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https://www.readbyqxmd.com/read/27852915/levels-of-influence-habituation-and-the-prevalence-of-declared-conflicts-of-interest
#1
REVIEW
Jillian R H Bernstein, George Maliha, Jaimo Ahn, Joseph Bernstein
BACKGROUND: The International Committee of Medical Journal Editors has devised a system of mandatory disclosure, under which authors are required to disclose all conflicts of interest and the sources of support for the submitted research. Because payments from industry to physicians generally are common, it is likely that many authors of medical manuscripts will have information to disclose. As a result, the signal-to-noise ratio of such declarations may be low, thereby undermining the effectiveness of disclosure...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27843677/commentary-on-laminectomy-plus-fusion-versus-laminectomy-alone-for-lumbar-spondylolisthesis-by-ghogawala-z-dziura-j-butler-we-dai-f-terrin-n-magge-sn-et-al-nejm-2016-374-15-1424-34
#2
Nancy E Epstein
BACKGROUND: How does an article involving only 66 patients randomized into two spinal surgical groups get into the New England Journal of Medicine? Nevertheless, this one did. The article by Ghogawala et al. entitled Laminectomy plus fusion versus laminectomy alone for lumbar spondylolisthesis, compared the efficacy/outcomes of pedicle/screw/rod instrumented posterolateral lumbar fusions vs. decompressions alone for treating lumbar stenosis with grade I degenerative spondylolisthesis (DS)...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27754015/br-04-1management-of-treatment-resistant-hypertension
#3
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#4
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27722281/structures-and-spectroscopy-of-protonated-ammonia-clusters-at-different-temperatures
#5
Alhadji Malloum, Jean Jules Fifen, Zoubeida Dhaouadi, Serge Guy Nana Engo, Nejm-Eddine Jaidane
The accurate determination of the solvation energies of a proton in ammonia is based on the precise knowledge of the structures of neutral and protonated ammonia clusters. In this work, we have investigated all the possible and stable structures of protonated ammonia clusters H(+)(NH3)n=2-9, along with their isomeric distribution at a specific temperature. New significant isomers are reported here for the first time and show that the structures of protonated ammonia clusters are not only branched linear as assumed by all previous authors...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27651214/commercial-conflict-of-interest-and-medical-publication-what-should-the-practising-physician-do-about-it
#6
Prem Pais
I read with interest the comment by Mark Wilson, which deals with possible conflict of interest (CoI) affecting publications in academic medical journals. This comment has specifically targeted the New England Journal of Medicine (NEJM) and its editor-in-chief Jeffrey Drazen on the "Vioxx scandal" which broke 15 years ago. Wilson's comment seems to be in response to a blog by Natarajan on CoI in medical publications. In the blog Natarajan writes of commercial CoI biasing publication of clinical trials and cites, among other examples, a publication in the NEJM on trials of voriconazole...
October 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27650288/reporting-and-dealing-with-missing-quality-of-life-data-in-rcts-has-the-picture-changed-in-the-last-decade
#7
REVIEW
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27642926/br-04-1management-of-treatment-resistant-hypertension
#8
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#9
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27637413/reporting-on-data-monitoring-committees-in-neonatal-randomised-controlled-trials-is-inconsistent
#10
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of Data Monitoring Committees (DMCs), the frequency of interim analysis, pre-specified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
September 16, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27608485/conflict-of-interest-and-bias-in-publication
#11
Ruth Macklin
In his excellent article about commercial conflict of interest, Mark Wilson quotes Dennis Thompson, a political scientist who provided a searching analysis of the concept of conflict of interest (Col). Using Thompson's analysis, Wilson writes: "Determining whether factors such as ambition, the pursuit of fame and financial gain had biased a judgment was challenging. Motives are not always clear to either the conflicted party or to an outside observer." In this commentary, I aim to broaden the discussion beyond the narrowly commercial aspects of Col...
October 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27604162/journal-bias-or-author-bias
#12
Ian Harris
I read with interest the comment by Mark Wilson in the Indian Journal of Medical Ethics regarding bias and conflicts of interest in medical journals. Wilson targets one journal (the New England Journal of Medicine: NEJM) and one particular "scandal" to make his point that journals' decisions on publication are biased by commercial conflicts of interest (CoIs). It is interesting that he chooses the NEJM which, by his own admission, had one of the strictest CoI policies and had published widely on this topic...
