerkar, Anagha R Joshi, Kapil Dewang, Swapnil M Bhisikar, Pavan Kalamdani, Vrushali Bichkar, Saikat Patra, Kapil Jiwnani, Mohammod Shahidullah, Sadeka C Moni, Ismat Jahan, Mohammad A Mannan, Sanjoy K Dey, Mst N Nahar, Mohammad N Islam, Kamrul H Shabuj, Ranmali Rodrigo, Samanmali Sumanasena, Thilini Abayabandara-Herath, Gayani K Chathurangika, Jithangi Wanigasinghe, Radhika Sujatha, Sobhakumar Saraswathy, Aswathy Rahul, Saritha J Radha, Manoj K Sarojam, Vaisakh Krishnan, Mohandas K Nair, Sahana Devadas, Savitha Chandriah, Harini Venkateswaran, Constance Burgod, Manigandan Chandrasekaran, Gaurav Atreja, Pallavi Muraleedharan, Jethro A Herberg, W K Kling Chong, Neil J Sebire, Ronit Pressler, Siddarth Ramji, Seetha Shankaran
BACKGROUND: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive care reduces death or moderate or severe disability after neonatal encephalopathy in south Asia. METHODS: We did a multicountry open-label, randomised controlled trial in seven tertiary neonatal intensive care units in India, Sri Lanka, and Bangladesh...
September 2021: Lancet Global Health