Terence M Williams, Eric Miller, Meng Welliver, Jeremy Brownstein, Gregory Otterson, Dwight Owen, Karl Haglund, Peter Shields, Erin Bertino, Carolyn Presley, Kai He, Naduparambil K Jacob, Steve Walston, Jeff Pan, Xiangyu Yang, Michael Knopp, Jean Koutou Essan, Joseph McElroy, Xiaokui Mo, Sohyun McElroy, David Carbone, Jose Bazan
PURPOSE: Primary tumor failure is common in patients treated with chemoradiation (CRT) for locally advanced NSCLC (LA-NSCLC). Stereotactic body radiation therapy (SBRT) yields high rates of primary tumor control (PTC) in early-stage NSCLC. This trial tested an SBRT boost to the primary tumor before the start of CRT to improve PTC. METHODS AND MATERIALS: Patients with LA-NSCLC received an SBRT boost in 2 fractions (central location 12 Gy, peripheral location 16 Gy) to the primary tumor, followed by standard CRT (60 Gy in 30 fractions)...
February 20, 2024: International Journal of Radiation Oncology, Biology, Physics