August 24, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27602672/nejm-org-20-years-on-the-web
#13
EDITORIAL
Edward W Campion, Lisa Scott, Andrea Graham, Jacqueline M Prince, Stephen Morrissey, Jeffrey M Drazen
The digital information revolution is now so well established that it is taken for granted, especially by younger people who have grown up with an e-first orientation. The World Wide Web was invented in 1989 as a system of interlinked documents that could be accessed on the Internet. In the early..
September 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27598112/single-walled-carbon-nanotubes-based-organic-memory-structures
#14
Sundes Fakher, Razan Nejm, Ahmad Ayesh, Amal Al-Ghaferi, Dagou Zeze, Mohammed Mabrook
The electrical behaviour of organic memory structures, based on single-walled carbon-nanotubes (SWCNTs), metal-insulator-semiconductor (MIS) and thin film transistor (TFT) structures, using poly(methyl methacrylate) (PMMA) as the gate dielectric, are reported. The drain and source electrodes were fabricated by evaporating 50 nm gold, and the gate electrode was made from 50 nm-evaporated aluminium on a clean glass substrate. Thin films of SWCNTs, embedded within the insulating layer, were used as the floating gate...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27585671/pioglitazone-is-equally-effective-for-diabetes-prevention-in-older-versus-younger-adults-with-impaired-glucose-tolerance
#15
Sara E Espinoza, Chen-Pin Wang, Devjit Tripathy, Stephen C Clement, Dawn C Schwenke, Mary Ann Banerji, George A Bray, Thomas A Buchanan, Robert R Henry, Abbas E Kitabchi, Sunder Mudaliar, Frankie B Stentz, Peter D Reaven, Ralph A DeFronzo, Nicolas Musi
To determine the efficacy of pioglitazone to prevent type 2 diabetes in older compared to younger adults with pre-diabetes. Six hundred two participants with impaired glucose tolerance (IGT) were randomized in double blind fashion to placebo or pioglitazone for diabetes prevention in the ACT NOW study (NEJM 364:1104-1115, 2011). Cox proportional hazard regression was used to compare time to development of diabetes over a mean of 2 years between older (≥61 years) and younger participants. We compared effects of pioglitazone versus placebo on metabolic profiles, inflammatory markers, adipokines, β cell function (disposition index), insulin sensitivity (Matsuda index), and body composition by ANOVA...
September 1, 2016: Age (2005-)
https://www.readbyqxmd.com/read/27557324/introducing-allergenic-foods-in-infants
#16
LETTER
Giampaolo Ricci, Francesca Cipriani
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27557323/introducing-allergenic-foods-in-infants
#17
LETTER
Katrina Allen, Jennifer Koplin
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27557322/introducing-allergenic-foods-in-infants
#18
LETTER
Michael R Perkin, Gideon Lack
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27470506/reporting-quality-of-randomised-controlled-trial-abstracts-among-high-impact-general-medical-journals-a-review-and-analysis
#19
Meredith Hays, Mary Andrews, Ramey Wilson, David Callender, Patrick G O'Malley, Kevin Douglas
OBJECTIVE: The aim of this study was to assess adherence to the Consolidated Standards of Reporting Trials (CONSORT) for Abstracts by five high-impact general medical journals and to assess whether the quality of reporting was homogeneous across these journals. DESIGN: This is a descriptive, cross-sectional study. SETTING: Randomised controlled trial (RCT) abstracts in five high-impact general medical journals. PARTICIPANTS: We used up to 100 RCT abstracts published between 2011 and 2014 from each of the following journals: The New England Journal of Medicine (NEJM), the Annals of Internal Medicine (Annals IM), The Lancet, the British Medical Journal (The BMJ) and the Journal of the American Medical Association (JAMA)...
July 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/27461619/majority-of-the-most-cited-articles-on-cutaneous-malignant-melanoma-are-published-in-non-dermatology-melanoma-specialized-journals
#20
Faruk Tas
BACKGROUND: The most-cited articles. (MCAs) are likely those that impressed other researchers and had profound influence on clinical practice or future developments in the related scientific field. AIM: This study was conducted to explore a bibliometric approach to assess in where the cutaneous malignant melanoma. (CMM) related MCAs have been published. MATERIALS AND METHODS: We identified journals for publications with the word "melanoma" in the title by using the ISI Web of Knowledge Database between 2000 and 2010...
April 2016: Journal of Cancer Research and Therapeutics
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